Article
Clinical Neurology
Roderick P. P. W. M. Maas, Steven Teerenstra, Ivan Toni, Thomas Klockgether, Dennis J. L. G. Schutter, Bart P. C. van de Warrenburg
Summary: The study found that a two-week daily cerebellar tDCS treatment did not have a significant effect on the severity and cerebellar-M1 connectivity of spinocerebellar ataxia type 3 (SCA3) patients. While some patients showed sustained symptom reduction, overall treatment effects varied between individuals.
Article
Clinical Neurology
Roderick P. P. W. M. Maas, Dennis J. L. G. Schutter, Ivan Toni, Dagmar Timmann, Bart P. C. van de Warrenburg
Summary: This study investigated whether repeated sessions of cerebellar transcranial direct current stimulation (tDCS) can modify the acquisition and/or timing of conditioned eyeblink responses (CRs) in patients with spinocerebellar ataxia type 3 (SCA3). The results showed that cerebellar tDCS had a significant treatment effect on the timing parameters of CRs, but did not affect CR acquisition. It was also found that the severity of disease measures and the duration of the disease were associated with the timing of CRs.
Article
Clinical Neurology
Gilles Naeije, Antonin Rovai, Virginie Destrebecq, Nicolas Trotta, Xavier De Tiege
Summary: This study aimed to investigate the effects of anodal cerebellar transcranial direct current stimulation (ctDCS) on ataxic and cognitive symptoms in individuals with Friedreich's ataxia (FRDA) and the activity of the secondary somatosensory (SII) cortex. Results showed that anodal ctDCS significantly improved the assessment and rating of ataxia and cerebellar cognitive affective syndrome scale in FRDA patients, while also reducing functional magnetic resonance imaging signal in the SII cortex. This study provides evidence that ctDCS stimulation is effective and safe in treating FRDA.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Xia Liu, Wei Lin, Lin Zhang, Wan-Li Zhang, Xiao-Ping Cheng, Yan-Hua Lian, Meng-Cheng Li, Shi-Zhong Wang, Xin-Yuan Chen, Shi-Rui Gan
Summary: This study aims to investigate the effects of transcranial alternating current stimulation (tACS) on patients with cerebellar ataxia (CA) and assess its safety. A total of 164 CA patients will be selected and randomly assigned to receive either active tACS or sham treatment. The results will provide insights into a potential novel non-invasive therapeutic approach for CA patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Environmental Sciences
Shu-Mei Wang, Ying-Wa Chan, Yiu-On Tsui, Fong-Yung Chu
Summary: Cerebellar transcranial direct current stimulation (cerebellar tDCS) is a promising therapy for cerebellar ataxias, with studies indicating potential improvements in disease severity, finger dexterity, and quality of life. However, the effects on gait control and balance remain inconclusive, highlighting the need for further research to optimize stimulation protocols and investigate detailed neural mechanisms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Neurosciences
Tiffany X. Chen, Chen-Ya Yang, Gloria Willson, Chih-Chun Lin, Sheng-Han Kuo
Summary: tDCS is an effective intervention for mitigating ataxia symptoms with lasting results that can be sustained for months. This treatment shows preferential effects on gait ataxia and is relatively safe.
Article
Neurosciences
Qurat-ul-ain, Zafran Ahmad, Summaiya Ishtiaq, Saad Ilyas, Irum Shahid, Iqbal Tariq, Arshad Nawaz Malik, Tian Liu, Jue Wang
Summary: This study compared the effects of anodal transcranial direct current stimulation (tDCS) on the cerebellum and cerebral motor cortex in stroke patients. The results showed that tDCS improved gait, balance, and the risk of falls in stroke patients, but did not significantly improve cognitive function.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yuting Shi, Guangdong Zou, Zhao Chen, Linlin Wan, Linliu Peng, Huirong Peng, Lu Shen, Kun Xia, Rong Qiu, Beisha Tang, Hong Jiang
Summary: This study compared the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) and intermittent Theta Burst Stimulation (iTBS) in SCA3 patients. The results showed that both 1 Hz rTMS and iTBS were effective in improving the symptoms of ataxia in SCA3 patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Qiuwen Gong, Rubing Yan, Han Chen, Xia Duan, Xiaoyu Wu, Xin Zhang, Yi Zhou, Zhou Feng, Ya Chen, Jianbo Liu, Peng Xu, Jing Qiu, Hongliang Liu, Jingming Hou
Summary: This study found that cerebellar transcranial direct current stimulation (tDCS) therapy can effectively and safely promote the recovery of upper limb motor function in stroke patients through a randomized trial.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Graziella Orru, Valentina Cesari, Ciro Conversano, Angelo Gemignani
Summary: The review found that tDCS has significant effects on motor function in patients with cerebellar ataxia, especially showing better outcomes in less impaired patients, suggesting a promising therapeutic approach.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Esra Erkoc Ataoglu, Ece Turksoy, Ilker Aslan, Evren Boran, Bulent Cengiz
Summary: The study found no effect of cerebellar tDCS on somatosensory temporal discrimination. However, further research with larger sample sizes and different methodologies is needed to investigate this relationship more thoroughly.
Article
Neurosciences
Keita Takano, Natsuki Katagiri, Takatsugu Sato, Masafumi Jin, Tadaki Koseki, Daisuke Kudo, Kaito Yoshida, Shigeo Tanabe, Masahiro Tsujikawa, Kunitsugu Kondo, Tomofumi Yamaguchi
Summary: This study investigated changes in corticospinal excitability and motor control during ctDCS in healthy individuals. The results showed that MEP amplitudes were decreased and pinch force control was impaired during anodal ctDCS. These findings contribute to a basic understanding of the clinical application of ctDCS to neurorehabilitation.
Article
Rehabilitation
Kerstin L. C. Erfmann, Phoebe R. Macrae, Richard D. Jones, Esther Guiu Hernandez, Maggie-Lee Huckabee
Summary: This study evaluated the effects of cerebellar tDCS on motor learning for swallowing and found that cerebellar tDCS inhibited temporal aspects of motor skill learning in swallowing.
DISABILITY AND REHABILITATION
(2022)
Article
Neurosciences
Haian Mao, Wenwu Xiao, Zengming Hao, Shengjun Wen, Huaichun Yang, Fahad Sultan, Chuhuai Wang
Summary: During forward swinging of the arm, the cerebellar network plays a crucial role in coordinating anticipatory postural adjustments (APAs), which are necessary to anticipate the effect of arm raising on the body. In this study, transcranial direct current stimulation (tDCS) was used to modulate different cerebellar regions and their polarities, leading to changes in the onset of APAs without affecting postural stability and arm raising kinematics. This study provides valuable insights into the cerebellar network involved in APAs and highlights the importance of cerebellar-brain connections in regulating APAs.
Article
Biotechnology & Applied Microbiology
Milan Pantovic, Daniel E. Lidstone, Lidio Lima de Albuquerque, Erik W. Wilkins, Irwin A. Munoz, Daniel G. Aynlender, Desiree Morris, Janet S. Dufek, Brach Poston
Summary: This study found that multi-day c-tDCS does not improve motor learning in a complex overhand throwing task or increase primary motor cortex (M1) excitability.
BIOENGINEERING-BASEL
(2023)
Article
Clinical Neurology
Benedict D. Michael, Dean Walton, Erica Westenberg, David Garcia-Azorin, Bhagteshwar Singh, Arina A. Tamborska, M. Netravathi, Mashina Chomba, Greta K. Wood, Ava Easton, Omar K. Siddiqi, Thomas A. Jackson, Thomas A. Pollak, Timothy R. Nicholson, Shalini Nair, Gerome Breen, Kameshwar Prasad, Kiran T. Thakur, Sherry H. -Y. Chou, Erich Schmutzhard, Jennifer A. Frontera, Raimund Helbok, Alessandro Padovani, David K. Menon, Tom Solomon, Andrea S. Winkler
Summary: Encephalopathy is a common and challenging condition among hospitalized COVID-19 patients, which can have a negative impact on prognosis. This review provides practical guidance on the management of COVID-19 encephalopathy through consensus agreement of the Global COVID-19 Neuro Research Coalition, covering definition, epidemiology, pathophysiology, clinical assessment, investigation, and both acute and long-term management.
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Clinical Neurology
Ettore Beghi, Elisabetta Pupillo, Elisa Bianchi, Valentina Bonetto, Silvia Luotti, Laura Pasetto, Caterina Bendotti, Massimo Tortarolo, Francesca Sironi, Laura Camporeale, Alexander V. Sherman, Sabrina Paganoni, Ada Scognamiglio, Fabiola De Marchi, Paolo Bongioanni, Renata Del Carratore, Claudia Caponnetto, Luca Diamanti, Daniele Martinelli, Andrea Calvo, Massimiliano Filosto, Alessandro Padovani, Stefano Cotti Piccinelli, Claudia Ricci, Stefania Dalla Giacoma, Nicoletta De Angelis, Maurizio Inghilleri, Rossella Spataro, Vincenzo La Bella, Giancarlo Logroscino, Christian Lunetta, Claudia Tarlarini, Jessica Mandrioli, Ilaria Martinelli, Cecilia Simonini, Elisabetta Zucchi, Maria Rosaria Monsurro, Dario Ricciardi, Francesca Trojsi, Nilo Riva, Massimo Filippi, Isabella Laura Simone, Gianni Soraru, Cristina Spera, Lucia Florio, Sonia Messina, Massimo Russo, Gabriele Siciliano, Amelia Conte, Maria Valeria Saddi, Nicola Carboni, Letizia Mazzini
Summary: This study is a clinical trial on the effects of RNS60 in ALS patients. The results indicate that RNS60 has positive effects on respiratory and bulbar function, suggesting further investigation is warranted.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Claudia Carrarini, Dario Calisi, Matteo Alessandro De Rosa, Angelo Di Iorio, Damiano D'Ardes, Raffaello Pellegrino, Stefano Gazzina, Andrea Pilotto, Andrea Arighi, Tiziana Carandini, Annachiara Cagnin, Stefano Mozzetta, Maurizio Gallucci, Domenico Marco Bonifati, Cinzia Costa, Fabrizia D'Antonio, Giuseppe Bruno, Francesco Cipollone, Claudio Babiloni, Alessandro Padovani, Marco Onofrj, Laura Bonanni
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Andrea Guerra, Gerd Tinkhauser, Alberto Benussi, Tommaso Bocci
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Kiran Samra, Amy Macdougall, Georgia Peakman, Arabella Bouzigues, Martina Bocchetta, David M. Cash, Caroline Greaves, Rhian S. Convery, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Fermin Moreno, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonca, Christopher R. Butler, Alexander Gerhard, Simon Ducharme, Isabelle Le Ber, Pietro Tiraboschi, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Jonathan D. Rohrer, Lucy L. Russell
Summary: A study on frontotemporal dementia found that neuropsychiatric symptoms occur in mutation carriers at all disease stages, with hallucinations and delusions providing additional staging benefit. The inclusion of these features in rating scales could improve the evaluation of disease progression.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
News Item
Clinical Neurology
Alessandro Padovani, Andrea Pilotto
Summary: A new study provides evidence for a link between COVID-19 and long-term neurological syndromes, emphasizing the need for further research and the development of strategies.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Susanna Lopez, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Alessandro Padovani, Flavio Nobili, Dario Arnaldi, Francesco Fama, Davide V. Moretti, Annachiara Cagnin, Giacomo Koch, Alberto Benussi, Marco Onofrj, Barbara Borroni, Andrea Soricelli, Raffaele Ferri, Carla Buttinelli, Franco Giubilei, Bahar Guntekin, Gorsev Yener, Fabrizio Stocchi, Laura Vacca, Laura Bonanni, Claudio Babiloni
Summary: This study compared the hubs of interdependencies in elderly individuals with and without Alzheimer's disease dementia (ADD) using rsEEG rhythms. The results showed that ADD patients have lower connectivity centrality and directionality compared to normal elderly individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Giancarlo Logroscino, Marco Piccininni, Caroline Graff, Orla Hardiman, Albert C. Ludolph, Fermin Moreno, Markus Otto, Anne M. Remes, James B. Rowe, Harro Seelaar, Eino Solje, Elka Stefanova, Latchezar Traykov, Vesna Jelic, Melissa Taheri Rydell, Niall Pender, Sarah Anderl-Straub, Myriam Barandiaran, Alazne Gabilondo, Johanna Kruger, Alexander G. Murley, Timothy Rittman, Emma L. van der Ende, John C. van Swieten, Paeivi Hartikainen, Gorana Mandic Stojmenovic, Shima Mehrabian, Luisa Benussi, Antonella Alberici, Maria Teresa Dell'Abate, Chiara Zecca, Barbara Borroni
Summary: This study examined the incidence of frontotemporal lobar degeneration (FTLD)-associated syndromes in Europe and found that they are more common than previously recognized, warranting diagnosis at any age. The findings have important implications for health and social care planning, as well as the design of future clinical trials.
Review
Cell Biology
Alberto Benussi, Giorgi Batsikadze, Carina Franca, Rubens G. Cury, Roderick P. P. W. M. Maas
Summary: This paper comprehensively reviews the clinical and neurophysiological effects of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and dentate nucleus deep brain stimulation (DBS) in patients with hereditary ataxias, as well as the underlying mechanisms at the cellular and network level and future research perspectives.
Article
Medicine, General & Internal
Barbara Risi, Stefano Cotti Piccinelli, Stefano Gazzina, Beatrice Labella, Filomena Caria, Simona Damioli, Loris Poli, Alessandro Padovani, Massimiliano Filosto
Summary: The MUNIX technique can estimate the number and size of surviving motor units (MUs). Previous studies found correlations between MUNIX and several clinical measures in ALS patients, but its potential as a predictor of disease progression rate (DPR) has not been thoroughly evaluated. Our study aimed to investigate the ability of MUNIX to predict DPR at a six-month follow up. The results showed that MUNIX could predict DPR in ALS patients and could be used as a prognostic tool.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Beatrice Labella, Gaetana Lanzi, Stefano Cotti Piccinelli, Filomena Caria, Simona Damioli, Barbara Risi, Enrica Bertella, Loris Poli, Alessandro Padovani, Massimiliano Filosto
Summary: This article discusses a rare genetic disorder called Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency, caused by mutations in the ACADVL gene. A case study of a 17-year-old boy with exercise-induced muscle pain and fatigue, as well as other symptoms, is reported. Various tests confirmed the diagnosis of VLCAD deficiency, and early dietary treatment is crucial for minimizing muscle damage and slowing disease progression.
Article
Clinical Neurology
Alice Galli, Andrea Pilotto, Benedetta Chiarini, Marcello Giunta, Daniele Corbo, Clara Tirloni, Daniel Ferreira, Enrico Premi, Alessandro Lupini, Cinzia Zatti, Laura Bonanni, Pietro Tiraboschi, Roberto Gasparotti, Alessandro Padovani
Summary: This study found that prodromal DLB and full-blown dementia stages are characterized by reduced occipital and posterior-temporal volume and thickness. Occipital atrophy is more sensitive than insular atrophy in differentiating prodromal DLB and healthy controls. The structural damage in the frontotemporal area increases along with occipital atrophy from prodromal DLB to full-blown dementia.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Morotti, Giorgio Busto, Gregoire Boulouis, Elisa Scola, Alessandro Padovani, Ilaria Casetta, Enrico Fainardi
Summary: The combined analysis of non-contrast CT and CT perfusion markers improves the prediction of hematoma expansion and outcome in intracerebral hemorrhage.
EUROPEAN RADIOLOGY
(2023)