☆ 4.7 Article

Respiratory function and other biological risk factors for completed suicide: 40 years of follow-up of European cohorts of the Seven Countries Study

JOURNAL OF AFFECTIVE DISORDERS (2010)

期刊

JOURNAL OF AFFECTIVE DISORDERS

卷 120, 期 1-3, 页码 249-253

出版社

ELSEVIER SCIENCE BV

DOI: 10.1016/j.jad.2009.03.022

关键词

Suicide; Violence; Respiratory function; Risk factors; Middle-aged men; Socio-economic status; Forced vital capacity

类别

Clinical Neurology Psychiatry

资金

National Heart, Lung, and Blood Institute, Bethesda, Md, US [HE 04697, HE 6090, HE 00278]

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Protocol

Reagent

摘要

Background: Prospective cohort studies on biological risk factors of completed suicide are scarce. We aimed to test which biological risk factors independently identify subjects at increased risk of suicidal death. Methods: In the prospective cohort of the Seven Countries Study, 5,321 middle-aged men from Finland, Serbia, Italy, and Greece were included. Completed suicide (ICD-8 codes E950-959) was assessed during 40 years of follow-up. Biological cardiovascular risk factors (including forced vital capacity [FVC] and height) were tested for their role as predictors in multivariable Cox models stratified by country. Results: There were 4518 deaths during follow-up, with 64 from suicide (1.4%). In univariable models, only FVC and height were strongly inversely related with suicide. Socio-economic status and being unmarried were potential confounders. In multivariable models taking these confounders into account, both a low FVC (0.30 for top vs. lowest quartile: 95% CI: 0.12-0.76: P=0.006 for trend) and a low FVC/height ratio (0.37 for top vs. lowest quartile; 95% CI: 0.17-0.82; P=0.004 for trend) were strongly inversely related with completed suicide. Limitations: Information oil proximal causes, such as prior Suicidal ideation, emotional distress and depression, was lacking at baseline. Conclusions: Poor respiratory function in middle-aged men was an independent risk factor for completed suicide. (C) 2009 Elsevier B.V. All rights reserved.

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