Article
Rheumatology
Jennifer C. E. Lane, James Weaver, Kristin Kostka, Talita Duarte-Salles, Maria Tereza F. Abrahao, Heba Alghoul, Osaid Alser, Thamir M. Alshammari, Carlos Areia, Patricia Biedermann, Juan M. Banda, Edward Burn, Paula Casajust, Kristina Fister, Jill Hardin, Laura Hester, George Hripcsak, Benjamin Skov Kaas-Hansen, Sajan Khosla, Spyros Kolovos, Kristine E. Lynch, Rupa Makadia, Paras P. Mehta, Daniel R. Morales, Henry Morgan-Stewart, Mees Mosseveld, Danielle Newby, Fredrik Nyberg, Anna Ostropolets, Rae Woong Park, Albert Prats-Uribe, Gowtham A. Rao, Christian Reich, Peter Rijnbeek, Anthony G. Sena, Azza Shoaibi, Matthew Spotnitz, Vignesh Subbian, Marc A. Suchard, David Vizcaya, Haini Wen, Marcel de Wilde, Junqing Xie, Seng Chan You, Lin Zhang, Simon Lovestone, Patrick Ryan, Daniel Prieto-Alhambra
Summary: This study found that the use of hydroxychloroquine to treat rheumatoid arthritis does not appear to increase the risk of depression, suicide/suicidal ideation, or psychosis compared to sulfasalazine. No consistent short-term or long-term effects were observed. Further investigation is needed for higher doses or different indications of use.
Article
Chemistry, Medicinal
Adam Wlodarczyk, Alicja Dywel, Wieslaw Jerzy Cubala
Summary: This study investigates the safety of intravenous ketamine treatment for treatment-resistant depression and finds a significant association between epilepsy and elevated BPRS scores.
Article
Psychiatry
Robert A. McCutcheon, Alistair Cannon, Sita Parmer, Oliver D. Howes
Summary: The dichotomies of 'typical/atypical' or 'first/second generation' used to classify antipsychotics for several decades are flawed from both clinical and pharmacological perspectives.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Nicolas Garel, Jessica Drury, Julien Thibault Levesque, Nathalie Goyette, Alexandre Lehmann, Karl Looper, David Erritzoe, Shannon Dames, Gustavo Turecki, Soham Rej, Stephane Richard-Devantoy, Kyle T. Greenway
Summary: This article presents the Montreal model, a comprehensive biopsychosocial approach to ketamine for severe treatment-resistant depression (TRD). The model aims to bridge the gap between biomedical and psychedelic treatments and provides a feasible, flexible, and standardized approach to ketamine for TRD.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Franciele Cordeiro Gabriel, Airton Tetelbom Stein, Daniela Oliveira de Melo, Gessica Caroline Henrique Fontes-Mota, Itamires Benicio dos Santos, Aliandra Fantinell de Oliveira, Renerio Fraguas, Eliane Ribeiro
Summary: This study aimed to evaluate the similarities and differences in the recommended sequence of strategies among clinical practice guidelines for the treatment of depression in adults who do not respond to first-line treatment. The study found shortcomings and divergences in the definition of inadequate response and the recommended sequence of strategies in these guidelines. Most guidelines recommend reassessing the diagnosis, evaluating comorbidities, adhering to treatment, increasing medication dosage, and considering psychotherapy as the first steps.
Article
Clinical Neurology
Tapio Paljarvi, Jari Tiihonen, Markku Lateenvuo, Antti Tanskanen, Seena Fazel, Heidi Taipale
Summary: This study aimed to establish the risk of suicide associated with incident psychotic depression (PD) compared to incident non-psychotic severe depression (NPD). The results showed that PD was associated with a twofold increased risk of suicide compared to NPD, with the highest relative risks for impact-related and suffocation-related suicides. This study revealed some characteristics of PD patients in terms of the severity of suicidal ideation and choice of self-harm methods.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Phillippa Harrison, Ewan Carr, Kimberley Goldsmith, Allan Young, Mark Ashworth, Diede Fennema, Suqian Duan, Barbara M. Barrett, Roland Zahn
Summary: This study developed a computerised decision-support tool to guide antidepressant treatment for general practitioners in UK primary care. Feasibility was not shown in the current study and several modifications are needed to overcome limitations.
Review
Medicine, General & Internal
Franciele Cordeiro Gabriel, Daniela Oliveira de Melo, Airton Tetelbom Stein, Gessica Caroline Henrique Fontes-Mota, Itamires Benicio dos Santos, Camila da Silva Rodrigues, Monica Cristiane Rodrigues, Tatiane Bomfim Ribeiro, Renerio Fraguas, Ivan D. Florez, Diogo Telles-Correia, Eliane Ribeiro
Summary: This study aimed to assess the quality of clinical practice guidelines for the pharmacological treatment of depression and explore factors associated with higher quality. The results showed that 27% of the guidelines were classified as high quality, with 11.1% having high-quality recommendations. Factors associated with higher quality included handling of conflicts of interest, multiprofessional teams, and type of institution.
Review
Pharmacology & Pharmacy
Meng Zhang, Xue Bai
Summary: Post-stroke depression (PSD) is the most common non-cognitive neuropsychiatric complication after stroke, and about a third of stroke patients have depression. Traditional Chinese Medicine (TCM) theory suggests that PSD is a combination of stroke and Yu Zheng. Shugan Jieyu capsule (SG), a classic TCM prescription, has been clinically proven to significantly improve the psychiatric symptoms of PSD patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Adam Wlodarczyk, Wieslaw J. Cubala, Maria Galuszko-Wegielnik, Joanna Szarmach
Summary: This study investigates the relationship between dissociative and psychometric measures in the course of intravenous ketamine treatment in TRD inpatients with major depressive disorder and bipolar disorder. The results demonstrate a good safety profile of intravenous ketamine as an add-on intervention to current psychotropic medication in TRD, with dissociation abating over time with no sequelae or harm, and dissociation not being associated with treatment outcome.
Article
Medicine, Research & Experimental
Chan Li, Jiping Zhang, Hanhe Liu, Huijie Yuan, Jianxin Cai, Manoela Fogaca, Yuan-Wei Zhang
Summary: This study discovered that Dajianzhong decoction (DJZT) can synergistically treat depression with ketamine by affecting bidirectional communication between the gut and the brain and inhibiting inflammation. This finding provides new insights into the systematic treatment of depression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Psychiatry
Steven L. Dubovsky, Biswarup M. Ghosh, Jordan C. Serotte, Victoria Cranwell
Summary: Psychotic depression is considered an independent trait that may accompany mood disorders of varying severity, with acute treatment typically involving a combination of antidepressants, antipsychotic drugs, or electroconvulsive therapy. Limited information exists on maintenance treatment for unipolar psychotic depression and on acute and chronic treatment for psychotic bipolar disorder, leading to a reliance on clinical experience for treatment decision-making.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2021)
Article
Pharmacology & Pharmacy
Tingting Zhang, Wei Wei, Surui Chang, Nanyang Liu, Hao Li
Summary: The Yizhiqinxin formula (YZQX) might treat comorbidities of Alzheimer's disease (AD) and major depression disorder (MDD) by acting on multiple targets and pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Mazlina Mazlan, Julia Patrick Engkasan
Summary: This Cochrane Review aimed to assess the effectiveness and adverse effects of pharmacological treatment of depression in people with primary brain tumours, but no eligible studies were found. Currently, there is a lack of high-quality evidence to support or oppose this treatment approach.
NEUROREHABILITATION
(2022)
Article
Medicine, General & Internal
H. Edmund Pigott, Thomas Kim, Colin Xu, Irving Kirsch, Jay Amsterdam
Summary: This study reanalyzed the patient-level data set of the STAR*D study and found that the reported cumulative remission rate was approximately half of what was reported.
Article
Pharmacology & Pharmacy
Laura Kalfsvel, Jorie Versmissen, Adriaan van Doorn, Walter van den Broek, Hugo van der Kuy, Floor van Rosse
Summary: The study found that students who spent more time and practiced more frequently with the e-learning modules, especially the P-scribe resource, were more likely to pass their pharmacotherapy assessments successfully.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Education, Scientific Disciplines
Suzanne Fikrat-Wevers, Karen Stegers-Jager, Marleen Groenier, Andries Koster, Jan Hindrik Ravesloot, Renske Van Gestel, Anouk Wouters, Walter van den Broek, Andrea Woltman
Summary: Applicant perceptions of selection methods can affect motivation, performance and withdrawal, and this study aimed to examine how different applicant subgroups perceive various selection methods. The findings showed that applicants prefer selection methods that give them a sense of control and allow them to showcase attributes beyond cognitive abilities. However, conflicting preferences and concerns were also identified.
Article
Education & Educational Research
Charlotte G. M. van Sassen, Pieter J. van den Berg, Silvia Mamede, Lilian Knol, Manon P. Eikens-Jansen, Walter W. van den Broek, Patrick J. E. Bindels, Laura Zwaan
Summary: The study aimed to identify and prioritize educational content from a malpractice claims database to enhance clinical reasoning education in General Practitioners' training. The prioritized conditions included complex common, complex rare, and more straightforward common conditions, often exhibiting atypical presentations or complex contextual factors.
ADVANCES IN HEALTH SCIENCES EDUCATION
(2023)
Article
Education & Educational Research
S. Fikrat-Wevers, K. M. Stegers-Jager, P. M. Afonso, A. S. Koster, R. A. Van Gestel, M. Groenier, J. H. Ravesloot, A. Wouters, W. W. Van Den Broek, A. M. Woltman
Summary: This study examined how selection procedures in health professions education impact student diversity. The results showed that different selection tools have different effects on the chances of selection for subgroups of applicants. The study highlights the importance of continuous evaluation and the use of alternative tools in order to improve diversity in health professions education.
ADVANCES IN HEALTH SCIENCES EDUCATION
(2023)
Article
Education & Educational Research
Telma Kremer, Silvia Mamede, Maria P. T. do Nunes, Walter W. van den Broek, Henk G. Schmidt
Summary: This study investigated the impact of negative emotions on medical residents' learning and whether cognitive reappraisal can counteract this effect. The results showed that negative emotions have a detrimental effect on medical residents' learning, and cognitive reappraisal is not effective in mitigating this effect. Further research on emotion regulation strategies in medical education is needed.
BMC MEDICAL EDUCATION
(2023)
Article
Psychiatry
Esther M. Pluijms, Poul T. Vinther, Astrid M. Kamperman, Tom K. Birkenhager
Summary: High relapse rates are observed after electroconvulsive therapy (ECT) for major depression. Identifying risk factors for relapse can help in intensifying treatment post-ECT, leading to reduced relapse rates. This study aimed to determine clinical characteristics associated with relapse within 2 years after successful ECT. Patients with psychotic features, higher symptom severity, and medication resistance prior to ECT showed a significantly decreased risk of relapse. A sustained remission rate of 50% over 2 years in patients with severe major depression treated with nortriptyline monotherapy after successful ECT is encouraging.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Education & Educational Research
J. Staal, K. Katarya, M. Speelman, R. Brand, J. Alsma, J. Sloane, W. W. van den Broek, L. Zwaan
Summary: Diagnostic errors are a major patient safety concern and can be prevented. This experiment studied the impact of feedback on medical interns' calibration and diagnostic process. Feedback improved interns' calibration and could be an effective tool to improve diagnostic accuracy.
ADVANCES IN HEALTH SCIENCES EDUCATION
(2023)
Article
Pharmacology & Pharmacy
L. S. Kalfsvel, L. E. J. Peeters, K. Hoek, C. Bethlehem, I. H. van der Sijs, P. H. M. van der Kuy, W. W. van den Broek, J. Versmissen, F. van Rosse
Summary: Formative assessments with personalized narrative feedback can motivate students and improve their prescribing skills. However, one formative assessment alone may not be enough to fully enhance clinical prescribing skills.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Education & Educational Research
Vera M. A. Broks, Karen M. Stegers-Jager, Suzanne Fikrat-Wevers, Walter. W. van den Broek, Andrea M. Woltman
Summary: The study found that students selected by assessment or weighted lottery showed higher levels of stress perception in Year-1 of medical school, while students selected by high grades had lower stress perception levels. Additionally, academic performance also had an impact on stress perception levels.
BMC MEDICAL EDUCATION
(2023)
Article
Education & Educational Research
S. Fikrat-Wevers, W. E. De Leng, W. W. van den Broek, A. M. Woltman, K. M. Stegers-Jager
Summary: This study evaluated the relationship between four free preparatory activities and the demographic composition of participating and non-participating applicants. The results showed that these activities contribute to student diversity in medical education, but participation is not directly associated with early academic performance.
BMC MEDICAL EDUCATION
(2023)
Article
Pharmacology & Pharmacy
Cornelis F. Vos, Tom K. Birkenhaeger, Willem A. Nolen, Walter W. van den Broek, Sophie E. ter Hark, Arnt F. A. Schellekens, Robbert-Jan Verkes, Joost G. E. Janzing
Summary: Early insomnia improvement (EII) is associated with positive treatment outcomes in psychotic depression (PD), regardless of the medication type. Further studies are required to validate these findings and examine the generalizability of EII as a predictor in depression treatment.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Afra van der Markt, Ursula Klumpers, Annemiek Dols, Nicole Korten, Marco P. Boks, Roel A. Ophoff, Aartjan Beekman, Ralph Kupka, Neeltje E. M. van Haren, Hugo Schnack
Summary: This study investigates the association between brain structures and illness progression in bipolar disorder (BD) and explores the potential of brain-predicted age difference (brain-PAD) as a biomarker for BD staging. The results suggest that higher brain-PAD is associated with impaired inter-episodic functioning, but this association loses significance after considering confounding factors such as lithium-use and comorbid anxiety disorders. There is no significant association between global and (sub)cortical brain measures and illness stages.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Education & Educational Research
Charlotte van Sassen, Silvia Mamede, Michiel Bos, Walter van den Broek, Patrick Bindels, Laura Zwaan
Summary: This study examined the impact of knowing that a diagnostic error resulted in a malpractice claim on diagnostic accuracy and self-reported confidence in future cases. The results showed that studying cases with or without malpractice claim information had no significant effect on diagnostic accuracy or self-reported confidence. Both versions were considered suitable for clinical reasoning education and more appropriate for advanced learners.
BMC MEDICAL EDUCATION
(2023)
Article
Pharmacology & Pharmacy
Laura Kalfsvel, Sarah Wilkes, Hugo van der Kuy, Walter van den Broek, Rianne Zaal, Floor van Rosse, Jorie Versmissen
Summary: The study aims to investigate the influence of doctors' experience level on the number and types of prescribing errors in a European academic teaching hospital using a computerized physician order entry system and clinical decision support system. The data collected from patient prescriptions revealed that non-specialty training doctors and specialty training doctors made more prescribing errors than consultants, and the types of errors varied among doctors with different experience levels. Therefore, specific additional education should be provided to medical students, non-specialty training doctors, and specialty training doctors.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
L. Kalfsvel, K. Hoek, C. Bethlehem, H. van der Kuy, W. van den Broek, J. Versmissen, F. van Rosse
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)