期刊
MUSCLE & NERVE
卷 52, 期 4, 页码 640-648出版社
WILEY-BLACKWELL
DOI: 10.1002/mus.24581
关键词
exercise; junctophilin 1; muscle injury; rats; trauma
资金
- U.S. Army Medical Research and Medical Command Combat Casualty Care Research Program
Introduction: In this investigation we aimed to determine whether: (1) physical activity protects rat skeletal muscle from ischemia/reperfusion (I/R) injury; and (2) continued activity after I/R improves the rate of healing. Methods: Rats were divided into sedentary or active (voluntary wheel running) groups. Active rats ran for 4 weeks before I/R or 4 weeks before plus 4 weeks after I/R. Results: Activity before I/R resulted in 73.2% less muscle damage (Evans blue dye inclusion). Sedentary and active rats had a similar decline in neural- evoked (similar to 99%) and directly stimulated (similar to 70%) in vivo muscle torque, and a similar reduction in junctophilin 1. Active rats produced 19% and 15% greater neural- evoked torque compared with sedentary rats at 14 and 28 days postinjury, respectively, although the rate of recovery appeared similar. Conclusions: Activity protects against long-term muscle damage, but not short-term neural injury or excitation-contraction uncoupling. Continued activity neither accelerates nor hinders the rate of functional recovery.
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