Article
Pharmacology & Pharmacy
Xiaohui Jin, Leilei Zhu, Shuaifei Lu, Caiyin Li, Ming Bai, Erping Xu, Jiduo Shen, Yucheng Li
Summary: This study investigated the effect of baicalin on mitophagy in the hippocampus of mice exposed to chronic unpredictable mild stress (CUMS) and explored its potential mechanism. The results showed that baicalin improved depressive-like behaviors in CUMS mice and ameliorated mitochondrial structural impairment in the hippocampus neuron. Baicalin increased NIX and AMPK, and improved mitophagy level and mitochondrial function in HT22 cells by directly binding to AMPK.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biology
Priya Balasubramanian, Anne E. Schaar, Grace E. Gustafson, Alex B. Smith, Porsha R. Howell, Angela Greenman, Scott Baum, Ricki J. Colman, Dudley W. Lamming, Gary M. Diffee, Rozalyn M. Anderson
Summary: Sarcopenia, the loss of skeletal muscle function with age, significantly reduces independence and quality of life. However, there are currently no pharmacological interventions for sarcopenia. In this study, AdipoRon, a pan-adiponectin receptor agonist, was found to improve muscle function in male mice by affecting skeletal muscle metabolism and tissue remodeling. The treatment also showed positive effects in young mice and nonhuman primate cultured cells, suggesting its potential as a therapeutic agent for sarcopenia in clinical application.
Article
Nutrition & Dietetics
Yoon-Young Sung, Seung-Hyung Kim, Dong-Seon Kim
Summary: This study found that BS21 has anti-obesity and antihyperlipidemic activities in high-fat diet-induced obese mice by increasing thermogenesis and energy expenditure, and regulating lipid metabolism.
Article
Food Science & Technology
Jingyue Zhang, Jiqiang Li, Yunge Liu, Rongrong Liang, Yanwei Mao, Xiaoyin Yang, Yimin Zhang, Lixian Zhu
Summary: The purpose of this study was to evaluate the impact of resveratrol on slow-twitch muscle fiber expression in bovine myotubes. The results showed that resveratrol enhanced the expression of slow myosin heavy chain (MyHC) and suppressed the expression of fast MyHC in bovine myotubes. Additionally, resveratrol increased the activities of succinic dehydrogenase (SDH) and malate dehydrogenase (MDH), as well as the mitochondrial DNA (mtDNA) content, while reducing lactate dehydrogenase (LDH) activity. Moreover, resveratrol upregulated the expression of AMPK, SIRT1, and PGC-1a. These findings suggest that resveratrol promotes the transition of muscle fiber type from fast-twitch to slow-twitch in bovine myotubes through the AMPK/PGC-1a signaling pathway and mitochondrial biogenesis.
Article
Biochemistry & Molecular Biology
Boyu Yang, Qiongli Yu, Bo Chang, Qi Guo, Sitong Xu, Xuejie Yi, Shicheng Cao
Summary: The study demonstrates the potential of AMPK/PGC-1 alpha pathway in mediating the secretion and/or production of MOTS-c in skeletal muscle, suggesting the roles of exercise intervention and recombinant MOTS-c in treating obesity and diabetes mellitus.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Min Ho Song, Jimeen Yoo, Jae Gyun Oh, Hyun Kook, Woo Jin Park, Dongtak Jeong
Summary: This study demonstrates that CCN5 gene transfer can ameliorate cardiac fibrosis, improve cardiac function, and enhance running performance in a mouse model of DMD-induced cardiomyopathy. Furthermore, CCN5 is found to be directly associated with the expression of utrophin, a novel transcriptional target.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Danning Tong, Enshuang Xu, Ruidong Ge, Mengxin Hu, Shengzi Jin, Jing Mu, Yun Liu
Summary: By establishing mouse models, the study found that aspirin can alleviate cisplatin-induced acute kidney injury, and its protective mechanisms are related to its anti-inflammatory, antioxidant, anti-apoptotic properties, and its ability to maintain mitochondrial function, mainly achieved through the activation of the AMPK-PGC-1 alpha pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Urology & Nephrology
Jun Wu, Jushuang Li, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li
Summary: Activation of the AMPK-PGC-1 alpha pathway improves PD-related PF by enhancing mitochondrial biogenesis, suggesting a potential new therapeutic approach for PD-related PF.
Article
Biochemistry & Molecular Biology
Shruthi Karnam, Nikolai P. Skiba, Ponugoti Rao
Summary: This study characterized lenses derived from dystrophin-deficient mice and found changes in the distribution of Dp71 and other integral membrane proteins, resulting in decreased lens stiffness. The reductions in DAPC levels in dystrophin-deficient lenses indicate the importance of dystrophin in maintaining lens clarity and function.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Emilly Sigoli, Rosangela Aline Antao, Maria Paula Guerreiro, Tatiana Oliveira Passos de Araujo, Patty Karina dos Santos, Daiane Leite da Roza, Dilson E. Rassier, Anabelle Silva Cornachione
Summary: This study investigated the effects of low-intensity aerobic training on the psoas muscle of mdx mice with Duchenne muscular dystrophy (DMD). The results showed that 37 sessions of exercise improved muscle morphology, increased the number of satellite cells, and elevated the content of PGC-1 alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Zhang Ruixia, Liu Chuanchuan, Guan Lu, Ma Shuang, Zhu Qiang, Tian Xiaofang, Ba Yinggui
Summary: The study found that under low-temperature and low-oxygen conditions, the body weight of rats decreased and affected lipid levels in the serum, while reducing the activity of fatty acid metabolism factors and increasing the activity of lipid metabolism-related enzymes. In addition, hypothermia and hypoxia also affect skeletal muscle morphology, and AMPK/PGC-1 alpha can regulate skeletal muscle cell proliferation.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jara Tabitha Hees, Angelika Bettina Harbauer
Summary: Mitochondria play a critical role in neuronal function by providing ATP and buffering Ca2+. The regulation of mitochondrial biogenesis at the transcriptional and translational level is necessary for neurons to adapt to local differences in mitochondrial demand. Defects in the localization of mRNAs encoding mitochondrial proteins and contact site formation between mitochondria and endolysosomes can lead to mitochondrial dysfunction in various neurological disorders.
Article
Multidisciplinary Sciences
Amelie Bravard, Celine Gerard, Clemence Defois, Berengere Benoit, Kassem Makki, Emmanuelle Meugnier, Dominique Rainteau, Jennifer Rieusset, Murielle Godet, Hubert Vidal
Summary: This study highlights the beneficial effects of the antidiabetic drug metformin in a mouse model, particularly through inhibiting the overexpression of genes related to glucose and fatty acid transport in the small intestine, modulating the profile of secondary bile acids in the caecum, and altering the composition of intestinal microbiota.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Hengmei Zhu, Zhi Fang, Jiehui Chen, Yun Yang, Jiacheng Gan, Liang Luo, Xiaojiang Zhan
Summary: This study investigated the interplay between PARP-1 and SIRT-1 in diabetic nephropathy (DN) through the AMPK/PGC-1 alpha signaling pathway. Results showed that PARP-1 and ECM marker FN were upregulated while SIRT-1 was downregulated in DN, and their levels were restored by specific treatments. Activation of the AMPK-PGC-1 alpha pathway may offer a potential therapeutic method for DN.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Qingjie Peng, Xiaojiang Chen, Xiaoxia Liang, Jiahui Ouyang, Qiangqiang Wang, Shuai Ren, Haibo Xie, Chunhong Wang, Yaqun Sun, Xin Wu, Hetao Liu, Changchun Hei, Miao Sun, Qing Chang, Xinrui Liu, Guangyong Li, Rui He
Summary: The study investigated the effect of metformin on PCOS using a PCOS mouse model and explored the mechanism of metformin in regulating PCOS mice through the ferroptosis pathway. The results showed that metformin not only improved body weight and metabolic disorders but also improved ovarian dysfunction in PCOS mice.
FRONTIERS IN ENDOCRINOLOGY
(2023)