Article
Clinical Neurology
Jose Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Joseph Jankovic
Summary: This study reviewed the medical records and video recordings of 155 TS patients and found that 26.5% of them had OM tics. Compared to classic tardive dyskinesia, OM tics have different manifestations and are more commonly associated with oromandibular and eye-rolling movements. Therefore, it is important to differentiate between the two.
JOURNAL OF NEUROLOGY
(2023)
Review
Food Science & Technology
Charenya Anandan, Joseph Jankovic
Summary: BoNT has evolved into a therapeutic modality for a variety of neurological and non-neurological disorders since its initial approval in 1989. It has shown effectiveness in treating neurologic movement disorders and is being researched for potential central nervous system applications. BoNT is considered safe when administered by knowledgeable clinicians and has shown promise in recent innovative pilot studies.
Review
Clinical Neurology
C. M. Ghadery, L. Kalia, B. S. Connolly
Summary: Movement disorders of the mouth involve hyperactive movements of the muscles in the orofacial complex, and they are rare conditions primarily described in case reports by neurologists, psychiatrists, and dentists. This review provides a phenomenological description of different oral motor disorders and offers management strategies based on current literature.
JOURNAL OF NEUROLOGY
(2022)
Review
Neurosciences
Jocelyn Wong, Tiffanie Pang, Natalie Kwok Wing Cheuk, Yingqi Liao, Tarun Bastiampillai, Sherry Kit Wa Chan
Summary: This review examines the effectiveness of clozapine as an intervention for tardive dyskinesia and dystonia in patients with various psychiatric conditions. The results suggest that clozapine has overall effectiveness in treating TD for patients with a range of psychiatric conditions, but different psychiatric diagnoses may require different treatment protocols in terms of response time and dosage. However, most of the studies identified have inadequate qualities, highlighting the need for high-quality studies to provide clearer evidence.
PSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Didem Tezen, Aysegul Gunduz, Meral Erdemir Kiziltan, Cengiz Yalcinkaya, Gunes Kiziltan
Summary: This report examines the case of a 5-year-old girl with early onset involuntary movements. The patient was found to have an ADCY5 gene mutation through whole exome sequencing. The study aims to contribute to a better understanding of the gene and the discovery of different treatment options.
NEUROLOGICAL SCIENCES
(2022)
Review
Food Science & Technology
Wolfgang H. Jost
Summary: Botulinum neurotoxin (BoNT) has been used for a wide range of indications in patients with Parkinson's syndrome, with approved indications including sialorrhea, cervical dystonia, and blepharospasm, while other indications like tremor and hyperhidrosis still lack sufficient data support.
Article
Multidisciplinary Sciences
Tomasz Gutowski, Ryszard Antkiewicz, Stanislaw Szlufik
Summary: This paper presents a solution for creating personalized medicine intake schedules for Parkinson's disease patients. By using machine learning models and optimization algorithms, it can reduce treatment errors and the time required to establish medication schedules, with the potential to significantly improve treatment outcomes.
Article
Veterinary Sciences
Sofia Cerda-Gonzalez, Rebecca A. Packer, Laurent Garosi, Mark Lowrie, Paul J. J. Mandigers, Dennis P. O'Brien, Holger A. Volk
Summary: Movement disorders in dogs encompass a range of clinical syndromes, including tremors, peripheral nerve hyperexcitability disorders, paroxysmal dyskinesia, and dystonia. This consensus statement outlines standard terminology for accurately describing these disorders, with a focus on paroxysmal dyskinesia, as well as a clinical approach to classifying and reporting cases. The goal is to facilitate consistent reporting, further understanding of these disorders, and potential identification of additional genetic mutations related to canine movement disorders.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Clinical Neurology
Mitchell Lycett, Cathy Kexin Cui, Dijana Dragicevich, Roger Harris, Karl Ng
Summary: This case report describes a patient with hypertrophic olivary degeneration (HOD) caused by secondary obstructive hydrocephalus. The patient presented with progressive hiccups and stridor, along with ocular pendular nystagmus and palatal myoclonus. MRI imaging showed T2 hyperintensity within the bilateral inferior olivary nuclei consistent with stage 3 radiological HOD. This is the first reported association of HOD with bilateral vocal cord adductor dystonia.
Article
Pharmacology & Pharmacy
Rohit Singh, Sankha Shubhra Chakrabarti, Upinder Kaur
Summary: The study highlights the atypical manifestation of antipsychotic-associated Rabbit syndrome in the presence of a serotonergic antidepressant. The syndrome is characterized by vertical rhythmic movements of the perioral region, has a late onset, and typically spares the tongue.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Clinical Neurology
Marcello Mario Mascia, Gianni Orofino, Paola Cimino, Gianluca Cadeddu, Tommaso Ercoli, Giovanni Defazio
Summary: Action tremor, including writing tremor, is common in Parkinson's disease and may have dystonic features. However, writing tremor is less frequent and task-specific compared to other tremor variants.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Engineering, Biomedical
Gabriel A. S. Ferreira, Joao Lucas S. Teixeira, Ana Lucia Z. Rosso, Antonio Mauricio F. L. Miranda De Sa
Summary: Parkinson's disease is a neurological disorder characterized by motor symptoms such as tremor and dyskinesia. This study aims to develop a method to distinguish Parkinson's disease, essential tremor, and medication-induced movement disorders. Classification using machine learning algorithms was performed, and decision trees and random forests were found to be the most suitable models for this problem.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Letter
Clinical Neurology
Mustafa Akkus
Summary: This case suggests that lithium-induced tardive dyskinesia may be reversible in a dose-dependent manner.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Davide Martino, Vikram Karnik, Roongroj A. Bhidayasiri, Deborah A. A. Hall, Robert A. Hauser, Antonella M. Macerollo, Tamara M. Pringsheim, Daniel A. Truong, Stewart A. Factor, Matej Skorvanek, Anette Schrag, IPMDS Rating Scales Review Comm
Summary: An International Parkinson and Movement Disorder Society subcommittee aimed to rate the psychometric quality of severity and screening instruments for antipsychotic-associated movement disorders. They identified 23 instruments, of which 7 severity rating instruments and 3 screening instruments were recommended with caveats due to insufficient psychometric properties and long duration of administration. New psychometric studies and revision of existing instruments are recommended to address these caveats and improve the clarity of their nomenclature.
MOVEMENT DISORDERS
(2023)
Article
Food Science & Technology
Nicolas P. Skarmeta, Giannina C. Katzmann, Constanza Valdes, Dominique Gaedechens, Francisca C. Montini
Summary: The article presents a clinical case of tardive oromandibular dystonia induced by Trazodone and discusses the importance of early identification and assessment of tardive symptoms for successful treatment. Trazodone-induced oromandibular dystonia is extremely rare and caution should be exercised when prescribing Trazodone to patients taking other medications with the potential to cause tardive syndromes.
Article
Cell Biology
Myoung Seok Ko, Ji Young Yun, In-Jeoung Baek, Jung Eun Jang, Jung Jin Hwang, Seung Eun Lee, Seung-Ho Heo, David A. Bader, Chul-Ho Lee, Jaeseok Han, Jong-Seok Moon, Jae Man Lee, Eun-Gyoung Hong, In-Kyu Lee, Seong Who Kim, Joong Yeol Park, Sean M. Hartig, Un Jung Kang, David D. Moore, Eun Hee Koh, Ki-up Lee
Summary: This study revealed the role of a specific gene, pink1, in mitochondrial autophagy, where its deficiency induces dysfunction in brown adipose tissue and obesity. Surprisingly, the induction of NLRP3 did not lead to canonical inflammasome activity, but instead caused brown adipocyte precursors to differentiate into white-like adipocytes. These findings suggest a new mitochondria-NLRP3 pathway that contributes to BAT dysfunction and provide potential therapeutic targets for obesity-related metabolic diseases.
Article
Clinical Neurology
Stella M. Papa, Patrik Brundin, Victor S. C. Fung, Un Jung Kang, David J. Burn, Carlo Colosimo, Han-Lin Chiang, Roy N. Alcalay, Claudia Trenkwalder
MOVEMENT DISORDERS
(2020)
Article
Clinical Neurology
Katerina Melachroinou, Min Suk Kang, Christopher Liong, Sushma Narayan, Najah Levers, Neal Joshi, Katie Kopil, Samantha J. Hutten, Marco A. S. Baptista, Shalini Padmanabhan, Un Jung Kang, Leonidas Stefanis, Roy N. Alcalay, Hardy J. Rideout
MOVEMENT DISORDERS
(2020)
Article
Clinical Neurology
Christina D. Orru, Thong C. Ma, Andrew G. Hughson, Bradley R. Groveman, Ankit Srivastava, Douglas Galasko, Rachel Angers, Patrick Downey, Karen Crawford, Samantha J. Hutten, Un Jung Kang, Byron Caughey
Summary: The study shows that an improved assay for diagnosing Parkinson's disease dramatically reduces the diagnosis time while maintaining high performance standards. Positive signals were found in 97% of Parkinson's disease cases compared to only 13% of healthy controls, with weak correlations between assay parameters and clinical measures observed. The assay's efficiency in diagnosing Parkinson's disease is supported by these findings.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Editorial Material
Neurosciences
Bastiaan R. Bloem, Claudia Trenkwalder, Alvaro Sanchez-Ferro, Lorraine V. Kalia, Roy Alcalay, Han-Lin Chiang, Un Jung Kang, Christopher Goetz, Patrik Brundin, Stella M. Papa
Summary: Despite concerns raised by people with Parkinson's disease (PD) and their physicians regarding the efficacy and safety of COVID-19 vaccines in the specific context of PD and its treatment, current literature and experience with widespread vaccination suggest that COVID-19 vaccination with approved vaccines is recommended for PD patients, unless there is a specific contraindication.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Suman Dutta, Simon Hornung, Adira Kruayatidee, Katherine N. Maina, Irish del Rosario, Kimberly C. Paul, Darice Y. Wong, Aline Duarte Folle, Daniela Markovic, Jose-Alberto Palma, Geidy E. Serrano, Charles H. Adler, Susan L. Perlman, Wayne W. Poon, Un Jung Kang, Roy N. Alcalay, Miriam Sklerov, Karen H. Gylys, Horacio Kaufmann, Brent L. Fogel, Jeff M. Bronstein, Beate Ritz, Gal Bitan
Summary: The study found that measuring α-syn in exosomes from blood can effectively distinguish between patients with PD and MSA with high sensitivity and specificity. A multinomial logistic model combining α-syn concentration, exosome concentration, and a ratio between α-syn concentrations in specific exosomes showed promising results in separating PD from MSA.
ACTA NEUROPATHOLOGICA
(2021)
Article
Medicine, Research & Experimental
Jay Li, Daniel S. Levin, Audrey J. Kim, Samuel S. Pappas, William T. Dauer
Summary: Research in a mouse model of DYT1 dystonia showed a critical requirement for torsinA in normal motor function and gene therapy, with a particular emphasis on its essential role during a developmental critical period. These findings suggest that torsinA-based therapeutic strategies need to be employed early in the course of DYT1 dystonia for effectiveness.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Correction
Clinical Neurology
Suman Dutta, Simon Hornung, Adira Kruayatidee, Katherine N. Maina, Irish del Rosario, Kimberly C. Paul, Darice Y. Wong, Aline Duarte Folle, Daniela Markovic, Jose-Alberto Palma, Geidy E. Serrano, Charles H. Adler, Susan L. Perlman, Wayne W. Poon, Un Jung Kang, Roy N. Alcalay, Miriam Sklerov, Karen H. Gylys, Horacio Kaufmann, Brent L. Fogel, Jeff M. Bronstein, Beate Ritz, Gal Bitan
Summary: A correction to the paper has been published.
ACTA NEUROPATHOLOGICA
(2021)
Letter
Clinical Neurology
Luis Concha-Marambio, Carly M. Farris, Bret Holguin, Yihua Ma, John Seibyl, Marco J. Russo, Un J. Kang, Samantha J. Hutten, Kalpana Merchant, Mohammad Shahnawaz, Claudio Soto
MOVEMENT DISORDERS
(2021)
Article
Multidisciplinary Sciences
Dhananjay Yellajoshyula, Samuel S. Pappas, Abigail E. Rogers, Biswa Choudhury, Xylena Reed, Jinhui Ding, Mark R. Cookson, Vikram G. Shakkottai, Roman J. Giger, William T. Dauer
Summary: THAP1 regulates myelination initiation by modulating GAG catabolism and ECM composition, with a lack of THAP1 leading to excess GAG accumulation and inhibition of OL maturation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Clinical Neurology
Dhananjay Yellajoshyula, Samuel S. Pappas, William T. Dauer
Summary: The development of genomics and neuroimaging techniques has shed light on the importance of neuronal-glial interactions and extracellular matrix in nervous system development, function, and plasticity. Abnormalities in neuronal-glial interactions play a key role in neurodevelopmental disorders.
MOVEMENT DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Cecilia Ostlund, Antonio Hernandez-Ono, Samantha J. Turk, William T. Dauer, Henry N. Ginsberg, Howard J. Worman, Ji-Yeon Shin
Summary: In this study, the occurrence of nuclear lipid droplets (LDs) in primary hepatocytes from mice following depletion of lamina-associated polypeptide 1 (LAP1) was investigated. The results revealed that LAP1-depleted hepatocytes contain frequent nuclear LDs, which differ from cytoplasmic LDs in their associated proteins. The study also demonstrated a relationship of LD formation with nutritional state.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Neurosciences
Giulietta Maria Riboldi, Marco J. Russo, Ling Pan, Kristen Watkins, Un Jung Kang
Summary: Non-motor symptoms like dysautonomia and REM sleep behavior disorder in Parkinson's disease may indicate different types of the disease. Through analysis of data from newly diagnosed Parkinson's patients, it was found that dysautonomia symptoms can predict disease progression more accurately.
NPJ PARKINSONS DISEASE
(2022)
Correction
Neurosciences
Giulietta Maria Riboldi, Marco J. Russo, Ling Pan, Kristen Watkins, Un Jung Kang
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Yong Hu, Thong C. Ma, Stephanie L. Alberico, Yunmin Ding, Lingjing Jin, Un Jung Kang
Summary: This study aimed to determine whether direct modulation of SNr GABAergic neurons and SNr projections to the PPN can regulate PD symptoms and levodopa-induced dyskinesia (LID). The results showed that suppressing SNr neuron activity improved akinesia, while increasing SNr neuronal activity significantly reduced LID. The projections from SNr to PPN likely mediate the antidyskinetic effect of increasing SNr neuronal activity.
MOVEMENT DISORDERS
(2023)
