Article
Clinical Neurology
Marina Picillo, Onanong Phokaewvarangkul, Yu-Yan Poon, Cameron C. McIntyre, Sinem Balta Beylergil, Renato P. Munhoz, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Alfonso Fasano
Summary: This study compared the efficacy and safety of levodopa versus dopamine agonist monotherapy after deep brain stimulation in Parkinson's disease. Results showed that in short- and mid-term follow-up, more than half of patients were able to safely continue monotherapy, with levodopa patients having a higher likelihood. In the long term, only a minority of patients were able to maintain levodopa monotherapy, while dopamine agonist monotherapy was not well tolerated.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Sara C. Staubo, Ole Martin Fuskevag, Mathias Toft, Ingeborg H. Lie, Kirsti M. J. Alvik, Pal Jostad, Stein H. Tingvoll, Hallvard Lilleng, Kristina Rosqvist, Elisabet Storset, Per Odin, Espen Dietrichs, Erik Sveberg Dietrichs
Summary: The study suggests that the occurrence of impulse control disorders (ICDs) among patients using ropinirole is dependent on serum concentration and drug exposure, while the use of pramipexole may inherently increase ICD risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Marie des Neiges Santin, Paul Voulleminot, Agathe Vrillon, Elodie Hainque, Matthieu Bereau, Ouhaid Lagha-Boukbiza, Thomas Wirth, Solveig Montaut, Eric Bardinet, Maeva Kyheng, Anne-Sophie Rolland, Jimmy Voirin, Sophie Drapier, Franck Durif, Alexandre Eusebio, Caroline Giordana, Nicolas Auzou, Jean-Luc Houeto, Cecile Hubsch, Bechir Jarraya, Chloe Laurencin, David Maltete, Mylene Meyer, Olivier Rascol, Tiphaine Rouaud, Melissa Tir, Caroline Moreau, Jean-Christophe Corvol, Francois Proust, David Grabli, David Devos, Christine Tranchant, Mathieu Anheim
Summary: The impact of subthalamic deep brain stimulation on impulse control disorders in patients with Parkinson's disease remains controversial. This study showed that subthalamic DBS can lead to improvement in impulse control disorders, with dopamine agonist dose reduction being the main driver. Patients with preoperative impulse control disorders were prone to postoperative apathy, while preoperative apathy increased the risk of developing postoperative de novo impulse control disorders.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Yijie Lai, Yunhai Song, Daoqing Su, Linbin Wang, Chencheng Zhang, Bomin Sun, Jorik Nonnekes, Bastiaan R. Bloem, Dianyou Li
Summary: Our study reveals the potential effectiveness of GPi-DBS in treating camptocormia in PD patients, showing significant improvement in patients' postural deformity. Pre-surgical TCC angle, levodopa responsiveness of the TCC angle, and structural connectivity from volume of tissue activated to somatosensory cortex are closely associated with improvement in the TCC angle.
NPJ PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
David Mata-Marin, Jose angel Pineda-Pardo, Mario Michiels, Cristina Pagge, Claudia Ammann, Raul Martinez-Fernandez, Jose Antonio Molina, Lydia Vela-Desojo, Fernando Alonso-Frech, Ignacio Obeso
Summary: This study provides evidence for the balance between enhanced desire towards reward and cognitive control deficits in patients with impulse-control disorder, specifically hypersexuality, in Parkinson's disease under dopamine replacement therapy. The study also identifies the underlying fronto-striatal and mesolimbic circuitry involved in uncontrollable sexual responses and demonstrates that cortical neuromodulation can alleviate this symptom.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Takao Nozaki, Kenji Sugiyama, Tetsuya Asakawa, Hiroki Namba, Masamichi Yokokura, Tatsuhiro Terada, Tomoyasu Bunai, Yasuomi Ouchi
Summary: This study investigated the impact of STN-DBS on neuronal terminal survival and found that STN-DBS can increase dopamine transporter levels in the anteroventral striatum, which is correlated with motor recovery and may suggest a regulatory effect of STN-DBS on dopaminergic terminals in Parkinson's disease patients.
JOURNAL OF NEUROSURGERY
(2022)
Article
Neurosciences
Yingchuan Chen, Guanyu Zhu, Yuye Liu, Defeng Liu, Tianshuo Yuan, Xin Zhang, Yin Jiang, Tingting Du, Jianguo Zhang
Summary: The study found that changes in brain morphology are associated with the initial motor response to subthalamic nucleus deep brain stimulation in Parkinson's disease patients, and can be used to predict individual initial stimulation-related motor responses.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Yongsheng Zhu, Kejia Wang, Tengfei Ma, Yuanyuan Ji, Yin Lou, Xiaoyu Fu, Ye Lu, Yige Liu, Wei Dang, Qian Zhang, Fangyuan Yin, Kena Wang, Bing Yu, Hongbo Zhang, Jianghua Lai, Yunpen Wang
Summary: This study identified neural pathways involved in controlling depressive-like behaviors and acute withdrawal symptoms after morphine withdrawal. Furthermore, a new DBS treatment protocol was developed to reverse abnormal plasticity and alleviate withdrawal symptoms and depressive-like behaviors.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Shawn Zheng Kai Tan, Chi Him Poon, Ying-Shing Chan, Lee Wei Lim
Summary: The study identified the critical time point during memory consolidation stage to disrupt fear memory via prelimbic cortex deep brain stimulation. The disruption was partially modulated by the inactivation of the ventral hippocampus and the transient changes in ventral hippocampus dopamine (D-2) receptors expression upon prelimbic cortex deep brain stimulation. Wide-scale changes of various neurotransmitters and their metabolites in ventral hippocampus were also observed, confirming its important role in response to prelimbic cortex deep brain stimulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Julia Loeser, Julia Luthardt, Michael Rullmann, David Weise, Osama Sabri, Jurgen Meixensberger, Swen Hesse, Dirk Winkler
Summary: The study aimed to evaluate the effects of STN-DBS on DAT availability and clinical symptoms in PD patients. The results showed that while DAT availability did not significantly change within one year, the improvement in UPDRS III scores was associated with an increase in DAT availability on an individual basis.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Alexander K. Song, Kaitlyn R. Hay, Paula Trujillo, Megan Aumann, Adam J. Stark, Yan Yan, Hakmook Kang, Manus J. Donahue, David H. Zald, Daniel O. Claassen
Summary: This study demonstrates that reward-based behaviors in Parkinson's disease are regulated by ventral striatal dopamine release, and suggests that loss of inhibitory feedback from midbrain autoreceptors may underlie the manifestation of impulsive-compulsive behaviors.
Article
Clinical Neurology
Martin M. Reich, Joey Hsu, Michael Ferguson, Frederic L. W. V. J. Schaper, Juho Joutsa, Jonas Roothans, Robert C. Nickl, Anneke Frankemolle-Gilbert, Jay Alberts, Jens Volkmann, Michael D. Fox
Summary: The study demonstrates that the decline in cognitive function caused by deep brain stimulation (DBS) is related to the connectivity between the stimulation site and a specific brain network associated with memory impairment. Transforming this network into a heat map can help identify DBS patients at risk of delayed-onset side-effects and guide reprogramming efforts.
Review
Clinical Neurology
Hengameh Zahed, Jose Rafael Pantoja Zuzuarregui, Ro'ee Gilron, Timothy Denison, Philip A. Starr, Simon Little
Summary: Sleep disturbances are common nonmotor complications of Parkinson's disease, potentially contributing to disease progression. Limited options currently exist to modulate sleep disturbances, prompting the need for further research into neurophysiological changes affecting sleep in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Letter
Clinical Neurology
Irene Litvan, Anthony E. Lang, Melissa Armstrong
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Margherita Tecilla, Michael Grossbach, Giovanni Gentile, Peter Holland, Sebastian Sporn, Angelo Antonini, Maria Herrojo Ruiz
Summary: This study examines the impact of dynamically inferring action-reward contingencies on motor performance. The results show that stronger predictions about the tendency of the action-reward contingency lead to faster movement tempo, but have little effect on reaction time. Additionally, we found no significant differences in this effect between age and Parkinson's disease.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Antigony Rigas, Tina Mainka, Tamara Pringsheim, Alexander Muenchau, Irene Malaty, Yulia Worbe, Andrea E. Cavanna, Andrew John Lees, Anthony E. Lang, Davide Martino, Christos Ganos
Summary: This study revealed that the diagnostic distinction between primary and functional tics is often difficult, even for expert clinicians, in the absence of clinical information.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Stefanie Jost, Marie-Ann Kaldenbach, Angelo Antonini, Pablo Martinez-Martin, Lars Timmermann, Per Odin, Regina Katzenschlager, Rupam Borgohain, Alfonso Fasano, Fabrizio Stocchi, Nobutaka Hattori, Prashanth Lingappa Kukkle, Mayela Rodriguez-Violante, Cristian Falup-Pecurariu, Sebastian Schade, Jan Niklas Petry-Schmelzer, Vinod Metta, Daniel Weintraub, Guenther J. Deuschl, Alberto J. Espay, Eng-King Tan, Roongroj Bhidayasiri, Victor S. C. Fung, Francisco Cardoso, Claudia Trenkwalder, Peter Jenner, K. S. Ray Chaudhuri, Haidar Dafsari
Summary: This study reviewed the investigations on drug therapy for Parkinson's disease since 2010 and proposed a new drug conversion formula. These conversion formulas can help us compare drug regimens across different clinical trials. The results are important for studying the pharmacological efficacy of Parkinson's disease treatments as well as other non-pharmacological interventions.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Tiago A. Mestre, Michael P. McDermott, Raquel Lobo, Joaquim J. Ferreira, Anthony E. E. Lang
Summary: This study evaluated the "lessebo effect" in disease modification trials in Parkinson's disease and found that it did not exist in these trials. However, the use of placebo instead of an active comparator was a limitation. Prospective measurement of expectation of benefit could help assess the various impacts of placebo use.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garri, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffaele De Caro, Gabor G. Kovacs, Angelo Antonini
Summary: This study revealed the presence of neuronal dysfunction and reactive gliosis in the duodenum of patients with Parkinson's disease, suggesting that the enteric nervous system is involved in the pathophysiology of the disease.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Ali Shojaie, Silvia Rota, Ahmad Al Khleifat, K. Ray Chaudhuri, Ammar Al-Chalabi
Summary: Amyotrophic lateral sclerosis and Parkinson's disease, both neurodegenerative diseases affecting the motor system, are now known to also impact non-motor pathways. Non-motor symptoms play a significant role in determining the quality of life in Parkinson's disease, and there is growing interest in understanding the extent and role of these symptoms in amyotrophic lateral sclerosis. Hence, we conducted a review to summarize the current knowledge of non-motor symptoms in amyotrophic lateral sclerosis based on insights from Parkinson's disease.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Angelo Antonini, Heinz Reichmann, Giovanni Gentile, Michela Garon, Chiara Tedesco, Anika Frank, Bjoern Falkenburger, Spyridon Konitsiotis, Konstantinos Tsamis, Georgios Rigas, Nicholas Kostikis, Adamantios Ntanis, Constantinos Pattichis
Summary: This article describes the results of two clinical studies validating the performance of a new wearable monitoring device, PDMonitor, in detecting Parkinson's disease-related motor symptoms. The studies demonstrated high accuracy and correlation between the severity of symptoms and expert evaluations, confirming the effectiveness of the system as a continuous telemonitoring solution for facilitating treatment decisions in patients with Parkinson's disease.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Valentina D'Onofrio, Nicoletta Manzo, Andrea Guerra, Andrea Landi, Valentina Baro, Sara Maeaettae, Luca Weis, Camillo Porcaro, Maurizio Corbetta, Angelo Antonini, Florinda Ferreri
Summary: Deep brain stimulation (DBS) is a promising treatment for neurological disorders, but its mechanisms of action are not fully understood. Transcranial magnetic stimulation (TMS) combined with DBS provides a unique approach to investigate the neurophysiology of the brain. Experimental studies have shown that DBS modulates cortical excitability and plasticity, which may contribute to its therapeutic effects. However, safety concerns limit the application of the TMS-DBS approach.
Review
Health Care Sciences & Services
Vinod Metta, Guy Chung-Faye, Hani T. S. Benamer, Rukmini Mrudula, Vinay Goyal, Cristian Falup-Pecurariu, Neha Muralidharan, Desh Deepak, Mohammed Abdulraheem, Rupam Borgohain, Kallol Ray Chaudhuri
Summary: Parkinson's disease is a chronic and progressive neurological disorder, ranking as the second most common neurodegenerative condition. This study highlights the prevalence, pathophysiology, and evidence-based treatment strategies for three commonly overlooked symptoms in Parkinson's disease: hiccups, hypersalivation, and hallucinations. Early recognition and treatment are crucial for improving the quality of life for patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Clinical Neurology
Angelo Antonini, Valentina D'Onofrio, Andrea Guerra
Summary: Advanced Parkinson's disease patients often experience poor mobility and functional decline despite medication adjustments. Drug delivery systems have been developed to bypass issues with oral levodopa absorption and have been proven effective in trials and real-world use. Future efforts should focus on early detection and global availability of these treatments.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Ali Shojaie, Ahmad Al Khleifat, Sarah Opie-Martin, Payam Sarraf, Ammar Al-Chalabi
Summary: This study aimed to examine the nature and extent of non-motor symptoms in ALS. Through an online questionnaire and sharing on social media platforms, a total of 1018 responses were received, including 506 people with ALS and 421 unaffected individuals. The study found that people with ALS were more likely to report autonomic symptoms, pain, and psychiatric symptoms, which significantly impacted their quality of life. Therefore, the identification and management of non-motor symptoms are crucial in the clinical care of ALS patients.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Immunology
Lorenzo Lupi, Anna Bordin, Gabriele Sales, Davide Colaianni, Adriana Vitiello, Alberto Biscontin, Alberto Reale, Alfredo Garzino-Demo, Angelo Antonini, Giancarlo Ottaviano, Carla Mucignat, Cristina Parolin, Arianna Calistri, Cristiano De Pitta
Summary: COVID-19 is a respiratory syndrome that can cause various symptoms, including deficits in smell and taste. Transcriptome analysis of olfactory mucosa revealed altered gene expression levels in patients with persistent olfactory deficits, with associations with inflammatory response and zinc homeostasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Kausar Raheel, Gemma Deegan, Irene Di Giulio, Diana Cash, Katarina Ilic, Valentina Gnoni, K. Ray Chaudhuri, Panagis Drakatos, Rosalyn Moran, Ivana Rosenzweig
Summary: Past research suggests that there are more cases and severe clinical manifestations of alpha-synucleinopathies in men, indicating potential neuroprotective properties of female sex hormones, especially estrogen. However, the underlying mechanisms of this effect are not well understood. This study aimed to systematically review and critically assess the current evidence on sex and gender differences in alpha-synucleinopathies.
FRONTIERS IN NEUROLOGY
(2023)
