Review
Biochemistry & Molecular Biology
Kazuo Yamagata, Yukio Yamori
Summary: Isoflavones, mainly found in soybean, are polyphenols with beneficial effects on various chronic diseases as phytoestrogens. Metabolic syndrome increases the risk of death due to arteriosclerosis in individuals with conditions like obesity, hypertension, hyperglycemia, and dyslipidemia. While the health benefits of soy-derived isoflavones are well-known, their effects on metabolic syndrome pathogenesis remain incomplete.
Article
Biochemistry & Molecular Biology
Mohd Farhan, Mohamed El Oirdi, Mohammad Aatif, Insha Nahvi, Ghazala Muteeb, Mir Waqas Alam
Summary: Cancer incidence varies globally, suggesting a correlation between food and cancer risk. Plant polyphenols, specifically isoflavones like genistein and daidzein found in soybeans, have been identified as potential anticancer agents. Epidemiological studies have shown that soy consumption is associated with a decreased risk of certain cancers. Our research demonstrates that isoflavones inhibit prostate cancer cell growth by increasing endogenous copper levels, highlighting the significance of copper dynamics and providing new insights into the potential use of isoflavones as cancer-fighting nutraceuticals.
Article
Food Science & Technology
Dino Grgic, Elisabeth Varga, Barbara Novak, Anneliese Mueller, Doris Marko
Summary: This review summarizes the metabolization of isoflavones in animals and their distribution in tissues, as well as the effects of isoflavones on livestock species. It also discusses the occurrence of isoflavones in feed materials and their co-occurrence with zearalenone.
Review
Microbiology
Fernanda Guilherme do Prado, Maria Giovana Binder Pagnoncelli, Gilberto Vinicius de Melo Pereira, Susan Grace Karp, Carlos Ricardo Soccol
Summary: This article summarizes the key biological characteristics of fermented soy products and their association with the reduction of chronic diseases, as well as their potential anticancer, anti-obesity, antidiabetic, anticholesterol, anti-inflammatory, and neuroprotective effects. The study also discusses the potential of fermented soybean molecules in fighting against SARS-CoV-2.
Review
Biochemistry & Molecular Biology
Maria-Eleni Grafakou, Christina Barda, Ekaterina-Michaela Tomou, Helen Skaltsa
Summary: The genus Genista, with its widespread distribution worldwide, has long been of interest for its medicinal properties, including treating respiratory diseases, rheumatic disorders, and diabetes. It contains over 108 flavonoids, with isoflavones being important secondary metabolites. The extracts of Genista species may have therapeutic effects on inflammation, pain, cancer, and other human ailments.
Article
Agriculture, Dairy & Animal Science
Ludmila Krizova, Zuzana Nemcova, Katerina Dadakova, Maria Chrenkova
Summary: The study aimed to determine the ruminal degradability of dry matter, daidzein, genistein, glycitein, and total isoflavones in ground full-fat soybean and solvent-extracted soybean meal using the in sacco method. The results showed differences in the degradation rates of isoflavones between the two sources, indicating that processing may affect the degradation process in the rumen.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Agronomy
Ji-Seok Lee, Hong-Sig Kim, Tae-Young Hwang
Summary: This study investigated the protein and isoflavone contents of 300 soybean germplasms from different countries, with findings showing variations both in terms of country of origin and size/color. Protein content was highest in soybeans from Korea, while total isoflavone content was highest in soybeans from Japan. Positive correlation was found among daidzein, glycitein, and genistein isoflavone contents, with a low negative correlation between total isoflavone and protein content.
Review
Biochemistry & Molecular Biology
Jurga Bernatoniene, Jurga Andreja Kazlauskaite, Dalia Marija Kopustinskiene
Summary: Isoflavones, plant-derived phytoestrogens with similarities to 17-beta-estradiol, have beneficial effects on degenerative disorders and are considered a natural alternative for treating menopause-related conditions. They may impact inflammation and various chronic degenerative diseases positively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Maria Gemma Albendin, Vanessa Aranda, Alejandro Corrales, Juan Bosco Ortiz-Delgado, Carmen Sarasquete, Juana Maria Arellano
Summary: Genistein and daidzein, isoflavones found in legumes, may be present in wastewater effluents and affect fish in the aquatic environment. This study evaluated the effects of these isoflavones on juveniles of Solea senegalensis and Solea solea and found that they did not inhibit the activity of acetylcholinesterase at the tested concentrations.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Review
Nutrition & Dietetics
Hans van der Eecken, Steven Joniau, Charlien Berghen, Kato Rans, Gert De Meerleer
Summary: The link between diet and cancer is being explored, with a focus on phytochemicals. Soy isoflavones, especially genistein, daidzein and the derivative equol, have been studied for their potential roles in reducing the risk of prostate cancer. Various mechanisms of action at the cellular level have been identified, spanning hormone-mediated pathways, cell cycle regulation, apoptosis, angiogenesis, metastasis, as well as antioxidant and anti-inflammatory effects. This review provides a comprehensive comparison of these mechanisms among the different soy isoflavones.
Article
Nutrition & Dietetics
Sebastian T. Soukup, Ann Katrin Engelbert, Bernhard Watzl, Achim Bub, Sabine E. Kulling
Summary: This study investigated the microbial metabolite profile of soy isoflavones and classified the population into 5 isoflavone metabotypes based on their metabolite profiles. These metabotypes differed significantly in their metabolite composition and estrogenic potency.
Article
Biochemistry & Molecular Biology
Feri Eko Hermanto, Warsito Warsito, Muhaimin Rifa'i, Nashi Widodo
Summary: This study reveals the mechanism of the cholesterol-lowering effect of soy isoflavones through computational simulations. It suggests that Genistin and Genistein may be appropriate candidates for HMGCR inhibitors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Food Science & Technology
Sebastian Tobias Soukup, Dominic Alexander Stoll, Nicolas Danylec, Alena Schoepf, Sabine Emma Kulling, Melanie Huch
Summary: This study investigated gut bacterial strains of the Eggerthellaceae family and the closely related Coriobacteriaceae family that are able to metabolize daidzein and genistein. Through in silico analysis, PCR detection, and fermentation experiments, it was found that certain bacterial strains can metabolize these isoflavones, shedding light on their metabolic pathways and providing new insights into the health effects of isoflavones.
Article
Plant Sciences
Dounya Knizia, Jiazheng Yuan, Nacer Bellaloui, Tri Vuong, Mariola Usovsky, Qijian Song, Frances Betts, Teresa Register, Earl Williams, Naoufal Lakhssassi, Hamid Mazouz, Henry T. Nguyen, Khalid Meksem, Alemu Mengistu, My Abdelmajid Kassem
Summary: This study constructed a genetic linkage map using SNP markers and identified 27 QTL controlling seed isoflavone traits, along with 130 candidate genes involved in isoflavone biosynthetic pathways. The identified QTL and candidate genes are valuable for breeding soybean cultivars with high beneficial isoflavone contents.
Article
Food Science & Technology
Souad Bensaada, Francois Chabrier, Pascal Ginisty, Carine Ferrand, Gabriele Peruzzi, Marc Valat, Catherine Bennetau-Pelissero
Summary: Soy is a popular source of protein, but the presence of isoflavones raises concerns due to their estrogenic activities. This study aims to develop a pilot-scale process for extracting isoflavones from soybeans while maintaining nutritional quality. The process involves optimizing key factors, scaling up the process, and adapting to technical constraints. The results show that the pilot treatment successfully reduces isoflavone levels while preserving nutritional characteristics, and techniques are used to recover isoflavones from process waters.