Review
Psychiatry
Anna Grunze, Sergey Mosolov, Heinz Grunze, Christoph Born
Summary: This narrative review examines the epidemiology, consequences, and treatment options of tobacco use disorder (TUD) and nicotine dependence (ND) in individuals with bipolar disorder (BD). The study found that smoking rates are 2-3 times higher in individuals with BD compared to community samples. Smoking has a detrimental impact on both mental and physical health as well as mortality in individuals with BD. Treatment options include pharmacological interventions and psychosocial interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Guido Cereda, Paolo Enrico, Valentina Ciappolino, Giuseppe Delvecchio, Paolo Brambilla
Summary: Most studies found no significant differences in vitamin D levels between bipolar disorder patients and other psychiatric disorders, with the average values in the bipolar population being sub-threshold for deficiency. Although an association between vitamin D levels and clinical symptoms was observed, it is not a specific marker for bipolar disorder but a common characteristic shared with other psychiatric disorders. Additionally, vitamin D supplementation was linked to a reduction in depressive and manic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Jungwon Cha, Sidra Speaker, Bo Hu, Murat Altinay, Parashar Koirala, Harish Karne, Jeffrey Spielberg, Amy Kuceyeski, Elvisha Dhamala, Amit Anand
Summary: Using emotional inhibition tasks in fMRI, this study found that MDD- subjects exhibited lower activation in various brain regions compared to both BDD and MDD+ groups. The study also showed efficient discrimination between MDD- and BDD as well as MDD+ subjects, but less efficient discrimination between BDD and MDD+ groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Rebecca E. Easter, Kelly A. Ryan, Ryne Estabrook, David F. Marshall, Melvin G. McInnis, Scott A. Langenecker
Summary: This study found that cognitive performance is largely unrelated to depressive and manic symptoms in patients with bipolar disorder. The results suggest that cognitive dysfunction is stable in BD and is not dependent on mood state. Future research could investigate how treatment affects the relationship between cognition and mood.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Norio Yasui-Furukori
Summary: This study investigated the long-term clinical outcomes of patients with bipolar disorder (BD) and identified several predictors of these outcomes. The findings can assist clinicians in predicting the course of the illness based on demographic and clinical characteristics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Michael Berk, Tamsyn E. Van Rheenen
Summary: The study found a significant increase in subjective cognitive dysfunction in patients with bipolar disorder during the COVID-19 pandemic, but no substantial differences were observed in mood symptoms, fear of COVID-19, lifestyle factors, and social rhythms between patients and healthy controls, indicating a degree of resilience in bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Lisa T. Eyler, Farren B. S. Briggs, Annemiek Dols, Soham Rej, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Brent P. Forester, Regan E. Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta, Benoit H. Mulsant, Sigfried Schouws, Nadine P. G. Paans, Sergio Strejilevich, Ashley Sutherland, Shangying Tsai, Martha Sajatovic
Summary: This study analyzed the symptom mixity in older-age bipolar disorder (OABD) and its association with everyday function. The results showed that mixed features are predominant in OABD and are associated with worse everyday function. Among those with mixed symptoms, the severity of depression is the main driver of poorer functioning.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychiatry
Xiuhua Song, Yufang Feng, Lei Yi, Baoliang Zhong, Yi Li
Summary: The objective of this case-control study is to determine whether the blood thyroid hormone levels in bipolar disorder patients are associated with different types of first onset. The study found that thyroid dysfunction may be involved in the disease progression of bipolar disorder and correlated with the clinical symptoms in patients with depression or mania as the first episode.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Danielle A. Goldman, Anjali Sankar, Alexandra Rich, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
Summary: This study aimed to identify functional connectivity differences between depressions of bipolar disorder (BD-Dep) and depressions of major depressive disorder (MDD-Dep). The results showed that there were significant differences in functional connectivity patterns between these two groups, suggesting the potential for early diagnosis and treatment strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Gordon Parker, Minas Coroneo
Summary: This study presents exemplars of pseudo-hallucinations experienced by individuals with bipolar disorder, suggesting their overrepresentation in this condition and arguing that their presence does not indicate psychosis. The historical definitions of pseudo-hallucinations are reviewed, and six profiles are presented, considering manifestations, sequencing, and response to medication in bipolar disorder patients. The findings indicate the richness of expression, variable time course, and response to medication of pseudo-hallucinations in individuals with bipolar disorder.
AUSTRALASIAN PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Gordon Parker
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Gordon Parker
Summary: If attention-deficit hyperactivity disorder and bipolar disorder are independent conditions, the rate of comorbidity between the two is much higher than chance. This article explores the explanations for such a high comorbid prevalence and its management implications.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Letter
Psychiatry
Gordon Parker, Gabriela Tavella
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
M. S. Hopcraft, R. McGrath, N. Stormon, G. Parker
Summary: This study investigated the prevalence of mental health conditions among Australian dental practitioners. The results showed that these practitioners experience high levels of psychological distress, burnout, and mental health issues, indicating a need for education and support programs to enhance their well-being.
AUSTRALIAN DENTAL JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Matthew S. Hopcraft, Nicole Stormon, Roisin McGrath, Gordon Parker
Summary: This study investigated the factors associated with suicidal ideation and suicide attempts among dental practitioners in Australia. The results showed that 17.6% of the dental practitioners reported suicidal ideation in the past 12 months, 31.4% had prior suicidal ideation, and 5.6% had attempted suicide. Male dental practitioners, those with a current diagnosis of depression, those experiencing severe psychological distress, those who reported illicit substance use, and those with previous suicide attempts had higher odds of suicidal ideation in the past 12 months.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Review
Psychiatry
Michael J. Spoelma, Anastasia Serafimovska, Gordon Parker
Summary: The objective of this paper was to review potential biomarkers of melancholia in order to improve differential diagnosis, clinical response, and treatment outcomes. By comparing melancholic with non-melancholic depression, we emphasized the importance of distinguishing melancholia as its own condition.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Michael J. Spoelma, Katherine M. Ponte, Gordon Parker
Summary: This study aimed to identify common concerns of caregivers in the management of individuals with bipolar disorder. The results showed that concerns about work capacity and family impacts were almost ubiquitous, along with general feelings of ineffectiveness and irritation. Caregivers were more likely to fear suicide during depressive phases, while they were more likely to experience anger, concerns for their own safety, and take safety precautions during hypo/manic phases.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Gordon Parker, Minas T. Coroneo, Michael J. Spoelma
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Gordon Parker, Michael J. Spoelma, Samuel J. Skidmore, Amelia Reid, Samuel Morris, Greta Ferguson, Michael H. Connors
Summary: This study describes the development of an observational measure for differentiating schizophrenia from mania. The researchers identified two sets of 10 items that best differentiated the two conditions. They also found that a difference score of +1 showed optimal differentiation between schizophrenia and mania.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Gordon Parker, Michael J. Spoelma
Summary: ChatGPT has shown the capability of providing basic and informative content related to bipolar disorders, including descriptions of symptoms, classification types, causes, and treatment options. It has also demonstrated creativity in generating songs that capture the nuances of bipolar symptoms.
Article
Clinical Neurology
Gabriela Tavella, Dusan Hadzi-Pavlovic, Adam Bayes, Artin Jebejian, Vijaya Manicavasagar, Peter Walker, Gordon Parker
Summary: This study examined the differentiation between burnout and depression using a new measurement tool and other variables. The results showed that while there were some differences in symptoms, many of the symptoms were not specific to burnout. Furthermore, burnout appeared to overlap more with non-melancholic depression, and differentiation may rely more on causal factors than symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Alexis E. Whitton, Poornima Kumar, Michael T. Treadway, Ashleigh V. Rutherford, Manon L. Ironside, Dan Foti, Garrett Fitzmaurice, Fei Du, Diego A. Pizzagalli
Summary: Leading professional health bodies advocate for the use of Patient Reported Outcome Measures, such as quality of life, to understand the continued rise of depression despite increased treatment rates. This study examined the relationship between anhedonia, a symptom of depression, and its neural correlates with changes in patient-reported quality of life among individuals seeking treatment for mood disorders. Findings showed that anhedonia strongly correlated with quality of life among individuals with mood disorders. Improvements in quality of life were associated with increased neural reward responsiveness and reduced anhedonia severity over time. Differences in quality of life between unipolar and bipolar mood disorders were mediated by differences in anhedonia severity. These findings highlight the importance of targeting anhedonia and normalizing brain reward function in depression treatment for improved overall health outcomes.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Gordon Parker, Gabriela Tavella, Matthew Hopcraft
Summary: This study aimed to examine the convergent validity of the Sydney Burnout Measure (SBM) by comparing it with the Maslach Burnout Inventory (MBI). It also explored the relationship between burnout and psychological distress. The results showed a high correlation between the two measures, supporting the convergent validity of the SBM. The study also found a significant correlation between the burnout measures and the measures of psychological distress.
PSYCHIATRY RESEARCH
(2023)
Article
Substance Abuse
Jacqueline K. Gollan, Gabrielle Liverant, Nancy C. Jao, Kayla A. Lord, Alexis E. Whitton, Lee Hogarth, Erica Fox, Anna-Marika Bauer, Mackenzie Hosie Quinn, Diego A. Pizzagalli, Frank T. Leone, George D. Papandonatos, Robert A. Schnoll, Brian Hitsman
Summary: This study investigated how adult daily smokers learned to seek reward during a 12-week treatment combining behavioral activation and varenicline. The results showed that smokers with more severe depressive symptoms experienced a decline in reward learning during smoking cessation treatment, posing challenges for standard smoking cessation approaches.
NICOTINE & TOBACCO RESEARCH
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)