Article
Plant Sciences
Yasser Nehela, Yasser S. A. Mazrou, Naglaa A. A. Taha, Abdelnaser A. A. Elzaawely, Tran Dang Xuan, Abeer H. H. Makhlouf, Asmaa El-Nagar
Summary: This study investigated the antifungal activity of four cinnamate derivatives against Alternaria alternata, the causal agent of early blight disease in tomato. The findings showed that these derivatives exhibited fungistatic action against A. alternata and reduced disease severity and improved growth traits and yield components of infected tomato plants. These derivatives could be potential eco-friendly alternatives to reduce the use of chemical fungicides against A. alternata.
Review
Chemistry, Multidisciplinary
Amandine L. Flourat, Jeanne Combes, Claire Bailly-Maitre-Grand, Kevin Magnien, Arnaud Haudrechy, Jean-Hugues Renault, Florent Allais
Summary: p-Hydroxycinnamic acids are phenolic compounds involved in lignin biosynthesis pathway, with attractive properties such as antioxidant, anti-UV, and anticancer activities, and are used as building blocks for various industries, but their production cost remains high.
Article
Biochemistry & Molecular Biology
Jacob Medeiros, Shufen Xu, Gary J. Pickering, Belinda S. Kemp
Summary: This study investigated the influence of caffeic acid, caftaric acid, fructose, and storage temperature on the formation of furan-derived compounds in base wines. The findings suggest that the addition of caffeic and caftaric acid can increase the concentration of homofuraneol.
Article
Food Science & Technology
Zi-Ying Wang, Ying Yin, Dong-Ni Li, Dan-Yue Zhao, Jun-Qing Huang
Summary: The review summarizes the protective effects of p-Hydroxycinnamic acids (HCAs) on the intestinal barrier. These effects are achieved through four mechanisms: preserving tight junction proteins, modulating pro-inflammatory cytokines, exerting antioxidant activity, and regulating the intestinal microbiota.
Article
Chemistry, Physical
Gabriela Petrisor, Ludmila Motelica, Denisa Ficai, Roxana Doina Trusca, Vasile-Adrian Surdu, Georgeta Voicu, Ovidiu Cristian Oprea, Anton Ficai, Ecaterina Andronescu
Summary: In this study, two types of mesoporous silica materials with different pore structures and volumes were synthesized and loaded with three types of polyphenols. The obtained materials were characterized from a morphological and structural point of view, and the differences between the two types of materials and the changes after loading with polyphenols were observed. In vitro studies demonstrated the potential biomedical applications of these materials.
Article
Biochemistry & Molecular Biology
In Ah Bae, Jae Won Ha, Joon Yong Choi, Yong Chool Boo
Summary: The antioxidant effect of Korean propolis on oxidative stress in human epidermal keratinocytes exposed to air particulate matter was studied. The hydrophilic fraction of propolis showed potential in inhibiting oxidative stress induced by particulate matter and reducing toxicity.
Article
Biochemistry & Molecular Biology
Marjeta Mencin, Katja Golob, Maja Krek, Tomaz Polak, Tomaz Pozrl, Petra Terpinc
Summary: This research examined the changes in phenolic antioxidants in germinated wheat and spelt seeds, and evaluated the use of whole grain flour from germinated seeds as a functional supplement. Longer germination time led to higher levels of total phenolic content, DPPH, and ABTS values in the entire germinated seed. However, the optimal germination time differed when considering the germ and the remaining germinated seed separately. In the germinated seed, most of the total phenolic content was bound phenolics, while the germ primarily consisted of extractable phenolic antioxidants. The addition of 5% germinated spelt or wheat flour in bread production showed the highest extractable total phenolic content, antioxidant activity, individual phenolic acids, specific volume, and improved appearance, aroma, and color.
Article
Biology
Maja Scepanovic, Laura Koscak, Valentina Sostarcic, Laura Pismarovic, Ana Milanovic-Litre, Kristina Kljak
Summary: This study aimed to investigate the inhibitory effects of different doses of specific phenolic acids on the early growth of Ambrosia artemisiifolia. Results showed that high doses of phenolic acids, including ferulic acid, vanillic acid, p-hydroxybenzoic acid, and a mixture of all phenolic acids, significantly reduced the shoot and radicle lengths, as well as seedling biomass of A. artemisiifolia. However, none of the phenolic acids tested were effective as bioherbicides at their naturally occurring doses. Further exploration of selected doses with reduced herbicide doses is needed to effectively control A. artemisiifolia.
Article
Chemistry, Multidisciplinary
Shuopeng Yang, Yanzhen Han, Kairui Wang, Yu Wang, Liping Li, Nan Li, Xiangdong Xu
Summary: A CE-CL method was developed for the simultaneous determination of four phenolic acids found in traditional Chinese medicine, demonstrating high sensitivity and reliability.
Article
Agriculture, Multidisciplinary
Bixia Fu, Gezhi Xiao, Yang Zhang, Jifeng Yuan
Summary: This study demonstrated the efficient conversion of lignin-derived substrates into gallic acid using Escherichia coli-based whole-cell biocatalytic systems. The synthesis of gallic acid from ferulic acid and p-coumaric acid was achieved with high conversion rates under optimal conditions, representing a promising approach for eco-friendly production of gallic acid from renewable feedstocks derived from lignin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kaili Cui, Lichao Zhang, Xiaoqin La, Haili Wu, Ruipeng Yang, Hanqing Li, Zhuoyu Li
Summary: This study investigated the mechanism underlying the impact of ferulic acid and p-coumaric acid on non-alcoholic fatty liver disease (NAFLD). The results suggested that these acids improve NAFLD by inhibiting free fatty acid uptake and may serve as potential dietary supplements and drugs for preventing NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Eva Moll, Amparo Chiralt
Summary: PHBV films incorporating ferulic acid or p-coumaric acid were prepared and their properties were studied. It was found that increasing the compound concentration enhanced the barrier capacity of the films to oxygen and water vapor, but also increased their brittleness. The release of active compounds varied depending on the food simulant.
Review
Chemistry, Multidisciplinary
Sami Fadlallah, Pallabi Sinha Roy, Gil Garnier, Kei Saito, Florent Allais
Summary: This review describes the prominent approaches for the synthesis of biobased monomers and polymers from lignin-derived compounds and evaluates the green aspects of these methods, providing quantitative bases for strategic decisions and pointing out improvement opportunities.
Article
Agriculture, Multidisciplinary
Xihui Wang, Cui Zhao, Xinyao Lu, Hong Zong, Bin Zhuge
Summary: A growth-coupled dual-layered dynamic regulation system was developed to boost the yield of caffeic acid. This system autonomously controls intracellular pyruvate supply and coordinates gene expression to redirect carbon metabolism for caffeic acid synthesis. The engineered strain achieved a caffeic acid titer of 559.7 mg/L in a 5 L bioreactor, demonstrating the efficiency and potential of this system in enhancing the production of aromatic compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Justyna Godos, Filippo Caraci, Agnieszka Micek, Sabrina Castellano, Emanuele D'Amico, Nadia Paladino, Raffaele Ferri, Fabio Galvano, Giuseppe Grosso
Summary: The study showed that higher intake of dietary phenolic acids, especially hydroxycinnamic acids, was significantly associated with lower risk of impaired cognition in older Italian adults.
Article
Endocrinology & Metabolism
Ines Delgado, Sofia Cussotto, Andrea Anesi, Sandra Dexpert, Agnes Aubert, Bruno Aouizerate, Cedric Beau, Damien Forestier, Patrick Ledaguenel, Eric Magne, Fulvio Mattivi, Lucile Capuron
Summary: This study found that chronic low-grade inflammation in obesity played an important role in depressive symptoms. One mechanism involved the effects of inflammation on tryptophan metabolism. High levels of high-sensitive C-reactive protein and low levels of indole-3-carboxaldehyde were associated with more severe depressive symptoms.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Mirella Nardini
Article
Biochemistry & Molecular Biology
Silvia Carlin, Cesare Lotti, Ludovica Correggi, Fulvio Mattivi, Panagiotis Arapitsas, Urska Vrhovsek
Summary: Understanding the behavior of wine aroma compounds under different storage conditions is crucial for understanding the changes in their sensory characteristics during shelf life. This study developed a fast, modern, robust, and comprehensive protocol for quantifying volatile compounds in wine and applied it to study the behavior of different wines under different storage conditions. The results showed changes in the main compounds and an increase in unwanted compounds.
Editorial Material
Food Science & Technology
Matteo Bordiga, Fulvio Mattivi
Article
Nutrition & Dietetics
Francesca Fava, Maria M. Ulaszewska, Matthias Scholz, Jan Stanstrup, Lorenzo Nissen, Fulvio Mattivi, Joan Vermeiren, Douwina Bosscher, Carlo Pedrolli, Kieran M. Tuohy
Summary: This study aimed to evaluate the effects of wheat aleurone supplemented foods on human health. The results showed that aleurone has the potential to modulate gut microbial metabolic output and increase the abundance of bifidobacteria in feces. However, it did not have a significant impact on plasma homocysteine or other cardiovascular disease biomarkers.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Food Science & Technology
Silvia Carlin, Maurizio Piergiovanni, Elisabetta Pittari, Maria Tiziana Lisanti, Luigi Moio, Paola Piombino, Matteo Marangon, Andrea Curioni, Luca Rolle, Susana Rio Segade, Andrea Versari, Arianna Ricci, Giuseppina Paola Parpinello, Giovanni Luzzini, Maurizio Ugliano, Daniele Perenzoni, Urska Vrhovsek, Fulvio Mattivi
Summary: Free varietal thiols play a crucial role in the primary aroma of wines, particularly contributing to passion fruit and box tree/cat urine scents. Muller-Thurgau wines were found to have the highest levels of 4MSP and 3-SH, which are correlated with odor descriptors.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Ximena Orozco-Ruiz, Andrea Anesi, Fulvio Mattivi, Monique M. B. Breteler
Summary: Visceral and subcutaneous adipose tissue function as endocrine organs and affect metabolic health through metabolite concentrations. This study found that certain metabolite concentrations associated with cardiometabolic risk markers are altered with increased visceral adipose tissue volume.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemical Research Methods
Andrea Anesi, Kirsten Berding, Gerard Clarke, Catherine Stanton, John F. Cryan, Noel Caplice, R. Paul Ross, Andrea Doolan, Urska Vrhovsek, Fulvio Mattivi
Summary: The modulation of host and dietary metabolites by gut microbiota is crucial for maintaining host physiology and understanding various pathologies. A new chromatography-mass spectrometry method was developed to quantitate 89 metabolites resulting from human-gut microbial cometabolism in plasma, serum, and urine. This method provides accurate and efficient measurement of metabolite concentrations in biological fluids, making it a valuable tool for studying changes in human-gut microbial cometabolism in health and disease.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Food Science & Technology
Lais Moro, Renata Vieira da Mota, Eduardo Purgatto, Fulvio Mattivi, Panagiotis Arapitsas
Summary: This study investigated the impact of methyl jasmonate (MeJa) treatment on grape juice production in two Brazilian regions using two Vitis labrusca cultivars. The results showed that MeJa treatment significantly improved the anthocyanic profile of Isabel Precoce juices. Furthermore, the concentration of hydroxycinnamates, especially their glucosides, increased with MeJa treatment. New biomarkers of MeJa treatment were identified, indicating a possible positive effect on the antioxidant properties of grape juice.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kirsten Berding, Thomaz F. S. Bastiaanssen, Gerard M. Moloney, Serena Boscaini, Conall R. Strain, Andrea Anesi, Caitriona Long-Smith, Fulvio Mattivi, Catherine Stanton, Gerard Clarke, Timothy G. Dinan, John F. Cryan
Summary: This study investigated the impact of a psychobiotic diet on the microbial profile and mental health in a healthy population. The results showed that the psychobiotic diet reduced perceived stress and improved stress levels, although it only had subtle effects on microbial composition and function. In addition, higher adherence to the diet was associated with greater decreases in perceived stress.
MOLECULAR PSYCHIATRY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Mirella Nardini
Article
Agriculture, Multidisciplinary
Maurizio Piergiovanni, Silvia Carlin, Cesare Lotti, Urska Vrhovsek, Fulvio Mattivi
Summary: The aim of this study was to optimize and validate a green, robust, and comprehensive method for the determination of volatile carbonyl compounds (VCCs) in wines. The method was successfully optimized and automated using HS-SPME-GC-MS/MS, and complied with the principles of green analytical chemistry. The study evaluated the performance of the method in terms of linearity, LOQs, repeatability, and recovery, and successfully applied it to determine the evolution of VCCs in white and red wines after accelerated aging. The results were in accordance with current models on carbonyl evolution in wine aging.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Mirella Nardini
Summary: This review focuses on the bioactive molecules of beer, particularly the composition of phenolic compounds and the antioxidant activity. The impact of adjuncts such as fruit, vegetables, herbs, and natural foods on the polyphenol content, antioxidant properties, and phenolic profile of beer is reviewed, along with emerging trends in brewing processes. Further studies are needed to identify and characterize the bioactive molecules in beer, as well as study their absorption and metabolic fate in humans.
Article
Plant Sciences
Isabella Ghiglieno, Silvia Carlin, Gabriele Cola, Urska Vrhovsek, Leonardo Valenti, Mar Garcia-Aloy, Fulvio Mattivi
Summary: Climate change affects grapevine production and wine quality, necessitating on-field adaptation strategies. Leaf removal and artificial shading have a significant impact on grape maturation, wine quality, and aroma production. These practices are particularly important for sparkling wine production where acidity is crucial for wine quality.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Chemistry, Analytical
Lapo Renai, Luca Marzullo, Giulia Bonaccorso, Serena Orlandini, Fulvio Mattivi, Maria Concetta Bruzzoniti, Massimo Del Bubba
Summary: In this study, thermal desorption in on-line solid phase extraction coupled with reversed phase liquid chromatography was proposed for the first time and proved to be effective for desorbing analytes retained by multiple interaction polymeric sorbents. The method was successfully applied to the targeted analysis of 34 human gut metabolites with diverse physicochemical properties. The thermally assisted desorption strategy outperformed conventional room temperature desorption strategies and provided negligible matrix effects and low method quantification limits in urine and serum.
ANALYTICA CHIMICA ACTA
(2023)
