Article
Biochemistry & Molecular Biology
Michael Maes, Decio Sabbatini Barbosa, Abbas F. Almulla, Buranee Kanchanatawan
Summary: This study aimed to develop a precision medicine model for temporal lobe epilepsy (TLE) and associated mental comorbidities. The results showed that oxidative stress and antioxidant biomarkers could explain a large part of the variability in TLE and psychopathology features. Based on these findings, a new phenotype class was constructed, characterized by increased severity of TLE, psychopathology, and oxidative stress features, and decreased antioxidant defenses. Furthermore, increased levels of malondialdehyde, decreased antioxidants, and nitric oxide metabolites were associated with increased episode frequency.
Article
Immunology
Justyna Dorf, Konrad Zareba, Joanna Matowicka-Karna, Anna Pryczynicz, Katarzyna Guzinska-Ustymowicz, Anna Zalewska, Mateusz Maciejczyk
Summary: The study evaluated the differences in nitrosative stress, protein and DNA oxidation/glycoxidation, as well as pro- and anti-inflammatory cytokines between CRC patients and healthy controls. The results showed that oxidation and glycoxidation products in CRC patients were positively correlated with pro-inflammatory and anti-inflammatory cytokines, indicating that redox damages may promote inflammation in CRC.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Redouane Rebai, Luc Jasmin, Abdennacer Boudah
Summary: The study showed that treatment with the antidepressant agomelatine reversed the inflammatory and oxidative stress effects caused by a high fat diet in obese rats, leading to improved anxiety and depressive behaviors. Agomelatine decreased levels of proinflammatory cytokines and oxidative stress markers, restored BDNF levels, and increased antioxidant enzyme activity in the brain.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Health Care Sciences & Services
Hussein Kadhem Al-Hakeim, Hadi Hasan Hadi, Ghoufran Akeel Jawad, Michael Maes
Summary: The present study investigated the biomarkers of affective symptoms in patients with type 2 diabetes, finding associations between copper, beta-arrestin-1, and calcium levels and these symptoms, while atherogenicity and insulin resistance played mediating roles.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Michael Maes
Summary: This paper discusses the use of machine learning in depression research and the development of precision psychiatry. Precision psychiatry aims to customize the best medical treatments based on individual's genomics, environmental, and lifestyle data. The paper outlines three steps in the development of precision medicine and highlights the challenges in developing precision psychiatry.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Kamila Landucci Bonifacio, Decio Sabbatini Barbosa, Estefania Gastaldello Moreira, Carine Farias Coneglian, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Juliana Brum Moraes, Michael Maes
Summary: The study found significant associations between nitro-oxidative stress toxicity, inflammatory pathways, atherogenicity, and mood disorders, especially in patients with mood disorders. Activated oxidative stress pathways play an important predictive role in increased blood pressure, especially through increased lipid peroxidation and protein oxidation.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Chemistry, Medicinal
Michael Maes, Marta Kubera, Kristina Stoyanova, Jean-Claude Leunis
Summary: This study aimed to construct a model of ME/CFS using PLS path analysis and data on causome, protectome, and AOP. The results showed that 31.6% of the variance in physiosomatic symptoms of ME/CFS could be explained by various factors. Cluster analysis revealed three distinct immune groups within ME/CFS, each characterized by different immune responses.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Clinical Neurology
Chaichana Jaroonpipatkul, Jaruwan Onwanna, Chavit Tunvirachaisakul, Nutchawan Jittapiromsak, Yothin Rakvongthai, Aurauma Chutinet, Thitiporn Supasitthumrong, Michael Maes
Summary: This study investigated the effects of white matter hyperintensities (WMHs) and infarction volume on poststroke depression symptoms. The results showed that infarction volume significantly predicted key depressive and concentration-tension symptoms, and lassitude three months after stroke, while total WMHs significantly predicted key depressive and concentration-tension symptoms, and lassitude, with these effects being mediated by right and left DWI stroke volumes and associated disabilities.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Asara Vasupanrajit, Ketsupar Jirakran, Chavit Tunvirachaisakul, Michael Maes
Summary: This meta-analysis identified increased immune activation, inflammation, neurotoxicity, and decreased neuroprotection in patients with suicide attempts compared to healthy controls and patients with fewer suicide attempts.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Karol Momot, Kamil Krauz, Katarzyna Czarzasta, Maciej Zarebinski, Liana Puchalska, Malgorzata Wojciechowska
Summary: Heart failure (HF) is a complex syndrome characterized by impaired cardiac function, with two common subtypes being heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). This study aimed to evaluate and compare plasma levels of 3-nitrotyrosine (3-NT) as a marker of nitrosative/oxidative stress and myeloperoxidase (MPO) as an indicator of inflammation between HFpEF and HFrEF patients. The results showed significantly higher levels of 3-NT in HFpEF patients compared to the control group and the HFrEF group, indicating intensified nitrosative/oxidative stress in HFpEF but not in HFrEF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Hussein Kadhem Al-Hakeim, Haneen Tahseen Al-Rubaye, Abbas F. F. Almulla, Dhurgham Shihab Al-Hadrawi, Michael Maes
Summary: This study investigates the association between body temperature and oxygen saturation during the acute phase of COVID-19 and the long-term physio-affective symptoms. It demonstrates that the severity of long COVID symptoms can be predicted by a neurotoxicity index, low calcium levels, peak body temperature and oxygen saturation during the acute phase, and prior vaccinations. The most important predictors of the physio-affective symptoms are calcium, C-reactive protein, interleukin-1 beta, advanced oxidation protein products, and myeloperoxidase.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Psychiatry
Michael Maes, Marta Kubera, Magdalena Kotanska
Summary: There is evidence that chronic fatigue spectrum disorders (CFAS-Ds), including myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), and chronic fatigue with physiosomatic symptoms, are characterized by neuroimmune and neuro-oxidative biomarkers. This study aimed to analyze the protein-protein interaction (PPI) network of CFAS-D and discover the enriched pathways, molecular patterns, and domains. The results revealed a highly connected network involving immune-oxidative-nitrosative and Wnt/beta-catenin subnetworks. The CFAS-D network was found to be associated with detoxification, inflammatory signaling, and dysfunctions in multicellular organismal homeostatic processes.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Jianping Wang, Yujiao Men, Zeyu Wang
Summary: We investigated the effects of polydatin on stress-induced depression and anxiety-like behaviors in a mouse model. Polydatin alleviated depressive-like and anxiety-like behaviors and restored synaptic function in the hippocampus. Polydatin also inhibited inflammation and oxidative stress in the hippocampus. These findings suggest the potential of polydatin as a therapeutic drug for affective disorders.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Gerwyn Morris, Ken Walder, Michael Berk, Andre F. Carvalho, Wolf Marx, Chiara C. Bortolasci, Alison R. Yung, Basant K. Puri, Michael Maes
Summary: The endocannabinoid system plays a crucial role in regulating various bodily functions and is associated with neuropsychiatric disorders. High levels of oxidative stress may impair CB1 and CB2 receptor activity, while upregulation of CB2 can reduce nitrosative stress and neuroinflammation.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Chemistry, Medicinal
Kurt Lucas, Moritz Rosch, Peter Langguth
Summary: Oxidative stress and mitochondrial dysfunction are common factors in causing various forms of fatigue, and antioxidant treatments are effective in relieving fatigue symptoms. This study discusses the antioxidant effects of molecular hydrogen intake and suggests that molecular hydrogen is well suited for the treatment of oxidative stress-associated temporary and chronic fatigue.
ARCHIV DER PHARMAZIE
(2021)
Article
Neurosciences
Halah Nori Asad, Hussein Kadhem Al-Hakeim, Shatha Rouf Moustafa, Michael Maes
Summary: This study aimed to investigate the associations between severity of fatigue and physio-somatic symptoms and glomerular filtration rate, inflammatory biomarkers, and Wnt/β-catenin pathway in ESRD patients. The results showed that ESRD patients exhibit high levels of fatigue and physio-somatic symptoms, which are associated with dialysis-induced changes in inflammatory pathways, the Wnt/β-catenin pathway, and copper levels.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Correction
Clinical Neurology
Andressa K. Matsumoto, Michael Maes, Thitiporn Supasitthumrong, Annabel Maes, Ana P. Michelin, Laura De Oliveira Semeao, Joao V. De Lima Pedrao, Estefania G. Moreira, Buranee Kanchanatawan, Decio S. Barbosa
Article
Neurosciences
Michael Maes, Laura Andres-Rodriguez, Aristo Vojdani, Sunee Sirivichayakul, Decio S. Barbosa, Buranee Kanchanatawan
Summary: This study aims to investigate the association between FF symptoms in schizophrenia and the breakdown of the paracellular pathway, zonulin, lowered natural IgM responses to oxidative specific epitopes (OSEs), and the BCPS-worsening index. Results showed that FF symptoms were correlated with paracellular pathway breakdown, pro-inflammatory cytokines, zonulin, IgA levels to TRYCATs, and inversely correlated with IgM levels to OSEs. It is concluded that physio-somatic symptoms of schizophrenia are driven by various pathways, including increased zonulin, breakdown of the paracellular tight-junctions pathway, immune activation, and neurotoxicity.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Hussein Kadhem Al-Hakeim, Haneen Tahseen Al-Rubaye, Dhurgham Shihab Al-Hadrawi, Abbas F. Almulla, Michael Maes
Summary: The immune-inflammatory response during the acute phase of COVID-19 predicts the severity of chronic fatigue, depression, and anxiety symptoms in Long COVID. SpO2 and PBT during acute infection affect immune and oxidative stress pathways in Long COVID.
MOLECULAR PSYCHIATRY
(2023)
Letter
Clinical Neurology
Abbas F. Almulla, Hussein Kadhem Al-Hakeim, Michael Maes
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Virology
Aristo Vojdani, Elroy Vojdani, Evan Saidara, Michael Maes
Summary: Long-haul COVID, also known as long COVID, is a novel syndrome that occurs in a significant percentage of individuals a few months after being infected with SARS-CoV-2. It is characterized by persistent, recurring, or new symptoms that affect various tissues and organs. There are similarities between long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), with infections, immune dysregulation, and inflammation playing a role in both conditions.
Article
Neurosciences
Hussein Kadhem Al-Hakeim, Anwar Khairi Abed, Shatha Rouf Moustafa, Abbas F. Almulla, Michael Maes
Summary: In this study, we found that severe Long COVID patients had low serum tryptophan, low oxygen saturation, high insulin resistance, high C-reactive protein, and high ratings on all symptom domains. Inflammatory responses, decreased tryptophan, and increased kynurenine may contribute to the physio-affective phenome of Long COVID.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Psychiatry
Ketsupar Jirakran, Asara Vasupanrajit, Chavit Tunvirachaisakul, Michael Maes
Summary: This study aimed to determine whether neuroticism is a feature of the acute state of major depressive disorder (MDD), including suicidal behaviors, and whether adverse childhood experiences are associated with neuroticism in MDD. The results showed that neuroticism was significantly higher in MDD patients compared to healthy controls, and it explained a large portion of the variance in the depression phenome. Neglect and abuse in childhood accounted for a significant portion of the variance in the latent vector representing MDD phenome, with neuroticism partially mediating the effects of neglect and completely mediating the effects of abuse.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Rosa Savino, Alessandro Medoro, Sawan Ali, Giovanni Scapagnini, Michael Maes, Sergio Davinelli
Summary: While autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome, studies have shown that oxidative stress and inflammation are common factors in ASD. Flavonoids, plant-derived compounds with antioxidant, anti-inflammatory, and neuroprotective effects, have been investigated for their potential impact on ASD. A review of preclinical and clinical studies found that flavonoids may improve oxidative stress parameters, reduce inflammation, and ameliorate core symptoms of ASD. However, more randomized placebo-controlled trials are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
George Anderson, Abbas F. Almulla, Russel J. Reiter, Michael Maes
Summary: There is increasing evidence that autoimmune processes play an important role in various medical conditions, including cancers, neurodegenerative diseases, and psychiatric disorders. These conditions are associated with alterations in mitochondrial function across cells. The mitochondrial melatonergic pathway is present in all body cells and has important implications for driving autoimmune processes.
Article
Cell Biology
Michael Maes, Asara Vasupanrajit, Ketsupar Jirakran, Pavit Klomkliew, Prangwalai Chanchaem, Chavit Tunvirachaisakul, Sunchai Payungporn
Summary: Maes et al. (2008) found that major depressive disorder (MDD) is associated with abnormalities in the microbiota-gut-brain axis, characterized by elevated IgM/IgA levels to lipopolysaccharides (LPS) from Gram-negative bacteria. In a study of Thai patients with MDD, fecal samples were analyzed using 16S rDNA sequencing. The results showed a specific profile of gut dysbiosis in MDD, with increased pathobionts and depleted beneficial microbiota, suggesting a potential biomarker of MDD.
Article
Neurosciences
Michael Maes, Abbas F. Almulla
Summary: Recent studies have developed valid precision models and diagnostic rules for recurrent MDD. This study aimed to construct precision models and RADAR scores for first-episode MDD, and examine their association with adverse childhood experiences, negative life events, suicidal behaviors, cognitive impairment, and phenome RADAR scores. The findings suggest that NLE and ACE have cumulative effects on the phenome of FEM, particularly emotional neglect and to a lesser extent physical abuse. The RADAR scores and plots should be used in research and clinical settings instead of binary diagnosis of MDD.
Article
Neurosciences
Michael Maes, Yoshiko Abe, Wandee Sirichokchatchawan, Junpen Suwimonteerabutr, Ussanee Sangkomkamhangd, Abbas F. F. Almulla, Sirina Satthapisit
Summary: This study found that immune profiles have an impact on the severity of prenatal depression, independent of adverse childhood experiences, premenstrual syndrome, and current psychological stressors. The immune system's expression during early and late pregnancy can influence the severity of depression symptoms.
Article
Psychiatry
Hussein Kadhem Al-Hakeim, Haneen Tahseen Al-Rubaye, Abdulsahib S. Jubran, Abbas F. Almulla, Shatha Rouf Moustafa, Michael Maes
Summary: This study examined the association between long COVID and increased insulin resistance, as well as its connection with neuroimmune and oxidative processes. The results showed that long COVID patients had increased insulin resistance, which was associated with depressive symptoms.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Michael Maes, Paul Thisayakorn, Yanin Thipakorn, Saran Tantavisut, Sunee Sirivichayakul, Aristo Vojdani
Summary: This study found that elevated IgA levels against neuronal self-antigens, AQP4, and HSP60 are risk factors for delirium. The breakdown of immune tolerance, activation of the immune-inflammatory response system, and injuries in neuronal and glial cells are involved in the pathophysiology of delirium.
EUROPEAN GERIATRIC MEDICINE
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)