Article
Clinical Neurology
John J. Soderholm, J. Lumikukka Socada, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: The course of illness differs between MDD, BD, and BPD patients. Bipolar depressive patients have an alternating course and the shortest time to first remission. The severity of BPD may predict the duration of remission from depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Claudia Delli Colli, Marta Borgi, Silvia Poggini, Flavia Chiarotti, Francesca Cirulli, Brenda W. J. H. Penninx, Francesco Benedetti, Benedetta Vai, Igor Branchi
Summary: The study elucidated the dynamic interaction of 5-HTTLPR gene with stress at different time points, highlighting the importance of time in influencing depression susceptibility.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Kimie Stefanie Ormstrup Sletved, Niels Henrik Falck Villemoes, Klara Coello, Sharleny Stanislaus, Hanne Lie Kjaerstad, Maria Faurholt-Jepsen, Kamilla Miskowiak, Jens Drachmann Bukh, Maj Vinberg, Lars Vedel Kessing
Summary: This study investigated the prevalence of comorbid personality disorders in patients with newly diagnosed BD and their unaffected first-degree relatives compared with healthy control individuals. The results showed that 25.5% of patients with newly diagnosed BD and 6.4% of their relatives fulfilled the criteria for comorbid personality disorders. Subthreshold personality disorders were also more prevalent in BD patients and their relatives. Comorbid personality disorders were associated with impaired functioning in BD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Hirotaka Sekiguchi, Geoff Pavey, Brian Dean
Summary: Dopamine dysregulation is known to have a major role in the pathophysiology of major depressive disorders (MDD) and bipolar disorders (BD). The dopamine transporter (DAT) plays a critical role in regulating dopamine concentration at the synaptic cleft and may be selectively affecting dopamine homeostasis in patients with MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Manuel Gardea-Resendez, Stacey J. Winham, Francisco Romo-Nava, Alfredo Cuellar-Barboza, Matthew M. Clark, Ana Cristina Andreazza, Alejandra Cabello-Arreola, Marin Veldic, David J. Bond, Balwinder Singh, Miguel L. Prieto, Nicolas A. Nunez, Hannah Betcher, Katherine M. Moore, Thomas Blom, Colin Colby, Richard S. Pendegraft, Sydney S. Kelpin, Aysegul Ozerdem, Alessandro Miola, Eleanna De Filippis, Joanna M. Biernacka, Susan L. McElroy, Mark A. Frye
Summary: This study aims to assess diet quality in bipolar disorder patients and find associations between unhealthy diet quality and depression, obesity, and cardiometabolic abnormalities. These associations were found to be stronger in female participants.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cell Biology
Colby E. Witt, Sergio Mena, Lauren E. Honan, Lauren Batey, Victoria Salem, Yangguang Ou, Parastoo Hashemi
Summary: This study used fast-scan controlled-adsorption voltammetry (FSCAV) to measure low-periodicity fluctuations in serotonin levels in mouse hippocampi. Correlation analyses revealed that these oscillations were present in vivo but not in vitro, and were not significantly different under different conditions (sex and stress paradigm). The administration of a selective serotonin reuptake inhibitor resulted in a shift in the frequency of the oscillations, suggesting regulation by transporter proteins. Additionally, the experimental parameters of FSCAV were optimized for higher temporal resolution, leading to more pronounced shifts in oscillation frequency and decreased amplitude.
Article
Multidisciplinary Sciences
Trent Davidson, David B. Braudt, Robert Keers, Elham Assary, Kathleen Mullan Harris, Jason D. Boardman
Summary: This study re-evaluated one of the most cited and disputed papers in gene-environment interaction literature, using a genome-wide polygenic indicator to examine the genetic determinants of stress sensitivity. The results supported the stress-diathesis perspective and validated the scientific contributions of the original paper.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Jinghua Yin, Tianqi Ma, Jinchen Li, Guogang Zhang, Xunjie Cheng, Yongping Bai
Summary: This study reveals that mood disorders have a significant impact on the progression from single cardiometabolic diseases to multimorbidity or mortality. Patients with comorbid mood disorders, such as depression or bipolar disorder, are more likely to develop multimorbidity, and mood disorders also increase the overall mortality rate.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Melis Orhan, Sigfried Schouws, Patricia van Oppen, Max Stek, Paul Naarding, Didi Rhebergen, Annemieke Dols, Nicole Korten
Summary: This study found that both older age bipolar disorder (OABD) and late life depression (LLD) are associated with cognitive dysfunction. OABD patients showed more severe cognitive dysfunction compared to LLD patients, regardless of the severity of depressive symptoms. These findings suggest that other disease characteristics may contribute to the differences in cognitive functioning between OABD and LLD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Linda Steinholtz, Johan Reutfors, Lena Brandt, Pia Nordanskog, Elin Thornblom, Jonas Persson, Robert Boden
Summary: Response rates to electroconvulsive therapy in depression may be lower in patients with concurrent personality or anxiety disorders, but the majority of patients still respond positively. The impact of comorbidity decreases with higher age and severity of depressive episode; subjective ratings of memory impairment do not differ between patients with and without comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Nikita Deo, Gregory Redpath
Summary: This article examines the important role of endocytosis in the cellular basis of depression and anxiety. It provides a detailed explanation of the endocytic regulation of 5-HT receptors and SERT, and explores how SSRIs and hallucinogenic compounds modulate serotonin signaling through endocytosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Clinical Neurology
Bianca E. Kavanagh, Melanie M. Ashton, Stephanie P. Cowdery, Olivia M. Dean, Alyna Turner, Michael Berk, Stella M. Gwini, Sharon L. Brennan-Olsen, Heli Koivumaa-Honkanen, Andrew M. Chanen, Lana J. Williams
Summary: This study aimed to investigate the impact of personality disorders on pharmacological treatment outcomes in adults with mood disorders. Through a systematic review and meta-analysis of 18 studies, it was found that comorbid personality disorders do not significantly affect the efficacy of pharmacological interventions for mood disorders in adults.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Kelly A. Ryan, Peisong Han, Yuhua Zhang, David F. Marshall, Anastasia K. Yocum, Melvin G. McInnis, Sebastian Zollner
Summary: Individuals with bipolar disorder tend to have higher neuroticism and lower extraversion and consciousness compared to healthy controls. Personality traits show only small changes over time, with neuroticism being the only trait associated with changes in mood state. Other factors beyond mood changes may influence changes in personality traits.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Linda Garvert, Kevin Kirchner, Hans J. Grabe, Sandra Van der Auwera
Summary: Recent GWAS have found many single nucleotide polymorphisms that affect depressive disorders, suggesting that depression is a heterogeneous disorder influenced by numerous genetic variants with small effect sizes. However, there is limited understanding of the interaction between different genetic risk factors. This study used a genome-wide gene-gene interaction approach and identified a significant interaction effect between the DPF1 gene and the 5-HTTLPR gene on lifetime depression. DPF1, previously not associated with depressive disorders, is expressed exclusively in the brain and plays a major role in neuronal development and neuroplasticity.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Mark Zimmerman, Caroline Balling, Iwona Chelminski, Kristy Dalrymple
Summary: Patients with both bipolar disorder and BPD exhibit more severe psychosocial morbidity compared to those with only one of these disorders.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Valerio Brunetti, Jessica Marotta, Giorgia Simoncini Malucelli, Giuseppe Marano, Marianna Mazza, Giacomo Della Marca
Summary: Pitolisant, a histamine 3-receptor antagonist/inverse agonist, is effective and safe for treating excessive daytime sleepiness and cataplexy in narcolepsy. However, our report highlights that caution should be exercised when prescribing pitolisant to patients with a predisposition to psychiatric disorders, especially during the initial phase of treatment. Considering the high prevalence of psychiatric comorbidities in narcolepsy, it is important to carefully evaluate the psychiatric background of narcoleptic patients.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Giovanni Martinotti, Bernardo Dell'Osso, Giorgio Di Lorenzo, Giuseppe Maina, Alessandro Bertolino, Massimo Clerici, Stefano Barlati, Gianluca Rosso, Marco Di Nicola, Matteo Marcatili, Giacomo d'Andrea, Clara Cavallotto, Stefania Chiappini, Sergio De Filippis, Giuseppe Nicolo, Pasquale De Fazio, Ileana Andriola, Raffaella Zanardi, Domenica Nucifora, Stefania Di Mauro, Roberta Bassetti, Mauro Pettorruso, Roger S. McIntyre, Stefano L. Sensi, Massimo di Giannantonio, Antonio Vita
Summary: This study aimed to compare the efficacy of esketamine in treating unipolar and bipolar treatment-resistant depression (TRD) and provide preliminary evidence of its effectiveness in bipolar TRD (B-TRD). The results showed that esketamine significantly reduced depressive symptoms in B-TRD patients compared to TRD patients, and it had a better anxiolytic action in B-TRD patients. The low risk of side effects confirmed the safety of this treatment.
Article
Clinical Neurology
Francesco Bartoli, Tommaso Callovini, Daniele Cavaleri, Cristina Crocamo, Ilaria Riboldi, Andrea Aguglia, Pasquale De Fazio, Giovanni Martinotti, Armando D'Agostino, Giovanni Ostuzzi, Corrado Barbui, Giuseppe Carra
Summary: This study examines the effect of long-acting injectable antipsychotics on hospitalization rates and number of days in individuals with bipolar disorder. The findings suggest that the initiation of LAI treatment leads to a significant decrease in hospitalization rates and days, supporting their effectiveness as maintenance treatment options for BD. However, the effect may not be significant for patients who continue the treatment for less than 6 months.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychiatry
Paola Rocca, Paola Rucci, Cristiana Montemagni, Alessandro Rossi, Alessandro Bertolino, Eugenio Aguglia, Carlo A. Altamura, Mario Amore, Ileana Andriola, Antonello Bellomo, Claudio Brasso, Bernardo Carpiniello, Elisa Del Favero, Liliana Dell'Osso, Fabio Di Fabio, Michele Fabrazzo, Andrea Fagiolini, Giulia Maria Giordano, Carlo Marchesi, Giovanni Martinotti, Palmiero Monteleone, Maurizio Pompili, Rita Roncone, Rodolfo Rossi, Alberto Siracusano, Elena Tenconi, Antonio Vita, Patrizia Zeppegno, Silvana Galderisi, Mario Maj
Summary: This study investigates the magnitude and clinical significance of social cognition changes in stable schizophrenia patients, and finds that these changes are associated with recovery.
EUROPEAN PSYCHIATRY
(2023)
Editorial Material
Pharmacology & Pharmacy
Alessandro Serretti
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Vincenzo Oliva, Giuseppe Fanelli, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Chiara Fabbri, Alessandro Serretti
Summary: This study found that different clinical subtypes of major depressive disorder (MDD), particularly melancholic features and typical neurovegetative symptoms, may be associated with distinct underlying genetics. These findings contribute to a better understanding of the genetic heterogeneity of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Genetics & Heredity
Raffaella Zanardi, Matteo Carminati, Francesco Attanasio, Chiara Fabbri, Alessandro Serretti
Summary: Nonpharmacological treatments for depression show effectiveness and tolerability in certain patients with diverse response. Genetic variables associated with treatment efficacy need to be examined to assist treatment selection. Most studies using candidate gene approach yielded poorly replicated findings due to small sample sizes, while a few methylome-wide and genome-wide association studies (GWASs) provided interesting results with the use of polygenic risk scores in small samples of electroconvulsive therapy (ECT) and cognitive-behavioral therapy. Further GWAS with larger sample sizes, such as the gen-ECT-ic consortium, can enhance our understanding of the genetic factors underlying treatment response in nonpharmacological therapies for depression.
PSYCHIATRIC GENETICS
(2023)
Article
Neurosciences
Mario Luciano, Gaia Sampogna, Bianca Della Rocca, Alessio Simonetti, Pasquale De Fazio, Marco Di Nicola, Giorgio Di Lorenzo, Maria Pepe, Fabio Sambataro, Maria Salvina Signorelli, Alexia Emilia Koukopoulos, Roberto Delle Chiaie, Gabriele Sani, Andrea Fiorillo
Summary: This study investigated the relationship between affective temperaments and suicidality. It found that certain affective dispositions were associated with the onset and intensity of suicidal ideation and behaviors. Therefore, evaluating affective dispositions in clinical settings can help identify individuals at risk of suicide and develop effective preventive interventions.
Review
Health Care Sciences & Services
Lorenzo Moccia, Georgios D. Kotzalidis, Giovanni Bartolucci, Sara Ruggiero, Laura Monti, Marco Biscosi, Beatrice Terenzi, Ottavia M. Ferrara, Marianna Mazza, Marco Di Nicola, Delfina Janiri, Alessio Simonetti, Emanuele Caroppo, Luigi Janiri, Gabriele Sani
Summary: Psychosis is a complex condition characterized by delusions, hallucinations, and disorganized thought, speech, or behavior. There is increasing concern about the potential link between COVID-19 and the development of new-onset psychosis. This article reviews the current evidence on the association between SARS-CoV-2 and the risk of psychosis as an acute or post-infectious manifestation of COVID-19. It also discusses the challenges in determining a causal pathogenic relationship between SARS-CoV-2 infection and new-onset psychosis.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Neurosciences
Marianna Mazza, Georgios D. Kotzalidis, Giuseppe Marano, Domenico De Berardis, Giovanni Martinotti, Enrico Romagnoli, Giuseppe Biondi-Zoccai, Antonio Abbate, Gabriele Sani
Summary: Lorcaserin is a drug that binds to 5-HT2C serotonin receptors in the hypothalamus and ventral tegmental area, regulating hunger, pleasure, and reward. It was initially developed for obesity treatment, but also showed potential for substance use and craving. However, it was voluntarily withdrawn from the US market due to an increased risk of certain cancers. If proven to be safe, ongoing research suggests lorcaserin may have therapeutic potential for various central nervous system disorders beyond obesity.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Clinical Neurology
Ambra Craba, Marianna Mazza, Giuseppe Marano, Maria Luigia Crosta, Federica Moroni, Salvatore Di Pietro, Marta Balocchi, Silvia Della Casa, Lucio Rinaldi, Luigi Janiri, Gabriele Sani
Summary: Dysfunctional parenting styles are risk factors for eating disorders. In this study, the researchers examined the relationship between perception of parental bonding and defense mechanisms in patients with anorexia and bulimia. The results showed that maternal care was associated with immature defense mechanisms, while paternal overprotection was associated with mature defense mechanisms. Patients with eating disorders tend to utilize more neurotic and primitive defense mechanisms, which are associated with greater severity of eating symptomatology.
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2023)
Article
Neurosciences
Alessio Simonetti, Marijn Lijffijt, Sherin Kurian, Johanna Saxena, Delfina Janiri, Marianna Mazza, Giulio Carriero, Lorenzo Moccia, Benson Mwangi, Alan C. Swann, Jair C. Soares
Summary: This study investigated the neural correlates of the late positive potential (LPP) in youth with pediatric bipolar disorder (PBD). The results showed that PBD patients had a stronger LPP response to happy faces and thinner cortex in prefrontal areas compared to healthy controls. Furthermore, the LPP amplitude was associated with variations in cortical thickness and deep gray matter volumes. These findings suggest that the dysregulation of emotion processing and control in PBD may be related to abnormalities in specific brain regions.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Neurosciences
Alessandro Serretti
Summary: Anhedonia is a core symptom of depression and other psychiatric disorders, referring to a lack of pleasure or reward. It is not only a psychological distress but also encompasses a range of reward processing deficits. Anhedonia is a relevant risk factor for suicidal behaviors and may operate independently of the severity of depressive episodes. It has also been associated with inflammation, which can have a reciprocal detrimental effect on depression. The neurophysiological bases of anhedonia mainly involve changes in striatal and prefrontal areas, with dopamine playing a key role as the neurotransmitter involved. Anhedonia is believed to have a significant genetic component and polygenic risk scores may be a tool for predicting an individual's risk for developing anhedonia. Traditional antidepressants have shown limited benefit in treating anhedonia, also considering their potential to worsen anhedonia in some individuals. Other treatments such as agomelatine, vortioxetine, ketamine, and transcranial magnetic stimulation may be more effective. Psychotherapy, particularly cognitive-behavioral therapy and behavioral activation, is widely supported as beneficial for anhedonia. In conclusion, evidence suggests that anhedonia is partially independent from depression and requires careful evaluation and targeted treatment.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Neurosciences
Maria Pepe, Giovanni Bartolucci, Ilaria Marcelli, Francesco Pesaresi, Andrea Brugnami, Romina Caso, Alessia Fischetti, Flavia Grisoni, Marianna Mazza, Giovanni Camardese, Marco Di Nicola, Gabriele Sani
Summary: The effectiveness of esketamine nasal spray in treating treatment-resistant depression has been confirmed by real-world studies. Patients' perceptions of the treatment aligned with clinicians' assessments, although some differences were observed in specific symptoms.
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)