Article
Biochemistry & Molecular Biology
Antony Gao, Sameesh Gupta, Han Shi, Yuyang Liu, Angie L. Schroder, Paul K. Witting, Gulfam Ahmad
Summary: The study found that acute serum amyloid A (SAA) induces crosstalk between NF-kappa B and Nrf2 transcriptional factors, leading to the induction of pro-inflammatory mediators and antioxidant response elements after 4 weeks of treatment. SAA treatment also resulted in renal dysfunction by promoting the IFN-gamma-iNOS-p38 MAPK axis, leading to renal fibrosis, as well as accelerated atherosclerosis formation and thinning of fibrous caps in cardiovascular tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Kan Huang, Chenshu Liu, Meixiu Peng, Qiao Su, Ruiming Liu, Zeling Guo, Sifan Chen, Zilun Li, Guangqi Chang
Summary: This study found that GUDCA attenuates the development of atherosclerosis by inhibiting foam cell formation, maintaining cholesterol homeostasis, and modulating gut microbiota.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Han Zhao, Peng Dan, Jiahui Xi, Zhengwang Chen, Ping Zhang, Wei Wei, Yanying Zhao
Summary: This study found that soybean polypeptide dglycin has a positive effect on preventing atherosclerosis. It reduces inflammation, lipid deposition, protects endothelial cells, and prevents foam cell formation, thus alleviating early-stage atherosclerosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cardiac & Cardiovascular Systems
Juan Ma, Hui-Min Ma, Meng-Qi Shen, Yuan Yuan Wang, Yu-Xin Bao, Yong Liu, Ya Ke, Zhong-Ming Qian
Summary: The role of iron in atherosclerosis remains controversial, but this study suggests that an increase in iron content in aortic tissues may contribute to ApoE deficiency-induced atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Wenhua Su, Liwen Liang, Liang Zhou, Yu Cao, Xiuli Zhou, Shiqi Liu, Qian Wang, Hong Zhang
Summary: This study identified a crucial gene, LILRB2, associated with the progression of peripheral atherosclerotic disease (PAD) through bioinformatics analysis. The role of this gene in PAD was validated using a mouse model.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Xuexue Xu, Jingchang Ma, Yongming Liu, Chujun Duan, Yitian Liu, Chongyang Feng, Wenpeng Li, Yuling Wang, Kun Cheng, Ran Zhuang
Summary: CD226 plays a crucial role in the development of atherosclerosis by promoting foam cell formation. CD226 deficiency reduces plaque accumulation and inhibits atherosclerosis progression.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Yutang Wang, Owen Sargisson, Dinh Tam Nguyen, Ketura Parker, Stephan J. R. Pyke, Ahmed Alramahi, Liam Thihlum, Yan Fang, Morgan E. Wallace, Stuart P. Berzins, Ernesto Oqueli, Dianna J. Magliano, Jonathan Golledge
Summary: The study found that hydralazine inhibits the formation and rupture of AAA by suppressing inflammatory gene expression and apoptosis, providing new insights for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Rubin-Garcia, Facundo Vitelli-Storelli, Laura Alvarez-Alvarez, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Dolores Corella, Alvaro Hernaez, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Luis Serra-Majem, Naomi Cano-Ibanez, Josep A. Tur, Alba Marcos-Delgado, Anna Tresserra-Rimbau, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emili Ros, Zenaida Vazquez-Ruiz, Nancy Babio, Rocio Barragan, Olga Castaner-Nino, Cristina Razquin, Lucas Tojal-Sierra, Enrique Gomez-Gracia, Sandra Gonzalez-Palacios, Marga Morey, Antonio Garcia-Rios, Sara Castro-Barquero, Maria Rosa Bernal-Lopez, Jose Manuel Santos-Lozano, Miguel Ruiz-Canela, Antoni Castro-Salomo, Eva Cristina Pascual-Castello, Veronica Moldon, Vanessa Bullon-Vela, Carolina Sorto-Sanchez, Juan Carlos Cenoz-Osinaga, Liliana Gutierrez, Maira Mengual, Rosa Maria Lamuela-Raventos, Vicente Martin-Sanchez
Summary: This study found an inverse association between the intake of certain subclasses of polyphenols and serum uric acid levels and hyperuricemia in individuals with metabolic syndrome. Further research is needed to confirm these findings.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Haruhito A. Uchida, Tetsuharu Takatsuka, Yoshiko Hada, Ryoko Umebayashi, Hidemi Takeuchi, Kenichi Shikata, Venkateswaran Subramanian, Alan Daugherty, Jun Wada
Summary: The study found that edaravone can attenuate angiotensin II-induced abdominal aortic aneurysms and atherosclerosis through its antioxidant and anti-inflammatory effects.
Article
Nutrition & Dietetics
Xin Dai, Si Liu, Lokyu Cheng, Ting Huang, Honghui Guo, Dongliang Wang, Min Xia, Wenhua Ling, Yunjun Xiao
Summary: Betaine supplementation reduces plasma SAH levels and protects against SAHH-deficiency-promoted atherosclerosis by inhibiting inflammation and smooth muscle cell proliferation and migration.
Article
Biochemistry & Molecular Biology
Ilayaraja Muthuramu, Mudit Mishra, Bart De Geest
Summary: Murine coronary arteries have high resistance to atherosclerosis, possibly due to their intramyocardial course. In this study, apo E deficient mice underwent transverse aortic constriction (TAC) and displayed advanced atherosclerosis in their left coronary artery, as well as increased cardiac hypertrophy and heart failure compared to control mice. These findings suggest that TAC in apo E deficient mice induces coronary atherosclerosis and exacerbates pathological cardiac hypertrophy and heart failure.
Article
Cardiac & Cardiovascular Systems
Danyu Wu, Yajie Pan, Shijun Yang, Chang Li, Yanzhao Zhou, Yingxuan Wang, Xiao Chen, Zihua Zhou, Yuhua Liao, Zhihua Qiu
Summary: The PCSK9Q beta-003 vaccine demonstrated its effectiveness in lowering LDL cholesterol, reducing plaque area, promoting plaque stability, regulating cholesterol transport, inhibiting inflammation infiltration, and reducing apoptosis in atherosclerosis, providing a potential novel therapeutic approach for the disease.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Review
Food Science & Technology
Huangrong Zhu, Danni Song, Xu Zhao
Summary: Dietary polyphenols have shown positive effects against hyperuricemia, with little to no side effects compared to drugs.
Article
Biochemistry & Molecular Biology
Lili Tan, Jie Lu, Chunyang Zhang, Liang Meng, Qi Zhu
Summary: Overexpression of BCAT1 in atherosclerosis worsens lipid deposition, pathological injury, and inflammatory response, suggesting that modulating BCAT1 might be a potential approach to prevent AS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Shouming Luo, Xiaogen Ma, Weiqiang Wu, Shu Lin, Mindian Li, Zhihui Zhang, Ping Zhu, Zhiyuan Song
Summary: Continuous hypobaric hypoxia (CHH) may accelerate the progression of atherosclerosis by promoting angiogenesis and inflammation.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Tatjana Ruskovska, Christine Morand, Carla Indianara Bonetti, Karimi Sater Gebara, Euclides Lara Cardozo Junior, Dragan Milenkovic
Summary: Mate consumption has been associated with health effects, particularly in preventing cardiometabolic disorders. This study investigated the nutrigenomic effects of mate consumption and found that it can modulate gene expression, potentially leading to a protective profile against cardiometabolic disorders. The study also identified various genes and regulatory networks involved in cell interactions, inflammation, and cell signaling, which may contribute to the cardiometabolic health benefits of mate.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Tatjana Ruskovska, Aleksandra Konic-Ristic, Andrzej Mazur, Dragan Milenkovic
Summary: This study aimed to investigate the transcriptomic changes in the aorta of rats under different fructose intake conditions. The results showed that fructose intake affected the expression of over 1700 genes related to vascular functions, cell signaling, and cellular metabolism. Partial substitution of fructose with inulin in the diet influenced the expression of over 1300 genes associated with endothelial and vascular functions. Moreover, there was a negative correlation between the gene expression profiles under the two dietary conditions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.
Article
Immunology
Pawel Zapolnik, Wojciech Kmiecik, Anna Nowakowska, Lukasz Jerzy Krzych, Henryk Szymanski, Lidia Stopyra, Teresa Jackowska, Dorota Darmochwal-Kolarz, Artur Mazur, Hanna Czajka
Summary: This article presents a study on the relationship between SARS-CoV-2 and tuberculosis vaccines, finding that further research is needed to determine the effect of BCG vaccination on the immune response to SARS-CoV-2.
Article
Public, Environmental & Occupational Health
Krzysztof Kalita, Justyna Leszczak, Ewelina Czenczek-Lewandowska, Artur Mazur
Summary: The study aimed to examine the relationship between the health behaviors and life satisfaction of diocesan priests in Poland. It found that factors such as internal health control, the influence of others, positive mental attitude, preventive behavior, eating habits, and health practices greatly influenced their quality of health and life satisfaction. The survey involved 250 diocesan priests who completed anonymous questionnaires, which were based on tools such as the HBI, MHLC, and SWLS. The priests exhibited moderate levels of health behavior and life satisfaction, placing importance on internal control and the influence of others.
JOURNAL OF RELIGION & HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Layanne Nascimento Fraga, Dragan Milenkovic, Sara Lima Anacleto, Michelle Salemi, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto
Summary: This study aimed to decipher the molecular mechanisms of flavanone metabolites in pancreatic beta-cells treated with high glucose concentration. It was found that these metabolites could modulate the expression of proteins and potentially prevent dysfunction of pancreatic beta-cells under stress induced by high glucose.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2023)
Review
Biochemistry & Molecular Biology
Pawel Zapolnik, Wojciech Kmiecik, Artur Mazur, Hanna Czajka
Summary: The Bacillus Calmette-Guerin (BCG) vaccine, in use for over 100 years, offers protection against severe, blood-borne forms of tuberculosis and enhances immunity against other diseases. This phenomenon, called trained immunity, is the result of increased response by non-specific immune cells upon repeated contact with a pathogen. In this review, we discuss the molecular mechanisms behind trained immunity and its potential application in managing the SARS-CoV-2 pandemic, while also addressing the challenges faced by the scientific community in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Rafal Podgorski, Sabina Galiniak, Artur Mazur, Agnieszka Domin
Summary: Prenatal alcohol exposure can cause fetal alcohol spectrum disorders (FASDs), leading to growth impairment and various developmental, physical, and cognitive disorders in children. This study aimed to investigate the levels of hormones related to the hypothalamic-pituitary-adrenal axis in FASD patients. Results showed that fasting proopiomelanocortin (POMC) levels were lower in FASD patients compared to controls. However, cortisol concentrations did not differ. The study suggests that hormonal dysregulation may contribute to the negative effects of FASDs on growth, development, and neurological functions.
Article
Nutrition & Dietetics
Jennifer E. Norman, Saivageethi Nuthikattu, Dragan Milenkovic, John C. Rutledge, Amparo C. Villablanca
Summary: Oxylipins, the oxidation products of polyunsaturated fatty acids, play a role in neurodegenerative disorders such as dementia. In this study, the effect of inhibiting soluble epoxide hydrolase (sEH) on brain oxylipin profile was comprehensively analyzed in male and female mice. The inhibitor affected more oxylipins in males compared to females and led to a more neuroprotective profile. The behavioral and cognitive effects of the inhibitor were observed in males but not in females. These findings provide novel insights into the sexual dimorphism in response to sEH inhibition and may help identify sex-specific treatment targets.
Article
Pediatrics
Miguel Vieira Martins, Nora Karara, Lukasz Dembinski, Martine Jacot-Guillarmod, Artur Mazur, Adamos Hadjipanayis, Pierre-Andre Michaud
Summary: Adolescent pregnancy and childbearing are widespread issues with potential consequences for both short and long-term health. Various factors such as social, economic, environmental, structural, and cultural aspects greatly influence adolescents' sexual and reproductive health, as well as early pregnancy. Healthcare professionals have a crucial role in preventing unplanned pregnancies. Strategies such as improved access to family planning, sexuality education in schools, community-based interventions, and policies contribute to reducing the risk of adolescent pregnancy and promoting responsible sexual behavior. Additionally, healthcare professionals can support pregnant adolescents in making informed decisions and provide appropriate healthcare.
FRONTIERS IN PEDIATRICS
(2023)
Article
Oncology
Jennifer Ose, Biljana Gigic, Stefanie Brezina, Tengda Lin, Anita R. Peoples, Pauline P. Schobert, Andreas Baierl, Eline van Roekel, Nivonirina Robinot, Audrey Gicquiau, David Achaintre, Augustin Scalbert, Fraenzel J. B. van Duijnhoven, Andreana N. Holowatyj, Tanja Gumpenberger, Petra Schrotz-King, Alexis B. Ulrich, Arve Ulvik, Per-Magne Ueland, Matty P. Weijenberg, Nina Habermann, Pekka Keski-Rahkonen, Andrea Gsur, Dieuwertje E. Kok, Cornelia M. Ulrich
Summary: Colorectal cancer is recognized as two separate diseases: colon cancer and rectal cancer, each with its own causes and outcomes. This study found that higher levels of plasma creatinine increased the risk of death in patients with rectal cancer but not colon cancer. Additionally, a biological pathway related to starch and sucrose metabolism was linked to worse clinical outcomes in colon cancer but not rectal cancer. Understanding these differences is crucial for tailored treatments.
Article
Biochemistry & Molecular Biology
Jennifer E. Norman, Saivageethi Nuthikattu, Dragan Milenkovic, Amparo C. Villablanca
Summary: This study reveals that Type 2 diabetes mellitus has an impact on the brain metabolome of both male and female mice and that this impact is influenced by sex. The study also identifies changes in the types and numbers of metabolites in the brain caused by T2DM. Additionally, T2DM leads to specific changes in metabolites in the brains of male and female mice.
Meeting Abstract
Endocrinology & Metabolism
Joanna Baran, Aneta Weres, Justyna Leszczak, Ewelina Czenczek-Lewandowska, Artur Mazur
ANNALS OF NUTRITION AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Jeanette A. M. Maier, Laura Locatelli, Giorgia Fedele, Alessandra Cazzaniga, Andre Mazur
Summary: Magnesium plays a crucial role in regulating metabolism and maintaining tissue homeostasis, including the brain. It is essential for nerve signal transmission and protecting the blood-brain barrier. Deficiency in magnesium can lead to systemic low-grade inflammation, which is common in various diseases, particularly neurodegenerative disorders. This review provides evidence linking magnesium imbalance to multiple sclerosis, Alzheimer's, and Parkinson's diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)