Review
Medicine, General & Internal
Bolin Wang, Zhihui Su, Lijun Wan, Tao He
Summary: This study conducted a meta-analysis to investigate the association between LncRNA polymorphism and the risk of coronary artery disease, and the results will be submitted to a peer-reviewed journal for publication.
Article
Clinical Neurology
Mohadese Rezaei, Mohammad Javad Mokhtari, Mahnaz Bayat, Anahid Safari, Mehdi Dianatpuor, Reza Tabrizi, Tahereh Asadabadi, Afshin Borhani-Haghighi
Summary: The rs217727 polymorphism of the H19 gene is correlated with the susceptibility to ischemic stroke, and H19 expression is significantly upregulated in patients with ischemic stroke. The study suggests that H19 expression within the first 24 hours from stroke onset may serve as a potential biomarker for the early diagnosis of ischemic stroke.
Review
Cardiac & Cardiovascular Systems
Soudeh Ghafouri-Fard, Mahdi Gholipour, Mohammad Taheri
Summary: Research has shown that long non-coding RNAs and circular RNAs play important roles in the pathogenesis of coronary artery disease, with some lncRNAs up-regulated and certain circRNAs down-regulated in CAD patients. These RNA molecules have been found to influence the function of endothelial cells or vascular smooth muscle cells, contributing to the development and progression of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jiao Huang, Minhua Li, Jinhong Li, Baoyun Liang, Zhaoxia Chen, Jialei Yang, Xiaojing Guo, Siyun Huang, Lian Gu, Li Su
Summary: The study showed an upregulated expression of lncRNA H19 in CAD patients and an association of rs4929984 polymorphism with CAD susceptibility in Han Chinese females, suggesting a potential diagnostic biomarker for CAD. Additionally, lncRNA H19 variants may influence lipid metabolism, inflammation, and coagulation function of CAD patients.
BIOCHEMICAL GENETICS
(2021)
Review
Pharmacology & Pharmacy
Jinghui Xie, Yuedi Hu, Dengdi Sun, Changan Liu, Zegeng Li, Jie Zhu
Summary: This review focuses on the regulatory role of H19 in various pulmonary diseases and collects potential therapeutic agents and molecular treatments. The aim is to demonstrate its underlying mechanism in pulmonary diseases and guide the translation of basic research targeting H19 into clinical drug development.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Xin Yu, Xueqing Zhu, Hongjun Xu, Linfeng Li
Summary: Keloids are pathological wound healing conditions that significantly impact patients by causing psychosocial and functional distress. The main pathophysiology of keloid is the deposition of extracellular matrix (ECM) and proliferation of human fibroblasts. Recent research has shown that deregulated long non-coding RNAs (LncRNAs) contribute to the formation of keloids. Exploring lncRNA-based methods holds promise as new effective therapies against keloids.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Haitao Tang, Hongli Zhong, Wanqing Liu, Yi Wang, Yuan Wang, Liuqing Wang, Songtao Tang, Huaqing Zhu
Summary: Recent studies show that non-coding RNAs (ncRNAs) play a crucial role in diabetic cardiomyopathy (DCM) pathophysiology. Melatonin has an anti-apoptotic effect on cardiomyocytes and regulates the lncRNA H19/miR-29c and MAPK pathways, providing a promising strategy for preventing DCM.
Article
Cell Biology
Yaqing Zhou, Sheng Zhang, Wenfeng Ji, Xiongkang Gan, Lei Hua, Can Hou, Jiaxin Chen, Yanjun Wang, Shu He, Hanxiao Zhou, Enzhi Jia
Summary: This study identified differentially expressed lncRNAs and mRNAs in atherosclerosis through RNA sequencing and validated their roles in smooth muscle cells, providing new targets for the diagnosis and treatment of atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
In-Jai Kim, Jeong-Yong Lee, Hyeon-Woo Park, Han-Sung Park, Eun-Ju Ko, Jung-Hoon Sung, Nam-Keun Kim
Summary: The study suggests that HOTAIR gene polymorphisms may serve as novel biomarkers for diagnosing coronary artery disease (CAD) and are closely associated with CAD susceptibility. Variations in genetic polymorphisms, genotype combinations, and haplotype analysis of HOTAIR are linked to disease occurrence and clinical factors contributing to disease susceptibility.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Senxiang Chen, Da Liu, Zimo Zhou, Sen Qin
Summary: Research on the targeting of lncRNA H19 in the treatment of osteoporosis shows promising prospects due to its effects on osteogenic differentiation processes. This review summarizes the molecular pathways and mechanisms of lncRNA H19 in the pathogenesis of osteoporosis and the progress of research on targeting H19 as a treatment option, indicating emerging possibilities for more effective treatments for bone metabolism diseases with molecular targets.
MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Juan Antonio Moreno, Eya Hamza, Melania Guerrero-Hue, Sandra Rayego-Mateos, Cristina Garcia-Caballero, Mercedes Vallejo-Mudarra, Laurent Metzinger, Valerie Metzinger-Le Meuth
Summary: Recent genomic research has uncovered a previously underestimated level of transcription within the genome, particularly involving long non-coding RNAs (lncRNAs) and their role in gene regulation. Understanding the intricate crosstalk between lncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) presents a significant challenge in modern molecular biology. Additionally, lncRNAs are emerging as potential prognostic biomarkers for both acute and chronic kidney diseases, with therapeutic opportunities being explored through targeting lncRNAs with antisense oligonucleotides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Lijie He, Hanmin Wang, Peng He, Yali Jiang, Feng Ma, Jing Wang, Jinping Hu
Summary: Research has shown that serum H19 expression is significantly downregulated in patients with IgA nephropathy, and a high level of H19 is associated with better renal outcome within 5 years.
JOURNAL OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yuyao Ji, Tao Yan, Shijie Zhu, Runda Wu, Miao Zhu, Yangyang Zhang, Changfa Guo, Kang Yao
Summary: This study explored the ceRNA mechanism in coronary artery disease (CAD) using bioinformatics analysis and identified three crucial ceRNA regulatory networks that play key roles in the occurrence and development of CAD, providing novel insights into the ceRNA mechanism in CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Lang Xiong, Yan Sun, Jingqi Huang, Pengjuan Ma, Xiaoran Wang, Jiani Wang, Baoxin Chen, Jieping Chen, Mi Huang, Shan Huang, Yizhi Liu
Summary: This study reveals the regulatory mechanism of lncRNA H19 in lens fibrosis. The researchers found that H19 was highly expressed in lens epithelial cells but downregulated after exposure to TGF-beta 2. Silencing H19 exacerbated TGF-beta 2-induced EMT, while overexpressing H19 partially reversed EMT. In vitro and in vivo experiments confirmed the important role of H19 in maintaining lens clarity.
Article
Oncology
Hao Jin, Huan Wang, Xin Jin, Wenbo Wang
Summary: Osteosarcoma, a prevalent type of bone tumor, is prone to pulmonary metastasis, leading to high relapse risk for patients. The overexpression of H19 is significantly associated with the progression of osteosarcoma, influencing tumor cell phenotype by regulating microRNA-29a-3p and LIM and SH3 domain protein 1. This study may contribute to a better understanding of osteosarcoma pathogenesis.
Article
Geriatrics & Gerontology
Juan Cai, Qi-Ming Wang, Jia-Wen Li, Fan Xu, Yun-Ling Bu, Man Wang, Xiang Lu, Wei Gao
Summary: This study suggests that lower serum Metrnl level is associated with weight loss and the severity of cardiac dysfunction in elderly patients with chronic heart failure.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biotechnology & Applied Microbiology
Hao Wang, Xiaoqing Lian, Wei Gao, Jie Gu, Haojie Shi, Yao Ma, Yafei Li, Yi Fan, Qiming Wang, Liansheng Wang
Summary: In this study, it was found that the long noncoding RNA H19 acts as a negative regulator in the progression of cardiac hypertrophy (CH). H19 regulates SMAD4 by sponging miR-145-3p, leading to a decrease in heart size and weight and improvement in cardiac function.
Article
Medicine, Research & Experimental
Jiao Chen, Can Zhao, Yingzi Huang, Hao Wang, Xiang Lu, Wei Zhao, Wei Gao
Summary: This study evaluated the prevalence and characteristics of malnutrition in COVID-19 patients with diabetes and found that malnutrition is associated with severe illness and poor prognosis.
JOURNAL OF BIOMEDICAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Chen-Lu Chang, Yan-Ru Li, Zhi-Yue Wang, Mei-Lin Li, Kai-Yue Jia, Hui-Xian Sun, Quan Wang, Can Zhao, Xiang Lu, Wei Gao
Summary: This study evaluated the association between serum RBP4 level and sarcopenia in older adults. The results showed a positive correlation between serum RBP4 level and the risk and severity of sarcopenia, indicating its potential as a biomarker for screening and evaluation of sarcopenia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Ze-Mu Wang, Di Zhao, Hao Wang, Qi-Ming Wang, Bo Zhou, Lian-Sheng Wang
Summary: This meta-analysis suggests that green tea consumption may be associated with a reduced risk of coronary heart disease, especially at low-to-moderate levels of consumption.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Xin-Xin Bu, Liang-Hua Zhu, Ze-Mu Wang, Chao Lu, Hui Chen, Di Yu
Summary: This study examined the relationship between obesity and headache among children and adolescents in the US. The results showed no independent association between obesity and headache. Further prospective studies with larger sample size are needed to validate these findings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Peripheral Vascular Disease
Kang-Zhen Zhang, Xiu-Zhen Li, Li Wang, Xi-Yu Shen, Shu-Shu Zhu, Xiang Lu, Wei Gao
Summary: The study investigated the relationship between serum adipokine retinol-binding protein 4 (RBP4) levels and essential hypertension, as well as the role and mechanism of RBP4-induced activation of the renin-angiotensin system (RAS) in adipocytes. The results showed that serum RBP4 levels were significantly higher in hypertensive patients compared to nonhypertensive subjects. The study also found that RBP4 can affect blood pressure through TLR4-mediated activation of the RAS. These findings contribute to a better understanding and potential treatment of hypertension.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Review
Nutrition & Dietetics
Ze-Mu Wang, Bei Chen, Bo Zhou, Di Zhao, Lian-Sheng Wang
Summary: A meta-analysis showed a significant association between green tea consumption and reduced risk of stroke, especially with moderate consumption. These findings support the recommendation of green tea consumption for primary prevention of stroke.
Review
Cardiac & Cardiovascular Systems
Ze-Mu Wang, Xin-Xin Bu, Bo Zhou, Ya-Fei Li, Zhen-Lin Nie
Summary: A meta-analysis of 18 prospective studies suggests a nonlinear association between dietary calcium intake and the risk of stroke, especially in Asian countries. This finding indicates that consuming adequate amounts of calcium may play a role in stroke prevention.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Medicine, General & Internal
Ze-Mu Wang, Bin Wang, Ya-Fei Li, Bei Chen, Qin Shen, Dian-Fu Li, Lian-Sheng Wang
Summary: Clinicians should be aware of the potential for severe thrombocytopenia when using tirofiban as it is widely used in patients undergoing percutaneous coronary intervention. This case report describes a 76-year-old Chinese man who developed severe thrombocytopenia after receiving tirofiban during percutaneous coronary intervention. Immediate discontinuation of all antiplatelet drugs and treatment with platelet transfusions and immunoglobulin G led to a significant improvement in platelet count.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Environmental Sciences
Yu-Jie Wu, Si-Bo Wang, Jia-Teng Sun, Ling-Feng Gu, Ze-Mu Wang, Bo Deng, Hao Wang, Lian-Sheng Wang
Summary: This study examined the relationship between urinary cadmium (U-Cd) and subclinical myocardial injury (SC-MI) in older people without cardiovascular disease (CVD). The results showed a significant association between U-Cd and cardiac infarction/injury score (CIIS) and a higher likelihood of SC-MI in the highest quartile of U-Cd. This suggests that U-Cd may be a novel risk factor for SC-MI.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Fatema Tabak, Saeed Assani, Wei Gao, Xiang Lu, Faming Zhang
Article
Genetics & Heredity
Hua Wan, Wei Gao, Wei Zhang, Zijiao Tao, Xiang Lu, Feng Chen, Jian Qin
Summary: This study constructed a transcription regulatory network for EMP2-induced vascular proliferation disorders and identified several master regulators. These master regulators play important roles in vasculature development, cell proliferation, and protein kinase B signaling, and may serve as potential biomarkers for EMP2-induced lesions.
Article
Nutrition & Dietetics
Jing Zhang, Yao Ma, Zemu Wang, Yafei Li, Hao Wang, Qiming Wang
Summary: This study found that green tea consumption is associated with a reduced risk of in-stent restenosis, with a significant dose-response relationship observed for both frequency and concentration of green tea intake.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2022)
Article
Geriatrics & Gerontology
Y. -S. Lin, Q. Wang, Z. -K. Shen, H. -X. Sun, C. Wu, H. He, G. -Q. Zou, F. Xu, Y. -L. Bu, J. -W. Li, C. Zhao, M. Hong, X. Lu, Jin-Shui Xu, Wei Gao
Summary: This study found that the loss of occlusal pairs of teeth is associated with an increased risk of sarcopenia in the elderly population in China, particularly in females and older individuals.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Biotechnology & Applied Microbiology
C. F. M. Menck, R. S. Galhardo, A. Quinet
Summary: Studies have shown that xeroderma pigmentosum variant (XP-V) patients have mutations in the POLH gene, resulting in a high frequency of skin tumors. However, it is paradoxical that the translesion synthesis DNA polymerase eta (Pol η) in these patients can actually suppress mutations, and the mechanism behind this is still unclear. Recent evidence suggests that cyclobutane pyrimidine dimers (CPDs) play an instructional role for Pol η, enabling accurate replication of these lesions, and the mutagenic effects induced by UV radiation are caused by the deamination of C-containing CPDs. This process leads to C>T transitions, which are the most common mutations in skin cancers. The delayed replication in XP-V cells amplifies the deamination of C in CPDs and increases the burden of C>T mutations through the activity of backup TLS polymerases.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
(2024)