Article
Environmental Sciences
Hossam G. Tohamy, Mohamed A. Lebda, Kadry M. Sadek, Mohamed S. Elfeky, Yasser S. El-Sayed, Dalia H. Samak, Heba S. Hamed, Tarek K. Abouzed
Summary: Silver nanoparticles have negative effects on the testicles, but cotreatment with alpha-lipoic acid (LA) or Ginkgo biloba (GB) can alleviate these effects. The study demonstrates that LA or GB reduces serum testosterone levels, mitigates oxidative stress and apoptosis markers, and protects the testicles in adult rats exposed to silver nanoparticles.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Medicinal
Fernanda Malanconi Thomaz, Jussara de Jesus Simao, Viviane Simoes da Silva, Meira Maria Forcelini Machado, Lila Missae Oyama, Eliane Beraldi Ribeiro, Maria Isabel Cardoso Alonso Vale, Monica Marques Telles
Summary: The study found that Ginkgo biloba extract (GbE) can modulate adipocyte differentiation, increasing lipid content and gene expression of major adipogenesis markers. GbE can modify key proteins involved in the differentiation process and accelerate the expression of mature adipocyte proteins.
Article
Agricultural Engineering
Bing He, Xin Han, Hailin Liu, Mengjia Bu, Peng Cui, Li-an Xu
Summary: This study revealed the genome-wide landscape of alternative splicing (AS) patterns in G. biloba, a relict tree species with rich medicinal value. Intron retention was found to be the dominant AS type, and the AS patterns of important secondary metabolites in G. biloba were analyzed. These findings have important implications for studying gene regulation and the synthesis mechanisms of secondary metabolites in woody plants.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Ying-Jie Yang, Hu Sun, Shi-Bao Zhang, Wei Huang
Summary: The study revealed in Ginkgo biloba, FDPs mainly protect PSI under fluctuating light, while CET plays a critical role under constant high light. The coordination of FDPs and CET fine-tune the photosynthetic apparatus under excess light.
Article
Infectious Diseases
Mohamed F. Ghaly, Zahraa M. Nasr, Amira I. Abousaty, Hanan G. Seadawy, Mohamed A. A. Shaheen, Sarah Albogami, Mohammad M. Al-Sanea, Mahmoud M. Bendary
Summary: The study found a high prevalence rate of Salmonella in meat products, with most isolates being multidrug-resistant but susceptible to cefotaxime. Out of 13 plant extracts, cinnamon oil and paprika water extract showed antimicrobial activity and synergistic effect with cefotaxime. Therefore, cinnamon oil is recommended as a food additive to combat resistant foodborne pathogens.
Review
Biochemistry & Molecular Biology
Alfredo Cordova-Martinez, Alberto Caballero-Garcia, Daniel Perez-Valdecantos, Enrique Roche, David Cesar Noriega-Gonzalez
Summary: The article reviews peripheral neuropathies and their treatment methods, focusing on the use of nutraceutical strategies to improve neuropathy symptoms in COVID-19 patients. Nutrients may play a key role in COVID-19 treatment, but can also lead to neuropathy.
Review
Nutrition & Dietetics
Simon Alesi, Carolyn Ee, Lisa J. Moran, Vibhuti Rao, Aya Mousa
Summary: This review provides an up-to-date, comprehensive synthesis of the highest level of evidence regarding the effects of nutritional supplements and complementary therapies in the treatment and management of polycystic ovary syndrome (PCOS). The evidence suggests that specific vitamins, vitamin-like nutrients, minerals, and some complementary approaches may be beneficial in PCOS. However, there are still uncertainties and limitations that need to be addressed.
ADVANCES IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Xiaoqian Wu, Jianrong Huang, Junyuan Tang, Yuling Sun, Guojun Zhao, Cuishi Yan, Zhenghong Liu, Wei Yi, Suowen Xu, Xiyong Yu
Summary: In this study, isoginkgetin (IGK) was found to protect against obesity-induced metabolic cardiomyopathy by activating the Nrf2 signaling pathway. IGK stabilized Nrf2 protein to protect against oxidative stress and mitochondrial damage induced by obesity. These findings highlight the potential therapeutic use of IGK in treating obesity-induced cardiomyopathy.
Article
Endocrinology & Metabolism
Giuseppe Derosa, Angela D'Angelo, Paola Stefania Preti, Pamela Maffioli
Summary: This study aimed to evaluate the efficacy of Avanafil + Blunorm forte therapy in treating erectile dysfunction in males with type 2 diabetes. The results showed that Avanafil + Blunorm forte treatment significantly reduced fasting plasma glucose and insulin resistance index, and improved the International Index of Erectile Function (IIEF) score.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Amina E. Essawy, Soad Ahmed El-Sayed, Ehab Tousson, Horeya S. Abd El-gawad, Reem Hasaballah Alhasani, Heba-Tallah Abd Elrahim Abd Elkader
Summary: The study demonstrates that Ginkgo biloba extract and L-carnitine have protective and therapeutic effects against epileptic seizures induced by pentylenetetrazol in rats. These substances ameliorate oxidative stress, improve antioxidant capacity, and modulate neurochemical parameters, thus reducing the impact of seizures.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Maryam Chudhary, Chenghong Zhang, Shiyu Song, Xiang Ren, Li Kong
Summary: Intense exposure to bright light can lead to retinal damage, while Ginkgo biloba extract has a protective effect on photoreceptor cell degeneration. Exposure to bright light increases oxidative stress-induced cell apoptosis, with EGb 761 treatment reversing these changes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sullim Lee, Yea Jung Choi, Chen Huo, Akida Alishir, Ki Sung Kang, Il-Ho Park, Taesu Jang, Ki Hyun Kim
Summary: Human skin is composed of the epidermis and dermis, which work together to maintain the skin's tensile strength. Skin aging, however, leads to the degradation of collagen and elastin fibers, resulting in wrinkles, pigmentation, and sagging. This study investigated natural products derived from ginkgo fruit that have protective effects against TNF-alpha-induced skin aging.
Article
Agriculture, Dairy & Animal Science
Anna Bergh, Irene Lund, Anna Bostrom, Heli Hyytiainen, Kjell Asplund
Summary: This study reviewed the scientific literature of 24 different complementary and alternative veterinary medicine (CAVM) therapies used in cats, dogs, and horses, and found that there is insufficient scientific documentation to draw clear conclusions about their clinical effect. The research assessed 42 eligible publications representing nine different CAVM therapies, with varying levels of bias and reported treatment effects. Further research is needed to better understand the efficacy of these CAVM therapies.
Article
Food Science & Technology
Teresa Delerue, M. Fatima Barroso, Monica Dias-Teixeira, Maria Figueiredo-Gonzalez, Cristina Delerue-Matos, Clara Grosso
Summary: The study found that the individual activities of Ginkgo biloba and Scutellaria baicalensis in Alzheimer's disease prevention and treatment are better than mixtures, with most interactions exhibiting varying degrees of antagonism. A slight synergism interaction was observed for a commercial multicomponent mixture against H2O2, but overall, the combination of the two plants did not enhance the neuroprotective effect.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Wenyu Hui, Wei Huang, Zuguo Zheng, Yi Li, Ping Li, Hua Yang
Summary: The study investigated the effects of Ginkgo biloba extract (EGb) on ischemic stroke and found that EGb reduced neurobehavioral scores, infarct volume, and inflammatory cytokine levels in mice with ischemia/reperfusion (I/R) brain injury. Furthermore, EGb increased the proportion of Treg cells and promoted their differentiation. Depletion of Treg cells weakened the neuroprotective effects of EGb. EGb's modulation of the HIF-1a/HK2 signaling pathway may contribute to its benefits in ameliorating ischemic stroke.
PHYTOTHERAPY RESEARCH
(2023)
Review
Neurosciences
Greg J. Duncan, Sohrab B. Manesh, Brett J. Hilton, Peggy Assinck, Jason R. Plemel, Wolfram Tetzlaff
Article
Clinical Neurology
Khalil S. Rawji, Adam M. H. Young, Tanay Ghosh, Nathan J. Michaels, Reza Mirzaei, Janson Kappen, Kathleen L. Kolehmainen, Nima Alaeiilkhchi, Brian Lozinski, Manoj K. Mishra, Annie Pu, Weiwen Tang, Salma Zein, Deepak K. Kaushik, Michael B. Keough, Jason R. Plemel, Fiona Calvert, Andrew J. Knights, Daniel J. Gaffney, Wolfram Tetzlaff, Robin J. M. Franklin, V. Wee Yong
ACTA NEUROPATHOLOGICA
(2020)
Article
Neurosciences
Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Madelene Ho, Ghazaleh Eskandari-Sedighi, Chris D. St. Laurent, Kelli A. McCord, Arjun Bains, Gaurav Sidhu, Susmita Sarkar, Jason R. Plemel, Matthew S. Macauley
Summary: The human CD33 short isoform (hCD33m), encoded by an AD-protective CD33 allele, has been shown to enhance phagocytosis in primary microglia and U937 cells, contrary to the inhibitory effect of the long isoform. scRNAseq revealed hCD33m(+) microglia enriched in a cell cluster with upregulated immediate early genes, supporting the gain-of-function role of hCD33m. This newly discovered function is cytoplasmic signaling motif-dependent and suggests potential therapeutic implications for Alzheimer's disease.
MOLECULAR NEURODEGENERATION
(2021)
Review
Neurosciences
Brady P. Hammond, Rupali Manek, Bradley J. Kerr, Matthew S. Macauley, Jason R. Plemel
Summary: The dynamic changes in microglia density, volume, and proliferation in the central nervous system play a crucial role in their function, with fluctuations affecting their ability to respond effectively to various stimuli. Microglia exhibit a robust proliferative capacity during development and in neurodegenerative diseases, but this capacity is largely absent at homeostasis. Proper microglial function in different states is heavily dependent on density fluctuations primarily induced by proliferation.
Editorial Material
Neurosciences
Jason R. Plemel, V. Wee Yong
Summary: Researchers discuss a new method - small-angle X-ray scattering tensor tomography approach, which provides a new way to evaluate myelin integrity in the brain.
TRENDS IN NEUROSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marije J. D. Huitema, Eva M. M. Strijbis, Antonio Luchicchi, John G. J. M. Bol, Jason R. Plemel, Jeroen J. G. Geurts, Geert J. Schenk
Summary: Multiple sclerosis is a demyelinating and neurodegenerative disease of the central nervous system. This study introduced and validated a novel standardized method for more precise myelin quantification in progressive MS brains. The method showed excellent inter-rater agreement and reliability in quantifying myelin content in human post-mortem samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Emily Kamma, Wendy Lasisi, Cole Libner, Huah Shin Ng, Jason R. Plemel
Summary: There are limited treatment options available for progressive multiple sclerosis (MS) due to a poor understanding of its pathophysiology. Microglia and macrophages play a vital role in the progressive phase of MS and may contribute to neurodegeneration. However, there is a lack of disease-modifying drugs that target these cells specifically in progressive MS.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Neurosciences
Martin Zirngibl, Peggy Assinck, Anastasia Sizov, Andrew Caprariello, Jason R. Plemel
Summary: This review provides an updated understanding of cuprizone-induced demyelination, showcasing two modes of action: intrinsic cell damage and extrinsic cellular damage. Recent developments in research on different forms of cell death induced by cuprizone are also summarized.
MOLECULAR NEURODEGENERATION
(2022)
Editorial Material
Neurosciences
Greg J. Duncan, Peggy Assinck, Jo Anne Stratton, Bahareh Ajami, Jason R. Plemel
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biology
Luke M. Healy, Sameera Zia, Jason R. Plemel
Summary: High dimensional single-cell analysis like sc/snRNAseq is widely used to explore microglia diversity, with findings of cellular heterogeneity being common, emphasizing the importance of a clear understanding of microglia heterogeneity in mitigating confusion among researchers.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Sameera Zia, Brady P. Hammond, Martin Zirngibl, Anastasia Sizov, Charbel S. Baaklini, Sharmistha P. Panda, Madelene F. S. Ho, Kelly V. Lee, Apurba Mainali, Mena K. Burr, Sioned Williams, Andrew V. Caprariello, Christopher Power, Thomas Simmen, Bradley J. Kerr, Jason R. Plemel
Summary: This study investigates the response of microglia during demyelination using a mouse model and in vitro culture system. The results indicate that microglia play multiple roles in the process of demyelination and exhibit a transcriptomic state similar to other neurodegenerative conditions.
MOLECULAR NEURODEGENERATION
(2022)
Article
Multidisciplinary Sciences
Aislinn D. Maguire, Timothy N. Friedman, Dania N. N. Villarreal Andrade, Fajr Haq, Jacob Dunn, Keiana Pfeifle, Gustavo Tenorio, Karen Buro, Jason R. Plemel, Bradley J. Kerr
Summary: This study explores sex differences in sensory neurons in the context of multiple sclerosis (MS) and neuropathic pain. The researchers found that female mice and sensory neurons exhibited a more resistant response to mitochondrial stress and displayed an inflammatory and regenerative phenotype, potentially contributing to greater nociceptor hyperexcitability and pain. Understanding these sex differences is crucial for the development of sex-specific treatments to prevent pain development.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Alex P. Vu, David Lam, Cayla Denney, Kelly V. Lee, Jason R. Plemel, Jesse Jackson
Summary: Social isolation is a significant psychological stress that affects a large proportion of society, and its impact on microglia has not been well investigated. This study found that social isolation caused an increase in microglia volume, territory, and endpoints in the dorsomedial hypothalamus and hippocampal CA2 region of adult male mice, and in the hypothalamus of female mice. These findings suggest a sexually dimorphic and brain region-specific response of microglia to social isolation, which may contribute to cognitive and behavioral changes associated with this prevalent form of psychological stress.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Editorial Material
Neurosciences
Jason R. Plemel, Jessica M. Rosin, Marie-eve Tremblay
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Aislinn D. Maguire, Jason R. Plemel, Bradley J. Kerr
Summary: Dorsal root ganglia (DRGs) are peripheral structures adjacent to the dorsal horn of the spinal cord, which contain sensory neurons and other cell types. Current culture protocols for DRGs often do not exclusively isolate neurons and include other cell types. In this study, we present an immunopanning method to selectively enrich neurons in cultured mouse DRGs by removing fibroblasts, immune cells, and Schwann cells.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)