Editorial Material
Oncology
Suresh S. Ramalingam
Summary: Cancer journal, as one of the oldest and most prestigious oncology journals, aims to bring the best of science to a broad audience, with a strong focus on research that directly impacts the lives of cancer patients.
Article
Endocrinology & Metabolism
Marko Rudar, Jane K. Naberhuis, Agus Suryawan, Hanh Nguyen, Barbara Stoll, Candace C. Style, Mariatu A. Verla, Oluyinka O. Olutoye, Douglas G. Burrin, Marta L. Fiorotto, Teresa A. Davis
Summary: It was found that intermittent bolus feeding does not increase skeletal muscle protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in preterm pigs. This suggests that premature birth attenuates the capacity of skeletal muscle to respond to cyclical surges in insulin and amino acids with intermittent feeding in early postnatal life. This attenuated anabolic response of muscle to intermittent bolus feeding in preterm pigs compared with those born at term may contribute to deficits in lean mass.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Business, Finance
Kartick Gupta, Chandra Krishnamurti
Summary: Existing literature suggests that firms with good corporate governance practices have lower cash holdings, while employee-friendly firms have higher cash holdings. The contradicting findings raise questions about whether firms should prioritize shareholder or stakeholder-friendly policies. Our study shows a negative relationship between cash holdings and employee-friendly practices. Additionally, we find that the impact of employee-friendly practices on cash holdings is stronger in countries with strong labor laws and regulations, indicating that country-level benefits complement those provided by the firm.
INTERNATIONAL REVIEW OF ECONOMICS & FINANCE
(2023)
Article
Hematology
Rohtesh S. Mehta, David Marin, Amin Alousi, Christopher G. Kanakry, Richard E. Champlin, Katayoun Rezvani, Elizabeth J. Shpall, Kristin Page, Shahinaz M. Gadalla, Daniel Weisdorf, Partow Kebriaei
Summary: In adult patients with acute lymphoblastic leukemia, younger haploidentical donors have better overall survival compared to older HLA-matched unrelated donors. Donor age is a prognostic factor for survival in hematopoietic cell transplantation.
Review
Biochemistry & Molecular Biology
Tuoxian Tang, Mahmudul Hasan, Daniel G. S. Capelluto
Summary: Phafin proteins are a family of proteins that contain PH and FYVE domains. They are classified into two groups, Phafin1 and Phafin2, and both groups bind to phosphatidylinositol 3-phosphate [PtdIns(3)P]. Phafin proteins are involved in cellular pathways such as apoptosis, endocytic cargo trafficking, and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ecology
Jackson W. Drew, Marion S. Bret-Harte, Agata Buchwal, Calvin Heslop
Summary: The Arctic is warming rapidly, leading to changes in tundra vegetation composition. The sensitivity of shrub secondary growth to climate has changed with increased warming, but the role of shrub age in this process is not well understood.
FUNCTIONAL ECOLOGY
(2023)
Article
Geriatrics & Gerontology
Yung-Li Hung, Ayami Sato, Yuka Takino, Akihito Ishigami, Shuichi Machida
Summary: This study found that estrogen enhances muscle hypertrophy induced by resistance training in postmenopausal women and has a significant effect on myonuclear domain size, but has no effect on satellite cells and ribosome biogenesis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Physiology
Tim Snijders, Andy M. Holwerda, Luc J. C. van Loon, Lex B. Verdijk
Summary: The study found that prolonged resistance exercise training in older adults leads to a decrease in the percentage of small muscle fibers and an increase in the percentage of the largest muscle fibers. The change in the percentage of small fibers is associated with an increase in overall myonuclear domain size, while the change in the percentage of the largest fibers is linked to an overall increase in myonuclear content.
Article
Green & Sustainable Science & Technology
Yana Akhtyrska, Franz Fuerst
Summary: The study found that energy management and indoor environment practices in LEED EBOM certification have an impact on energy consumption, but the achieved rental premiums appear to be independent of the lease type.
Article
Immunology
Heinz-J. Schmitt, Gerhard Dobler, Dace Zavadska, Zane Freimane, Dimitrios Fousteris, Wilhelm Erber, Luis Jodar, Andreas Palmborg
Summary: The study compared the age distribution of TBE cases and TBE vaccine failures in three endemic countries, showing that VF cases in Sweden were generally older than in Latvia and Southern Germany. The differences were attributed to diagnostic practices, vaccine uptake between age groups, behavioral patterns, and underlying medical conditions. There is no scientific rationale for giving an extra priming dose of TBE vaccine to subjects aged 50 and older.
Article
Biochemistry & Molecular Biology
Antoine Perrin, Aurelie Khimoun, Anthony Ollivier, Yves Richard, Anton Perez-Rodriguez, Bruno Faivre, Stephane Garnier
Summary: There is ongoing debate among ecologists about the effects of habitat fragmentation on biodiversity, and whether these effects are positive or negative. This study found that habitat fragmentation has a greater impact on parasite prevalence in birds than habitat loss or landscape heterogeneity. The effects of fragmentation also vary between different regions.
Review
Food Science & Technology
Ming Li, Venea Dara Daygon, Vicky Solah, Sushil Dhital
Summary: Granule size is a crucial factor affecting the functional properties and applicability of starch. This review critically evaluates the biological and environmental factors influencing starch granule size, as well as the methods for separation and measurement. Furthermore, the structure and properties of starch based on different granule sizes are elucidated by highlighting typical applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Zoology
Ana Gabriela Jimenez, Evan Nash-Braun, Jason R. Meyers
Summary: The Mexican cavefish has two morphotypes: an obligate cave-dwelling form and a surface form. The study compared the aerobic and anaerobic metabolic profiles of their white muscle metabolism, as well as their muscle structures, and found that the two morphotypes have different metabolic profiles and muscle structures.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2023)
Article
Psychology, Multidisciplinary
Lianshan Zhang, Eun Hwa Jung
Summary: Drawing upon uses and gratifications perspectives and socioemotional selectivity theory, this study examined the differences in the use of Facebook features among younger, middle-aged, and older adults, and explored the association between Facebook activities and users' perceived enjoyment for different age groups.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Eleanor A. Sheridan, Jeremy A. Fonvielle, Samuel Cottingham, Yi Zhang, Thorsten Dittmar, David C. Aldridge, Andrew J. Tanentzap
Summary: Plastic debris pollutes freshwaters extensively, and the leachate from plastic shopping bags has a significant influence on microbial metabolism and bacterial biomass. Plastic pollution may stimulate aquatic food webs, suggesting possible strategies for pollution mitigation.
NATURE COMMUNICATIONS
(2022)
Article
Anatomy & Morphology
Henrique Mansur, Joao Luiz Quagliotti Durigan, Marcos de Noronha, Michael Kjaer, S. Peter Magnusson, Bruno Abdo Santana de Araujo, Rita de Cassia Marqueti
Summary: Increasing age affects morphologic changes in major tendons, but its effects on the cross-sectional area (CSA) of different ankle tendons are less understood. This study found significant differences in CSA among age groups and along different tendon regions. However, there were no differences in tendon CSA between sexes.
JOURNAL OF ANATOMY
(2023)
Article
Sport Sciences
Jens Rithamer Jakobsen, Abigail Louise Mackey, Manuel Koch, Thomas Imhof, Jens Hannibal, Michael Kjaer, Michael Rindom Krogsgaard
Summary: The myotendinous junction (MTJ) is structurally specialized to transmit force. Muscles with a high content of type II muscle fibers are more prone to strain injury compared to those with type I muscle fibers. Confocal microscopy analysis revealed that the surface area of the MTJ is smaller in type II muscle fibers compared to type I fibers. This suggests that type II muscle fibers have lower resistance to strain and are therefore more susceptible to injury.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Cell Biology
Mark R. Viggars, Daniel J. Owens, Claire Stewart, Catherine Coirault, Abigail L. Mackey, Jonathan C. Jarvis
Summary: PCM1 is detected in single isolated myofibers and cross sections from mice and humans, playing an important role in the subcellular location of myonuclei. It is found in the nuclear envelope of mature myofibers and newly formed myotubes, as well as in the centrosomes of proliferating myogenic precursors. Although not completely specific to myonuclei, PCM1 may be useful as a marker of satellite cell dynamics.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Orthopedics
Allan Cramer, Grith Hojfeldt, Peter Schjerling, Jakob Agergaard, Gerrit van Hall, Jesper Olsen, Per Holmich, Michael Kjaer, Kristoffer Weisskirchner Barfod
Summary: The study aimed to investigate the turnover of tendon tissue before and after an Achilles tendon rupture. The results showed that there was already increased turnover of tendon tissue before the rupture, and the synthesis rate of collagen remained relatively constant in the first two weeks after the rupture. This suggests that the formation of new tendon tissue is not an immediate process during the regeneration of ruptured tendons in patients.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Neurosciences
Naiara Demnitz, Anne T. Gates, Erik L. Mortensen, Ellen Garde, Cathrine L. Wimmelmann, Hartwig R. Siebner, Michael Kjaer, Carl-Johan Boraxbekk
Summary: Understanding individual variability in response to physical activity is crucial for developing more effective and personalized interventions for healthy aging. This study used longitudinal data from a randomized-controlled trial to investigate individual differences in a 12-month muscle strengthening intervention for older adults. Results showed significant differences in baseline physical function, sex, and depressive symptoms between trajectory groups. Improvers and decliners also exhibited significant grey matter differences in specific brain regions.
HUMAN BRAIN MAPPING
(2023)
Article
Physiology
Ching-Yan Chloe Yeung, Annesofie T. Olesen, Richard Wilson, Shireen R. Lamande, John F. Bateman, Rene B. Svensson, S. Peter Magnusson, Michael Kjaer
Summary: Both aging and physical activity can affect the amount of intramuscular connective tissue in skeletal muscle. This study investigated the impact on specific extracellular matrix (ECM) proteins and found that aging is associated with an increased abundance of these proteins. However, regular physical activity did not alter the ECM protein levels. These findings indicate that age-related changes in the intramuscular ECM solubility can occur, but physical training does not have the same effect.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Physiology
Rikke Hoeffner, Rene B. Svensson, Franciele Dietrich-Zagonel, Daniel Schefte, Michael Kjaer, Pernilla Eliasson, S. Peter Magnusson
Summary: Permanent loss of muscle function after Achilles tendon rupture may be due to tendon elongation and accompanying muscle shortening. In rats, Achilles tendon transection resulted in increased tendon length, decreased muscle mass and length, and reduced serial sarcomere number, regardless of suturing. These changes led to an overshoot lengthening of the sarcomeres.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Cell Biology
Anders Karlsen, Ching-Yan Chloe Yeung, Peter Schjerling, Linda Denz, Christian Hoegsbjerg, Jens R. Jakobsen, Michael R. Krogsgaard, Manuel Koch, Stefano Schiaffino, Michael Kjaer, Abigail L. Mackey
Summary: Through single-nucleus RNA sequencing, we identified distinct clusters of myonuclei in the myotendinous junction (MTJ) of humans, characterized by different gene expression profiles and fiber types, which has important implications for understanding the specialization of the MTJ.
JOURNAL OF CELL SCIENCE
(2023)
Review
Physiology
Michael D. Roberts, John J. McCarthy, Troy A. Hornberger, Stuart M. Phillips, Abigail L. Mackey, Gustavo A. Nader, Marni D. Boppart, Andreas N. Kavazis, Paul T. Reidy, Riki Ogasawara, Cleiton A. Libardi, Carlos Ugrinowitsch, Frank W. Booth, Karyn A. Esser
Summary: Mechanisms underlying mechanical overload-induced muscle hypertrophy have been extensively researched. Most studies support the involvement of enhanced mTORC1 signaling, expansion of translational capacity, increased satellite cell abundance and myonuclear accretion, and increased muscle protein synthesis rates. However, additional mechanisms may also be involved.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Sport Sciences
Louise B. Nielsen, Rene B. Svensson, Niels U. Fredskild, Kenneth H. Mertz, S. Peter Magnusson, Michael Kjaer, Monika L. Bayer
Summary: This study aimed to investigate the effects of a muscle strain injury in the gastrocnemius muscle on muscle fascicle length, pennation angle, and the morphology of the deep aponeurosis at rest and during muscle contraction. Electromyography (EMG) was also used to measure muscle activity during a unilateral heel rise.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Cell Biology
Grith Hojfeldt, Trent Sorenson, Alana Gonzales, Michael Kjaer, Jesper L. Andersen, Abigail L. Mackey
Summary: This study aimed to systematically investigate myofibre branching and fibre type in human skeletal muscle undergoing adult regenerative myogenesis. The findings suggest that myofibre branching is more likely to be fusion of myotubes, explained by incomplete regeneration after necrosis-inducing event.
Article
Geriatrics & Gerontology
Casper Soendenbroe, Anders Karlsen, Rene B. Svensson, Michael Kjaer, Jesper L. Andersen, Abigail L. Mackey
Summary: This study reveals the relationship between myofiber shape and age in humans and suggests that it independently predicts volumetric and functional assessments of muscle health. Resistance training can modify the shape of myofibers.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)