Article
Medicine, Research & Experimental
Jonas D. Senft, Thomas Fleischhauer, Jona Frasch, Wiebke van Rees, Manuel Feisst, Simon Schwill, Christine Fink, Regina Poss-Doering, Michel Wensing, Uwe Mueller-Buehl, Joachim Szecsenyi
Summary: The UCC trial aims to evaluate the effectiveness of the Ulcus Cruris Care intervention for patients with VLU. The trial will assess outcomes such as wound healing time, health-related quality of life, and utilization of medical resources. If the intervention proves to be effective, comprehensive implementation in primary care may be considered.
Article
Health Care Sciences & Services
Jonas D. Senft, Thomas Fleischhauer, Regina Poss-Doering, Jona Frasch, Manuel Feisst, Sinclair Awounvo, Uwe Muller-Buhl, Attila Altiner, Joachim Szecsenyi, Gunter Laux
Summary: Despite the proven effectiveness of compression therapy for venous leg ulceration, it is only applied in a small percentage of patients, leading to unnecessary complications. The Ulcus Cruris Care project aims to develop a new disease-management concept to support evidence-based treatment. This study shows that the intervention has led to more frequent application of guideline-conform compression therapy and improved patient self-help and education.
Article
Dermatology
Kai Siang Chan, Zhiwen Joseph Lo, Zifei Wang, Priya Bishnoi, Yi Zhen Ng, Stacy Chew, Tze Tec Chong, David Carmody, Shin Yuh Ang, Enming Yong, Yam Meng Chan, Jackie Ho, Nicholas Graves, Keith Harding
Summary: This study evaluates the wound healing and quality of life for patients with venous leg ulcers (VLUs) in a Southeast Asian population. The median time to wound healing was 4.5 months, with complete healing rates of 47.0% at 3 months and 60.9% at 6 months. The duration of the wound at baseline was associated with worse wound healing. Patients with healed VLU had a significantly higher incidence of perfect EQ-5D-5L health states at 6 months.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Evan Darwin, Guodong Liu, Robert S. Kirsner, Hadar Lev-Tov
Summary: This study investigated factors associated with the development of first occurrence of venous leg ulcerations and identified risk factors such as male gender, older age, history of nonvenous leg ulceration, anticoagulant use, and preexisting venous insufficiency. Protective factors included venous surgery, compression stockings, prescribed statin medications, and pain medications. The findings support a paradigm shift towards prevention of venous leg ulceration.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Medicine, General & Internal
Melissa Andreia de Moraes Silva, Luis C. U. Nakano, Ligia L. Cisneros, Fausto Miranda
Summary: Chronic venous insufficiency (CVI) is a common disease that affects the lower limb venous systems. Balneotherapy, a form of water-based physiotherapy, may be a cost-effective treatment option for CVI. This review assessed the effectiveness and safety of balneotherapy for people with CVI, and found that it moderately improves disease severity and slightly improves pain and skin pigmentation changes, with uncertain effects on health-related quality of life and other symptoms.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Dermatology
Benjamin Juntermanns, Knut Kroeger, Peter Waldhausen, Gabor Gaebel
Summary: Venous ulcus cruris is a chronic disease caused by chronic venous insufficiency. Conservative treatment includes compression treatment and exudate management, while surgical treatment involves resolving pathological venous reflux, ulcer surgery, and fascia surgery in rare cases.
Review
Dermatology
Sheryl Li Xin Lim, Rui En Chung, Samantha Holloway, Keith G. Harding
Summary: Leg ulcers remain a significant burden in healthcare, with proper identification of arterial occlusive disease being crucial for effective treatment. Modified compression therapy (MCT) can aid in healing mixed arterial venous leg ulcers with moderate arterial insufficiency, but personalized treatment plans are essential for optimal outcomes.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Dermatology
Olga Krizanova, Adela Penesova, Alica Hokynkova, Andrea Pokorna, Amir Samadian, Petr Babula
Summary: Chronic venous disease is a condition that affects the veins in the lower extremities, characterized by impaired blood return. This review discusses the etiology, risk factors, and pathophysiology of venous leg ulcers (VLU), and compares the treatment options.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Multidisciplinary Sciences
Dong-Hoon Yang, Mansu Kim, Joong Won Yang, Jae Man Cho, Sang Jin Park, Heum Dai Kwon
Summary: This study aimed to investigate the clinical differences in leg pain and determine the incidence of chronic venous disorder (CVD) among patients visiting a spine center. The results showed that the most common symptom area in CVD was the calf and foot, while in lumbar spinal disease it was the calf and thigh. Tingling-paresthesia was the most common symptom type for both, with pain and cramping more common in CVD and pain more common than cramping in lumbar spinal disease. The study suggested that early-stage venous reflux is a symptomatic disease and a possible cause of leg pain and other symptoms.
SCIENTIFIC REPORTS
(2023)
Article
Nursing
Sebastian Probst, Paul Bobbink, Laurence Sechaud, Monika Buehrer Skinner
Summary: The study found that the incidence of venous leg ulcer recurrence was 33.1%, with little variation in self-efficacy, social support and quality of life scores between measurement points and subgroups. Qualitative findings identified themes of accidentally damaging the skin and avoiding recurrence as main factors.
JOURNAL OF ADVANCED NURSING
(2021)
Article
Surgery
Dexter Yak Seng Chan, Naren Kumar Surendra, Yi Zhen Ng, Sze-Han Lee, Enming Yong, Qiantai Hong, Cheng Cheng Goh, Tina Peiting Lai, Audrey Hui Min Tan, Chelsea Chiew Chie Law, Shanying Liang, Josip Car, Zhiwen Joseph Lo
Summary: This study aims to evaluate the clinical and economic burden of venous leg ulcers (VLUs) in an Asian population. The findings suggest that VLUs have a significant impact on patients and incur high treatment costs, but successful healing can improve patients' quality of life. These results provide important insights for economic evaluations of VLU treatments.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)
Review
Medicine, General & Internal
Joseph D. Raffetto, Daniela Ligi, Rosanna Maniscalco, Raouf A. Khalil, Ferdinando Mannello
Summary: Venous leg ulcers (VLUs) are a common type of ulcer in the lower extremity with significant socioeconomic and psychological impact. The pathogenesis involves factors such as endothelial cell injury and inflammatory responses, while treatment primarily includes compression therapy and endovenous ablation. Proper wound care and therapy usually result in healing within 6 months.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Benedikt Weber, Elias Marquart, Julia Deinsberger, Stanislava Tzaneva, Kornelia Boehler
Summary: Endovenous thermal and non-thermal therapeutic approaches have become standard for venous insufficiency treatment, but comparative studies in venous leg ulcer patients are scarce. This study compared the efficacy of endovenous laser ablation (EVLA) and ultrasound-guided foam sclerotherapy (UGFS) for venous leg ulcers (VUs). Results showed similar rates of ulcer resolution and healing time after endovenous intervention, but a significantly higher relapse rate in UGFS treated patients.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Kai Siang Chan, Shanying Liang, Yuan Teng Cho, Yam Meng Chan, Audrey Hui Min Tan, Sivakami Muthuveerappa, Tina Peiting Lai, Cheng Cheng Goh, Annie Joseph, Qiantai Hong, Enming Yong, Li Zhang, Lester Rhan Chaen Chong, Glenn Wei Leong Tan, Sadhana Chandrasekar, Zhiwen Joseph Lo
Summary: The study investigated the intra- and inter-rater reliability of the WA imaging system in patients with venous leg ulcers, demonstrating high reliability of the system and excellent consistency with traditional measurement methods.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Surgery
Wanchai Chinchalongporn, Parichat Tanmit, Kanin Pruekprasert, Tossapol Prapassaro, Kiattisak Hongku, Suteekhanit Hahtapornsawan, Nattawut Puangpunngam, Khamin Chinsakchai, Chumpol Wongwanit, Chanean Ruangsetakit, Nuttawut Sermsathanasawadi
Summary: The study aimed to investigate the prevalence and predictors of combined >50% iliocaval venous obstruction (ICVO) and superficial venous reflux (SVR) in patients with chronic venous insufficiency (CVI) with a healed or an active venous leg ulcer (VLU). The data of patients with CVI and SVR who were treated at the institution from February 2017 to January 2018 were retrospectively reviewed. The prevalence of >50% ICVO in the patients with SVR was 31.6%, and history of deep vein thrombosis, VLU in the left leg, and recurrent VLUs were independent predictors of combined >50% ICVO and SVR in patients with CVI.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)