Article
Clinical Neurology
Qing Chen, Yanmeng Bi, Xiaohua Zhao, Yuqi Lai, Weixin Yan, Lingpeng Xie, Tingting Gao, Shuwen Xie, Ting Zeng, Jun Li, Shanshan Kuang, Lei Gao, Zhiping Lv
Summary: This study investigated abnormalities in spontaneous brain activity in MDD patients, finding that mean ALFF and fALFF could potentially serve as neuroimaging markers to differentiate MDD patients from healthy controls.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Li Yang, An-Hai Wei, Tan-Te Ouyang, Zhen-Zhen Cao, Ao-Wen Duan, He-Hua Zhang
Summary: The study found that depression affects normal neurodevelopment, maturation, and aging processes, and patients with different ages of onset show dynamic changes in brain function.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Yujun Gao, Xi Wang, Zhenying Xiong, Hongwei Ren, Ruoshi Liu, Yafen Wei, Dongbin Li
Summary: This study investigated the clinical diagnostic value of fALFF based on SVM method for MDD diagnosis. Increased fALFF in the left mid cingulum, right precuneus, and left SFG may serve as a neuroimaging marker for first-episode MDD, with the combination of increased fALFF in right precuneus and left SFG showing the best diagnostic value.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Jong-ha Lee, SuHyuk Chi, Minsoo Ko, Minjae Song, Byung-Joo Ham, Young-Hoon Ko, Sang-il Suh, Moon-Soo Lee
Summary: The study found that compared to healthy controls, patients with MDD had significantly increased FA values, but these values decreased after 3 months of treatment. This suggests that early pharmacological treatment may help restore brain integrity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Qinger Guo, Jingfeng Duan, Shuyang Cai, Jiaxi Zhang, Tao Chen, Hong Yang
Summary: This study aimed to investigate the role of white matter (WM) structure and function in the neurobiological mechanisms of major depressive disorder (MDD). Results showed abnormal amplitude of low frequency fluctuation (ALFF) in specific frequency bands in WM of drug-naive first-episode MDD patients. It was also found that functional damage of WM may precede structural damage in MDD, and ALFF value in superior longitudinal fasciculus (SLF) was negatively correlated with HAMA-2 score.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Weiliang Yang, Yuting Wang, Wen Qin, Meijuan Li, Huan Mao, Chi Zhou, Xueying Liu, Jie Li
Summary: This study investigated the changes in temporal properties of dynamic functional network connectivity (dFNC) in first-episode, drug-naive patients with major depressive disorder (MDD). The results showed that these changes in temporal properties could serve as potential biomarkers for MDD, with good diagnostic performance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Le Li, Yun-Ai Su, Yan-Kun Wu, Francisco Xavier Castellanos, Ke Li, Ji-Tao Li, Tian-Mei Si, Chao-Gan Yan
Summary: This study found significant intrinsic functional connectivity decreases in extensive brain networks after antidepressant treatment, indicating considerable antidepressant effects. There were no significant differences in resting-state functional connectivity between treatment-naive MDD patients and healthy controls.
HUMAN BRAIN MAPPING
(2021)
Article
Psychiatry
Nils R. Winter, Ramona Leenings, Jan Ernsting, Kelvin Sarink, Lukas Fisch, Daniel Emden, Julian Blanke, Janik Goltermann, Nils Opel, Carlotta Barkhau, Susanne Meinert, Katharina Dohm, Jonathan Repple, Marco Mauritz, Marius Gruber, Elisabeth J. Leehr, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Igor Nenadic, Markus M. Noethen, Andreas Forstner, Marcella Rietschel, Joachim Gross, Jochen Bauer, Walter Heindel, Till Andlauer, Simon B. Eickhoff, Tilo Kircher, Udo Dannlowski, Tim Hahn
Summary: Neurobiological differences between patients with major depressive disorder (MDD) and healthy individuals were found to be remarkably small, making individual prediction difficult and highlighting the predominance of group similarity.
Article
Neurosciences
Lan Mei, Yuting Wang, Chunyang Liu, Jingping Mou, Yizhi Yuan, Lihua Qiu, Qiyong Gong
Summary: Some important clinical characteristics of major depressive disorder (MDD) differ between sexes. This study explored abnormal brain activity in MDD patients and its relationship to clinical manifestations in male and female patients. The results suggest that sex-specific abnormal brain activity might be a potential pathomechanism contributing to different symptoms in male and female MDD patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychiatry
Shihong Xiong, Wei Li, Yang Zhou, Hongwei Ren, Guorong Lin, Sheng Zhang, Xi Xiang
Summary: This study found that vortioxetine modulates brain signals in patients with MDD, leading to increased ALFF values in certain brain regions after 8 weeks of treatment.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Yongbo Hu, Shiyi Li, Jin Li, Youjin Zhao, Meiling Li, Weigang Cui, Xiaolong Peng, Zaiquan Dong, Lianqing Zhang, Haizhen Xu, Li Gao, Xiaoqi Huang, Weihong Kuang, Qiyong Gong, Hesheng Liu
Summary: Perceptual dysfunctions are fundamental causes of cognitive and emotional problems in patients with major depressive disorder. This study found that visual system impairment, including reductions in functional connectivities, can interfere with inhibition control in visual-motor processing in patients with major depressive disorder.
Article
Psychology, Multidisciplinary
Yang Zhou, Yu Song, Cheng Chen, Shu Yan, Mo Chen, Tao Liu
Summary: This study used neuroimaging data to analyze the amplitude of low-frequency fluctuation (ALFF) in adolescent MDD patients with suicidal attempts (SAs) and found reduced ALFF values in the bilateral medial superior frontal gyrus and bilateral precuneus. These abnormalities may be involved in the pathogenesis of MDD with SA and could help identify at-risk adolescents. Reduced ALFF in the bilateral medial superior frontal gyrus and bilateral precuneus may serve as indicators of MDD and SA in adolescent patients.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychiatry
Xiaoya Fu, Huabing Li, Meiqi Yan, Jindong Chen, Feng Liu, Jingping Zhao, Wenbin Guo
Summary: The study found that MDD patients with concomitant GI symptoms exhibited more severe depressive symptoms, with distinct alterations in fALFF patterns in specific brain regions. These changes in fALFF may serve as distinctive neurobiological features of MDD patients with GI symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Lulu Zhang, Xinghua Wei, Jingping Zhao
Summary: This study observed the characteristics of low-frequency oscillation (LFO) in first-episode drug-naive patients with major depressive disorder (MDD), and found that abnormal neurological activity in multiple brain regions may be involved in the neurobiological mechanisms of MDD.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Psychiatry
Yan Qiu, Min Yang, Sujuan Li, Ziwei Teng, Kun Jin, Chujun Wu, Xuelei Xu, Jindong Chen, Hui Tang, Jing Huang, Hui Xiang, Wenbin Guo, Bolun Wang, Haishan Wu
Summary: This study found abnormal brain activities in patients with bipolar disorder (BD) and major depressive disorder (MDD) and their correlation with cognition, particularly in BD patients. The abnormality in the cerebellum may have the potential to differentiate between BD and MDD patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neuroimaging
Jin Zhao, Yan Zhang, Feng Liu, Jindong Chen, Jingping Zhao, Wenbin Guo
Summary: The study revealed abnormal global-brain functional connectivity in drug-naive first-episode adolescent-onset schizophrenia patients, showing increased connectivity in the right middle frontal gyrus and decreased connectivity in several other brain regions. Furthermore, the findings suggest potential abnormalities in processing self-monitoring and sensory prediction in AOS patients, shedding light on the pathophysiology of AOS.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Neurosciences
Lin Ma, Mengge Liu, Kaizhong Xue, Caihua Ye, Weiqi Man, Meng Cheng, Zhixuan Liu, Dan Zhu, Feng Liu, Junping Wang
Summary: This study found alterations in spontaneous brain activity in white matter in ASD patients, including decreased ReHo in certain regions and weaker structural-functional coupling.
Article
Geriatrics & Gerontology
Pan Pan, Lu Wang, Chujun Wu, Kun Jin, Song Cao, Yan Qiu, Ziwei Teng, Sujuan Li, Tiannan Shao, Jing Huang, Haishan Wu, Hui Xiang, Jindong Chen, Feng Liu, Hui Tang, Wenbin Guo
Summary: This study found abnormalities in functional connectivity in patients with major depressive disorder (MDD), particularly in different regions of interest. The findings showed increased connectivity in the left medial superior frontal gyrus and decreased connectivity in the right supplementary motor area. The decreased connectivity in the right SMA was positively correlated with vitamin D levels and Hamilton Anxiety Scale scores.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Lin Ma, Tengfei Yuan, Wei Li, Lining Guo, Dan Zhu, Zirui Wang, Zhixuan Liu, Kaizhong Xue, Yaoyi Wang, Jiawei Liu, Weiqi Man, Zhaoxiang Ye, Feng Liu, Junping Wang
Summary: Autism spectrum disorders (ASDs) are associated with impaired dynamic functional connectivity (DFC). This study identified specific DFC alterations in patients with ASDs and found significant relationships between these alterations and symptom severity. Moreover, the molecular mechanisms underlying the DFC disruptions were explored through transcription-neuroimaging association analyses and gene-wise spatial correlation analysis.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Xiaoya Fu, Yudan Ding, Jindong Chen, Feng Liu, Huabing Li, Jingping Zhao, Wenbin Guo
Summary: This study revealed the influence of comorbid gastrointestinal symptoms on functional asymmetry in major depressive disorder (MDD) patients. Increased parameter of asymmetry (PAS) scores in the left inferior frontal gyrus (IFG) and superior medial prefrontal cortex (MPFC) might represent an unbalanced regulation of brain over gastrointestinal function and could be regarded as distinctive features related to functional gastrointestinal symptoms in MDD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Feng Liu, Jiayuan Xu, Lining Guo, Wen Qin, Meng Liang, Gunter Schumann, Chunshui Yu
Summary: Individual differences in human brain structure, function, and behavior can be explained by genetic variations, environmental exposures, and their interactions. While genetic variants associated with brain imaging phenotypes have been identified, the environmental exposures related to these phenotypes are largely unknown. This study proposes that research in environmental neuroscience should focus on understanding the associations between lifetime environmental exposures and brain imaging phenotypes, as well as identifying cumulative environmental effects and their vulnerable age windows.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Meiqi Yan, Xiaoya Fu, Yangpan Ou, Feng Liu, Huabing Li, Wenbin Guo
Summary: This study aimed to explore distinctive brain image alterations in major depressive disorder (MDD) with gastrointestinal (GI) symptoms, and to differentiate MDD patients with and without GI symptoms from healthy controls. The results showed abnormal global functional connectivity (GFC) in multiple networks, including the default mode network and cortico-limbic mood-regulating circuit, in MDD with GI symptoms. GFC could be used as a potential biomarker to discriminate MDD patients with GI symptoms from those without GI symptoms and healthy controls.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Mengjing Cai, Jiawei Liu, Xuexiang Wang, Juanwei Ma, Lin Ma, Mengge Liu, Yao Zhao, He Wang, Dianxun Fu, Wenqin Wang, Qiang Xu, Lining Guo, Feng Liu
Summary: Neuroimaging studies have shown that spontaneous brain activity in specific regions is altered in migraine patients. To better understand the neuropathology of migraine, a meta-analysis of resting-state functional imaging studies was conducted. The analysis revealed consistent brain activity changes in migraineurs, including decreased activity in the angular gyrus, visual cortex, and cerebellum, as well as increased activity in the caudate, thalamus, pons, and prefrontal cortex. Higher pain scores in migraine patients were associated with increased activity in the left thalamus. These findings provide valuable insights into the pathophysiology of migraine.
HUMAN BRAIN MAPPING
(2023)
Article
Psychiatry
Xiaoya Fu, Xiaolun Yang, Xilong Cui, Feng Liu, Huabing Li, Meiqi Yan, Guangrong Xie, Wenbin Guo
Summary: The study investigates the differences in functional hub changes between melancholic and non-melancholic major depressive disorder (MDD). It found that both types of MDD had altered functional connectivity in the insula and the posterior cingulate cortex/precuneus. However, melancholic MDD showed additional connectivity changes in the thalamus, inferior parietal lobule, cerebellum, and temporal lobe. The results suggest that hyperconnectivity in the inferior parietal lobule and cerebellum might be distinctive neuropathological features of melancholic MDD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Kaizhong Xue, Lining Guo, Wenshuang Zhu, Sixiang Liang, Qiang Xu, Lin Ma, Mengge Liu, Yong Zhang, Feng Liu
Summary: Recent studies have shown alterations in functional and structural network gradients in major depressive disorder (MDD), but the changes in cortical morphometric similarity (MS) network gradient and its relationship with gene expression remain unknown. This study found that the MS network gradient was significantly decreased in sensorimotor regions and increased in visual-related regions in MDD patients compared to healthy controls. Furthermore, the altered gradient was associated with symptom severity and correlated with gene expression patterns related to neurobiologically relevant pathways.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Wenshuang Zhu, Feng Liu, Jilian Fu, Wen Qin, Kaizhong Xue, Jie Tang, Yong Zhang, Chunshui Yu
Summary: This study identified 903 clinically sensitive genes and 633 clinically insensitive genes associated with ALFF alterations in MDD. The sensitive genes were enriched for cell differentiation and development, while the insensitive genes were enriched for ion transport and synaptic signaling.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Haohao Yan, Yiding Han, Xiaoxiao Shan, Huabing Li, Feng Liu, Ping Li, Jingping Zhao, Wenbin Guo
Summary: This study found abnormal spontaneous neural activity in the fear networks of patients with panic disorder (PD). Pharmacotherapy can partially normalize these abnormalities and the abnormal neural activity can predict treatment response.
Article
Neuroimaging
Juanwei Ma, Feng Liu, Yang Wang, Lin Ma, Yali Niu, Jing Wang, Zhaoxiang Ye, Jing Zhang
Summary: This study investigates the functional abnormalities in white matter (WM) associated with cognitive impairment in vascular cognitive impairment (VCI) patients. Using resting-state functional MRI, the researchers identify changes in functional connectivity and amplitude of WM networks in VCI patients. They find significant decreases in connectivity and amplitude in multiple brain regions in VCI patients, which are positively correlated with cognitive performances.
NEUROIMAGE-CLINICAL
(2022)
Article
Psychiatry
Mengjing Cai, Rui Wang, Mengge Liu, Xiaotong Du, Kaizhong Xue, Yuan Ji, Zirui Wang, Yijing Zhang, Lining Guo, Wen Qin, Wenshuang Zhu, Jilian Fu, Feng Liu
Summary: This study conducted a meta-analysis to identify consistent changes in resting-state local functional connectivity in schizophrenia. The findings revealed that patients with schizophrenia showed higher connectivity in the bilateral medial superior frontal gyrus and lower connectivity in the bilateral postcentral gyrus, right precentral gyrus, and right middle occipital gyrus compared to healthy controls. The results were robust and reliable, and illness duration was found to be negatively correlated with connectivity abnormalities in specific regions.
Article
Psychology, Clinical
Kaizhong Xue, Sixiang Liang, Bingbing Yang, Dan Zhu, Yingying Xie, Wen Qin, Feng Liu, Yong Zhang, Chunshui Yu
Summary: Patients with major depressive disorder (MDD) show reduced dynamic regional homogeneity (dReHo) in brain areas associated with emotional and cognitive regulation. These alterations may be related to complex polygenetic and polypathway mechanisms.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)