Article
Dermatology
Kristian Reich, Ulrich Mrowietz, Christina Sorbe, Ralph von Kiedrowski, Sebastian Diemert, Lisa Schaeffer, Natalia Kirsten, Nesrine Ben-Anaya, Matthias Augustin
Summary: This study examines the effectiveness of fumaric acid esters (FAEs) for the treatment of plaque psoriasis in real-world practice. The results show that FAEs have a favorable response at 12 months, largely independent of patient characteristics. The baseline psoriasis area and severity index (PASI) is the only significant factor affecting the odds of response.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Clinical Neurology
Ruth Ruscheweyh, Theresa Klonowki, Gudrun Gossrau, Torsten Kraya, Charly Gaul, Andreas Straube, Tim Patrick Juergens, Joerg Scheidt, Stefanie Foerderreuther
Summary: Although effective treatment options exist for many headache disorders, not all patients benefit and disability remains significant. To improve headache care, the German Migraine and Headache Society has established the DMKG Headache Registry to observe real-world data. Initial findings show that the majority of participants in the registry have a diagnosis of migraine and experience high levels of headache severity and disability.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
William Kristian Karlsson, Hakan Ashina, Christopher Kjaer Cullum, Rune Haeckert Christensen, Haidar Muhsen Al-Khazali, Faisal Mohammad Amin, Messoud Ashina, Afrim Iljazi, Andreas Vinther Thomsen, Basit Ali Chaudhry, Betel Tesfay, Janu Thuraiaiyah, Lili Kokoti, Nadja Bredo Rasmussen, Rogelio Dominguez-Moreno, Thien Phu Do, Zixuan Alice Zhuang
Summary: The REFORM study aims to discover biomarkers that can predict response to erenumab in migraine patients. This article provides a comprehensive description of the study methodology and the baseline characteristics of the study population. Future publications will report the results of the investigations.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Public, Environmental & Occupational Health
Haidao Guan, Guiyan Yang, Jiashi Gao, Xiaoya Lin, Chao Liu, Han Ren, Duyue Chen, Lingyao Zhou, Qian Hu, Yongzhen Huang, Yumei Zhao, Shilu Tong, Zhaohui Lu, Shijian Liu, Dan Wang
Summary: The study suggests that a tropical climate may alleviate the symptoms of allergic diseases in migratory-bird old people.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Genetics & Heredity
Markus Ries, Grecia Mendoza, Laila Arash-Kaps, Yasmina Amraoui, Folker Quack, Brigitte Hardt, Stefan Diederich, Michael Beck, Eugen Mengel
Summary: Gangliosidoses are a group of inherited neurogenetic disorders that usually present with macrocephaly, developmental delay, and regression, leading to significant morbidity and premature death. This study utilizes a disease registry to provide a quantitative definition of the disease and support clinical development of specific therapies.
GENETICS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Stephanie Korn, Katrin Milger, Dirk Skowasch, Hartmut Timmermann, Christian Taube, Marco Idzko, Hans Werner Voss, Annette Holtdirk, Eckard Hamelmann, Roland Buhl
Summary: This study collected long-term data from patients with severe asthma in Germany, revealing suboptimal asthma control and identifying factors associated with exacerbations and/or poor control.
RESPIRATORY MEDICINE
(2022)
Article
Clinical Neurology
John W. Winkelman, Julia Purks, Benjamin Wipper
Summary: The study investigated individuals included in the National RLS Opioid Registry who were currently taking opioids for treating RLS. Results showed that most participants used opioids at low doses with minimal dose changes, but about one-third increased their dose over a 1-year period, with larger dose increases being associated with specific features.
Article
Gastroenterology & Hepatology
Manisha Balwani, William Balistreri, Lorenzo D'Antiga, Jennifer Evans, Emilio Ros, Florian Abel, Don P. Wilson
Summary: The study describes the population enrolled in the International Lysosomal Acid Lipase Deficiency Registry established in 2013. The findings suggest that diagnosis of LAL-D is often delayed, and abnormal liver enzyme levels, hepatomegaly, and dyslipidemia can prompt earlier diagnosis of the disease.
LIVER INTERNATIONAL
(2023)
Article
Dermatology
April W. Armstrong, Timothy Fitzgerald, Robert R. McLean, Amanda Teeple, Jonathan P. Uy, Mobolaji Olurinde, Katelyn Rowland, Lin Guo, Ying Shan, Kristina Callis Duffin
Summary: This study aimed to investigate the real-world effectiveness of guselkumab among patients with psoriasis of different severities. The results showed that disease activity and patient-reported outcome measures improved after 9-12 months of persistent guselkumab treatment.
DERMATOLOGY AND THERAPY
(2023)
Article
Clinical Neurology
Shu-Hong Wang, Xue-Yu Chen, Xiao-Ping Wang
Summary: The study aims to investigate the association between restless legs syndrome (RLS) and increased cardiovascular risk, providing important scientific evidence for early detection and prevention of CVD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Health Care Sciences & Services
Stefan Kleinert, Peter Bartz-Bazzanella, Cay von der Decken, Johannes Knitza, Torsten Witte, Sandor P. Fekete, Matthias Konitzny, Alexander Zink, Georg Gauler, Patrick Wurth, Peer Aries, Kirsten Karberg, Christoph Kuhn, Florian Schuch, Susanna Spaethling-Mestekemper, Wolfgang Vorbrueggen, Matthias Englbrecht, Martin Welcker
Summary: Real-world data, provided by the German RHADAR registry, play a crucial role in improving the management of patients with rheumatic and musculoskeletal diseases. The digital modules in the registry facilitate personalized patient care and continuous improvement, ultimately enabling comprehensive and timely patient management along the entire disease pathway.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Rheumatology
Clementina Lopez-Medina, Rafaela Ortega-Castro, M. Carmen Castro-Villegas, Pilar Font-Ugalde, M. Angeles Puche-Larrubia, Ignacio Gomez-Garcia, Ivan Arias-de la Rosa, Nuria Barbarroja, Ruxandra Schiotis, Eduardo Collantes-Estevez
Summary: Psoriasis influences the clinical expression, disease activity, and burden in patients with both axial and peripheral phenotypes of spondyloarthritis (SpA), with psoriatic patients showing more symptoms of dactylitis and increased use of medication compared to non-psoriatic patients.
Article
Orthopedics
Sebastian Serong, Moritz Schutzbach, Stefan Fickert, Philipp Niemeyer, Christian Sobau, Gunther Spahn, Wolfgang Zinser, Stefan Landgraeber
Summary: This study analyzed patient- and joint-related baseline data of a large cohort of patients with cam-derived femoroacetabular impingement syndrome using the German Cartilage Registry. Factors such as age, sex, body mass index (BMI), and previous hip surgery confirmation were identified to significantly affect preoperative iHOT-33 scores.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Zhenli Kwan, Nurakmal Baharum, Shin Shen Yong, Azura Mohd Affandi, Asmah Johar
Summary: This study aimed to determine the frequency of sexual difficulties and associated factors among adult patients with psoriasis. Results showed that sexual difficulties were reported among 9.5% of subjects, with significant predictors identified as younger age, male gender, married status, ethnicity, nail involvement, face and neck involvement, and severity of disease. Smokers were more likely to report experiencing sexual difficulties. However, the presence of either ischemic heart disease, diabetes mellitus, hypertension, or dyslipidemia was associated with lower odds of sexual issues due to psoriasis.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Tobias J. Pfeffer, Bernd Auber, Brigitte Pabst, Kuebra C. Agca, Dominik Berliner, Tobias Konig, Denise Hilfiker-Kleiner, Johann Bauersachs, Melanie Ricke-Hoch
Summary: No high prevalence of HSPB6 gene variants was found in PPCM patients from the German PPCM registry compared to DCM patients. Further genetic analyses in larger cohorts and in cohorts of different etiologies of PPCM patients are needed to determine the role of genetic background in the pathogenesis of PPCM.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Dermatology
R. Stalder, N. Brembilla, C. Conrad, N. Yawalkar, A. Navarini, Wh Boehncke, G. Kaya
Summary: Using specific biomarkers and cell markers to analyze different types of ND can help differentiate between them, aiding in the diagnosis and treatment of these diseases in clinical practice.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Rheumatology
Barbara Russo, Julia Borowczyk, Pietro Cacialli, Philippe Moguelet, Marie-Elise Truchetet, Ali Modarressi, Nicolo C. Brembilla, Julien Bertrand, Wolf-Henning Boehncke, Carlo Chizzolini
Summary: IL-25 plays a role in regulating skin fibrosis, and its decreased expression in systemic sclerosis may contribute to the excessive accumulation of extracellular matrix and progress of fibrosis.
Article
Rheumatology
Christopher T. Ritchlin, Philip J. Mease, Wolf-Henning Boehncke, John Tesser, Elena Schiopu, Soumya D. Chakravarty, Alexa P. Kollmeier, Xie L. Xu, May Shawi, Yusang Jiang, Shihong Sheng, Yanli Wang, Stephen Xu, Joseph F. Merola, Iain B. McInnes, Atul Deodhar
Summary: The study evaluated the efficacy of guselkumab in PsA patients and found that both Q4W and Q8W treatments resulted in robust and sustained improvements in signs and symptoms across subgroups defined by diverse baseline characteristics.
Meeting Abstract
Rheumatology
P. J. Mease, I. Mcinnes, L. S. Tam, R. Rajalingam, S. Peterson, F. Hassan, S. D. Chakravarty, C. Contre, A. Armstrong, W. H. Boehncke, C. T. Ritchlin
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Philip J. Mease, Iain B. McInnes, Lai-Shan Tam, Raji Rajalingam, Steve Peterson, Fareen Hassan, Soumya D. Chakravarty, Christine Contre, Alison Armstrong, Wolf-Henning Boehncke, Christopher Ritchlin
Summary: The objective of this study was to update the network meta-analysis (NMA) comparing guselkumab with other targeted therapies for PsA. The results showed that guselkumab demonstrated better skin efficacy than most other PsA treatments and had comparable ACR responses to most agents.
Article
Rheumatology
Proton Rahman, Wolf-Henning Boehncke, Philip J. Mease, Alice B. Gottlieb, Iain B. McInnes, May Shawi, Yanli Wang, Shihong Sheng, Alexa P. Kollmeier, Elke Theander, Jenny Yu, Evan Leibowitz, A. Marilise Marrache, Laura C. Coates
Summary: The safety of guselkumab (GUS) in patients with psoriatic arthritis (PsA) was assessed in both TNFi-naive and TNFi-experienced patients through the end of the studies, up to 2 years. The results showed that the safety profile of GUS remained favorable in both patient groups, without any notable differences.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Cell & Tissue Engineering
Nicolo C. Brembilla, Hubert Vuagnat, Wolf-Henning Boehncke, Karl-Heinz Krause, Olivier Preynat-Seauve
Summary: Chronic wounds have a significant impact on quality of life and healthcare costs. Adipose-derived stromal cells (ASC) have emerged as a promising therapy for chronic wounds. Studies have shown the clinical efficacy of ASC-based therapies in treating chronic wounds.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Dermatology
Jan Koren, Jo L. W. Lambert, Simon F. F. Thomsen, Helen McAteer, Gabriella Fabbrocini, Valeria Corazza, Denis Jullien, Matthias Augustin, Richard B. B. Warren, Menno A. A. de Rie, Elizabeth Lazaridou, Lluis Puig, Loic Guillevin, Marius Grosser, Wolf-Henning Boehncke
Summary: By combining the perspectives of patients, clinicians, and payors, we identified multiple themes to improve the standard of care for patients with psoriasis. Through a Delphi process, consensus was reached on these themes and a set of practical 'Calls to Action' were proposed. Improving healthcare systems, patient access, quality-of-life measures, relevance and reach of guidelines, and patient education were all recognized as important factors.
DERMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Alen Zabotti, Gabriele De Marco, Laure Gossec, Xenofon Baraliakos, Daniel Aletaha, Annamaria Iagnocco, Paolo Gisondi, Peter Balint, Heidi Bertheussen, Wolf-Henning Boehncke, Nemanja S. Damjanov, Maarten de Wit, Enzo Errichetti, Helena Marzo-Ortega, Mikhail Protopopov, Lluis Puig, Ruben Queiro, Piero Ruscitti, Laura Savage, Georg Schett, Stefan Siebert, Tanja A. Stamm, Paul Studenic, Ilaria Tinazzi, Filip E. Van den Bosch, Annette van der Helm-van Mil, Abdulla Watad, Josef S. Smolen, Dennis G. McGonagle
Summary: This study proposes EULAR guidelines for the early diagnosis of psoriatic arthritis (PsA) by conducting research on multiple patients. It also establishes standardized operating procedures for clinical practice and trials, providing guidance and consensus in the field of prevention and interception of PsA for psoriasis patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Dermatology
Raphael Andre, Wolf-Henning Boehncke, Emmanuel Laffitte
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
A. Gonzalez-Cantero, W. H. Boehncke, J. De Sutter, J. L. Zamorano, J. Lambert, L. Puig
Summary: This study aims to provide dermatologists with a tool to systematize the treatment of dyslipidemia in psoriasis and aid in decision-making. The study resulted in a list of concepts and recommendations for managing cardiovascular risk and using statin therapy in moderate-severe psoriasis patients. The application of these recommendations will help dermatologists manage patients' dyslipidemia and reduce their cardiovascular risk.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Immunology
Nicolo Costantino Brembilla, Wolf-Henning Boehncke
Summary: Psoriasis is a common chronic inflammatory skin disease, and TH17 lymphocytes are believed to be the central effector cells. However, recent research has shown that the simple linear pathogenetic model may not fully explain the disease. Other IL-17 homologues and IL-23 independent cells also play a role in psoriasis. This review will summarize the current knowledge about IL-17A and its homologues in relation to skin inflammation and psoriasis, and propose a more comprehensive pathogenetic model.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nicolo Costantino Brembilla, Ali Modarressi, Dominik Andre-Levigne, Estelle Brioudes, Florian Lanza, Hubert Vuagnat, Stephane Durual, Laurine Marger, Wolf-Henning Boehncke, Karl-Heinz Krause, Olivier Preynat-Seauve
Summary: This study evaluates the influence of a gelatin sponge on adipose-derived stromal cells (ASC). The results show that the gelatin sponge strongly influences the transcriptome of ASC and acted as a concentrator and reservoir of the regenerative ASC secretome. The gelatin sponge also increased angiogenesis in vivo and promoted wound healing.
Article
Multidisciplinary Sciences
Maria S. Shutova, Julia Borowczyk, Barbara Russo, Sihem Sellami, Justyna Drukala, Michal Wolnicki, Nicolo C. Brembilla, Gurkan Kaya, Andrei I. Ivanov, Wolf-Henning Boehncke
Summary: Abnormal mechanotransduction and compromised epithelial barrier function are observed in various human pathologies, including inflammatory skin disorders. This study investigates the cytoskeletal mechanisms involved in the regulation of inflammatory responses in the epidermis. The results suggest that inflammation up-regulates the Rho-myosin II pathway and disrupts adherens junctions, leading to YAP nuclear entry. The disruption of adherens junctions, increased paracellular permeability, and YAP nuclear translocation are regulated by ROCK2 independently of myosin II activation. The inhibitor KD025 demonstrates the effects of ROCK2 on the inflammatory response in the epidermis through cytoskeletal and transcription-dependent mechanisms.
Article
Rheumatology
Christopher T. Ritchlin, Atul Deodhar, Wolf-Henning Boehncke, Enrique R. Soriano, Alexa P. Kollmeier, Xie L. Xu, Federico Zazzetti, May Shawi, Yusang Jiang, Shihong Sheng, Philip S. Helliwell
Summary: This study evaluated the efficacy and safety of guselkumab, an interleukin-23p19-subunit inhibitor, in patients with active psoriatic arthritis (PsA) who had previously used a tumor necrosis factor inhibitor (TNFi). The results showed that guselkumab provided sustained improvements across multiple domains in both TNFi-naive and TNFi-experienced patients with active PsA, and TNFi-naive patients were more likely to achieve treatment goals related to physical function and pain.
ACR OPEN RHEUMATOLOGY
(2023)