期刊
MUSCLE & NERVE
卷 51, 期 5, 页码 743-749出版社
WILEY-BLACKWELL
DOI: 10.1002/mus.24465
关键词
contact heat evoked potentials; polyneuropathy; quantitative sensory testing; reference values; small-fiber neuropathy
资金
- Profileringsfonds azM of the MUMC
- European Union [602273]
- Prinses Beatrix Spierfonds [W.OR12-01]
- Talecris Biotherapeutics
- GBS/CIDP International Foundation
- Talents Program Foundation
- Peripheral Nerve Society
IntroductionContact heat evoked potentials (CHEPs) may be an objective, non-invasive diagnostic tool in small-fiber neuropathy (SFN). This study establishes normal CHEP values and examines their applicability in SFN patients. Methods: Standardized CHEPs were administered at the wrist and ankle. The N-2 and P-2 latencies and N-2-P-2 peak-peak amplitude were recorded by electroencephalography. We examined healthy subjects (n=97), stratified by age and gender, and SFN patients with abnormal intraepidermal nerve fiber density (n=42). CHEP reproducibility and interobserver values were also investigated. Results: CHEP normative values were determined. There was a 9-16% increase in latency per centimeter of height with increasing age. Amplitudes were higher in women than men, and decreased (17-71%) with aging. Test-retest reproducibility and interobserver values were >0.61 and >0.96, respectively. CHEPs were abnormal in 73.8% of the patients. Conclusion: In this study we have established normal values, reliability, and clinical applicability of CHEPs in SFN. Muscle Nerve, 2015 Muscle Nerve51:743-749, 2015
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据