Article
Pediatrics
Saara Lehtiranta, Minna Honkila, Merja Kallio, Kimmo Halt, Niko Paalanne, Tytti Pokka, Terhi Tapiainen
Summary: The study found that in acutely ill children receiving moderately hypotonic fluid therapy in the emergency department, one child developed severe hyponatremia.
PEDIATRIC NEPHROLOGY
(2022)
Article
Obstetrics & Gynecology
Funda Tuzun, Yagmur Akcura, Nuray Duman, Hasan Ozkan
Summary: This study compared the use of isotonic and hypotonic fluids for hospitalized term newborns and found that hypotonic fluids may lead to unsafe decreases in plasma sodium levels. However, larger studies are still needed to determine the safety of using hypotonic fluids in term newborns.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Pediatrics
Basma Ehab Amer, Omar Ahmed Abdelwahab, Ahmed Abdelaziz, Youssef Soliman, Ahmed Mostafa Amin, Maged Ahmed Mohamed, Khaled Albakri, Esraa Mohamed Zedan, Naema Hamouda
Summary: This meta-analysis compares the safety and efficacy of isotonic and hypotonic intravenous maintenance fluid therapy (IV-MFT) in hospitalized children. The study finds that isotonic IV-MFT significantly reduces the risk of mild hyponatremia in hospitalized children compared to hypotonic IV-MFT. However, isotonic IV-MFT may increase the risk of hypernatremia in neonates and may lead to renal dysfunction. Therefore, the authors propose using balanced isotonic IV-MFT in hospitalized children as it is better tolerated by the kidneys than 0.9% saline.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medicine, General & Internal
M. Denis, A. Di Giacomo, E. Lacotte, F. Porcheret, N. Letouze, B. Lauzier, I. Goyer, D. Brossier
Summary: This case report of a 4-week-old Caucasian child admitted for acute bronchiolitis receiving hypotonic maintenance fluids and developing severe hyponatremia highlights the need to reevaluate current guidelines for maintenance intravenous fluid prescription in children. The latest recommendations from the American Academy of Pediatrics emphasize the use of isotonic fluids in children.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Review
Critical Care Medicine
David W. Brossier, Lyvonne N. Tume, Anais R. Briant, Corinne Jotterand Chaparro, Clemence Moullet, Shancy Rooze, Sascha C. A. T. Verbruggen, Luise Marino, Fahad Alsohime, Sophie Beldjilali, Fabrizio Chiusolo, Leonardo Costa, Capucine Didier, Stavroula Ilia, Nyandat L. Joram, Martin C. J. Kneyber, Eva Kuhlwein, Jorge Lopez, Jesus Lopez-Herce, Huw F. Mayberry, Fortesa Mehmeti, Magdalena Mierzewska-Schmidt, Maria Minambres Rodriguez, Claire Morice, John Pappachan, Florence Porcheret, Leonor Reis Boto, Luregn J. Schlapbach, Hakan Tekguc, Konstantinos Tziouvas, Jean-Jacques Parienti, Isabelle Goyer, Frederic V. Valla
Summary: Prescribing intravenous maintenance fluid therapy in acute and critically ill children varies greatly among healthcare professionals. The European Society of Pediatric and Neonatal Intensive Care conducted a systematic review to provide up-to-date guidelines. The review found inconsistent outcome reporting and produced a series of recommendations, including the use of isotonic balanced solutions and regular monitoring of electrolyte levels and fluid balance.
INTENSIVE CARE MEDICINE
(2022)
Article
Obstetrics & Gynecology
Krishna Dathan, Mangalabharathi Sundaram
Summary: This study compared isotonic and hypotonic intravenous fluid for maintenance therapy in neonates, and found that hypotonic fluid did not show a significant advantage in reducing the incidence of hyponatremia in neonates.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Pediatrics
Norfarahin Hasim, Mimi Azliha Abu Bakar, Md Asiful Islam
Summary: This meta-analysis aimed to compare the safety and efficacy of isotonic versus hypotonic intravenous maintenance fluid in hospitalized children. The study found that hypotonic fluid significantly increases the risk of hyponatremia, while isotonic fluid increases the risk of hypernatremia. There was no significant difference in adverse outcomes between the two groups.
Article
Agriculture, Dairy & Animal Science
Raphael Vezina-Audette, Marta Kantyka, Giacomo Gianotti, Deborah C. Silverstein
Summary: In this prospective clinical trial, the effect of a bolus of balanced isotonic crystalloid solutions containing acetate buffers on hypotension in anesthetized dogs was studied. The results showed that none of the dogs experienced a paradoxical hypotensive reaction or an increase in blood pressure after receiving a fluid bolus. This study suggests that the use of these solutions is safe and does not exacerbate hypotension in anesthetized dogs.
Article
Oncology
Amadeus T. Heinz, Thomas Eichholz, Manon Queudeville, Ulrike Hartmann, Alexandra Ott, Oliver Heinzel, Rupert Handgretinger, Martin Ebinger
Summary: The study findings suggest that using isotonic fluids in pediatric oncology can effectively reduce the incidence of hospital-acquired hyponatremia without causing hypernatremia. Although there may be an increase in the use of furosemide, it does not raise the risk of acute kidney injury.
PEDIATRIC HEMATOLOGY AND ONCOLOGY
(2022)
Article
Nutrition & Dietetics
JohnEric W. Smith, Marissa L. Bello, Ffion G. Price
Summary: Proper hydration during exercise is crucial for athletes, but sweat rate can vary significantly day-to-day and in different temperature conditions. This study found that there were significant differences in sweat rate variability between different temperature ranges, and a single assessment may not accurately represent an individual's typical sweat rate even in similar environmental conditions.
Article
Pharmacology & Pharmacy
Buster Mannheimer, Cecilia Fahlen Bergh, Henrik Falhammar, Jan Calissendorff, Jakob Skov, Jonatan D. Lindh
Summary: Thiazide diuretics are the most common cause of drug-induced hyponatremia. This study in Sweden found that individuals initiating thiazide treatment faced an immediate increase in risk for hospitalization due to hyponatremia, which gradually declined over time. However, thiazides were still attributed to more than one in four individuals hospitalized for hyponatremia, with an absolute risk for subsequent hospitalization being modest for most individuals.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Integrative & Complementary Medicine
Maria Facchini, Chiara Ruini
Summary: Music therapy in pediatric oncology shows good feasibility and positive effects on mental and physical health, with significant reduction in psychological distress and increase in well-being. However, the effects on subjective pain and other biological parameters are inconclusive, requiring further research.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Review
Pediatrics
Natalia Soulages Arrese, Michael L. Green
Summary: This review summarizes current literature on fluid management for critically ill children, including crystalloid fluid used throughout the critical illness course, management of fluid output, and complications with fluid overload. Recent studies show mixed results regarding the risk of mortality and kidney injury with 0.9% saline and crystalloid fluid. Fluid restrictive strategies may be well tolerated in critically ill adults with septic shock, but further trials are needed in pediatrics. High-quality studies are needed to define the type, timing, and rate of intravenous fluid for critically ill children.
CURRENT OPINION IN PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Julie Martin-Grace, Maria Tomkins, Michael W. O'Reilly, Chris J. Thompson, Mark Sherlock
Summary: Hyponatremia is a common electrolyte disturbance with significant clinical outcomes. This article reviews and compares the current recommendations, guidelines, and literature for diagnosis and treatment options for both acute and chronic hyponatremia, using case studies as examples.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Clinical Neurology
Andrea L. Fidler, Sara Voorhees, Eric S. Zhou, Jeanne-Marie Stacciarini, David A. Fedele
Summary: This study aims to examine factors that influence pediatric inpatient sleep and determine the effectiveness of sleep promotion interventions among hospitalized children. A systematic literature search identified 45 articles, which suggested that most sleep disturbances in hospitalized children are caused by environmental disruptions. Although most interventions targeted the child level using relaxation techniques, preliminary findings indicate positive impacts on sleep duration. The study proposes the Pediatric Inpatient Sleep Model to illustrate connections between sleep disturbances, factors influencing sleep, and existing intervention components. This review suggests the need for replication studies and larger-scale sleep promotion interventions among hospitalized children.