期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 151, 期 3, 页码 1097-1101出版社
ELSEVIER
DOI: 10.1016/j.jad.2013.09.003
关键词
Major depressive disorder; Fractional amplitude of low frequency fluctuations; Default mode network; Independent component analysis
资金
- National Natural Science Foundations of China [81260210, 30900483]
- Natural Science Foundations of Guangxi [2013GXNSFAA019107]
- Ministry of Health of the Peoples' Republic of China [201002003]
Background: Major depressive disorder (MDD) is associated with altered neural activity in the default mode network (DMN). In the present study, we used a fractional amplitude of low-frequency fluctuations (fALFF) approach to directly investigate the features of spontaneous brain activity of the DMN in patients with the first episode, drug naive MDD at rest. Methods: Twenty-four first-episode, drug naive patients with MDD and 24 age-, gender-, and education matched healthy subjects participated in the study. The fALFF and independent component analysis (ICA) approaches were utilized to analyze the data. Results: Patients with MDD exhibited a dissociation pattern of resting state fALFF in the DMN, with increased fALFF in the left dorsal medial prefrontal cortex (MPFC) and decreased fALFF in the left parahippocampal gyrus (PHG). The increased fALFF values of the left dorsal MPFC were positively correlated to the Hamilton Rating Scale for Depression (HRSD) scores. Conclusions: Our results first suggested that there was a dissociation pattern of resting state fALFF in the DMN in patient with MDD, which highlighted the importance of the DMN in the pathogenesis of MDD. (C) 2013 Elsevier B.V. All rights reserved
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