Article
Neurosciences
Emma L. Twait, Kim Blom, Huiberdina L. Koek, Maarten H. T. Zwartbol, Rashid Ghaznawi, Jeroen Hendrikse, Lotte Gerritsen, Mirjam I. Geerlings
Summary: This study used high-field 7T MRI to explore the association between psychosocial factors and hippocampal (subfield) volumes. The results showed that depression and anxiety were not associated with specific hippocampal (subfield) volumes, while childhood maltreatment and recent stressful life events may have an impact on hippocampal volume. Additionally, low social support was associated with smaller CA3 volume.
HUMAN BRAIN MAPPING
(2023)
Article
Psychiatry
Kangcheng Wang, Xingyan Li, Xiaotong Wang, Bernhard Hommel, Xiaodi Xia, Jiang Qiu, Yixiao Fu, Zheyi Zhou
Summary: This study aimed to investigate the abnormalities in the hippocampus and subfields in patients with schizophrenia (SCZ) and major depressive disorder (MDD). The results showed that SCZ patients had volume reductions in multiple subfields, and the reductions were more significant in the left molecular layer, dentate gyrus, CA2/3, and CA4 compared to the MDD group. The composite analyses demonstrated smaller hippocampal volumes in the SCZ group compared to healthy controls in all bilateral measures, and reduced volumes compared to the MDD group in left measures only.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Jeonghwan Lee, Gawon Ju, Hyemi Park, Seungwon Chung, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, Siekyeong Kim
Summary: Despite an abundance of research on the functional and structural changes in the brain of geriatric depression patients, there is a lack of knowledge about early alterations such as decreased white matter connectivity and their association with cognitive decline. This study aimed to investigate early changes in hippocampal microstructure and their associations with memory function in geriatric patients with subclinical depression. The results showed that hippocampal microstructure is disrupted and associated with memory in patients with subclinical depression.
Article
Clinical Neurology
Franz Riederer, Rene Seiger, Rupert Lanzenberger, Ekateriana Pataraia, Gregor Kasprian, Lars Michels, Spyros Kollias, Thomas Czech, Johannes A. Hainfellner, Johannes Beiersdorf, Christoph Baumgartner
Summary: Hippocampal sclerosis is a common pathological substrate in drug resistant temporal lobe epilepsy, with different types defined based on patterns of cell loss. Automated volumetry of specific hippocampal subfields using high resolution MRI can predict patterns of cell loss in hippocampal sclerosis, particularly for type 1 HS.
Article
Clinical Neurology
Yang Yang, Wei Liang, Yongjun Wang, Dechang Peng, Liang Gong, Na Wang, Zhongjie Huang, Weikang Yang
Summary: The study aimed to investigate the pattern of volume changes in neurofunctional hippocampal subfields in patients with insomnia and their associations with risk of development of insomnia. Results showed that hippocampal volume atrophy in specific neurofunctional subfields was not only associated with insomnia but also a significant risk factor predicting the development of insomnia. The study also developed a practical and visual competing risk-nomogram tool for individual prediction of insomnia risk with high accuracy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Sophia Vinci-Booher, Margaret L. Schlichting, Alison R. Preston, Franco Pestilli
Summary: The hippocampus is a complex brain structure with distinct cellular organizations in its subfields. The relationship between the cellular organization within each subfield and inference and memory functions during development is not well understood. This study examined the development of tissue microstructure and its relationship to performance on inference tasks. The results showed that each subfield had a unique relationship with age in terms of cellular organization, with the dentate gyrus related to memory-based inference and the subiculum related to perception-based inference.
Article
Clinical Neurology
Julia Van der A, Jesca E. De Jager, Edwin van Dellen, Rene C. W. Mandl, Metten Somers, Marco P. M. Boks, Iris E. C. Sommer, Jasper O. Nuninga
Summary: This study investigated the association between hippocampal structural changes and cognitive decline after electroconvulsive therapy (ECT) in patients with major depression. The results showed that volume increase in hippocampal subfields, as well as changes in perfusion and diffusion, were correlated with decreases in cognitive functioning. Due to methodological restrictions, neuroplasticity was indirectly measured using MRI. Therefore, the study suggests that neuroplastic processes may affect cognitive processes after ECT.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhiyong Zhao, Huaying Cai, Manli Huang, Weihao Zheng, Tingting Liu, Di Sun, Guocan Han, Linhui Ni, Yi Zhang, Dan Wu
Summary: The study found that patients with PSD showed specific alterations in the transmission and reception of information in the hippocampal subfields, leading to decreases in inward information flow and increases in outward information flow. Additionally, there were significant correlations between cognitive scores and dFCs in the PSD group related to the hippocampal subfields. Furthermore, dFCs of the hippocampus and its subfields improved the classification between PSD and PSND patients compared to clinical and demographic parameters alone, with high accuracy, sensitivity, and specificity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Psychology, Clinical
Bethany Little, Ossama Alshabrawy, Daniel Stow, I. Nicol Ferrier, Roisin McNaney, Daniel G. Jackson, Karim Ladha, Cassim Ladha, Thomas Ploetz, Jaume Bacardit, Patrick Olivier, Peter Gallagher, John T. O'Brien
Summary: Late-life depression (LLD) is associated with poor social functioning. A novel wearable device was tested to measure speech as an indicator of social interaction. Results showed that LLD patients had lower speech activity levels than controls, and speech activity was related to psychomotor retardation in LLD.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Clinical
Ben Chen, Mingfeng Yang, Xiaomei Zhong, Qiang Wang, Huarong Zhou, Meiling Liu, Min Zhang, Le Hou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning
Summary: The slowed information processing speed is the core cause of cognitive impairment in patients with late-life depression (LLD). The hippocampus, which is an important link between depression and dementia, may be involved in the slowing of information processing speed in LLD patients. The study found that the dynamic connectivity and connectivity changes of hippocampal subregions in LLD patients were associated with slowed information processing speed.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Gregoire Pin, Pierrick Coupe, Louis Nadal, Jose Manjon, Catherine Helmer, Helene Amieva, Bernard Mazoyer, Jean-Francois Dartigues, Gwenaelle Catheline, Vincent Planche
Summary: The study revealed a connection between changes in hippocampal subfields volume in older adults and vascular brain injuries, especially when affecting deep/subcortical structures. This association was confirmed in both cross-sectional and longitudinal analyses.
Article
Biochemistry & Molecular Biology
Ermelinda De Meo, Emilio Portaccio, Elio Prestipino, Benedetta Nacmias, Silvia Bagnoli, Lorenzo Razzolini, Luisa Pasto, Claudia Niccolai, Benedetta Goretti, Angelo Bellinvia, Mattia Fonderico, Antonio Giorgio, Maria Laura Stromillo, Massimo Filippi, Sandro Sorbi, Nicola De Stefano, Maria Pia Amato
Summary: The BDNF Val66Met polymorphism may have a protective role in multiple sclerosis patients against both hippocampal atrophy and cognitive impairment.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Emre Hari, Elif Kurt, Ali Bayram, Gozde Kizilates-Evin, Burak Acar, Tamer Demiralp, Hakan Gurvit
Summary: This study aimed to track volumetric changes of hippocampal subfields in the Alzheimer's disease continuum (ADC) by comparing three stages. The results showed significant volume reductions in CA1, DG, and SUB in Alzheimer's disease dementia (ADD) patients compared to both amnestic mild cognitive impairment (MCI) and subjective cognitive impairment (SCI) groups. No significant volumetric changes were found between the SCI and MCI groups. The results highlight the importance of significant volume loss in DG and the resilience of the CA3 sector.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Pierre Wibawa, Mark Walterfang, Charles B. B. Malpas, Yifat Glikmann-Johnston, Govinda Poudel, Adeel Razi, Anthony J. J. Hannan, Dennis Velakoulis, Nellie Georgiou-Karistianis
Summary: This study examined the volumes of hippocampal subfields in individuals with early symptomatic Huntington disease (HD) using T1-weighted MRI. The results showed significantly lower subfield volumes in the symptomatic HD group compared to the pre-symptomatic HD and control groups. These findings suggest the involvement of specific hippocampal subregions in the memory impairment observed in early symptomatic HD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mohamed Salah Khlif, Emilio Werden, Laura J. Bird, Natalia Egorova-Brumley, Amy Brodtmann
Summary: This study evaluated longitudinal hippocampal subfield atrophy in the first year poststroke compared to healthy individuals. The results showed that stroke-induced effects were observed mainly in the anterior CA1 and posterior hippocampal tail of the ipsilesional hippocampus, suggesting that atrophy in these regions may be more closely linked to cognitive impairment than whole hippocampal atrophy.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)