Letter
Medicine, General & Internal
Odile Launay, Marine Cachanado, Liem B. Luong Nguyen, Laetitia Ninove, Marie Lachatre, Ines Ben Ghezala, Marc Bardou, Catherine Schmidt-Mutter, Karine Lacombe, Fabrice Laine, Jean-Sebastien Allain, Elisabeth Botelho-Nevers, Marie-Pierre Tavolacci, Christian Chidiac, Patricia Pavese, Bertrand Dussol, Stephane Priet, Dominique Deplanque, Amel Touati, Laureen Curci, Eleine Konate, Nadine Ben Hamouda, Anissa Besbes, Eunice Nubret, Florence Capelle, Laurence Berard, Alexandra Rousseau, Eric Tartour, Tabassome Simon, Xavier de Lamballerie
Summary: In a small trial, boost immunization with beta-adjuvanted spike proteins resulted in the highest levels of antibodies and activated T cells after two weeks.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yue-Mei Hu, Zhao-Feng Bi, Ya Zheng, Li Zhang, Feng-Zhu Zheng, Kai Chu, Ya-Fei Li, Qi Chen, Jia-Li Quan, Xiao-Wen Hu, Xing-Cheng Huang, Kong-Xin Zhu, Ya-Hui Wang-Jiang, Han -Min Jiang, Xia Zang, Dong-Lin Liu, Chang -Lin Yang, Hong-Xing Pan, Qiu-Fen Zhang, Ying-Ying Su, Shou-Jie Huang, Guang Sun, Wei-Jin Huang, Yue Huang, Ting Wu, Jun Zhang, Ning-Shao Xia
Summary: This study evaluated the immunogenicity and safety of the Escherichia coli-produced second-generation nonavalent HPV vaccine (Cecolin 9). The results showed that Cecolin 9 had good immunogenicity against all nine HPV types and was well tolerated.
Article
Immunology
Abdi Naficy, Adrienne Kuxhausen, Paola Pirrotta, Brett Leav, Jacqueline Miller, Kate Anteyi, Jasur Danier, Thomas Breuer, Agnes Mwakingwe-Omari
Summary: Coadministration of mRNA-1273 COVID-19 booster vaccine and recombinant zoster vaccine showed similar safety profiles and immune responses as sequential administration, which supports the idea of improving vaccination coverage by coadministration and reducing morbidity and mortality.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Xingmei Yao, Wengang He, Xianghong Wu, Jianxiang Gu, Jing Zhang, Bizhen Lin, Zhaofeng Bi, Yingying Su, Shoujie Huang, Yuemei Hu, Ting Wu, Jun Zhang, Ningshao Xia
Summary: The study assessed the long-term immunopersistence and safety of the E. coli-produced HPV-16/18 bivalent vaccine. The results showed that girls aged 9-17 years who received 2 or 3 doses remained seropositive for up to 30 months post vaccination, and their antibody levels were higher than those in women aged 18-26 years who received 3 doses.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Infectious Diseases
Marianna Riekkinen, Sari H. Pakkanen, Veronik Hutse, Inge Roukaerts, Jukka Ollgren, Helena Kayhty, Christian Herzog, Lars Rombo, Anu Kantele
Summary: This study examined the influence of coadministration of HepA and PCV13 on safety and immunogenicity. The results showed that coadministration of PCV13 significantly impaired antibody responses to HepA, but did not impact the response to PCV13. Overall, there were no major safety concerns.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Pediatrics
Yi Zeng, Anna-Barbara Moscicki, Heide Woo, Chiu-Hsieh Hsu, Troy J. J. Kemp, Ligia A. A. Pinto, Eva Szabo, Eileen Dimond, Julie Bauman, Vikrant V. V. Sahasrabuddhe, H-H Sherry Chow
Summary: This study evaluated the efficacy of a single dose of the nonavalent HPV vaccine and found that it induced persistent and stable HPV16 and HPV18 antibody responses up to 24 months. These findings contribute important immunogenicity data to support the feasibility of a single-dose HPV vaccination paradigm.
Article
Immunology
Junli Li, Huicong Xie, Lili Fu, Xiaonan Guo, Jiaxin Dong, Miao Xu, Guozhi Wang, Aihua Zhao
Summary: To achieve maximum efficacy, vaccines require the inclusion of adjuvants, which enhance and prolong immune response while influencing its type. This study developed an HPV bivalent vaccine using a BC02 adjuvant and HPV 16 and 18 L1 VLP antigens, resulting in improved immunogenicity in mice.
Article
Immunology
Yajun Shu, Yebin Yu, Ying Ji, Li Zhang, Yuan Li, Haiyang Qin, Zhuhang Huang, Zhiqiang Ou, Meilian Huang, Qiong Shen, Zehong Li, Meng Hu, Chunyun Li, Gaoxia Zhang, Jikai Zhang
Summary: This study demonstrates that the novel 4- and 9-valent HPV vaccines are non-inferior to Gardasil 4 in terms of immunogenicity and safety. The vaccines are highly immunogenic and well tolerated.
Article
Immunology
Walter E. P. Beyer, Abraham M. Palache, Mimoun Boulfich, Albert D. M. E. Osterhaus
Summary: In older adults, the use of adjuvanted inactivated influenza vaccine (IIV) can increase antibody levels by up to 1.5-fold compared to standard aqueous IIV. Setting a threshold of 1.5 may indicate superiority of adjuvanted vaccine formulations, although the clinical relevance of this increase remains a topic of debate.
Article
Immunology
Juan Li, Li -Wei Shi, Bang-Wei Yu, Li-Rong Huang, Ling-Yun Zhou, Li Shi, Zhi-Wei Jiang, Jie-Lai Xia, Xuan-Yi Wang, Rong-Cheng Li, Lin Yuan, Yan-Ping Li, Chang-Gui Li
Summary: This study evaluated the safety and immunogenicity of a novel pichia pastoris-expressed bivalent HPV vaccine in Chinese females aged 9-45 years. The results showed that the vaccine was safe and effective, with the low dosage (0.5 mL) selected for further study on immunogenicity and efficacy.
Article
Immunology
Jamiyah Hassan, Teck-Hock Toh, Selva Kumar Sivapunniam, Ruziaton Hasim, Nor Faizah Ghazali, Sofiah Sulaiman, Mia Tuang Koh, Stephanie Meyer, Myew-Ling Toh, Celine Zocchetti, Claire Vigne, Cesar Mascarenas
Summary: The study conducted in Malaysia among healthy children aged 9-13 found that the immunogenicity and safety profiles of CYD-TDV and quadrivalent HPV vaccines were unaffected when administered concomitantly or sequentially in dengue-seropositive participants. There were no safety concerns identified, and antibody titers for both HPV and dengue were similar between treatment groups.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Immunology
Petra J. Woestenberg, Alejandra E. Guevara Morel, Johannes A. Bogaards, Mariette Hooiveld, Tessa M. Schurink-van't Klooster, Christian J. P. A. Hoebe, Marianne A. B. van der Sande, Birgit H. B. van Benthem
Summary: The study indicates that the 2vHPV vaccine provides partial protection against anogenital warts, especially when administered in early adolescence.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Fanghui Zhao, Archana Jastorff, Ying Hong, Shangying Hu, Wen Chen, Xiaoqian Xu, Yejiang Zhu, Jiahong Zhu, Xun Zhang, Wenhua Zhang, Dacheng Xu, Dali Wang, Rong Tang, Yonghong Sun, Yiping Shen, Qinjing Pan, Jian Yin, Daokuan Liu, Bin Liu, Naveen Karkada, Chunmei Jiang, Jianfeng Cui, Feng Chen, Jun Bi, Yuqing Bao, Xin Zhou, Cyrille Cartier, Yuemei Hu, Dorota Borys
Summary: The AS04-HPV-16/18 vaccine demonstrated acceptable safety and long-term protection in Chinese women aged 26 years or above, with a good efficacy against HPV-16/18 infections and cytological lesions.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Immunology
Joske Hoes, Petra J. Woestenberg, Johannes A. Bogaards, Audrey J. King, Hester E. de Melker, Johannes Berkhof, Christian J. P. A. Hoebe, Marianne A. B. van der Sande, Birgit H. B. van Benthem
Summary: This study assessed trends in HPV prevalence over 8 years postvaccination among men and women in the Netherlands. Significant declines were observed in vaccine types HPV-16/18 among women, heterosexual men, and unvaccinated women, while increases were observed for certain HPV types in women and unvaccinated women. The results provide evidence of herd effects against HPV-16/18 among heterosexual men and cross-protective types, as well as herd effects against vaccine types among unvaccinated women.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Health Care Sciences & Services
Kai Chu, Zhao-Feng Bi, Wei-Jin Huang, Ya-Fei Li, Li Zhang, Chang-Lin Yang, Han -Min Jiang, Xia Zang, Qi Chen, Dong-Lin Liu, Hong-Xing Pan, Yue Huang, Feng-Zhu Zheng, Qiu-Fen Zhang, Guang Sun, Ying-Ying Su, Shou-Jie Huang, Hui-Rong Pan, Ting Wu, Yue-Mei Hu, Jun Zhang, Feng-Cai Zhu, Ning-Shao Xia
Summary: This phase 1 clinical trial evaluated the safety and immunogenicity of a second-generation nonavalent HPV vaccine and showed that it was well tolerated and immunogenic, providing encouragement for further studies in larger cohorts and a wider age range.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Pediatrics
Urban Johansson Kostenniemi, David Norman, Mats Sellin, Sven-Arne Silfverdal
Article
Critical Care Medicine
Urban Johansson Kostenniemi, Linda Karlsson, Sven-Arne Silfverdal, Christer Mehle
NEUROCRITICAL CARE
(2020)
Review
Pediatrics
Antonia Reuter, Sven-Arne Silfverdal, Kristin Lindblom, Anders Hjern
Article
Genetics & Heredity
Olga Egorova, Robin Myte, Jorn Schneede, Bruno Hagglof, Sven Bolte, Erik Domellof, Barbro Ivars A'roch, Fredrik Elgh, Per Magne Ueland, Sven-Arne Silfverdal
Review
Pediatrics
Anders Hjern, Kristin Lindblom, Antonia Reuter, Sven-Arne Silfverdal
Review
Pediatrics
Amit Bhavsar, Jussi Mertsola, Anja Poulsen, Sven-Arne Silfverdal
Summary: The infant pertussis vaccination schedules and coverage were similar across the four Nordic countries, with Denmark having a higher mean incidence possibly due to lack of recommendations for adolescent pertussis booster vaccination. Further investigations are needed.
Article
Nutrition & Dietetics
Ellen Lundkvist, Elisabeth Stoltz Sjostrom, Richard Lundberg, Sven-Arne Silfverdal, Christina E. West, Magnus Domellof
Summary: This study found that moderate consumption of fruit pouches is not associated with excess weight in toddlers at 18 months. However, the BMI z-score at 18 months was positively correlated with maternal BMI, gestational weight gain, fruit juice consumption, and inversely correlated with breastfeeding duration.
Article
Pediatrics
Giacomo Casabona, Md Ahsan Habib, Michael Povey, Marianne A. Riise Bergsaker, Carl-Erik Flodmark, Ketil Arne Espnes, Camilla Tondel, Sven-Arne Silfverdal
Summary: The study demonstrates high efficacy of two doses of varicella vaccine in Norwegian and Swedish children, with rates of 92.1% compared to 72.3% and 58.0% in the one-dose group. Incidences of adverse events and serious adverse events were similar in the Norwegian and Swedish study populations.
Article
Pediatrics
Kathy Falkenstein-Hagander, Emma Appelqvist, Ann-Sofie Frisk Cavefors, Henrik Kallberg, Lennart Jan Nilsson, Sven-Arne Silfverdal, Jann Storsaeter, Bernice Aronsson
Summary: Measures to reduce the spread of COVID-19 have been linked to reductions in other respiratory infections. A national Swedish cohort study found that the number of infant pertussis cases decreased significantly during the COVID-19 pandemic, indicating that strategies to mitigate the spread of COVID-19 may have impacted pertussis incidence in infants.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Medicine, General & Internal
Samuel Videholm, Urban Kostenniemi, Torbjorn Lind, Sven-Arne Silfverdal
Summary: Preterm birth and other perinatal factors are associated with an increased risk of severe infections in young children. Therefore, clinical guidelines for assessing infection risks in young children should take perinatal factors into consideration.
Editorial Material
Pediatrics
Sven Arne Silfverdal
Article
Pediatrics
Annelie Thoren, Tobias Filipsson, Erling Englund, Olof Sandstrom, Annika Janson, Sven Arne Silfverdal
Summary: This study evaluated the effect of a combined treatment targeting parents on the body mass index standard deviation score (BMI-SDS) of children with obesity, and found that the parent-focused intervention significantly improved BMI-SDS in these children.
Article
Multidisciplinary Sciences
Natalie Zarabi, Martina Aldven, Sigrid Sjoelander, Hanna Fues Wahl, Goran Bencina, Kelly D. D. Johnson, Sven-Arne Silfverdal
Summary: This study investigated the burden of pneumococcal disease in Swedish adults. The results showed that the clinical and economic burden of pneumococcal disease increased with age, with hospitalizations accounting for the majority of costs. The findings can help prioritize prevention strategies for pneumococcal disease in adult and elderly populations.
Article
Endocrinology & Metabolism
Annelie Thoren, Annika Janson, Erling Englund, Sven-Arne Silfverdal
OBESITY SCIENCE & PRACTICE
(2020)
Article
Medicine, General & Internal
Samuel Videholm, Thomas Wallby, Sven-Arne Silfverdal
Summary: This study found that the duration of exclusive breastfeeding was negatively associated with the risk of hospitalisations for infectious diseases, with exclusive breastfeeding for at least 4 months being recommended to reduce the risk of infection-related hospitalisations.