Article
Medicine, Research & Experimental
Haoshen Feng, Rui Zheng
Summary: Chronic obstructive pulmonary disease (COPD) is an inflammatory disease caused by smoking. The study found that M1 polarization levels were decreased in smokers and COPD patients, while M2 polarization was unchanged. Further experiments showed that smoking may suppress M1 polarization of AMs by inhibiting NLRP3.
Article
Physiology
Markus Fleischmann, Andrew G. Jarnicki, Andrew S. Brown, Chao Yang, Gary P. Anderson, Natalio Garbi, Elizabeth L. Hartland, Ian R. van Driel, Garrett Z. Ng
Summary: Cigarette smoke exposure depletes alveolar macrophages and increases the severity of Legionnaires' disease, while these macrophages play a major role in bacterial clearance.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Goncalves da Silva, Flavio Santos da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valenca, Manuella Lanzetti, Martina Schmidt, Emanuel Kennedy-Feitosa
Summary: This study investigates the role of eugenol (EUG) in cigarette smoke-induced acute lung injury (ALI) and how it modulates macrophage activity. The results show that EUG reduces inflammatory response and oxidative stress markers in vivo, and balances oxidative stress and cytokine release in vitro, indicating that it acts as a modulator of macrophage activity.
Article
Biochemistry & Molecular Biology
Yun-Ho Kim, Min-Kyung Kang, Eun-Jung Lee, Dong Yeon Kim, Hyeongjoo Oh, Soo-Il Kim, Su Yeon Oh, Woojin Na, Jae-Hoon Shim, Il-Jun Kang, Young-Hee Kang
Summary: The study found that astragalin can alleviate smoking-induced pulmonary thrombosis and alveolar inflammation, and interrupt the PAR and MAPK signaling pathways to block pulmonary thromboembolism caused by smoking-induced oxidative stress and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alexis White, Zhengke Wang, Xing Wang, Michelle King, Cynthia Guo, Chris Mantsounga, Alfred Ayala, Alan R. Morrison, Gaurav Choudhary, Frank Sellke, Eboni Chambers, Lorraine B. Ware, Sharon Rounds, Qing Lu
Summary: Cigarette smoke exposure increases the incidence and severity of acute respiratory distress syndrome (ARDS), but the mechanisms are unclear. This study found that cigarette smoke impairs mitophagy flux and exacerbates mitochondrial damage and NLRP3 inflammasome activation, leading to increased acute lung injury. Inhibition of inflammasome or downstream component IL-1 beta attenuates the cigarette smoke-induced lung injury.
Article
Cell Biology
Jing Zhao, Haibo Xia, Yan Wu, Lu Lu, Cheng Cheng, Jing Sun, Quanyong Xiang, Tao Bian, Qizhan Liu
Summary: Cigarette smoke is a main risk factor for emphysema, and a recent study found that circular RNA can regulate cigarette smoke-induced autophagy and apoptosis in alveolar epithelial cells by inhibiting miRNA. This discovery provides new insights and information for the diagnosis and treatment of emphysema.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dong-Uk Shin, Ji-Eun Eom, Hyeon-Ji Song, Sun Young Jung, Thi Van Nguyen, Kyung Min Lim, Ok Hee Chai, Hyun-Jin Kim, Gun-Dong Kim, Hee Soon Shin, So-Young Lee
Summary: Cigarette smoke is a major factor in the development of chronic obstructive pulmonary disease (COPD). This study investigated the protective effects of Camellia sinensis extract against pulmonary inflammation in a COPD mouse model. The extract suppressed immune cell infiltration, cytokine secretion, mucus hypersecretion, and lung parenchyma injuries. In vitro experiments revealed its inhibitory effect on inflammation-related molecules in various cell types. The results suggest that Camellia sinensis extract could be an effective approach for treating or preventing chronic pulmonary diseases.
Article
Biochemistry & Molecular Biology
Marco Buscetta, Marta Cristaldi, Maura Cimino, Agnese La Mensa, Paola Dino, Fabio Bucchieri, Francesca Rappa, Santina Amato, Tommaso Silvano Aronica, Elisabetta Pace, Alessandro Bertani, Chiara Cipollina
Summary: The mechanisms and consequences of GSDMD activation in cigarette smoke-associated inflammation and lung disease are not well understood. This study shows that cigarette smoke extract (CSE) can activate caspase-1 and induce GSDMD cleavage and increased cell permeability. The activation of caspase-4 and caspase-8 by CSE further promotes GSDMD cleavage. These findings suggest that ASC-independent activation of caspase-1, -4, and -8 and subsequent GSDMD cleavage may contribute to macrophage dysfunction and chronic inflammation in the lungs of smokers.
Article
Oncology
Aibin Liu, Xin Zhang, Ronggang Li, Mingzhu Zheng, Shasha Yang, Longxia Dai, Anhua Wu, Chengping Hu, Yanming Huang, Mingxuan Xie, Qiong Chen
Summary: The study investigated the expression and location of ACE2 in a cigarette smoke-exposed mouse model and human lung tissues, finding significant overexpression of ACE2 in bronchial and alveolar epithelial cells in smokers. Decreased ACE2 expression was observed in ex-smokers and correlated positively with HIF-1 alpha, iNOS, and 4-HNE levels.
JOURNAL OF PATHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jared Radbel, Jaclynn A. Meshanni, Carol R. Gardner, Le-Hoang Oanh, Jessica Cervelli, Jeffrey D. Laskin, Andrew J. Gow, Debra L. Laskin
Summary: This study describes a novel flow cytometric method to assess the ability of macrophages to engulf apoptotic neutrophils (PMNs). It was found that resident alveolar macrophages can be more easily identified as efferocytotic or non-efferocytotic when incubated with D12730-labeled PMNs, compared to PKH26-labeled PMNs. This method will be useful in studying the role of efferocytosis in the resolution of inflammation in response to toxicant exposure.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Respiratory System
Patrick F. Asare, Hai B. Tran, Plinio R. Hurtado, Griffith B. Perkins, Phan Nguyen, Hubertus Jersmann, Eugene Roscioli, Sandra Hodge
Summary: In COPD, the deficiency of Rubicon protein in alveolar macrophages is associated with impaired efferocytosis and increased inflammation. Exposure to cigarette smoke leads to decreased Rubicon protein levels in both mice and human macrophages, affecting efferocytosis. Additionally, exposure of THP-1 macrophages to cigarette smoke extract results in higher levels of key components of the LAP pathway.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2021)
Article
Immunology
Simone N. De Luca, Stanley M. H. Chan, Aleksandar Dobric, Hao Wang, Huei Jiunn Seow, Kurt Brassington, Kevin Mou, Rana Alateeq, Alina Akhtar, Steven Bozinovski, Ross Vlahos
Summary: Chronic obstructive pulmonary disease (COPD) is a respiratory condition caused by cigarette smoking. People with COPD often experience neurocognitive disorders such as cognitive dysfunction, anxiety, and depression. The role of inflammation and oxidative stress in the onset of these disorders is still unclear.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Medicine, Research & Experimental
Tingting Wu, Keye Xu, Chaobo Liu, Yan Li, Mingcai Li
Summary: This study aimed to investigate the effect of interleukin-37 (IL-37) on cigarette smoke-induced lung inflammation. By administering IL-37-expressing lentivirus to mice, it was found that IL-37 can alleviate weight loss and pulmonary inflammation induced by cigarette smoke. IL-37 also significantly inhibited inflammatory cell recruitment, reduced inflammatory cell increase, and suppressed the production of pro-inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Toxicology
Xiaojiang Qin, Anqi Gao, Xiaomin Hou, Xinrong Xu, Liangjin Chen, Lin Sun, Yuxuan Hao, Yiwei Shi
Summary: Pulmonary hypertension is a chronic progressive disease associated with cigarette smoke exposure and abnormal alterations in connexin expression. Smokers have a higher risk of developing PH and increased mortality. Current treatments are unable to reverse vascular remodeling associated with PH. Therefore, early intervention is crucial in preventing the development of PH.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Immunology
Tiantian Cen, Yifeng Mai, Jie Jin, Minxuan Huang, Mingcai Li, Shanshan Wang, Hongying Ma
Summary: Our study aimed to investigate the ability of IL-41 to protect against CS-induced lung inflammation in vivo. The results showed that IL-41 pre-treatment alleviated pulmonary inflammatory infiltration and lung tissue lesions, limited CS-induced weight loss, and promoted the polarization of M2 macrophages. IL-41 also increased the levels of IL-10 and reduced the production of TNF-α, IL-6, and IL-1β.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shanmugam Muthulakshmi, Alok K. Chakrabarti, Sanjay Mukherjee
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2015)
Article
Multidisciplinary Sciences
Sanjay Mukherjee, Renuka Subramaniam, Han Chen, Anthony Smith, Shiva Keshava, Homayoun Shams
Article
Virology
Gunisha Pasricha, Sanjay Mukherjee, Alok K. Chakrabarti
Article
Infectious Diseases
Sanjay Mukherjee, Veena C. Vipat, Alok K. Chakrabarti
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2013)
Article
Genetics & Heredity
Sanjay Mukherjee, K. B. Sainis, Deepti D. Deobagkar
JOURNAL OF GENETICS
(2014)
Article
Biochemical Research Methods
Deepti D. Deobagkar, Chitra Panikar, Shriram N. Rajpathak, Nayana S. Shaiwale, Sanjay Mukherjee
Article
Virology
Alok K. Chakrabarti, Veena C. Vipat, Sanjay Mukherjee, Rashmi Singh, Shailesh D. Pawar, Akhilesh C. Mishra
Article
Virology
Sanjay Mukherjee, Veena C. Vipat, Akhilesh C. Mishra, Shailesh D. Pawar, Alok K. Chakrabarti
Article
Virology
Sanjay Mukherjee, Shamik Majumdar, Veena C. Vipat, Akhilesh C. Mishra, Alok K. Chakrabarti
Article
Biotechnology & Applied Microbiology
Sanjay Mukherjee, Evagelia C. Laiakis, Albert J. Fornace, Sally A. Amundson
Article
Biology
Sanjay Mukherjee, Veljko Grilj, Constantinos G. Broustas, Shanaz A. Ghandhi, Andrew D. Harken, Guy Garty, Sally A. Amundson
RADIATION RESEARCH
(2019)
Article
Multidisciplinary Sciences
Jian Gu, Alan Norquist, Carla Brooks, Mikhail Repin, Sanjay Mukherjee, Jerome Lacombe, Jianing Yang, David J. Brenner, Sally Amundson, Frederic Zenhausern
Article
Virology
Gunisha Pasricha, Sanjay Mukherjee, Alok K. Chakrabarti
ADVANCES IN VIROLOGY
(2018)
Article
Multidisciplinary Sciences
Sanjay Mukherjee, Krishna B. Sainis, Deepti Deobagkar