Review
Psychiatry
Marta Ielmini, Ivano Caselli, Flavio Critelli, Michele Mattia, Alessandro Bellini, Camilla Callegari
Summary: This systematic review with meta-analysis evaluates the utility of pharmacogenetic tests (PGTs) in the routine clinical treatment of mood disorders. The results indicate that PGT suggestions can lead to better efficacy outcomes for patients with major depressive disorder (MDD), but not for patients with bipolar disorder (BD). However, PGTs show promising results in terms of setting up more tolerated therapies. Overall, PGTs are important in supporting clinicians' choices in psychopharmacological therapies.
PSYCHIATRY RESEARCH
(2022)
Review
Chemistry, Medicinal
Marek Krzystanek, Stanislaw Surma, Artur Palasz, Monika Romanczyk, Krzysztof Krysta
Summary: The antidepressant effects of memantine in bipolar depression are promising, with both experimental and clinical evidence supporting its efficacy. The presented case study demonstrates that memantine can be an effective and safe adjunct treatment for mood stabilization in bipolar depression. This suggests that memantine may offer a new approach for patients who do not respond well to traditional medications.
Article
Clinical Neurology
Elisa M. T. Melloni, Beatrice Bravi, Sara Poletti, Sara Dallaspezia, Barbara Barbini, Raffaella Zanardi, Francesco Benedetti
Summary: This study found that total sleep deprivation and light therapy can reduce the severity of depression, and this effect is closely related to changes in the concentrations of glutamate and glutamine+glutamate. This finding contributes to a better understanding of the antidepressant mechanism of chronotherapy.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Antonio Del Casale, Leda Marina Pomes, Luca Bonanni, Federica Fiasche, Clarissa Zocchi, Alessio Padovano, Ottavia De Luca, Gloria Angeletti, Roberto Brugnoli, Paolo Girardi, Robert Preissner, Marina Borro, Giovanna Gentile, Maurizio Pompili, Maurizio Simmaco
Summary: Pharmacogenomics-guided treatment may be effective in the cure of treatment-resistant depression. This study evaluated the clinical changes after PGT in patients with TRD and found that the PGT group showed significant improvements in efficacy index and clinical global impression compared to the control group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Gianluca Serafini, Gustavo Vazquez, Fiammetta Monacelli, Matteo Pardini, Maurizio Pompili, Mario Amore
Summary: This study compared the socio-demographic and clinical features of bipolar disorder patients treated vs. not treated with antidepressant drugs (ADs). The results showed that patients treated with ADs were older, more likely to be retired, and more likely to have had a first major depressive episode. Patients receiving ADs also had more affective episodes and longer illness duration compared to those not treated with ADs.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Ju-Wei Hsu, Li-Chi Chen, Shih-Jen Tsai, Kai-Lin Huang, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu -Hong Chen
Summary: Studies have shown that there is a positive relationship between resistance to antidepressants and the progression of bipolar disorder. However, the specific influence of different types of antidepressants, such as SSRIs and SNRIs, in this context has not been thoroughly investigated. This study recruited a total of 5,285 young people with antidepressant-resistant depression and 21,140 with antidepressant-responsive depression. It was found that those with resistance to antidepressants, especially to both SSRIs and SNRIs, were at an increased risk of developing bipolar disorder.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Chih-Ken Chen, Lawrence Shih-Hsin Wu, Ming-Chyi Huang, Chian-Jue Kuo, Andrew Tai-Ann Cheng
Summary: This study investigates the effects of individual genomics and antidepressant medication on the risk of manic switch in bipolar I disorder. The results suggest that the rs10262219 variant on chromosome 7 and antidepressant treatment significantly increase the risk of manic switch after bipolar depression.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Psychiatry
Ashley N. Siegel, Joshua D. Di Vincenzo, Elisa Brietzke, Hartej Gill, Nelson B. Rodrigues, Leanna M. W. Lui, Kayla M. Teopiz, Jason Ng, Roger Ho, Roger S. McIntyre, Joshua D. Rosenblat
Summary: This review evaluated the effects of intranasal esketamine and intravenous ketamine on patients with suicidal ideation. Results indicate that ketamine may rapidly reduce suicidal ideation and depressive symptoms, with potential short-lasting effects. The treatment was deemed relatively safe in the short term, and future clinical trials are encouraged to include this study population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Behavioral Sciences
Mina Jahandideh, Erfan Ebrahimi, Mohammad Hosein Farzaei, Ebrahim Barzegari
Summary: This study aimed to investigate the genomics underlying the enlarged volume of the hippocampus in bipolar disorder patients after long-term lithium administration. The results suggest that lithium may promote the generation of new neurons and their differentiation into neuroblasts, neurons, or microglia, leading to hippocampal enlargement. Several genes, including CCND1, LOXL2, and PRNP, were identified as being involved in the drug response and chronic effects of lithium in hippocampal cells. GSK-3β was also found to be a key hub in the pharmacogenomic network of lithium.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Ma-Li Wong, Mauricio Arcos-Burgos, Sha Liu, Alice W. Licinio, Chenglong Yu, Eunice W. M. Chin, Wei-Dong Yao, Xin-Yun Lu, Stefan R. Bornstein, Julio Licinio
Summary: Rare functional variants were identified in antidepressant drug response, serving as potential genetic markers for predicting drug response. Limitations include small sample size and inability to use antidepressant blood level as a covariate. Further studies with larger cohorts are warranted.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Giuseppe Fanelli, Katharina Domschke, Alessandra Minelli, Massimo Gennarelli, Paolo Martini, Marco Bortolomasi, Eduard Maron, Alessio Squassina, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Bernhard T. Baune, Alessandro Serretti, Chiara Fabbri
Summary: The study investigated the possible association of polygenic risk scores (PRSs) for bipolar disorder, major depressive disorder (MDD), neuroticism, and schizophrenia (SCZ) with antidepressant non-response or non-remission in patients with MDD. Results did not show significant associations after Bonferroni correction, but a potential link was found between MDD-PRS and non-remission. Methodological improvements in PRS calculation may enhance their predictive performance in precision psychiatry.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Tuyen T. Le, Joshua D. Di Vincenzo, Kayla M. Teopiz, Yena Lee, Danielle S. Cha, Leanna M. W. Lui, Nelson B. Rodrigues, Roger C. Ho, Bing Cao, Kangguang Lin, Flora Nasri, Hartej Gill, Orly Lipsitz, Mehala Subramaniapillai, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger S. McIntyre
Summary: Psychotic depression is a severe subtype of major depressive disorder with high relapse and mortality rates. Ketamine may be an alternative pharmacotherapy, but its efficacy and safety in patients with psychotic depression have not been established.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Dogukan Koc, Ecem Ince, Tugba San, Pinar Akan, Ahu Paketci, Ece Bober, Nese Direk Tecirli, Neslihan Inal, Aynur Pekcanlar Akay
Summary: This study aimed to explore the association between thyroid autoimmunity and treatment-emergent mania (ATEM) in pediatric mood disorders. The findings showed that the seroprevalence and titer of anti-thyroid peroxidase antibodies (TPO-abs) were significantly higher in patients with ATEM compared to controls. Logistic regression analysis revealed a significant association between TPO-abs seroprevalence and ATEM even after adjusting for various factors. These findings suggest that TPO-abs could potentially serve as a biomarker for assessing the risk of ATEM in children and adolescents.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Monica Macellaro, Nicolaja Girone, Laura Cremaschi, Monica Bosi, Bruno Mario Cesana, Federico Ambrogi, Valentina Caricasole, Federica Giorgetti, Terence A. Ketter, Bernardo Dell'Osso
Summary: This study retrospectively evaluated the applicability and progression of four staging models in a sample of 100 bipolar disorder patients. The results showed a pattern of stage worsening for each model, with a significant increase at each time point. Patients with lower education level, younger age at first episode, shorter illness duration, and shorter duration of untreated illness showed greater stage increases. Lower stage values were associated with certain characteristics, such as BD II, no psychiatric hospitalization, depressive onset, and few lifetime episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Mehmet Utku Kucuker, Aysegul Ozerdem, Deniz Ceylan, Alejandra Cabello-Arreola, Ada M. C. Ho, Boney Joseph, Lauren M. Webb, Paul E. Croarkin, Mark A. Frye, Marin Veldic
Summary: This systematic review examined the role of DNA repair enzymes, particularly base excision repair (BER), in mood disorders. The study found that SNPs of several BER genes are associated with MDD and BD, but conflicting findings and limited studies make it difficult to draw definitive conclusions about BER gene expression. Further research comparing DNA repair during episodes of mood disorders to remission may provide valuable insights into the role of DNA repair in these conditions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Nicolas A. Nunez, Boney Joseph, Mehak Pahwa, Rakesh Kumar, Manuel Gardea Resendez, Larry J. Prokop, Marin Veldic, Ashok Seshadri, Joanna M. Biernacka, Mark A. Frye, Zhen Wang, Balwinder Singh
Summary: This study compared the efficacy and discontinuation of augmentation agents in adult patients with treatment-resistant depression through a systematic review and network meta-analyses. The findings suggest that certain adjunctive atypical antipsychotics, thyroid hormones, dopamine compounds, and lithium are superior in terms of efficacy. However, ziprasidone, mirtazapine, and cariprazine had higher discontinuation rates. Further research and head-to-head studies are needed to strengthen treatment options for treatment-resistant depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Manuel Gardea-Resendez, Monica J. Taylor-Desir, Francisco Romo-Nava, David Bond, Eric J. Vallender, Alfredo B. Cuellar-Barboza, Miguel L. Prieto, Nicolas Nunez, Marin Veldic, Aysegul Ozerdem, Balwinder Singh, Matej Markota, Colin L. Colby, Brandon J. Coombes, Joanna M. Biernacka, Susan L. McElroy, Mark A. Frye
Summary: This study aimed to evaluate the clinical correlates and antipsychotic use patterns of tardive dyskinesia (TD+) in patients with bipolar disorder (BD). The prevalence rate of TD was 5.1%. TD+ participants were older, more likely to be female, and have type I bipolar illness compared to the TD- group. Limitations of the study included a cross-sectional design and the lack of severity assessment for tardive illness.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Nicolas A. Nunez, Brandon J. Coombes, Francisco Romo-Nava, David J. Bond, Jennifer Vande Voort, Paul E. Croarkin, Nicole Leibman, Manuel Gardea Resendez, Marin Veldic, Hannah Betcher, Balwinder Singh, Colin Colby, Alfredo Cuellar-Barboza, Miguel Prieto, Katherine M. Moore, Aysegul Ozerdem, Susan L. McElroy, Mark A. Frye, Joanna M. Biernacka
Summary: Bipolar disorder with co-occurring attention deficit-hyperactivity disorder (ADHD) is associated with a younger age of onset, male predominance, higher rates of comorbid anxiety and substance use disorders, and poorer response to mood stabilizing treatments. Genetic analysis shows that all subsets of bipolar disorder patients have higher genetic risk for both bipolar disorder and ADHD, with BD+cADHD patients having a higher ADHD genetic risk.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Manuel Gardea-Resendez, Stacey J. Winham, Francisco Romo-Nava, Alfredo Cuellar-Barboza, Matthew M. Clark, Ana Cristina Andreazza, Alejandra Cabello-Arreola, Marin Veldic, David J. Bond, Balwinder Singh, Miguel L. Prieto, Nicolas A. Nunez, Hannah Betcher, Katherine M. Moore, Thomas Blom, Colin Colby, Richard S. Pendegraft, Sydney S. Kelpin, Aysegul Ozerdem, Alessandro Miola, Eleanna De Filippis, Joanna M. Biernacka, Susan L. McElroy, Mark A. Frye
Summary: This study aims to assess diet quality in bipolar disorder patients and find associations between unhealthy diet quality and depression, obesity, and cardiometabolic abnormalities. These associations were found to be stronger in female participants.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Alessandro Miola, Eleanna De Filippis, Marin Veldic, Ada Man-Choi Ho, Stacey J. Winham, Mariana Mendoza, Francisco Romo-Nava, Nicolas A. Nunez, Manuel Gardea Resendez, Miguel L. Prieto, Susan L. McElroy, Joanna M. Biernacka, Mark A. Frye, Alfredo B. Cuellar-Barboza
Summary: This review focuses on the genomic studies of bipolar disorder (BD) with obesity and type 2 diabetes (T2D), highlighting promising genome-wide associations and potential biological impacts. However, limitations in the research are acknowledged, calling for further studies to refine cardiometabolic phenotypes, test gene-environment interactions, and increase population diversity to enhance our understanding of genetic associations.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Mehak Pahwa, Mehmet U. Kucuker, Man Choi Ho, Ajeng Puspitasari, Katherine M. Moore, Hannah K. Betcher, Mark A. Frye, Balwinder Singh, Aysegul Ozerdem, Marin Veldic
Summary: This systematic review found that women with BD have higher psychiatric and medical comorbidities compared to women without BD or other major psychiatric illness. These comorbidities, along with various psychosocial factors, have been shown to affect the course of BD. Therefore, gender-specific screening and interventions are needed for patients with BD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Rakesh Kumar, Boney Joseph, Vanessa M. Pazdernik, Jennifer Geske, Nicolas A. Nunez, Mehak Pahwa, Kianoush B. Kashani, Marin Veldic, Hannah K. Betcher, Katherine M. Moore, Paul E. Croarkin, Aysegul Ozerdem, Alfredo B. Cuellar-Barboza, Susan L. McElroy, Joanna M. Biernacka, Mark A. Frye, Balwinder Singh
Summary: This study investigates the association between long-term lithium therapy and chronic kidney disease in patients with bipolar disorder. It found that discontinuation of lithium treatment increases the risk of relapse and shortens the time to the first mood episode.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manuel Gardea-Resendez, Brandon J. Coombes, Marin Veldic, Susannah J. Tye, Francisco Romo-Nava, Aysegul Ozerdem, Miguel L. Prieto, Alfredo Cuellar-Barboza, Nicolas A. Nunez, Balwinder Singh, Richard S. Pendegraft, Alessandro Miola, Susan L. McElroy, Joanna M. Biernacka, Eva Morava, Tamas Kozicz, Mark A. Frye
Summary: This study investigated the relationship between mitochondrial function and the risk of treatment-emergent mania in patients with bipolar disorder. The results showed that antidepressants that increased mitochondrial energetics were associated with a higher risk of treatment-emergent mania. These findings suggest the need for a reclassification of antidepressants based on mitochondrial energetics and encourage future studies on specific antidepressants and mitochondrial activity.
MOLECULAR PSYCHIATRY
(2023)
Review
Clinical Neurology
Alessandro Miola, Neri A. Alvarez-Villalobos, Fernando Gerardo Ruiz-Hernandez, Eleanna De Filippis, Marin Veldic, Miguel L. Prieto, Balwinder Singh, Jorge A. Sanchez Ruiz, Nicolas A. Nunez, Manuel Gardea Resendez, Francisco Romo-Nava, Susan L. McElroy, Aysegul Ozerdem, Joanna M. Biernacka, Mark A. Frye, Alfredo B. Cuellar-Barboza
Summary: Insulin resistance (IR) is associated with poorer clinical outcomes and inadequate treatment response in patients with bipolar disorder (BD). BD patients with IR exhibit impairments in verbal memory and executive function, as well as smaller hippocampal volumes and prefrontal neurochemical alterations. They are also more likely to have chronic and rapid cycling courses and lower Global Assessment of Functioning scores. BD patients with impaired glucose metabolism also have a higher rate of poor response to mood stabilizers.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Francisco Romo-Nava, Thomas Blom, Alfredo B. Cuellar-Barboza, Francisco J. Barrera, Alessandro Miola, Nicole N. Mori, Miguel L. Prieto, Marin Veldic, Balwinder Singh, Manuel Gardea-Resendez, Nicolas A. Nunez, Aysegul Ozerdem, Joanna M. Biernacka, Mark A. Frye, Susan L. McElroy
Summary: This study evaluated the clinical features and comorbidities of patients with bipolar disorder and a history of asthma. The study found that being female and having an evening chronotype were significant predictors of asthma, and individuals with asthma had higher odds of having other medical comorbidities.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Meeting Abstract
Psychiatry
M. Kucuker, A. Ozerdem, D. Ceylan, A. Cabello-Arreola, M. C. Ho, B. Joseph, L. Webb, P. Croarkin, M. Frye, M. Veldic
EUROPEAN PSYCHIATRY
(2022)
Meeting Abstract
Clinical Neurology
Aysegul Ozerdem, Marin Veldic, Balwinder Singh, Deniz Ceylan, Mark Frye, Thomas Schulze, Joanna Biernacka, Stacey J. Winham
Meeting Abstract
Pharmacology & Pharmacy
N. Nunez, B. Coombes, A. Ozerdem, F. Romo-Nava, B. Singh, M. Gardea Resendez, A. Cuellar-Barboza, M. Veldic, K. Moore, J. Vande Voort, P. Croarkin, H. Betcher, S. Kung, S. McElroy, J. Biernacka, M. Frye
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Meeting Abstract
Pharmacology & Pharmacy
N. Nunez, F. Romo-Nava, K. Moore, A. Ozerdem, A. Seshadri, J. Baruth, K. Lindstrom Bremer, G. Georgiev, M. Veldic, H. Betcher, B. Singh, J. Vande Voort, P. Croakrin, A. Cuellar-Barboza, M. Skime, J. Biernacka, S. McElroy, M. Frye
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
