Article
Virology
Sigrid Regauer, Olaf Reich
Summary: Most research on HPV-related squamous cervical carcinogenesis focuses on glycogenated squamous epithelium, while the role of immature squamous metaplastic epithelium and reserve cells as targets of HPV infection has been less explored. Future research should shift focus to reserve cells as target cells and reservoirs of HPV.
CURRENT OPINION IN VIROLOGY
(2021)
Article
Immunology
Takeo Shibata, Sumit Shah, Teresa Evans, Hannah Coleman, Benjamin J. Lieblong, Horace J. Spencer, Charles M. Quick, Toshiyuki Sasagawa, Owen W. Stephens, Erich Peterson, Donald Johann, Yong-Chen Lu, Mayumi Nakagawa
Summary: The use of high-throughput sequencing has shown that HPV vaccine can induce specific T cell expansion in both peripheral blood and cervical tissue. This approach not only confirms the presence of vaccine-specific T cells in the body, but also provides a novel method to assess vaccine-specific responses in various anatomical areas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Chao Liu, Min Zhang, Xinlong Yan, Yanli Ni, Yandong Gong, Cong Wang, Xiaoling Zhang, Lingfei Wan, Hui Yang, Chen Ge, Yunqiao Li, Wenxue Zou, Rui Huang, Xiaohui Li, Bing Sun, Bing Liu, Jinbo Yue, Jinming Yu
Summary: By performing single-cell RNA sequencing on human cervical tissues at different stages of malignancy, this study reveals the transcriptional tumorigenic trajectory of cervical epithelial cells in cervical squamous cell carcinoma (CESC) and identifies key factors involved in CESC initiation and progression. It also shows significant correlations between specific myeloid, lymphoid, and endothelial cell populations and CESC progression, as well as their association with patients' prognosis. Furthermore, the study demonstrates the tumor-promoting function of matrix cancer-associated fibroblasts via the NRG1-ERBB3 pathway in CESC. This research provides valuable insights for refining CESC diagnosis and designing optimal treatment strategies.
Article
Immunology
Mariana Lopez-Filloy, Flor J. Cortez, Tarik Gheit, Omar Cruz y Cruz, Fernando Cruz-Talonia, Monserrat Chavez-Torres, Cristina Arteaga-Gomez, Ismael Mancilla-Herrera, Juan J. Montesinos, Victor Adrian Cortes-Morales, Cecilia Aguilar, Massimo Tommasino, Sandra Pinto-Cardoso, Leticia Rocha-Zavaleta
Summary: Cervical ectopy, a benign condition in the lower genital tract, is common among reproductive-age women. Although it is considered a physiological condition, some women experience symptoms that require medical intervention. While cervical ectopy is not linked to cervical cancer, it may facilitate the acquisition of sexually transmitted diseases. This study examined the presence of HPV and its impact on the cervicovaginal microenvironment in women with symptomatic cervical ectopy. The results showed that HPV infection and dysbiotic vaginal communities were associated with delayed recovery of the cervical epithelium and increased risk of STD acquisition.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Letter
Dermatology
Camille Isnard, Johan Chanal, Christine Bergeron, Olivier Aynaud
Summary: We conducted the first study on cervical HPV lesions in female partners of males with PHSILs. In 81% of cases, histologically confirmed cervical SIL was observed, with high-grade SIL in more than two-thirds of cases and low-grade SIL in one-third. Screening of females with male partners who have PHSIL is important to detect and treat clinical HPV lesions early. Our results suggest that HPV testing and reflex cytology should be performed for female partners of males with PHSILs. Colposcopy should be done if there is an abnormal Pap smear.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Stephan Polterauer, Olaf Reich, Andreas Widschwendter, Laudia Hadjari, Gerhard Bogner, Alexander Reinthaller, Elmar Joura, Gerda Trutnovsky, Alexandra Ciresa-Koenig, Julia Ganhoer-Schimboeck, Ina Boehm, Regina Berger, Eva Langthaler, Stephan W. Aberle, Georg Heinze, Andreas Gleiss, Christoph Grimm
Summary: This study investigates the non-inferiority of topical IMQ therapy compared to LLETZ in patients diagnosed with HSIL. The results show that IMQ treatment leads to lower HPV clearance rates compared to LLETZ, suggesting that LLETZ remains the standard treatment for HSIL patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Line Winther Gustafson, Anne Hammer, Mary Holten Bennetsen, Christina Blach Kristensen, Huda Majeed, Lone Kjeld Petersen, Berit Andersen, Pinar Bor
Summary: The detection of CIN2+ in women aged >= 45 years with TZ3 is underestimated if relying on biopsy results alone. To reduce the risk of underdiagnosis and overtreatment, future studies should explore the use of new biomarkers for risk stratification.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Kamylla Conceicao Gomes Nascimento, Elyda Goncalves Lima, Zhilbelly Mota Nunes, Marconi Rego Barros Junior, Marcus Vinicius de Aragao Batista, Antonio Roberto Lucena Araujo, Jacinto da Costa Silva Neto, Barbara Simas Chagas, Ana Pavla Almeida Diniz Gurgel, Antonio Carlos de Freitas
Summary: This study found that only HPV DNA detected in the cervix was associated with cervical lesions, while there was no direct association between HPV DNA in the blood and cervical lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ching-Wei Wang, Yi-An Liou, Yi-Jia Lin, Cheng-Chang Chang, Pei-Hsuan Chu, Yu-Ching Lee, Chih-Hung Wang, Tai-Kuang Chao
Summary: This study presents the first fully automated cervical lesions analysis on conventional Pap smear samples and achieves high precision, recall, F-measure, and Jaccard index in detecting high-grade cervical lesions. The proposed deep learning-based system demonstrates the ability to detect HSILs or higher with high precision and sensitivity, outperforming state-of-the-art benchmark methods in both accuracy and efficiency. The method is proven to be effective in rapidly processing whole slide images for practical clinical usage, showing promising potential for improving early diagnosis and treatment of cervical cancer.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Rongrong Jin, Xumei Yang, Jingjing Bao, Wenyan Zhang, Rongrong Dou, Donglan Yuan, Qinxin Yang, Lin Jiang, Hong Yu
Summary: The study investigated the distribution of HPV genotypes in patients with cervical lesions in Taizhou, China, revealing a high prevalence of HPV infections with variations in genotype distribution. Routine HPV tests covering all common genotypes are essential in clinical practice.
Article
Radiology, Nuclear Medicine & Medical Imaging
Leehi Joo, Yun Jung Bae, Young Jun Choi, Yoon Se Lee, Sae Rom Chung, Chong Hyun Suh, Seon-Ok Kim, Jung Hwan Baek, Jeong Hyun Lee
Summary: A risk scoring system based on clinical and imaging findings was developed and validated to predict lymph node metastasis from HPV+ oropharyngeal squamous cell carcinomas. The system showed good discriminative ability and calibration in both training and test sets, and is expected to aid in clinical decision-making.
EUROPEAN RADIOLOGY
(2021)
Article
Cell Biology
Cindrilla Chumduri, Rajendra Kumar Gurumurthy, Hilmar Berger, Oliver Dietrich, Naveen Kumar, Stefanie Koster, Volker Brinkmann, Kirstin Hoffmann, Marina Drabkina, Panagiota Arampatzi, Dajung Son, Uwe Klemm, Hans-Joachim Mollenkopf, Hermann Herbst, Mandy Mangler, Jorg Vogel, Antoine-Emmanuel Saliba, Thomas F. Meyer
Summary: The transition zones of squamous and columnar epithelia are prone to cancer, often associated with metaplasia. Through mouse models and single-cell RNA sequencing, it was discovered that the cervical epithelial cells in the endo- and ectocervix have distinct origins from stem cells regulated by opposing Wnt signals from the stroma. Additionally, a mouse model of cervical metaplasia showed that the stroma in the endocervix undergoes remodeling and increases expression of the Wnt inhibitor DKK2, promoting the outgrowth of ectocervical stem cells.
NATURE CELL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Qing Wu, Yu Jiang, Jun Ding, Lihua Xia, Haiou Xu
Summary: This study investigated the predictors of residual disease in patients who underwent a hysterectomy following a LEEP for CIN 3. The results revealed that positive ECC, positive margin of LEEP samples, type III transformation zone, and HPV18 infection were reliable prognostic markers of residual disease.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Hillary Hosier, Sangini S. Sheth, Carlos R. Oliveira, Lauren E. Perley, Alla Vash-Margita
Summary: The current consensus recommends against initiating cervical cancer screening for immunocompetent adolescent females before the age of 21, as the incidence of cervical cancer is very low in this age group. This study aimed to assess trends and factors associated with unindicated cervical cancer screening tests in adolescent females. Despite reductions in unindicated screening, there are still areas for improvement in adherence to guidelines and utilization of evidence-based strategies.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Kathleen R. Bartemes, Benjamin R. Gochanour, David M. Routman, Daniel J. Ma, Karen A. Doering, Kelli N. Burger, Patrick H. Foote, William R. Taylor, Douglas W. Mahoney, Calise K. Berger, Xiaoming Cao, Sara S. Then, Travis J. Haller, Alyssa M. Larish, Eric J. Moore, Joaquin J. Garcia, Rondell P. Graham, Jamie N. Bakkum-Gamez, John B. Kisiel, Kathryn M. Van Abel
Summary: This study aimed to find novel biomarkers for early identification of human papillomavirus associated oropharyngeal squamous cell carcinoma (HPV (+) OPSCC). By evaluating the expression of 21 methylated DNA markers in tissues, it was found that most markers had higher discrimination in HPV (+) cervical squamous cell carcinoma (CSCC) than in HPV (+) OPSCC.