Article
Cell Biology
Nobuhiro Nakano, Jiro Kitaura
Summary: Mucosal mast cells (MMCs) in the intestinal mucosa play a crucial role in the development of IgE-mediated food allergies. Recent research has revealed that MMCs are distinct from connective tissue mast cells found in the skin and other tissues. The mechanism of MMC expansion and their cellular functions are not well understood. Research focusing on MMCs can provide valuable insights into the underlying mechanisms of food allergies and advance their treatment.
Article
Virology
Siva Thirugnanam, Edith M. Walker, Faith Schiro, Pyone P. Aye, Jay Rappaport, Namita Rout
Summary: Previous studies have shown that the loss of CD161-expressing CD4(+) Th17 cells is associated with the progression of chronic HIV infection. These cells are significantly reduced in the peripheral blood and gut mucosa of HIV-infected individuals, leading to inflammation and disruption of the gut barrier. However, the impact of HIV infection on CD161-expressing CD8(+) T cells is still unclear.
Article
Oncology
Najmeh Bozorgmehr, Isobel Okoye, Olaide Oyegbami, Lai Xu, Amelie Fontaine, Nanette Cox-Kennett, Loree M. Larratt, Mark Hnatiuk, Andrei Fagarasanu, Joseph Brandwein, Anthea C. Peters, Shokrollah Elahi
Summary: The study found that CD160 was the most upregulated co-inhibitory receptor in patients with CLL, and its expression was associated with an exhausted T cell phenotype. EVs were identified as a source of CD160 in the plasma of CLL patients. Additionally, a dominantly proinflammatory cytokine profile, especially elevated interleukin-16, was observed in CLL patients' plasma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Yijia Li, Yangzhe Wu, Yi Hu
Summary: The cellular metabolism of cancer and immune cells in the tumor microenvironment (TME) has been gaining attention, with evidence showing competition for nutrients and inhibitory effects on immune effector cells. However, there is potential for targeting the metabolic vulnerabilities of cancer cells to enhance the anti-tumor functions of immune effector cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Isis Benoit-Lizon, Elise Jacquin, Thaiz Rivera Vargas, Corentin Richard, Aurelie Roussey, Ludivine Dal Zuffo, Tiffany Martin, Andrea Melis, Daria Vinokurova, Sayyed Hamed Shahoei, Alvaro Baeza Garcia, Cassandre Pignol, Stephane Giorgiutti, Raphael Carapito, Romain Boidot, Frederique Vegran, Richard A. Flavell, Bernhard Ryffel, Eric R. Nelson, Pauline Soulas-Sprauel, Toby Lawrence, Lionel Apetoh
Summary: Activation of STING signaling enhances the differentiation and antitumor functions of T(H)1 and T(H)9 cells by increasing their production of IFN-gamma and interleukin-9, respectively. IRF3 and IFNARs are required for the enhancement of T(H)1 cell differentiation, while mTOR signaling is implicated in T(H)9 cell differentiation in response to STING activation. STING activation boosts the antitumor activity of T(H)1 and T(H)9 cells through their cytokine production, and enhances the efficacy of T(H)9 cells in adoptive transfer against melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Srinivas Akula, Miia Riihimaki, Ida Waern, Magnus Abrink, Amanda Raine, Lars Hellman, Sara Wernersson
Summary: This study provides the first insight into the phenotype of equine MCs in bronchoalveolar lavage fluid (BALF) and their potential role in the airways of asthmatic horses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Tyler E. Billipp, Marija S. Nadjsombati, Jakob von Moltke
Summary: Tuft cells are rare chemosensory epithelial cells that monitor the environment and initiate immune responses in different tissues based on their unique receptors and effector functions tuned to the surrounding tissue's physiology.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
D. Brooke Widner, Chun Liu, Qingxia Zhao, Sarah Sharp, Matthew R. Eber, Sun H. Park, D. Clark Files, Yusuke Shiozawa
Summary: This study found that activated skeletal muscle-resident mast cells are enriched in cachectic muscles, suggesting that skeletal muscle-resident mast cells may serve as a biomarker and mediator for cachexia development to improve patient diagnosis and prognosis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Tongqian Wu, Shirong Yan, Yu-Wen Yeh, Yu Fang, Zou Xiang
Summary: This study found that mast cells expressing only FcγRIIB or FcγRIIIA undergo caspase-independent apoptosis in response to IgG immune complex treatment. Lower frequencies of connective tissue mast cells (CTMC) were recorded in mice lacking either FcγRIIB or FcγRIIIA compared with wild-type mice, especially in aged mice. This suggests that FcγR-mediated mast cell apoptosis may explain the more robust persistence of CTMC compared to mucosal mast cells (MMC). The results were replicated in a mast cell engraftment model, ruling out possible confounding effects of mast cell recruitment or FcγR expression by other cells on mast cell number regulation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Willemijn F. Rijnink, Tom H. M. Ottenhoff, Simone A. Joosten
Summary: Recent studies have shown that B cells and antibodies play an important role in combating Mycobacterium tuberculosis. They exist in different functional subsets and may serve as potential biomarkers.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Edna Ayerim Mandujano-Tinoco, Eliya Sultan, Aner Ottolenghi, Orly Gershoni-Yahalom, Benyamin Rosental
Summary: The evolution of the immune system is aimed at protecting organisms from infections and providing regenerative capacities and tissue maintenance. Despite the diverse range of effector cells, common features and interesting convergent mechanisms can be observed across different animals. The review explores the evolution of phagocytic and cytotoxic immune lineages, highlighting the diverse function plasticity within evolved immune effector cells.
Review
Biochemistry & Molecular Biology
Mohd Hatimi Tukiman, Mohd Nor Norazmi
Summary: Tuberculosis remains a major threat to global public health. This review seeks to explore the mucosal immunometabolism of resident effector cells in response to Mtb infection and how Mtb manipulates them for its survival and growth, with the aim of filling knowledge gaps and potentially contributing to future vaccination and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Antonio Bensussen, Maria Angelica Santana, Otoniel Rodriguez-Jorge
Summary: CD8+T lymphocytes are key cells of the immune system that protect against various threats. Metabolic disturbances can inhibit the differentiation and function of these cells, but overactivation of mTORC2 may restore their functionality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Andrew P. Hederman, Harini Natarajan, Leo Heyndrickx, Kevin K. Arien, Joshua A. Wiener, Peter F. Wright, Evan M. Bloch, Aaron A. R. Tobian, Andrew D. Redd, Joel N. Blankson, Amihai Rottenstreich, Gila Zarbiv, Dana Wolf, Tessa Goetghebuer, Arnaud Marchant, Margaret E. Ackerman
Summary: This study investigates the breadth and potency of antibodies after infection and vaccination. The findings reveal that variants associated with vaccination have significantly greater functional antibody breadth and potency compared to those associated with immunologically vulnerable populations. However, convalescent individuals exhibit higher antibody functional activity against the endemic coronavirus OC43, indicating recognition differences between close and distant human coronavirus strains associated with exposure history.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Bianca Balbino, Pauline Herviou, Ophelie Godon, Julien Stackowicz, Odile Richard-Le Goff, Bruno Iannascoli, Delphine Sterlin, Sebastien Brule, Gael A. Millot, Faith M. Harris, Vera A. Voronina, Kari C. Nadeau, Lynn E. Macdonald, Andrew J. Murphy, Pierre Bruhns, Laurent L. Reber
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Review
Immunology
Julien Stackowicz, Friederike Jonsson, Laurent L. Reber
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Allergy
Sophie Goyard, Bianca Balbino, Rebecca S. Chinthrajah, Shu-Chen Lyu, Yves L. Janin, Pierre Bruhns, Pascal Poncet, Stephen J. Galli, Kari C. Nadeau, Laurent L. Reber, Thierry Rose
Article
Immunology
Philipp Starkl, Martin L. Watzenboeck, Lauren M. Popov, Sophie Zahalka, Anastasiya Hladik, Karin Lakovits, Mariem Radhouani, Arvand Haschemi, Thomas Marichal, Laurent L. Reber, Nicolas Gaudenzio, Riccardo Sibilano, Lukas Stulik, Frederic Fontaine, Andre C. Mueller, Manuel R. Amieva, Stephen J. Galli, Sylvia Knapp
Correction
Immunology
Philipp Starkl, Martin L. Watzenboeck, Lauren M. Popov, Sophie Zahalka, Anastasiya Hladik, Karin Lakovits, Mariem Radhouani, Arvand Haschemi, Thomas Marichal, Laurent L. Reber, Nicolas Gaudenzio, Riccardo Sibilano, Lukas Stulik, Frederic Fontaine, Andre C. Mueller, Manuel R. Amieva, Stephen J. Galli, Sylvia Knapp
Editorial Material
Immunology
Thomas Marichal, Onur Boyman, Laurent L. Reber
FRONTIERS IN IMMUNOLOGY
(2020)
Letter
Allergy
Jean-Baptiste Quinta, Francois Montastruc, Agnes Sommet, Anthony Touafchia, Michel Galinier, Laurent Reber, Vanessa Rousseau, Laurent Guilleminault
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Immunology
Marine Michelet, Bianca Balbino, Laurent Guilleminault, Laurent L. Reber
Summary: Food allergy poses a significant public health issue without an approved therapy, with IgE antibodies playing a crucial role in diagnosis and treatment. Recent advances in regulating IgE production and understanding its function in food allergy offer hope for better management and treatment options. Clinical studies on anti-IgE therapeutic monoclonal antibodies provide insights into blocking IgE effector functions and improving outcomes for individuals with food allergies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Allergy
Philipp Starkl, Nicolas Gaudenzio, Thomas Marichal, Laurent L. Reber, Riccardo Sibilano, Martin L. Watzenboeck, Frederic Fontaine, Andre C. Mueller, Mindy Tsai, Sylvia Knapp, Stephen J. Galli
Summary: The study found that IgE sensitization enhances MC detoxification of honeybee venom by promoting proteolytic degradation and heparin-related interference with toxicity. This research emphasizes the importance of IgE, MCs, and specific MC products in defense against honeybee venom.
Review
Allergy
M. Michelet, L. L. Reber, L. Guilleminault
Summary: Food allergy is a common disease with high morbidity and mortality, for which there is currently no approved therapeutic option. Oral immunotherapy (OIT) and monoclonal antibodies directed against IgE are potential strategies for treatment. Combining omalizumab with OIT appears to have promising results in increasing allergen tolerance and reducing side effects in food allergy patients.
REVUE FRANCAISE D ALLERGOLOGIE
(2021)
Editorial Material
Multidisciplinary Sciences
Jasper B. J. Kamphuis, William P. M. Worrall, Julien Stackowicz, Aurelie Mougel, Emilie Maure, Eva Conde, Pierre Bruhns, Laurent Guilleminault, Nicolas Gaudenzio, Jinmiao Chen, Rebecca Gentek, Laurent L. Reber
Summary: The researchers found that interleukin-33 can induce accumulation of tumor-associated macrophages expressing the Fc epsilon RI receptor, but raised concerns about the specificity of the anti-Fc epsilon RI antibody used in the study.
Article
Multidisciplinary Sciences
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noemie Caillot, Fabien Colaone, Samir Hamdi, Raissa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, Francois Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurelie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Geraldine Grouard-Vogel, Laurent L. Reber
Summary: The study developed vaccines targeting IL-4 and IL-13, demonstrating promising prophylactic and therapeutic effects in mouse models of asthma. Vaccines specific for human IL-4 and IL-13 also showed efficient neutralization of these cytokines in mice, suggesting a potential long-term therapeutic strategy for allergic asthma.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Allergy
Eva Conde, Pierre Bruhns, Vincent Serra, Laurent L. Reber
Article
Immunology
Julien Stackowicz, Nicolas Gaudenzio, Nadine Serhan, Eva Conde, Ophelie Godon, Thomas Marichal, Philipp Starkl, Bianca Balbino, Axel Roers, Pierre Bruhns, Friederike Jonsson, Philippe Moguelet, Sophie Georgin-Lavialle, Lori Broderick, Hal M. Hoffman, Stephen J. Galli, Laurent L. Reber
Summary: Gain-of-function mutations in NLRP3 gene cause CAPS, with neutrophils potentially being the main cellular drivers of CAPS pathology.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Simona Nemska, Francois Daubeuf, Adeline Obrecht, Dominique Israel-Biet, Marc Stern, Romain Kessler, Antoine Roux, Reza Tavakoli, Pascal Villa, Adrien Tissot, Richard Danger, Laurent Reber, Eugenie Durand, Aurore Foureau, Sophie Brouard, Antoine Magnan, Nelly Frossard
Summary: The study demonstrates that inhibition of the proinflammatory mitogen- and stress-activated kinase 1 (MSK1) kinase can effectively alleviate damage caused by lung transplantation, suggesting its potential as a therapeutic target for chronic lung allograft dysfunction (CLAD).