Article
Medicine, General & Internal
Alexandra J. Morquette, Jason B. Lee, Shoshana K. Grossman, Sylvia Hsu
Summary: The treatment with rutoside and ascorbic acid can effectively alleviate the symptoms of Schamberg disease, with lesions completely clearing within months. Further research into the effectiveness of this treatment may lead to its use as a standard care for PPD.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Medicine, General & Internal
Cristina B. Spigariolo, Serena Giacalone, Gianluca Nazzaro
Summary: Pigmented purpuric dermatoses (PPD) is a group of skin diseases characterized by multiple petechial hemorrhage as consequence of capillaritis. The lesions typically present as red to purple macules on the lower extremities, progressing to a golden-brown color. Diagnosis and treatment of PPD can be challenging for both general practitioners and specialists, as the condition may be asymptomatic or associated with mild pruritus.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Maryam Nasimi, Masoud Bonabiyan, Vahideh Lajevardi, Arghavan Azizpour, Afsaneh Nejat, Shayan Dasdar, Nika Kianfar
Summary: This study identified distinct dermoscopic characteristics in PMF and PPD lesions, with fine short linear vessels and spermatozoa-like structures more common in PMF, while erythematous globules and reticular pigmentation predominated in PPD. Dermoscopy was found to be useful in differentiating between PMF and PPD cases, but further long-term studies are needed for validation.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Yasuhiro Horiuchi
Summary: Pigmented purpuric dermatosis is a rare skin disorder characterized by petechiae, red rashes, and brown pigmented patches on the lower extremities. The exact cause and treatment for this condition have not been established. This case report presents a 72-year-old female with persistent pigmented purpuric dermatosis for 20 years. Treatment with ozone nanobubble water was successful, but additional interventions were needed to reduce pigmentation.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Alexandra Valeska Matter, Isabel Kolm, Werner Kempf
Summary: This study reports the largest case series of Granulomatous Pigmented Purpuric Dermatosis (GPPD) to date and compares its histopathological findings with other subtypes of Pigmented Purpuric Dermatoses (PPD). GPPD predominantly affects the lower extremities of adult male patients and exhibits distinct histopathological features.
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Article
Dermatology
Franchesca Marie D. Ilagan, Yu-Hung Wu
Summary: In patients with pigmented purpuric dermatosis (PPD), the most common findings on direct immunofluorescence (DIF) were vascular deposition of fibrinogen and C3, sometimes accompanied by immunoglobulin (Ig) presence. Hypertension was associated with fibrinogen deposition and may play a role in its pathophysiology.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Review
Dermatology
John S. Runge, Mio Nakamura, Annette Nichole Sullivan, Paul W. Harms, May P. Chan
Summary: Pigmented purpuric dermatosis (PPD) is a group of skin disorders characterized by red, brown, or golden macules and patches. We present 6 new cases of PPD involving the hand and review 17 previously reported cases. Cases of PPD involving the hand are rare and often require biopsy for accurate diagnosis.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Dermatology
Ceyda Caytemel, Basak Baykut, Senay Agirgol, Nazli Caf, Filiz Topaloglu Demir, Zafer Turkoglu, Esen Gul Uzuner
Summary: In this retrospective study of patients with pigmented purpuric dermatoses (PPD) from January 2010 to May 2019, it was found that mycosis fungoides (MF) should be considered in the differential diagnosis of PPD cases presenting with longstanding and widespread involvement.
JOURNAL OF CUTANEOUS PATHOLOGY
(2021)
Article
Dermatology
Erin McClure, Laura Valaas, Heather Brandling-Bennett
Summary: This article reports two cases of Morphea developing as an isotopic response after a preceding benign skin disease. The importance of return to care recommendations for benign skin conditions such as lichen striatus and pigmented purpuric dermatoses is highlighted, due to the rare possibility of subsequent Morphea development.
PEDIATRIC DERMATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ishfaq Ahmad Rather, Feroz Ahmad Sofi, Mohsin Ahmad Bhat, Rashid Ali
Summary: A facile method to obtain a new one-walled mesa-substituted phenylboronic acid-functionalized calix[4]pyrrole (C4P) has been demonstrated, and its excellent sensitivity and stability in electrochemical sensing of dopamine (DA) have been confirmed.
Review
Dermatology
Ko Eun Kim, Hye-Rim Moon, Hwa Jung Ryu
Summary: This study analyzed the common dermoscopic characteristics of PPD in 60 patients, revealing a correlation between dermoscopic findings and histopathologic features. Results showed that red globules and dots were common dermoscopic features, with lichenoid pattern associated with coppery red pigmentation in pathologic analysis. The study suggests that dermoscopic examination is helpful in clinical diagnosis and pathological prediction of PPD.
ANNALS OF DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose, Yasuyuki Kakihana
Summary: This study found that early administration of ascorbic acid (AsA) can protect vascular endothelial cells by inhibiting the oxidation of BH4 in septic mice, reducing organ dysfunction and improving survival.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Phouphien Keoingthong, Yiting Xu, Shengkai Li, Jieqiong Xu, Liang Zhang, Zhuo Chen, Weihong Tan
Summary: In this study, a magnetic CoRh@G nanozyme with high catalytic efficiency, unique physicochemical properties, and excellent stability was successfully synthesized and used for sensitive colorimetric sensing of dopamine and ascorbic acid. The CoRh@G nanozyme showed superior peroxidase-like activity and high affinity towards 3,3',5,5'-tetramethylbenzydine oxidation.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Rheumatology
Divita Jhaveri, Frances Zhao
Summary: This article presents a rare case of PPD induced by TNF-alpha inhibitors, which improved after switching to an Interleukin-17 inhibitor. PPD is a benign skin condition with unknown exact etiology and no standardized treatment, but it often regresses on its own once the causative agent is removed.
Review
Pharmacology & Pharmacy
Yimin Zhu, Danni Li, Felisa Reyes-Ortega, Holly R. Chinnery, Elena K. Schneider-Futschik
Summary: Highly effective CFTR modulator therapies have been shown to improve clinical metrics and quality of life for CF patients. However, their use during pregnancy and breastfeeding may affect the development of the infant's lens.
FRONTIERS IN PHARMACOLOGY
(2023)