Article
Psychology, Multidisciplinary
Lidia Pamies-Aubalat, Yolanda Quiles Marcos, Maria Soledad Torregrosa Diez
Summary: Different psychosocial variables are related to disordered eating attitudes in adolescents, especially in girls. This study analysed the psychosocial profile related to disordered eating attitudes separately in boys and girls. The results showed that both boys and girls present similar profiles, with low self-esteem, body dissatisfaction, perfectionism, social comparison, pressure to lose weight, and dieting being related to disordered eating attitudes. Further longitudinal studies are needed to understand the risks and protective factors of eating disorders.
CURRENT PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Izabela Michalus, Anna Lupinska, Izabela Woch, Katarzyna Wieczorek-Szukala, Danuta Chlebna-Soko, Andrzej Lewinski
Summary: This retrospective study explored the bone turnover and bone mass disorders in children with hypophosphatemic rickets. The results showed that bone metabolism disturbances and worse bone quality were found in these patients. It is crucial to monitor the progress and treatment effects by determining bone turnover markers, dual-energy X-ray absorptiometry findings, and indices of quantitative ultrasound examination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Valeria Nobrega da Silva, Tamara Beres Lederer Goldberg, Carla Cristiane Silva, Cilmery Suemi Kurokawa, Luciana Nunes Mosca Fiorelli, Anapaula da Conceicao Bisi Rizzo, Jose Eduardo Corrente
Summary: Metabolic syndrome may be associated with reduced bone mineral density and biochemical markers of bone formation and resorption in adolescents with excess weight, as observed through a cross-sectional study evaluating 271 adolescents.
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pediatrics
Carmela de Lamas, Paula Sanchez-Pintos, Maria Jose de Castro, Miguel Saenz de Pipaon, Maria Luz Couce
Summary: This systematic review evaluates the relationship between screen time and bone health in children and teenagers, finding a negative association between total and TV viewing screen time with bone health, while recreational computer use showed no significant impact. The findings suggest that strategies for improving bone health in adolescents should consider the implications of different technological devices on screen time.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Jakob Starup-Linde, Marie Juul Ornstrup, Thomas Nordstrom Kjaer, Simon Lykkeboe, Aase Handberg, Soren Gregersen, Torben Harslof, Steen Bonlokke Pedersen, Peter Vestergaard, Bente Lomholt Langdahl
Summary: This study compared bone structure, bone density, and bone turnover markers between non-diabetic overweight men with MetS and overweight men with T1D or T2D. The results showed lower bone turnover in men with T2D, but no clinically significant differences in bone density or structure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Minkyung Je, Kyeonghoon Kang, Jun-Il Yoo, Yoona Kim
Summary: This review aims to investigate the effects of macronutrients on bone health in elderly people based on human studies. The results suggest that carbohydrate intake has limited effects on bone fracture but further research is needed on its effects on bone mineral density and bone turnover markers. Additionally, inconsistent results were found regarding the beneficial effects of animal, vegetable, soy, or milk proteins on bone health. Further studies are required to establish a clear association between macronutrients and bone health in elderly people.
Article
Endocrinology & Metabolism
Polyzois Makras, Natasha M. Appelman-Dijkstra, Socrates E. Papapoulos, Sandra van Wissen, Elizabeth M. Winter, Stergios A. Polyzos, Maria P. Yavropoulou, Athanasios D. Anastasilakis
Summary: The duration of denosumab treatment significantly influences the efficacy of subsequent zoledronate infusion in maintaining bone mineral density gains. Frequent follow-up of patients treated with denosumab for more than 3 years is advisable as additional therapeutic interventions may be necessary.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Chiara Mele, Marina Caputo, Alice Ferrero, Tommaso Daffara, Beatrice Cavigiolo, Daniele Spadaccini, Antonio Nardone, Flavia Prodam, Gianluca Aimaretti, Paolo Marzullo
Summary: Obesity is a global health challenge and effective treatments are needed to prevent its associated comorbidities. Bariatric surgery, while effective for weight control in obese individuals, can lead to accelerated bone loss and skeletal weakness. The response of bone to bariatric surgery includes decreased bone density and altered bone structure, increasing the risk of falls and fractures. Factors such as malabsorption, mechanical unloading, and changes in molecular interactions between adipose tissue, bone, and muscle may contribute to these effects. Evaluating and monitoring bone health, as well as implementing specific interventions such as nutrient supplementation, physical activity, and rehabilitation programs, are important for individuals undergoing bariatric surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fnu Deepika, Siresha Bathina, Reina Armamento-Villareal
Summary: The burden of obesity and osteoporosis is increasing and becoming a major public health concern. Recent evidence has identified novel adipokines that play a role in bone metabolism. Obesity, characterized by adipose tissue inflammation, negatively impacts bone health. Adipokines secreted from white adipose tissue and bone marrow adipose tissue have effects on osteoblasts and osteoclasts. Understanding the complex interplay between fat cells and bone is crucial in the context of osteoporosis. This review summarizes recent advances in the understanding of adipokines' role in bone metabolism.
Article
Endocrinology & Metabolism
Hai-yan Huang, Zhi-qi Huang, Ling-yan Hua, Wang-shu Liu, Feng Xu, Xiao-qin Ge, Chun-feng Lu, Jian-bin Su, Xue-qin Wang
Summary: The study found a significant association between low-normal serum sodium levels and low bone turnover, as well as a positive correlation between high serum sodium levels and high bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Di Yang, Rongrong Xu, Yinfang Tu, Yunfeng Xiao, Hongwei Zhang, Weijie Liu, Pin Zhang, Haoyong Yu, Yuqian Bao, Ying Yang, Junfeng Han
Summary: Sleeve gastrectomy leads to a decrease in femoral neck and total hip bone mineral density (BMD) in both women and men. Changes in body composition are associated with BMD loss at different time points and bone sites.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Elena Tsourdi, M. Carola Zillikens, Christian Meier, Jean-Jacques Body, Elena Gonzalez Rodriguez, Athanasios D. Anastasilakis, Bo Abrahamsen, Eugene McCloskey, Lorenz C. Hofbauer, Nuria Guanabens, Barbara Obermayer-Pietsch, Stuart H. Ralston, Richard Eastell, Jessica Pepe, Andrea Palermo, Bente Langdahl
Summary: Discontinuation of denosumab results in increased bone turnover, rapid bone loss, and risk of multiple vertebral fractures in some patients. Prior bisphosphonate therapy or subsequent antiresorptive treatment may help mitigate the biochemical rebound phenomenon after denosumab discontinuation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Josefa Mora Vallellano, Carmen Delgado Pecellin, Isabel Delgado Pecellin, Esther Quintana Gallego, Jose Luis Lopez-Campos
Summary: This study found that CF patients with normal nutritional status and without acute lung disease had normal bone mineral density but altered bone remodeling. Various bone turnover biomarkers were associated with CF, with factors like PTH, CTX, and OPG being significant predictors of BMD. Additionally, certain markers like PTH, TNF alpha, calcium, 1,25-vitamin D, and OPG were significantly linked to CF.
Article
Endocrinology & Metabolism
Andrew P. Demidowich, Jordan A. Levine, Ginikanwa I. Onyekaba, Shahzaib M. Khan, Kong Y. Chen, Sheila M. Brady, Miranda M. Broadney, Jack A. Yanovski
DIABETES OBESITY & METABOLISM
(2019)
Article
Hospitality, Leisure, Sport & Tourism
Keisuke Ejima, Stephanie L. Dickinson, Andrew W. Brown, Jack A. Yanovski, Kathryn A. Kaiser, Kevin D. Hall, Steven B. Heymsfield, David B. Allison
PSYCHOLOGY OF SPORT AND EXERCISE
(2020)
Article
Endocrinology & Metabolism
Andrew P. Demidowich, Jordan A. Levine, Sheila M. Brady, Cheryl D. Johnson, Steven J. Soldin, Jack A. Yanovski
DIABETES OBESITY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Adrian M. Wong, Tushar P. Patel, Elizabeth K. Altman, Nicol Tugarinov, Giampaolo Trivellin, Jack A. Yanovski
Summary: The Tg(Adipoq-cre)1Evdr mouse has an unknown integration site for the transgene, but it has been found to be located between exons 6 and 7 of Tbx18 on mouse chromosome 9. The study also detected transgene-transgene fusion and used droplet digital polymerase chain reaction to identify the Cre copy number in order to potentially identify homozygous mice.
Article
Endocrinology & Metabolism
Shannon E. Marwitz, Megan Gaines, Sheila M. Brady, Sarah J. Mi, Miranda M. Broadney, Susan Z. Yanovski, Van S. Hubbard, Jack A. Yanovski
ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Neurosciences
Katherine M. Cole, Shau-Ming Wei, Pedro E. Martinez, Tuong-Vi Nguyen, Michael D. Gregory, J. Shane Kippenhan, Philip D. Kohn, Steven J. Soldin, Lynnette K. Nieman, Jack A. Yanovski, Peter J. Schmidt, Karen F. Berman
Summary: This study aims to investigate the impact of increased sex steroid production during puberty on neurodevelopment, and explores the relationships with various endocrine events through longitudinal research, as well as assessing the effects of gonadal development on brain structure and function.
Article
Endocrinology & Metabolism
Ashley H. Shoemaker, Heidi J. Silver, Maciej Buchowski, James C. Slaughter, Jack A. Yanovski, Clinton Elfers, Christian L. Roth, M. Jennifer Abuzzahab
Summary: Treatment with a GLP1RA can decrease food intake but also lead to a disproportionate decrease in total energy expenditure compared to changes in body composition.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Pediatrics
Crescent B. Martin, Bryan Stierman, Jack A. Yanovski, Craig M. Hales, Neda Sarafrazi, Cynthia L. Ogden
Summary: This study examines the differences in adiposity by race/Hispanic origin among US youth and explores how those differences relate to differences in BMI using the most recent national data, including non-Hispanic Asian youth.
Article
Nutrition & Dietetics
Megan N. Parker, Loie M. Faulkner, Lisa M. Shank, Natasha A. Schvey, Lucy K. Loch, Hannah E. Haynes, Bess F. Bloomer, Nasreen A. Moursi, Syeda Fatima, Jennifer A. Te-Vazquez, Sheila M. Brady, Shanna B. Yang, Sara A. Turner, Marian Tanofsky-Kraff, Jack A. Yanovski
Summary: Pre-meal heart rate variability is positively related to perceived loss-of-control eating during a laboratory meal designed to simulate an episode of loss-of-control eating. However, this association is only significant among participants with recent reported episodes of loss-of-control eating.
Article
Pediatrics
Anna Zenno, Sheila M. Brady, Loie M. Faulkner, Kaitlin L. Ballenger, Syeda Fatima, Jack A. Yanovski
Summary: This study found no significant association between circadian variation in serum leptin concentrations during childhood and long-term changes in adiposity.
Article
Pharmacology & Pharmacy
Julia Lazareva, Sheila M. M. Brady, Jack A. A. Yanovski
Summary: Bardet-Biedl Syndrome (BBS) is a rare ciliopathy with a high incidence of obesity. Setmelanotide, an MC4R agonist, can potentially alleviate obesity and improve comorbid conditions associated with obesity in BBS individuals, although it may have some side effects such as skin darkening.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olanrewaju A. A. Ogunleye, Harish Raviprakash, Ashlee M. M. Simmons, Rhasaan T. M. Bovell, Pedro E. E. Martinez, Jack A. A. Yanovski, Karen E. F. Berman, Peter J. J. Schmidt, Elizabeth C. C. Jones, Hadi Bagheri, Nadia M. M. Biassou, Li-Yueh Hsu
Summary: In this study, an automated convolutional neural network approach using Dixon-based MRI was proposed to quantify abdominal adipose tissue in children and adolescents. The results showed excellent agreement with the reference measurements and accurate abdominal wall segmentation.
Article
Pediatrics
M. M. Broadney, F. Shareef, S. E. Marwitz, S. M. Brady, S. Z. Yanovski, J. P. DeLany, J. A. Yanovski
Article
Family Studies
Amanda Skoranski, Nichole R. Kelly, Rachel M. Radin, Katherine A. Thompson, Ovidiu Galescu, Andrew P. Demidowich, Sheila M. Brady, Kong Y. Chen, Marian Tanofsky-Kraff, Jack A. Yanovski, Lauren B. Shomaker
JOURNAL OF CHILD AND FAMILY STUDIES
(2018)
Article
Pediatrics
C. S. Suelter, N. Schvey, N. R. Kelly, M. Shanks, K. A. Thompson, R. Mehari, S. Brady, S. Z. Yanovski, C. L. Melby, M. Tanofsky-Kraff, J. A. Yanovski, L. B. Shomaker