Article
Engineering, Environmental
Feng Cui, Yunlong Zhu, Shanshan Di, Xinquan Wang, Yiming Zhang, Tingting Chai
Summary: The study found that exposure to S-fluoxetine can disrupt the brain serotonergic system in zebrafish more severely than exposure to racemate and R-fluoxetine, and this disruption mechanism shows sex-specific differences. In addition, enantioselective enrichment and biotransformation of fluoxetine occur in zebrafish, with higher concentrations observed in females.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Daniela Correia, Ines Domingues, Melissa Faria, Miguel Oliveira
Summary: Fluoxetine, a selective serotonin reuptake inhibitor, is commonly detected in aquatic environments at concentrations ranging from ng/L to μg/L. It can have adverse effects on fish, including neurotoxicity, genetic and biochemical changes, and behavioral dysfunction. However, contradictory results have been found. A comprehensive review is needed to understand the effects of fluoxetine on fish at different biological levels, identify patterns, and discuss potential causes for contradictory results. This review also highlights the need for standardized testing with representative aquatic models to assess the actual environmental risk of fluoxetine to aquatic ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Neurosciences
George M. Anderson, Isabella Bruno-Pacella
Summary: This article assesses the bioeffect of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and compares them using neuroimaging and in vitro measurements. The study finds that these drugs typically result in a 70-90% reduction in platelet serotonin (5-HT) content. The bioeffect is similar among different types of SSRIs and SNRIs and is consistent with other assessment methods.
PSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yui Suganuma, Chiho Sumi-Ichinose, Taiki Kano, Kazuhisa Ikemoto, Taei Matsui, Hiroshi Ichinose, Kazunao Kondo
Summary: In this study, it was found that QDPR deficiency suppresses platelet aggregation by impairing 5-HT biosynthesis in mice.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Joseph Grech, Melissa Victoria Chan, Chinedu Ochin, Amber Lachapelle, Florian Thibord, Zoe Schneider, Bongani Brian Nkambule, Paul Charles John Armstrong, Catherine Wallace de Melendez, Katherine L. Tucker, Mahdi Garelnabi, Timothy David Warner, Ming-Huei Chen, Andrew Danner Johnson
Summary: Depression is associated with cardiovascular disease, and platelet reactivity is related to the use of antidepressants, especially those affecting serotonin.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Clinical Neurology
Varsha Ramesh, Vettriselvi Venkatesan, Balakrishnan Ramasamy
Summary: The 5HTTLPR and SLC6A4 intron 2 polymorphisms are associated with treatment response, with the l/l genotype and 12-copy allele showing a tendency towards better outcomes, respectively.
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
(2022)
Editorial Material
Hematology
Julie Rayes
Summary: The intestinal IL-33-ST2-serotonin axis plays a key role in immune-endocrinal crosstalk during hemostasis and platelet-dependent neutrophil recruitment during inflammation.
Article
Cell Biology
Colby E. Witt, Sergio Mena, Lauren E. Honan, Lauren Batey, Victoria Salem, Yangguang Ou, Parastoo Hashemi
Summary: This study used fast-scan controlled-adsorption voltammetry (FSCAV) to measure low-periodicity fluctuations in serotonin levels in mouse hippocampi. Correlation analyses revealed that these oscillations were present in vivo but not in vitro, and were not significantly different under different conditions (sex and stress paradigm). The administration of a selective serotonin reuptake inhibitor resulted in a shift in the frequency of the oscillations, suggesting regulation by transporter proteins. Additionally, the experimental parameters of FSCAV were optimized for higher temporal resolution, leading to more pronounced shifts in oscillation frequency and decreased amplitude.
Article
Cell Biology
Huangfei Yu, Tianyin Qu, Jinlan Yang, Qing Dai
Summary: In this study, it is reported that serotonin transporter (SERT) transports serotonin into colorectal cancer cells, enhancing Yes-associated protein (YAP) expression and promoting colon cancer cell growth. The transglutaminase 2 (TG2) mediates RhoA serotonylation and activates RhoA-ROCK1/2 signaling to upregulate YAP expression. Blocking SERT with citalopram reverses serotonin-induced YAP expression and cell proliferation. In addition, SERT expression is correlated with YAP in human colorectal cancer samples and the levels of serotonin are significant in patients with colorectal cancer. Therefore, targeting the serotonin-SERT-YAP axis may be a potential therapeutic strategy for colorectal cancer.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Psychiatry
David E. Nichols
Summary: At first glance, the molecular structures of MDMA and MDA seem similar, but their activity stereochemistry differs. MDMA is distinct from classical hallucinogenic phenethylamines in structure and psychopharmacology. It promotes affiliative social behavior, has acute anxiolytic effects, and induces introspection and personal reflection. Its mechanism of action involves the transport and release of neuronal serotonin.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Nikita Deo, Gregory Redpath
Summary: This article examines the important role of endocytosis in the cellular basis of depression and anxiety. It provides a detailed explanation of the endocytic regulation of 5-HT receptors and SERT, and explores how SSRIs and hallucinogenic compounds modulate serotonin signaling through endocytosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Electrochemistry
Chase Stucky, Michael A. Johnson
Summary: In this study, it was found that three different SSRIs significantly decrease the oxidation current of serotonin when using the commonly used Jackson waveform. Coating carbon-fiber microelectrodes with Nafion further reduces the current and increases response times. To address fouling issues, an extended serotonin waveform was used, which alleviated the decrease in current, indicating reduced electrode fouling.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Developmental Biology
Erin Z. Aprison, Svetlana Dzitoyeva, Ilya Ruvinsky
Summary: Declining germline quality is a major cause of reproductive senescence. Regulatory pathways that promote germline quality, such as serotonin signaling, offer potential remedies. The effects of serotonin reuptake inhibitors and a C. elegans male pheromone, ascr#10, on germline quality have been studied, revealing possible therapeutic interventions for reproductive aging.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Ruediger Eberhard Scharf, Daniel Duerschmied, Nancy Schanze
Summary: This study found that deficiency of the serotonin transporter (SERT) is associated with metabolic derangements in mice. High-fat diet feeding in SERT-deficient mice resulted in enhanced insulin resistance, liver steatosis, and adipose tissue inflammation. These findings suggest that SERT deficiency may contribute to altered inflammatory processes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Juhee Lim, Yeojin Bang, Kyeong-Man Kim, Hyun Jin Choi
Summary: This study investigated the effects of differentiation on the serotonergic neuronal phenotype of the mouse hippocampal neuronal cell line HT22. The results showed that differentiation promoted neurite outgrowth and upregulation of N-methyl-D-aspartate receptor and choline acetyltransferase in HT22 cells. Furthermore, proteins required for serotonergic neurotransmission were significantly upregulated in differentiated HT22 cells. These findings suggest that differentiated HT22 cells have enhanced functional serotonergic properties and could be used for assessing the efficacy of antidepressant 5-HT reuptake inhibitors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Gabriele Baristaite, David Gurwitz
Summary: Epidemiological studies have found a slightly higher risk of severe Covid-19 symptoms and fatalities in men compared to women of similar age following SARS-CoV-2 infection. This difference may be attributed to variations in immune system regulation between males and females, driven by different levels of sex hormones, especially higher plasma estradiol in women. In vitro treatment of A549 human lung epithelial cells with 17-beta-estradiol was found to reduce the mRNA levels of ACE2 and TMPRSS2, which are proteins involved in the entry of SARS-CoV-2 into lung cells. This suggests that 17-beta-estradiol may decrease the infection of lung epithelial cells by SARS-CoV-2, providing a possible explanation for the lower incidence of severe Covid-19 and fatalities among women compared to men of similar age.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Chemistry, Medicinal
Gabriele Baristaite, David Gurwitz
Summary: Several comorbidities, including diabetes, immune deficiency, and chronic respiratory disorders, increase the risk of severe Covid-19 and fatalities among SARS-CoV-2 infected individuals. Our findings suggest that chronic diabetic-like conditions may facilitate SARS-CoV-2 infection of lung epithelial cells by dysregulating the transcription of key genes involved in viral entry and immune response. Developing special treatment protocols for diabetic patients is crucial in addressing the higher risk of severe Covid-19 in this population.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Microbiology
Sheelu Monga, Basem Fares, Rami Yashaev, Dov Melamed, Meygal Kahana, Fuad Fares, Abraham Weizman, Moshe Gavish
Summary: Macrophages are important immune cells responsible for creating an inflammatory immune response. This study found that a natural-based formulation (NBF) can inhibit the inflammatory response of macrophages and attenuate the release of inflammatory markers. NBF may be a potential candidate for the treatment of inflammatory diseases.
Article
Chemistry, Medicinal
Adva Hadar, Irena Voinsky, Olga Parkhomenko, Monika Puzianowska-Kuznicka, Jacek Kuznicki, Illana Gozes, David Gurwitz
Summary: With increased life expectancies, cancer rates are rising among the elderly. However, some centenarians are able to reach exceptionally old age without experiencing cancer. This study found higher ATM mRNA expression in LCLs from female centenarians and lower hsa-miR-181a-5p levels targeting ATM. These findings suggest a potential role for ATM in protecting against age-related diseases.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Infectious Diseases
Barak Pertzov, Guy Shapira, Simon Abushkara, Sharon Cohen, Adi Turjeman, Mordechai R. Kramer, David Gurwitz, Noam Shomron
Summary: This study found that patients admitted due to severe COVID-19 had lower levels of A1AT compared to patients admitted due to non-COVID pneumonia. Multivariate analysis showed that diabetes, older age, and high A1AT levels were all associated with increased mortality in COVID-19 patients.
INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Irena Voinsky, Oleg Y. Fridland, Adi Aran, Richard E. Frye, David Gurwitz
Summary: Early diagnosis of ASD is crucial, but the current process is lengthy due to the lack of reliable biomarkers. In this study, we used RNA-sequencing to identify dysregulated genes in ASD children and developed machine learning models for ASD diagnosis. Our models achieved an accuracy of 82% in distinguishing ASD children from NT children, but further validation is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Noa Katz Shroitman, Assif Yitzhaky, Dorit Ben Shachar, David Gurwitz, Libi Hertzberg
Summary: Schizophrenia is a chronic and debilitating mental disorder with unknown causes. This study investigated the expression of ATP synthase encoding genes in postmortem brain samples of individuals with schizophrenia. The results showed down-regulation of ATP synthase genes in schizophrenia, supporting the hypothesis that reduced ATP synthesis is associated with this disorder. The findings highlight the importance of abnormal cellular energy metabolism in schizophrenia.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Yael Yuhas, Shai Ashkenazi, Eva Berent, Abraham Weizman
Summary: Schizophrenia is a chronic neurodevelopmental psychotic disorder that involves the immune system and neuroinflammation. Clozapine, an atypical antipsychotic, has been found to have immunomodulatory effects in an astroglial model of neuroinflammation. This study suggests that clozapine can inhibit the production of inflammatory mediators and increase COX2 expression, potentially benefiting patients with treatment-resistant schizophrenia and neuroinflammatory markers.
Article
Pediatrics
Gherta Brill, Iris Manor, Roberta Bril Paroz, Shai Ashkenazi, Shira Cohen, Avivit Golan-Cohen, Ilan Green, Ariel Israel, Shlomo Vinker, Abraham Weizman, Eugene Merzon
Summary: This study evaluated the association between growth hormone treatment and the risk of COVID-19 infection in children. The results show that children receiving growth hormone treatment have a lower risk of SARS-CoV-2 positivity, suggesting that growth hormone may act as a protective factor possibly due to its immunomodulatory activity.
Article
Nutrition & Dietetics
Orit Uziel, Hadar Dickstein, Einat Beery, Yael Lewis, Ron Loewenthal, Eran Uziel, Zipi Shochat, Abraham Weizman, Daniel Stein
Summary: The length of telomeres in anorexia nervosa (AN) patients is shorter and does not recover after inpatient treatment. Patients with the restricting type of AN have longer telomeres compared to those with the binge/purge type. Age is the only factor associated with telomere shortening.
Article
Chemistry, Medicinal
Irena Voinsky, Elad Shapira, David Gurwitz
Summary: Biobanks play a crucial role in biomedical research by providing human cell lines for drug development projects. RNA-sequencing of large panels of cell lines from individuals with certain disorders and healthy controls, or with different drug response phenotypes, is commonly performed. In this study, we demonstrate that extracting RNAs directly from long-term frozen human cell lines yields high-quality RNA samples suitable for optimal RNA-sequencing, comparable to those obtained from growing cell lines.
DRUG DEVELOPMENT RESEARCH
(2023)
Editorial Material
Chemistry, Medicinal
David Gurwitz, Noam Shomron
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Liron Mizrahi, Ashwani Choudhary, Polina Ofer, Gabriela Goldberg, Elena Milanesi, John R. Kelsoe, David Gurwitz, Martin Alda, Fred H. Gage, Shani Stern
Summary: Bipolar disorder is a mood disorder characterized by recurrent episodes of mania and depression. Many patients do not respond to the first-line treatment drug lithium, making clinical management challenging. By analyzing gene expression in lymphoblastoid cell lines, we identified potential biomarkers for diagnosing and treating bipolar disorder. We also developed machine learning algorithms that accurately predicted lithium response in different patient cohorts. This methodology shows promise for guiding therapeutic interventions.
MOLECULAR PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Eugene Merzon, Eli Magen, Shai Ashkenazi, Abraham Weizman, Iris Manor, Beth Krone, Ilan Green, Avivit Golan-Cohen, Shlomo Vinker, Stephen V. Faraone, Ariel Israel
Summary: This study found an association between G6PD deficiency and an increased risk of ADHD diagnosis. Individuals with G6PD deficiency were more likely to seek care from adult neurologists and psychiatrists. Moreover, they had a higher usage of stimulant medications.
Article
Education, Special
Hagit Nagar Shimoni, Yael Leitner, Roni Yoran-Hegesh, Ya'arit Bokek-Cohen, Shahar Gindi, Abraham Weizman
Summary: Clinical observations suggest that girls suspected to have ASD may have better performance in social and emotional tasks than boys, leading to under-diagnosis of girls with ASD. The study found that girls diagnosed with ASD performed better than boys in the Person index of the Social Attribution Task (SAT), indicating that girls with ASD may not have better social understanding than boys, except when prompted to name human traits.
INTERNATIONAL JOURNAL OF DISABILITY DEVELOPMENT AND EDUCATION
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)