Article
Psychology, Experimental
Sami R. Yousif, Monica D. Rosenberg, Frank C. Keil
Summary: The study found that task-irrelevant spatial structure can improve working memory, independent of long-term spatial associations and unique to space rather than other features. It also showed that spatial structure can be separated from spatial interference, challenging the theories of 'spatial interference' and 'visuospatial bootstrapping'.
Article
Oncology
Mitsutoshi Nakada, Riho Nakajima, Hirokazu Okita, Yusuke Nakade, Takeo Yuno, Shingo Tanaka, Masashi Kinoshita
Summary: The study demonstrates that awake surgery for right frontal lobe glioma can successfully preserve visuospatial cognition and spatial working memory with satisfying resection rates.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Neurosciences
Erin Goddard, Erika W. Contini, Muireann Irish
Summary: This study used MEG to measure the activity of the posteromedial cortex (PMC) in healthy human participants during a visuospatial working memory task. The findings suggest that the PMC plays a role in shaping object representations in other cortical regions and influences the retrieval process.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Hanlu Tang, Qiong Wu, Shiwei Li, Yehong Fang, Zhijun Yang, Bo Wang, Xingchao Wang, Pinan Liu
Summary: This study investigated different types of working memory in adults with NF1, finding deficits in visuospatial working memory but not in verbal working memory. These findings contribute to a better understanding of working memory in the context of NF1.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jose-Antonio Cervantes, Sonia Lopez, Salvador Cervantes, Adriana Mexicano, Jonathan-Hernando Rosales
Summary: This paper proposes a bio-inspired computational model to endow autonomous UAVs with visuospatial working memory, allowing them to maintain coherent and continuous representation of visual and spatial relationships among objects. The model was tested in various environments, demonstrating its ability to classify and locate objects even when visual stimulus is lost due to occlusion.
APPLIED SCIENCES-BASEL
(2021)
Article
Behavioral Sciences
Pierandrea Mirino, Sara Mercuri, Anna Pecchinenda, Maddalena Boccia, Andrea Di Piero, Marta Soldani, Cecilia Guariglia
Summary: This study used a new visuospatial working memory task, the Time Squares Sequences, to investigate the effect of implicit variations in stimuli presentation time on task performance. The results showed impaired performance when S1 had a fixed presentation time and S2 had a variable presentation time. These findings suggest a monitoring process sensitive to temporal variations and increased cognitive load due to S2 timing difference.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Psychology, Educational
Zhanhong Liang, Peiqi Dong, Yanlin Zhou, Shanshan Feng, Qiong Zhang
Summary: The research found that verbal working memory significantly predicted mathematics achievement for fifth graders, while visuospatial working memory played a substantive role in both first and fifth graders' mathematical performance. The different roles of the two working memory components also depended on various fields of mathematics.
BRITISH JOURNAL OF EDUCATIONAL PSYCHOLOGY
(2022)
Article
Neurosciences
Courtney Glavis-Bloom, Casey R. Vanderlip, John H. Reynolds
Summary: Research on aging marmosets has shown that aged animals exhibit delayed onset of learning, slowed learning rate after onset, and decreased asymptotic working memory performance, which are not accounted for by age-related impairments in motor speed and motivation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Mengtian Du, Stacy L. Andersen, Nicole Schupf, Mary F. Feitosa, Megan S. Barker, Thomas T. Perls, Paola Sebastiani
Summary: The study identified that the APOE epsilon 4 allele is a risk factor for poorer episodic memory in older adults, with participants carrying at least one copy showing lower scores in both immediate and delayed recall. However, there was no significant longitudinal effect of the epsilon 4 allele, and no significant association was found with the epsilon 2 allele on cognitive test scores.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Diana C. Oviedo, Ambar R. Perez-Lao, Julio A. Flores-Cuadra, Alcibiades E. Villarreal, Maria B. Carreira, Shantal A. Grajales, Gabrielle B. Britton
Summary: This study investigated the relationship between APOE ε4 expression and cognitive function in Panamanian older adults, revealing that individuals with at least one copy of APOE ε4 performed significantly lower in various cognitive domains, regardless of diagnosis. This contributes to a better understanding of the impact of APOE ε4 on specific cognitive functions in elderly Hispanics.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
C. Fernandez-Baizan, M. Caunedo-Jimenez, J. A. Martinez, J. L. Arias, M. Mendez, G. Solis
Summary: This study evaluated short-term and visuospatial working memory performance in preterm infants at 12 to 22 months and found that they scored lower than full-term children, although their skills improved over time. Memory performance was directly associated with cognitive development level and behavior characteristics.
CHILD NEUROPSYCHOLOGY
(2021)
Article
Geriatrics & Gerontology
Si Zhang, Weijie Fan, Hao Hu, Li Wen, Mingfu Gong, Bo Liu, Junhao Hu, Guanghui Li, Dong Zhang
Summary: In this study, early menopausal women exhibited significant subcortical volumetric loss in the left and right amygdala compared to premenopausal controls, along with higher serum FSH levels, more evident climacteric and depressive symptoms, decreased sleep quality, and lower working memory and executive functions. FSH levels were correlated with lower working memory accuracy and longer reaction time. Decreased subcortical volume in the bilateral amygdala was also associated with lower working memory accuracy and longer executive reaction time in early menopausal women, suggesting estradiol deficiency in early menopausal women may lead to subcortical volume and functional brain changes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Chemistry, Analytical
Jia-Hsun Lo, Han-Pang Huang, Su-Ching Sung
Summary: This research proposes an approach to evaluate working memory ability using electroencephalography (EEG) analysis. The study shows that there are certain characteristics in the EEG signals of subjects when performing working memory tasks, and a working memory model is developed to describe the changes in EEG signals within alpha, beta, and gamma waves. The study also predicts the working memory ability of subjects using multi-linear support vector regression (SVR) combined with fuzzy C-mean (FCM) clustering and knowledge-based fuzzy support vector regression (FSVR).
Article
Education & Educational Research
Katie Allen, David Giofre
Summary: Despite evidence for the involvement of working memory in mathematics attainment, this study found contrasting patterns in the relationship between working memory components and individual areas of mathematics. The results showed a level of specificity with regard to the component of working memory engaged depending on the component of mathematics being assessed. Implications for educators and further research are discussed.
EDUCATIONAL PSYCHOLOGY
(2021)
Article
Clinical Neurology
Valentina Ciullo, Federica Piras, Nerisa Banaj, Daniela Vecchio, Fabrizio Piras, Gabriele Sani, Giuseppe Ducci, Gianfranco Spalletta
Summary: This study examines timing abilities in bipolar disorder patients and finds increased variability of the internal clock, which is related to major depressive episodes and working memory functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Editorial Material
Clinical Neurology
Merida Teran Jimenez, Philippe Salles Gandara, Alberto J. Espay
Article
Clinical Neurology
Luca Marsili, Kevin R. Duque, Nathan Gregor, Elhusseini Abdelghany, Jesus Abanto, Andrew P. Duker, Matthew C. Hagen, Alberto J. Espay, Matteo Bologna
Summary: This study found no significant differences in the features of bradykinesia between patients with synucleinopathies and tauopathies.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Alonso Zea Vera, Adrienne Bruce, Travis R. Larsh, Zachary Jordan, Norbert Bruggemann, Ana Westenberger, Alberto J. Espay, Donald L. Gilbert, Steve W. Wu
Summary: POLR3A-related disorders exhibit significant phenotypic pleomorphism, including a range of movement disorders such as parkinsonism, dystonia, ataxia, and spasticity. Vertical gaze dysfunction and T2-weighted/FLAIR hyperintensity of the superior cerebellar peduncles and midbrain may be useful signs suggestive of this condition.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
John L. Robinson, Sharon X. Xie, Daniel R. Baer, EunRan Suh, Vivianna M. Van Deerlin, Nicholas J. Loh, David J. Irwin, Corey T. McMillan, David A. Wolk, Alice Chen-Plotkin, Daniel Weintraub, Theresa Schuck, Virginia M. Y. Lee, John Q. Trojanowski, Edward B. Lee
Summary: In this retrospective study, the incidence of 10 pathologies in neurodegenerative disease (ND) and normal aging was examined, with up to seven pathologies observed concurrently resulting in 161 different combinations. The presence of multiple additive pathologies was associated with factors such as longer disease duration, clinical dementia, older age, and APOE e4 status.
Article
Clinical Neurology
Matteo Bologna, Alberto J. Espay, Alfonso Fasano, Giulia Paparella, Mark Hallett, Alfredo Berardelli
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Danielle S. Abraham, Thanh Phuong Pham Nguyen, Leah J. Blank, Dylan Thibault, Shelly L. Gray, Sean Hennessy, Charles E. Leonard, Daniel Weintraub, Allison W. Willis
Summary: This study examined the differential prescribing patterns between new and established treatments for common neurological conditions. Using data from a national sample of US commercially insured adults from 2005-2019, the study compared new users of recently approved medications for three conditions: diabetic peripheral neuropathy, Parkinson disease psychosis, and epilepsy. The results showed that newer medications were more frequently prescribed to individuals with prior treatment, suggesting potential bias in comparative effectiveness and safety studies. The study emphasizes the importance of reporting propensity score non-overlap in comparative studies involving newer medications and suggests methodological approaches to address channeling bias.
Editorial Material
Clinical Neurology
Alberto J. Espay, Kevin McFarthing
Summary: The process of protein aggregation involves the transformation of soluble peptides into insoluble cross-beta amyloids. In Parkinson's disease, soluble monomeric a-synuclein transforms into the amyloid state known as Lewy pathology. Most disease-modifying projects in the therapeutic pipeline for Parkinson's disease aim to reduce the insoluble a-synuclein fraction, while none aim to increase soluble a-synuclein levels. We propose rebalancing the therapeutic pipeline to include treatments that restore soluble a-synuclein within a normal range.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Ashwani Jha, Alberto J. Espay, Andrew J. Lees
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Paula Saffie Awad, Daniel Teixeira-dos-Santos, Bruno Lopes Santos-Lobato, Sarah Camargos, Mario Cornejo-Olivas, Carlos Roberto de Mello Rieder, Ignacio F. Mata, Pedro Chana-Cuevas, Christine Klein, Artur F. Schumacher Schuh
Summary: This study conducted a systematic review and meta-analysis on genetic parkinsonism in Latin America, finding pathogenic variants in 19 different genes among Latin American patients. The frequency of pathogenic variants in LRRK2, PRKN, and GBA1 genes were 1.38%, 1.16%, and 4.17% respectively. Further research is needed in the region for better understanding and personalized therapies.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Daniel Weintraub
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hubert H. Fernandez, Daniel Weintraub, Eric Macklin, Irene Litvan, Michael A. Schwarzschild, Jamie Eberling, Aleksandar Videnovic, Christopher J. Kenney
Summary: In patients with Parkinson disease dementia (PDD), SYN120 did not improve cognition significantly but showed potential benefits in cognitive activities of daily living and apathy.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Thanh Phuong Pham Nguyen, Shelly L. Gray, Craig W. Newcomb, Qing Liu, Ali G. Hamedani, Daniel Weintraub, Sean Hennessy, Allison W. Willis
Summary: This study found that there were no significant differences in medication prescriptions between Parkinson disease (PD) patients hospitalized for serious injury and those hospitalized for other reasons, indicating a missed opportunity to deprescribe high-risk medications during care transitions.
PARKINSONISM & RELATED DISORDERS
(2023)
Letter
Clinical Neurology
Dafne Dalledone Moura, Vanderci Borges, Henrique Ballalai Ferraz, Artur F. S. Schuh, Carlos Roberto de Mello Rieder, Ignacio F. Mata, Manuelina Mariana Capellari Macruz Brito, Vitor Tumas, Bruno Lopes Santos-Lobato
Summary: The prevalence of Parkinson's disease (PD) is increasing worldwide, and there may be a connection between household pesticide exposure and this trend. Our study revealed that individuals with high exposure to household pesticides have twice the risk of developing PD. Exposure to household pesticides does not affect the age at which PD symptoms appear.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Vindhya Koneru, Alberto J. Espay, Allan J. Cole, Daniel Weintraub, Kathleen Crist, Maria B. Pascual, William G. Ondo
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Daniel Weintraub
MOVEMENT DISORDERS
(2023)