Article
Psychology, Clinical
Chantelle S. Lloyd, Andrew A. Nicholson, Maria Densmore, Jean Theberge, Richard W. J. Neufeld, Rakesh Jetly, Margaret C. McKinnon, Ruth A. Lanius
Summary: The study found that military and public safety-related PTSD patients have different neural activation patterns when processing moral injury events compared to controls exposed to moral injury but not suffering from PTSD. When recalling MI events, PTSD patients may experience an increase in blame-related processing and regulatory strategies in the brain regions aimed at increasing cognitive control and inhibiting emotional effects.
DEPRESSION AND ANXIETY
(2021)
Article
Multidisciplinary Sciences
Giovanni Leone, Charlotte Postel, Alison Mary, Florence Fraisse, Thomas Vallee, Fausto Viader, Vincent de La Sayette, Denis Peschanski, Jaques Dayan, Francis Eustache, Pierre Gagnepain
Summary: This study combines computational modeling and brain connectivity analyses to investigate the influence of predictions of future threat on memory recall, specifically in individuals with post-traumatic stress disorder (PTSD). The findings reveal that individuals with PTSD have exaggerated predictive control and reduced reactive control, leading to maladaptive avoidance behaviors. The imbalance in prediction and control mechanisms is linked to the severity of avoidance symptoms in PTSD patients. These findings highlight a potential pathological mechanism occurring in individuals with PTSD, providing insights into the relationship between the brain's predictive and control mechanisms.
NATURE COMMUNICATIONS
(2022)
Review
Clinical Neurology
Valerie La Buissonniere-Ariza, Kate Fitzgerald, Avner Meoded, Laurel L. Williams, Gary Liu, Wayne K. Goodman, Eric A. Storch
Summary: The systematic review of functional MRI studies in youths with negative valence disorders suggests that variations in neural functioning may impact response to CBT. However, the overall weak to moderate quality and limited number of studies, as well as the heterogeneity in study designs and results, considerably restrict the conclusions that can be drawn from this literature.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Kirsten C. Morley, Warren B. Logge, Isabel Fraser, Richard W. Morris, Andrew J. Baillie, Paul S. Haber
Summary: The GABA B agonist baclofen has shown to reduce alcohol consumption in alcohol dependent individuals and those with comorbid anxiety. Using fMRI, this study found that high dose (75 mg/day) baclofen can significantly reduce insula activation during anticipatory threat cue-elicited neural responses in treatment seeking alcohol patients. This suggests that baclofen may modulate emotional regulation and attentional allocation during high threat stimuli through GABA B receptors, providing a potential mechanism of action for its beneficial effects in treating alcohol use disorder.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Editorial Material
Psychology, Biological
Lisa M. Shin, Samuel R. Sommers
Summary: Increased exposure to media coverage of traumatic events is linked to greater symptoms of post-traumatic stress, especially in youth with specific patterns of brain activation that may make them more vulnerable to trauma.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Behavioral Sciences
Jonathan M. Lieberman, Daniela Rabellino, Maria Densmore, Paul A. Frewen, David Steyrl, Frank Scharnowski, Jean Theberge, Richard W. J. Neufeld, Christian Schmahl, Rakesh Jetly, Sandhya Narikuzhy, Ruth A. Lanius, Andrew A. Nicholson
Summary: This study investigated the connectivity between the posterior cingulate cortex (PCC) and the default mode network (DMN) and salience network (SN) in individuals with posttraumatic stress disorder (PTSD). The results suggest that regulating PCC activity may lead to improvements in PTSD symptoms by recalibrating neural connectivity within the DMN and SN.
BRAIN AND BEHAVIOR
(2023)
Article
Psychology, Clinical
Cindy van Sleeuwen, Mirjam van Zuiden, Saskia B. J. Koch, Jessie L. Frijling, Dick J. Veltman, Miranda Olff, Laura Nawijn
Summary: Although no neurobiological correlates of alexithymia were observed in this study, high levels of alexithymia were confirmed in patients with PTSD, highlighting its relevance in the clinical phenotype of PTSD.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)
Article
Psychiatry
Shishun Fu, Sipei Liang, Chulan Lin, Yunfan Wu, Shuangcong Xie, Meng Li, Qiang Lei, Jianneng Li, Kanghui Yu, Yi Yin, Kelei Hua, Wuming Li, Caojun Wu, Xiaofen Ma, Guihua Jiang
Summary: Neuroimaging studies have found abnormalities in multiple brain regions among patients with comorbid Posttraumatic-Major depression disorder (PTSD-MDD). This study investigates resting-state brain functional activity using entropy in patients who developed PTSD-MDD during the COVID-19 pandemic. The results show that PTSD-MDD patients have reduced entropy in frontal and basal ganglia regions, which are related to emotional regulation and cognitive deficits.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Lisa A. Brenner, Jeri E. Forster, Jaimie L. Gradus, Trisha A. Hostetter, Claire A. Hoffmire, Colin G. Walsh, Mary Jo Larson, Kelly A. Stearns-Yoder, Rachel Sayko Adams
Summary: This study aimed to identify the associations of military-related traumatic brain injury (TBI) with suicide and new-onset mental health conditions. The findings showed that soldiers with a history of TBI had higher rates of new-onset mental health conditions and were at greater risk of suicide. These results highlight the need for increased efforts to address the cumulative risk associated with multiple military-related exposures.
Article
Psychiatry
M. C. Pfaltz, M. M. Plichta, C. J. Bockisch, L. Jellestad, U. Schnyder, K. Stocker
Summary: Individuals with PTSD showed passive time-moving outlook towards the future, while healthy controls exhibited active ego-moving perspective. These findings may have implications for the conceptualization and treatment of PTSD.
PSYCHIATRY RESEARCH
(2021)
Article
Education, Scientific Disciplines
Katrin Jaradeh, Francesco Sergi, Coleen Kivlahan, Cesar Nava Gonzales, Mar Cury, Triveni DeFries
Summary: This study describes the implementation of trauma-informed care principles in a student-run asylum clinic, highlighting the importance of these principles in supporting individuals seeking asylum during forensic medical evaluations. The clinic completed 160 evaluations over a three-year period, with positive feedback from participants. Future research should focus on assessing secondary trauma and resilience within these clinics.
Article
Psychiatry
Katja I. Seitz, Kai Ueltzhoeffer, Lena Rademacher, Frieder M. Paulus, Marius Schmitz, Sabine C. Herpertz, Katja Bertsch
Summary: This study aimed to investigate whether retrospectively reported adverse childhood experiences (ACE), specifically maternal antipathy, are related to monetary and social reward anticipation in a transdiagnostic adult sample. The findings suggest that childhood maternal antipathy may increase risk for aberrant social reward anticipation in adulthood. This study is important for interventions targeting reward expectations from social interactions.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Behavioral Sciences
Camilla L. Nord, Sarah N. Gar
Summary: The recognition of the dynamic coupling between the brain and body has enhanced our understanding of mental health conditions. Disruptions to the interoceptive system may contribute to anxiety, depression, and psychosis. This review examines the nature of interoceptive disturbances in mental health conditions and explores the interoceptive pathways of existing and potential treatments.
TRENDS IN COGNITIVE SCIENCES
(2022)
Article
Psychiatry
Carole E. Siegel, Eugene M. Laska, Ziqiang Lin, Mu Xu, Duna Abu-Amara, Michelle K. Jeffers, Meng Qian, Nicholas Milton, Janine D. Flory, Rasha Hammamieh, Bernie J. Daigle, Aarti Gautam, Kelsey R. Dean, Victor Reus, Owen M. Wolkowitz, Synthia H. Mellon, Kerry J. Ressler, Rachel Yehuda, Kai Wang, Leroy Hood, Francis J. Doyle, Marti Jett, Charles R. Marmar
Summary: The study identified two clinical subtypes of PTSD in veterans using machine learning methods and blood biomarkers, showing that one subtype (S2) had more severe symptoms compared to the other subtype (S1) and healthy controls. Multi-omic blood markers were effective in distinguishing between these subtypes and healthy controls, with methylation, micro RNA, and lactate markers showing a biological role in symptom severity.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychiatry
Hyangwon Lee, Sohyun Oh, Eunji Ha, Yoonji Joo, Chaewon Suh, Yejin Kim, Hyeonseok Jeong, In Kyoon Lyoo, Sujung Yoon, Haejin Hong
Summary: This study examined 112 trauma-exposed individuals with PTSD and 112 demographically-matched healthy controls. They found that individuals with persistent PTSD displayed cortical thinning in specific brain regions associated with coping strategies and resilience, suggesting that these structural changes contribute to the persistence of PTSD symptoms.
PSYCHIATRY RESEARCH
(2023)
Article
Psychology, Clinical
Daniel M. Stout, Katia M. Harle, Sonya B. Norman, Alan N. Simmons, Andrea D. Spadoni
Summary: Data-driven subtyping of comorbid PTSD/AUD patients identified a subgroup associated with improvement in PTSD symptoms, characterized by specific connectivity patterns. These findings provide insights into the neural mechanisms underlying the efficacy of individual psychotherapy.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Social Sciences, Interdisciplinary
Tianna Loose, Marc Wittmann, Alejandro Vasquez-Echeverria
Summary: The COVID-19 pandemic has disrupted people's lives and caused psychosocial distress among students. Dispositional time attitudes impact the capacity to cope with the pandemic, with negative time attitudes leading to more psychological distress.
Article
Anesthesiology
Tiffany Toor, Emily Murphy, Alan N. Simmons, Sarah Palyo, Sara C. Librodo, Irina A. Strigo
Summary: The United States is facing a crisis due to high rates of chronic pain, opioid use disorder, and overdose deaths. While craving is a core symptom of addiction, its role in prescription opioid use among patients with chronic pain is not well understood. Understanding the degree to which craving should be considered in patients with chronic pain is critical for developing effective interventions to support patients in reducing their opioid use.
Article
Neuroimaging
Alison Myoraku, Adam Lang, Charles T. Taylor, R. Scott Mackin, Dieter J. Meyerhoff, Susanne Mueller, Irina A. Strigo, Duygu Tosun
Summary: The study found that differences in brain morphology between MDD patients and healthy controls are dependent on age and brain region, with significant age-by-group interactions in the lateral orbital frontal gyrus and insular subregions, making these regions potential targets for future longitudinal studies of MDD.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Imanuel Lerman, Ruth Klaming, Andrea Spadoni, Dewleen G. Baker, Alan N. Simmons
Summary: The study found that transcutaneous cervical nVNS has valence-specific effects on reaction time and response patterns in healthy individuals during fMRI anticipation tasks, enhancing responsiveness to negatively valenced images and diminishing responsiveness to positively valenced images.
Article
Neurosciences
Sara H. Timtim, Alan N. Simmons, Chelsea Hays, Irina Strigo, Scott Sorg, Ronald Ellis, John R. Keltner
Summary: In this study, the authors examined white matter microstructure in HIV patients with distal sensory polyneuropathy (HIV-DSP). They found that severity of neuropathy was associated with decreased white matter integrity along certain pathways, suggesting cortical white matter degeneration and cingulum degeneration.
JOURNAL OF NEUROVIROLOGY
(2022)
Correction
Neurosciences
Daniel M. Stout, Alan. N. Simmons, Caroline M. Nievergelt, Arpi Minassian, Nilima Biswas, Adam X. Maihofer, Victoria B. Risbrough, Dewleen G. Baker
NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Neurosciences
Alan N. Simmons, Irina A. Strigo
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Nynke A. Groenewold, Janna Marie Bas-Hoogendam, Alyssa R. Amod, Max A. Laansma, Laura S. Van Velzen, Moji Aghajani, Kevin Hilbert, Hyuntaek Oh, Ramiro Salas, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, James R. Blair, Karina S. Blair, Joy Hirsch, Spiro P. Pantazatos, Franklin R. Schneier, Ardesheer Talati, Karin Roelofs, Inge Volman, Laura Blanco-Hinojo, Narcis Cardoner, Jesus Pujol, Katja Beesdo-Baum, Christopher R. K. Ching, Sophia Thomopoulos, Andreas Jansen, Tilo Kircher, Axel Krug, Igor Nenadic, Frederike Stein, Udo Dannlowski, Dominik Grotegerd, Hannah Lemke, Susanne Meinert, Alexandra Winter, Michael Erb, Benjamin Kreifelts, Qiyong Gong, Su Lui, Fei Zhu, Benson Mwangi, Jair C. Soares, Mon-Ju Wu, Ali Bayram, Mesut Canli, Rasit Tukel, P. Michiel Westenberg, Alexandre Heeren, Henk R. Cremers, David Hofmann, Thomas Straube, Alexander G. G. Doruyter, Christine Lochner, Jutta Peterburs, Marie-Jose Van Tol, Raquel E. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Courtney A. Filippi, Andrea L. Gold, Anita Harrewijn, Andre Zugman, Robin Buelow, Hans J. Grabe, Henry Voelzke, Katharina Wittfeld, Joscha Boehnlein, Katharina Dohm, Harald Kugel, Elisabeth Schrammen, Peter Zwanzger, Elisabeth J. Leehr, Lisa Sindermann, Tali M. Ball, Gregory A. Fonzo, Martin P. Paulus, Alan Simmons, Murray B. Stein, Heide Klumpp, K. Luan Phan, Tomas Furmark, Kristoffer N. T. Mansson, Amirhossein Manzouri, Suzanne N. Avery, Jennifer Urbano Blackford, Jacqueline A. Clauss, Brandee Feola, Jennifer C. Harper, Chad M. Sylvester, Ulrike Lueken, Dick J. Veltman, Anderson M. Winkler, Neda Jahanshad, Daniel S. Pine, Paul M. Thompson, Dan J. Stein, Nic J. A. Van der Wee
Summary: Limited convergence exists in neuroimaging investigations of subcortical brain region volumes in social anxiety disorder (SAD). Variations in methodological approaches and sample selection based on age and clinical characteristics may contribute to inconsistent findings. A global mega-analysis initiated by the ENIGMA-Anxiety Working Group revealed subtle volumetric alterations in subcortical regions in SAD patients. Differences were found in putamen and pallidum volumes, with additional factors such as comorbid anxiety disorders and age of SAD onset influencing these volumetric differences.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Sergio Garcia Guerra, Andrea Spadoni, Jennifer Mitchell, Irina A. Strigo
Summary: This study investigates the interaction between opioidergic and dopaminergic processing in the human brain during pain-related experiences using radioligand studies. The results show that there is a functional overlap between opioid and dopamine activations in most regions, but also some unique activation areas.
Article
Psychology, Developmental
Katia M. Harle, Tiffany C. Ho, Colm G. Connolly, Alan Simmons, Tony T. Yang
Summary: Unforeseen obstacles disrupting reward seeking behavior can lead to negative affect in adolescents, potentially contributing to the development of depression. However, the neurocognitive mechanisms underlying this impact on reward processing in adolescent depression have not been characterized. This study uses neuroimaging and a novel paradigm to examine how incidental action obstruction affects reward-based decision making. Rating: 7 out of 10.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Biographical-Item
Neurosciences
Anders Blomqvist, Henry C. Evrard, Jonathan O. Dostrovsky, Irina A. Strigo, Wilfrid Jaenig
Summary: Bud Craig, an exceptional neuroscientist, made unique contributions to the fields of pain and interoception. His research challenged major dogmas and provided powerful explanations for central pain and subjective awareness of feelings, significantly impacting our understanding of consciousness.
NATURE NEUROSCIENCE
(2023)
Article
History & Philosophy Of Science
Carlos Montemayor, Marc Wittmann
Summary: The passage of time involves the dynamic occurrence of anticipated future events merging into present actuality and becoming the past. Time perception is not just a passive reception of sensory stimulation, but is generated by predictive processes of the brain and proactive sensorimotor activity of the whole body. While some philosophical approaches consider psycho-biological evidence, the biological basis of time passage has not been thoroughly examined from a scientific perspective.
Article
Clinical Neurology
Irina A. Strigo, Andrea D. Spadoni, Alan N. Simmons
Summary: Our study identified three subgroups with different functional connectivity patterns, despite similar demographic and diagnostic characteristics. These findings suggest the existence of neurobiologically dissociable biotypes with different mechanisms for managing pain and trauma, which may have implications for tailored interventions targeting specific neurological systems.
FRONTIERS IN PAIN RESEARCH
(2022)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)