期刊
JOURNAL OF ADHESION
卷 85, 期 2-3, 页码 126-138出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00218460902782188
关键词
2-chloro-4; 5-dihydroxyphenylalanine; Adhesive protein; Cement; Phragmatopoma californica; Sandcastle worm
资金
- NIH [R01DE018468]
- UCSB Chemistry Department
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE018468] Funding Source: NIH RePORTER
The sandcastle worm Phragmatopoma californica, a marine polychaete, constructs a tube-like shelter by cementing together sand grains using a glue secreted from the building organ in its thorax. The glue is a mixture of post-translationally modified proteins, notably the cement proteins Pc-1 and Pc-2 with the amino acid, 3,4-dihydroxyphenyl-L-alanine (DOPA). Significant amounts of a halogenated derivative of DOPA were isolated from the worm cement following partial acid hydrolysis and capture of catecholic amino acids by phenylboronate affinity chromatography. Analysis by tandem mass spectrometry and 1H NMR indicates the DOPA derivative to be 2-chloro-4, 5-dihydroxyphenyl-L-alanine. The potential roles of 2-chloro-DOPA in chemical defense and underwater adhesion are considered.
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