☆ 4.7 Article

Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder

JOURNAL OF AFFECTIVE DISORDERS (2010)

期刊

JOURNAL OF AFFECTIVE DISORDERS

卷 126, 期 3, 页码 430-435

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ELSEVIER

DOI: 10.1016/j.jad.2010.07.006

关键词

Antidepressant; Brain derived neurotrophic factor; Major depressive disorder; Single nucleotide polymorphism

类别

Clinical Neurology Psychiatry

资金

Department of Health, Taiwan [DOH96-TD-D-113-041]

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摘要

Backgrounds: To determine the association between the brain derived neurotrophic factor (BDNF) Val66Met polymorphism and short-term antidepressant response in Taiwanese patients with major depressive disorder (MDD). Methods: We recruited 117 MDD patients who were randomized to fluoxetine or venlafaxine treatment and 106 controls. The association between genotypes and percentage changes in the Hamilton Rating Scale for Depression (HAM-D) scores over time was analyzed by repeated-measures ANOVA. The antidepressants were included in the model as covariates. Results: The frequency of the BDNF Val66Met polymorphisms was not significantly different between patient and control groups. Significantly changes in HAM-D scores were noted after 2 and 4 weeks of venlafaxine treatment among different genotypes. Conclusions: Results suggest antidepressants acting through different mechanisms may affect the BDNF Val66Met polymorphism differently. (C) 2010 Elsevier B.V. All rights reserved.

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Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.

JOURNAL OF AFFECTIVE DISORDERS (2024)

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Article Clinical Neurology

Effect of dietary living microbe intake on depression symptom in American adult: An opinion from NHANES study

Yumeng Shi, Chao Yu

Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.

JOURNAL OF AFFECTIVE DISORDERS (2024)

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Article Clinical Neurology

Analysis of sleep for the American population: Result from NHANES database

Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen

Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.

JOURNAL OF AFFECTIVE DISORDERS (2024)

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