Article
Medicine, General & Internal
Federica Piras, Nerisa Banaj, Valentina Ciullo, Fabrizio Piras, Giuseppe Ducci, Francesco Demaria, Stefano Vicari, Gianfranco Spalletta
Summary: In a study of children and adolescents with OCD, certain dysfunctional beliefs and cognitive traits were found to predict symptom severity. Self-oriented and socially prescribed perfectionism and intolerance to uncertainty were associated with higher obsession severity, while excessive concerns with the expectations of others were linked to greater severity of obsessions and compulsions about harm due to aggression/injury/violence/natural disasters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Srinivas Balachander, Sandra Meier, Manuel Matthiesen, Furkhan Ali, Anand Jose Kannampuzha, Mahashweta Bhattacharya, Ravi Kumar Nadella, Vanteemar S. Sreeraj, Dhruva Ithal, Bharath Holla, Janardhanan C. Narayanaswamy, Shyam Sundar Arumugham, Sanjeev Jain, Y. C. Janardhan Reddy, Biju Viswanath
Summary: The study found a high concordance of OCD symptom dimensions within multiplex families, indicating significant heritability of OCD symptom dimensions. Future genetic and neurobiological studies in OCD should consider symptom dimensions as a key parameter in their analyses.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Basak Sahin, Yasir Safak, Kadir Ozdel
Summary: This study aimed to identify cognitive differences specific to symptom dimensions of OCD and investigate the relationship between these dimensions and cognitive features. The results showed that certain cognitive features were closely associated with specific symptom dimensions and could even predict these dimensions.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Esengul Ekici, Mustafa Ugurlu, Fatih Yigman, Yasir Safak, Kadir Ozdel
Summary: Obsessive-Compulsive Disorder (OCD) is a heterogeneous disorder, and the dimensions of contamination, harm, unwanted thoughts, and symmetry may vary in each patient. This study found that cognitive and emotional factors and their relations varied depending on the OCD dimensions. Identifying cognitive and emotional factors related to these differences is of significance for therapeutic interventions.
CURRENT PSYCHOLOGY
(2023)
Article
Psychiatry
Ana Beatriz Ravagnani Salto, Marcos L. Santoro, Marcelo Q. Hoexter, Andrea Parolin Jackowski, Pedro M. Pan, Maria Conceicao Rosario, Sintia Belangero, Pedro Gomes Alvarenga, Victoria Fogaca Doretto, Afonso Mazine Tiago Fumo, Marcelo C. Batistuzzo, Pedro Macul Ferreira de Barros, Kiara R. Timpano, Vanessa K. Ota, Luis Augusto Rohde, Euripedes Constantino Miguel, James F. Leckman, Andre Zugman
Summary: The study found a significant relationship between OCS and the symmetrized percent change (SPC) of the right thalamus volume in children, but there was no significant relationship between changes in thalamic volume SPC and OCD-PRS. These findings suggest the need for further research to confirm the results and further characterize the specific nature of OCS symptoms associated with thalamic volumes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Angel Rosa-Alcazar, Jose Luis Parada-Navas, Maria Dolores Garcia-Hernandez, Andrea Pozza, Paolo Tondi, Ana Isabel Rosa-Alcazar
Summary: The COVID-19 pandemic is associated with a worsening of obsessive-compulsive symptoms. This study aimed to examine the long-term changes in severity and dimensions of obsessive-compulsive disorder (OCD) during the pandemic. The results showed intragroup differences in severity, with contamination and somatic dimensions being affected more.
Article
Psychology, Clinical
Katherine Parkin, Shanquan Chen, Marjan Biria, James Plaistow, Helen Beckwith, Isaac Jarratt-Barnham, Nuria Segarra, Yulia Worbe, Naomi A. Fineberg, Rudolf N. Cardinal, Trevor W. Robbins, Emilio Fernandez-Egea
Summary: Obsessive-compulsive symptoms (OCS) commonly occur in patients treated with clozapine and can significantly affect subjective wellbeing. This study found that OCS severity had a negative impact on wellbeing scores, independent of depressive and psychotic symptoms. However, OCS did not impair general functioning. Obsessional thinking and hoarding behavior, rather than compulsions, were specifically associated with decreased wellbeing, possibly due to the nature of the compulsions.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Hollie A. L. Burton, Luise Pickenhan, Claire Carson, Paul Salkovskis, Fiona Alderdice
Summary: This review synthesized evidence on the experiences of maternity care and mental health care for women with Obsessive Compulsive Disorder (OCD) during pregnancy and postpartum. The findings revealed three descriptive themes: experiences of barriers to treatment and care, experiences of treatment/care decision making, and experiences of treatment and care. Three analytic themes were also identified, which demonstrated tensions in balancing the health and safety of the baby and the mother, as well as the perception of a normal perinatal experience. The review highlighted significant gaps in the literature, particularly regarding maternity and pharmacological care experiences. Balancing these tensions is crucial to ensure that women with OCD receive the necessary care.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Benjamin Klugah-Brown, Chenyang Jiang, Elijah Agoalikum, Xinqi Zhou, Liye Zou, Qian Yu, Benjamin Becker, Bharat Biswal
Summary: This study aimed to identify robust brain structural markers for compulsivity across substance use disorders and obsessive-compulsive disorder. The findings indicate widespread GMV reductions in the left inferior frontal gyrus (IFG) in both disorders, suggesting a transdiagnostic brain structural marker. The IFG plays a key role in the cognitive control network and exhibits bidirectional interactions with the striatum.
HUMAN BRAIN MAPPING
(2021)
Article
Psychology, Multidisciplinary
Liliana Dell'Osso, Benedetta Nardi, Chiara Bonelli, Davide Gravina, Francesca Benedetti, Luca Del Prete, Gabriele Massimetti, Giulia Amatori, Barbara Carpita, Ivan Mirko Cremone
Summary: Recent research emphasizes the importance of a dimensional perspective on mental disorders, particularly the conceptualization of an obsessive-compulsive spectrum. The current study aims to evaluate the psychometric characteristics of the Obsessive-Compulsive Spectrum-Short Version (OBS-SV) questionnaire. The results demonstrate strong reliability and validity of the OBS-SV, showing significant correlations with other measures of obsessive-compulsive symptoms.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Psychiatry
Tamar C. Katz, Thanh Hoa Bui, Jennifer Worhach, Gabrielle Bogut, Kinga K. Tomczak
Summary: Tourettic OCD (TOCD) is a unique condition with overlapping symptoms of OCD and CTD. It is characterized by complex tic-like behaviors with compulsive and anxious features. TOCD is an intermediate neuropsychiatric disorder distinct from TS or OCD alone. The treatment of TOCD is complex and often resistant to treatment, requiring a combination of pharmacology and behavioral therapy.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Mariela Rance, Zhiying Zhao, Brian Zaboski, Stephen A. Kichuk, Emma Romaker, William N. Koller, Christopher Walsh, Cheyenne Harris-Starling, Suzanne Wasylink, Thomas Adams Jr, Patricia Gruner, Christopher Pittenger, Michelle Hampson
Summary: This study aimed to use fMRI neurofeedback as a treatment for OCD. The results showed that neurofeedback targeting the aPFC can reduce symptoms in OCD, but did not significantly affect control over the aPFC. Future studies should optimize the training protocol and clarify the mechanism of action.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Omer Linkovski, Hadar Naftalovich, Mor David, Yuval Seror, Eyal Kalanthroff
Summary: Studies have shown that alertness can impact inhibitory control, which is crucial for individuals with Obsessive-Compulsive Disorder (OCD). Chronotype, the mechanism governing fluctuation of alertness throughout the day, plays a role in OCD symptoms. In a study, OCD patients completed a symptom-provocation stop signal task (SP-SST) three times per day for a week, and results showed that stopping was harder during symptom-provocation trials and better during optimal times of day based on chronotype.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Javier Labad, Cristian Sebastian Melia, Cinto Segalas, Pino Alonso, Neus Salvat-Pujol, Eva Real, Alex Ferrer, Susana Jimenez-Murcia, Carles Soriano-Mas, Virginia Soria, Jose Manuel Menchon
Summary: The study revealed sex differences in the association between OCD subtypes and specific HPA axis measures. For example, there was a positive association between current ordering/symmetry symptoms and AWE diurnal cortisol slope in men, while an inverse association was found in women. Additionally, there were similar sex by OCD dimensions interactions for lifetime aggressive and ordering/symmetry symptoms and both diurnal cortisol slopes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Nur Dikmeer, Lutfullah Besiroglu, Maria A. Di Biase, Andrew Zalesky, Meltem I. Kasal, Aslihan Bilge, Ercan Durmaz, Serap Polat, Fazil Gelal, Nabi Zorlu
Summary: In comparison to healthy controls, OCD patients showed reduced FA and increased RD in certain key areas of the brain. OCD group also exhibited weaker connectivity in the right hemisphere compared to controls. Siblings of OCD patients had intermediate levels of white matter microstructure and connectivity, suggesting a familial predisposition for OCD.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Psychology, Developmental
A. D. Jassi, P. Vidal-Ribas, G. Krebs, D. Mataix-Cols, B. Monzani
Summary: Despite the high comorbidity, there is limited knowledge about the clinical features and treatment outcomes for youth with Obsessive-Compulsive Disorder (OCD) and Autism Spectrum Disorder (ASD). This study compared young people with OCD and ASD to those with OCD alone, and found that those with OCD + ASD had poorer insight into their OCD, greater impairment in functioning, higher levels of concurrent psychopathology, more family accommodation, and higher medication usage. Treatment outcomes were also poorer for the OCD + ASD group, with greater functional impairment and medication usage mediating the difference in outcomes. Further research and treatment improvements are needed to enhance outcomes for youth with OCD + ASD.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Tianyang Zhang, Angla Mantel, Bo Runeson, Anna Sidorchuk, Christian Ruck, Olof Stephansson, Henrik Larsson, Zheng Chang, David Mataix-Cols, Lorena Fernandez de la Cruz
Summary: Cesarean delivery (CD) is associated with an increased risk of suicide attempts during the first postpartum year, but is not associated with deaths by suicide. A study in Sweden showed that CD slightly increased the risk of suicide attempts, compared to vaginal delivery. Understanding the association between CD and maternal suicidal behaviors can help improve maternal mental well-being and reduce the risk of suicide.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Fabian Lenhard, Kristina Aspvall, Erik Andersson, Johan Ahlen, Eva Serlachius, Malin Lavner, Anna Brodin, David Mataix-Cols
Summary: This study compares the economic costs of pediatric OCD with a control group and finds that pediatric OCD is associated with higher healthcare costs, parental absence from work, and school productivity loss. The total societal burden of pediatric OCD in Sweden is estimated to be 94.3 million euros per year.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Psychology, Developmental
Chris Hollis, Charlotte L. Hall, Kareem Khan, Rebecca Jones, Louise Marston, Marie Le Novere, Rachael Hunter, Per Andren, Sophie D. Bennett, Beverley J. Brown, Liam R. Chamberlain, E. Bethan Davies, Amber Evans, Natalia Kouzoupi, Caitlin McKenzie, Charlotte Sanderson, Isobel Heyman, Joseph Kilgariff, Cristine Glazebrook, David Mataix-Cols, Eva Serlachius, Elizabeth Murray, Tara Murphy
Summary: This study evaluated the long-term clinical and cost effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for treating tics. The results showed that online ERP therapy reduced tic severity and had long-lasting effects at 12 and 18 months after treatment initiation. The economic evaluation indicated that online ERP therapy is a cost-effective intervention.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychiatry
Josef Isung, Kayoko Isomura, Kyle Williams, Tianyang Zhang, Paul Lichtenstein, Lorena Fernandez de la Cruz, Anna Sidorchuk, David Mataix-Cols
Summary: This cohort study found that maternal primary antibody immunodeficiencies (PIDs) were associated with an increased risk of psychiatric disorders and suicidal behavior in offspring, while paternal PIDs were not. Furthermore, the risk was highest when PIDs co-occurred with autoimmune diseases.
Article
Psychology, Clinical
Johan Ahlen, Johan Bjureberg, Fabian Lenhard, Tove Wahlund, Johanna Linde, David Mataix-Cols
Summary: This study found that there is a group of individuals who experience impairing levels of obsessional jealousy and perceive a need for help with their difficulties. Further research is needed to explore the prevalence and clinical characteristics of these individuals. The development of jealousy-specific psychological models and treatments is recommended.
BRITISH JOURNAL OF CLINICAL PSYCHOLOGY
(2023)
Article
Clinical Neurology
David Mataix-Cols, Kayoko Isomura, Gustaf Brander, Isabell Brikell, Paul Lichtenstein, Zheng Chang, Henrik Larsson, Ralf Kuja-Halkola, Kevin J. Black, Anna Sidorchuk, Lorena Fernandez de la Cruz
Summary: A Swedish study found that 20% of children with tic disorders continued to have chronic tic disorders into adulthood, with childhood psychiatric comorbidities and family history of psychiatric disorders being the strongest risk factors for tic disorder persistence.
MOVEMENT DISORDERS
(2023)
Article
Psychology, Clinical
Oskar Flygare, Erik Andersson, Gjermund Glimsdal, David Mataix-Cols, Diana Pascal, Christian Rueck, Jesper Enander
Summary: This study conducted a cost-effectiveness analysis of internet-delivered cognitive behaviour therapy for body dysmorphic disorder (BDD-NET) and found that BDD-NET is more cost-effective compared to online supportive psychotherapy.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2023)
Article
Psychology, Clinical
Lina Lundstrom, Oskar Flygare, Ekaterina Ivanova, David Mataix-Cols, Jesper Enander, Diana Pascal, Long -Long Chen, Erik Andersson, Christian Ruck
Summary: This study evaluated the implementation of therapist-guided internet-delivered cognitive behaviour therapy (ICBT) for obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) in the Swedish public health system. The results showed that ICBT was efficacious in reducing symptoms and could be reproduced in a clinical setting. The implementation of OCD-NET and BDD-NET in the Swedish public health service was deemed suitable.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2023)
Article
Psychology, Clinical
Klara Olofsdotter Lauri, Erik Andersson, David Mataix-Cols, Lisa Norlin, Viktor Eriksson, Karin Melin, Fabian Lenhard, Eva Serlachius, Kristina Aspvall
Summary: This study presents two-year follow-up data from a non-inferiority trial comparing stepped-care and in-person CBT for pediatric obsessive-compulsive disorder. Both treatment approaches demonstrated similar long-term effects, with the majority of participants showing positive responses two years after treatment.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2023)
Article
Health Care Sciences & Services
Jennifer S. Cox, Elanor C. Hinton, Julian Hamilton Shield, Natalia S. Lawrence
Summary: This study trialed a smartphone app called FoodT as an adjunctive treatment for pediatric weight management. However, recruitment and retention of participants were not satisfactory, and important lessons were learned regarding intervention design and data collection.
JMIR FORMATIVE RESEARCH
(2023)
Review
Psychiatry
Thiago Blanco-Vieira, Joaquim Radua, Livia Marcelino, Michael Bloch, David Mataix-Cols, Maria Conceicao do Rosario
Summary: This study is the first systematic review and meta-analysis of obsessive-compulsive disorder (OCD) genetic epidemiology, aiming to update the current knowledge in the field. The findings include the high prevalence and familial nature of OCD, especially among the relatives of children and adolescent probands, with a phenotypic heritability of around 50%, and the higher correlations of OCD symptoms between monozygotic twins are mainly attributed to genetic and non-shared environmental factors.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Behavioral Sciences
Klara Olofsdotter Lauri, Kristina Aspvall, David Mataix-Cols, Eva Serlachius, Christian Rueck, Erik Andersson
Summary: This study evaluated the initial efficacy, feasibility, and acceptability of an online self-guided cognitive intervention for new parents with distressing unwanted intrusive thoughts (UITs). The intervention significantly reduced distress and impairment associated with UITs post-intervention and at the 1-month follow-up. The intervention was deemed feasible and acceptable by participants. Change in negative appraisals mediated the reduction in UITs. Large-scale trials are needed to further validate these findings.
COGNITIVE BEHAVIOUR THERAPY
(2023)
Letter
Psychiatry
Johan Ahlen, Paulina Ghaderi, Rebecka Boyaci, David Mataix-Cols
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Oskar Flygare, John Wallert, Long-Long Chen, Lorena Fernandez de la Cruz, Lina Lundstroem, David Mataix-Cols, Christian Rack, Erik Andersson
Summary: This study evaluated cutoffs for treatment response and remission in OCD using the self-rated Obsessive-Compulsive Inventory-Revised (OCI-R). The results showed that OCI-R is a simple and time-efficient way to determine treatment response and remission in OCD.
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)