Review
Metallurgy & Metallurgical Engineering
S. V. Satya Prasad, S. B. Prasad, Kartikey Verma, Raghvendra Kumar Mishra, Vikas Kumar, Subhash Singh
Summary: This review paper summarizes the importance of magnesium and its material properties in engineering applications, including the influence of alloying elements on mechanical properties, corrosion behavior, and manufacturing techniques. Additionally, it discusses the recent trends of magnesium alloys, their applications in the biomedical field, and techniques to overcome biocorrosion.
JOURNAL OF MAGNESIUM AND ALLOYS
(2022)
Article
Metallurgy & Metallurgical Engineering
Jiangfeng Song, Jing Chen, Xiaoming Xiong, Xiaodong Peng, Daolun Chen, Fusheng Pan
Summary: In 2021, over 4000 papers on Mg and Mg alloys were published and indexed in the Web of Science (WoS) Core Collection database. The main research focus was on the microstructure, mechanical properties, and corrosion of Mg alloys. Mg ion batteries and hydrogen storage Mg materials attracted significant attention. Chinese universities and research institutions, along with institutions from Germany, the United States, Australia, Japan, Korea, and Iran, made important contributions to the research and development of magnesium alloys.
JOURNAL OF MAGNESIUM AND ALLOYS
(2022)
Review
Metallurgy & Metallurgical Engineering
Yan Yang, Xiaoming Xiong, Jing Chen, Xiaodong Peng, Daolun Chen, Fusheng Pan
Summary: This article provides a comprehensive summary of the developments in the structural and functional properties of magnesium and magnesium alloys in 2022. The results of bibliometric analyses show that the microstructure, mechanical properties, and corrosion of magnesium alloys remain the main research focus. Additionally, the article highlights the increasing interest in bio-Mg materials, Mg ion batteries, and hydrogen storage Mg materials.
JOURNAL OF MAGNESIUM AND ALLOYS
(2023)
Review
Chemistry, Physical
Jianhui Dong, Tao Lin, Huiping Shao, Hao Wang, Xueting Wang, Ke Song, Qianghua Li
Summary: This paper reviews the degradation mechanism, influencing factors, and corrosion products of magnesium alloys, and discusses the control methods and goals of degradation.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Review
Metallurgy & Metallurgical Engineering
Frank Czerwinski
Summary: This article outlines the highlights of major Canadian research projects over the past two decades that aimed at advancing the applications of magnesium and its alloys. It also discusses the activities of the industrial sector in designing and building machinery for magnesium processing and production. The article highlights the various processing technologies and emerging research directions, such as magnesium air batteries, biodegradable alloys, additive manufacturing, and magnesium-rich high entropy alloys.
JOURNAL OF MAGNESIUM AND ALLOYS
(2023)
Review
Chemistry, Physical
Yuan Qi Li, Feng Li, Fu Wei Kang, Hua Qiu Du, Zi Yu Chen
Summary: Extrusion process is a main method for forming lightweight and low plastic magnesium alloy components. New processes and methods are constantly emerging and applied to solve the long-term bottlenecks that restrict the rapid development of magnesium alloy extrusion forming technology. It provides scientific guidance and technical reserves for accelerating the development of magnesium and its alloys' deep processing technology, and expands the application range of high value-added magnesium alloy products.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Review
Engineering, Biomedical
Weijie Weng, Arne Biesiekierski, Yuncang Li, Matthew Dargusch, Cuie Wen
Summary: The study focuses on the biological impact and application of rare-earth elements (REEs) in biodegradable Mg-based biomaterials. Despite the effectiveness of REEs in improving corrosion, mechanical, and manufacturability properties of Mg alloys, their physiological effects are still poorly understood. The review provides guidance for the development of new biomedical alloys and emphasizes areas of concern and unclear knowledge. Key findings include current clinical and preclinical work summary, highlighting Sc as the most promising REE in terms of physiological impact, while caution is advised when considering other REEs as alloying elements.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Wei Lu, Yinling Zhang, Taolei Wang
Summary: This paper investigates the merging mechanism of Mg-Zn and HA particles in Mg-Zn/HA composites prepared using powder metallurgy. The distribution of HA in the matrix is examined using SEM and micro-CT images, and the mechanical properties and biocompatibility of the composites are discussed in detail. The results highlight the importance of optimizing the HA content in Mg-Zn/HA composites for bone implants, with composites containing a moderate HA content showing the most promising characteristics.
Article
Materials Science, Multidisciplinary
C. S. Neves, I. Sousa, M. A. Freitas, L. Moreira, C. Costa, J. P. Teixeira, S. Fraga, E. Pinto, A. Almeida, N. Scharnagl, M. L. Zheludkevich, M. G. S. Ferreira, J. Tedim
Summary: The study investigated the cytotoxicity and corrosion behavior of Mg1Ca and Mg10Gd alloys in different electrolytes, revealing that Mg1Ca alloy has a lower degradation rate and lower cytotoxicity, showing promise for biomedical implants.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Review
Polymer Science
Diego Cuartas-Marulanda, Laura Forero Cardozo, Adriana Restrepo-Osorio, Patricia Fernandez-Morales
Summary: Magnesium alloys have unique properties but degrade easily when in contact with body fluids, hence the need for protective coatings. This review focuses on the application of natural biopolymer coatings and modification techniques on magnesium alloys, and compares them with inorganic coatings in terms of corrosion resistance, cell adhesion, proliferation, and biodegradability.
Review
Chemistry, Physical
Liming Xu, Xingwang Liu, Kang Sun, Rao Fu, Gang Wang
Summary: Magnesium alloys possess excellent biocompatibility and biodegradability, but their corrosion resistance is relatively lower. This study reviews the corrosion mechanism of magnesium alloys and proposes reasonable methods for preventing and modeling corrosion. Additionally, composition design, structural treatment, and surface processing techniques can be used to control degradation rate and improve the biological properties of magnesium alloys.
Review
Biochemistry & Molecular Biology
Rui Wang, Chaoshu Tang
Summary: China has been conducting biomedical research on hydrogen sulfide (H2S) metabolism and function for the past 20 years, leading the way in investigating the correlation between abnormal H2S metabolism and cardiovascular diseases. Chinese research teams have made significant breakthrough discoveries in areas such as hypertension, atherosclerosis, and pulmonary hypertension, advancing both laboratory study and clinical applications. An integrated and collaborative research strategy can further promote and sustain H2S biomedical research in China and globally.
Article
Materials Science, Coatings & Films
Jingyao Li, Jian Li, Qingyang Li, Haili Zhou, Guomin Wang, Xiang Peng, Weihong Jin, Zhentao Yu, Paul K. Chu, Wei Li
Summary: The study focused on nanocrystalline zinc coating for magnesium medical implants, which can reduce corrosion current density but accelerate magnesium substrate dissolution. The composite coating provides better long-term protection in physiological environments.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Yi Zhu, Yuezhu Liu, Lanping Wu, Qian Yang
Summary: In recent years, there has been a significant increase in research interest in biodegradable materials, particularly in the field of biomedicine. China, along with the Chinese Academy of Sciences, has made a significant contribution to research on biodegradable magnesium-based materials for biomedical applications. The research hotspots in this area currently focus on corrosion and mechanical properties.
FRONTIERS IN MATERIALS
(2023)
Article
Materials Science, Coatings & Films
Jian Li, Nian He, Jingyao Li, Qingyun Fu, Mingcheng Feng, Weihong Jin, Wei Li, Yin Xiao, Zhentao Yu, Paul K. Chu
Summary: The study focuses on the fabrication of a magnesium-aluminum layered double hydroxide coating intercalated with silicate (LDH-SiO3) on anodized AZ31B Mg alloy to control corrosion rate and cytocompatibility. The LDH-SiO3 coating reduces the corrosion current density, exhibits self-healing ability, and enhances cell attachment and proliferation.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jieni Fu, Xiangmei Liu, Zhenduo Cui, Yufeng Zheng, Hui Jiang, Yu Zhang, Zhaoyang Li, Yanqin Liang, Shengli Zhu, Paul K. Chu, Kelvin Wai Kwok Yeung, Shuilin Wu
Summary: Probiotic-based nanoparticles can effectively treat immunocompetent primary and immunocompromised secondary bacterial pneumonia by restoring host immunity. These nanoparticles can kill common pathogens, modulate lung microbiota, and alleviate overactive immune responses. This research provides a new strategy for treating bacterial pneumonia in individuals with normal and compromised immunity.
NATIONAL SCIENCE REVIEW
(2023)
Review
Materials Science, Multidisciplinary
Zhaojun Jia, Xiaoxue Xu, Donghui Zhu, Yufeng Zheng
Summary: Trauma-and disease-related skeletal defects and illnesses are causing problems for millions of people, particularly in an aging world. The convergence of additive manufacturing (AM) and bone tissue engineering (BTE) has opened up the era of personalized bone healthcare, by using design, printing, and engineering to create custom 3D architected scaffolds. This review provides an overview of theories, advances, and trends in this field, covering biomaterials, computational tools, and engineering processes. The goal is to produce customized and biomimetic (bio)scaffolds for next-generation bone healthcare.
PROGRESS IN MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Qunle Ouyang, Yuxuan Zeng, Yi Yu, Lei Tan, Xiangmei Liu, Yufeng Zheng, Shuilin Wu
Summary: This study explores the sonocatalytic properties of TiO2 nanoparticles with different phases and finds that anatase-brookite TiO2 has the best antibacterial efficiency. It provides a new noninvasive and efficient treatment strategy for wound biofilm infection.
Article
Chemistry, Physical
Yuxuan Zeng, Qunle Ouyang, Yi Yu, Lei Tan, Xiangmei Liu, Yufeng Zheng, Shuilin Wu
Summary: Sonodynamic therapy (SDT) has attracted attention for treating deep-seated tumors or infections due to its non-invasiveness and high tissue-penetrating ability. This study develops a defective homojunction porphyrin-based metal-organic framework (MOF) that greatly enhances sonocatalytic ability for SDT of MRSA-infected osteomyelitis. The MOF structure is modified using acetic acid and benzoic acid, and the defect-induced homojunction structure is found to improve the SDT effect by enhancing ultrasound-triggered reactive oxygen species production.
Article
Engineering, Biomedical
Yingchao Su, Jiayin Fu, Juncen Zhou, Elias Georgas, Shaokang Du, Yi-Xian Qin, Yadong Wang, Yufeng Zheng, Donghui Zhu
Summary: Zinc (Zn) is a bioresorbable metal that has potential applications in cardiovascular stent material, orthopedic implants, wound closure devices, etc. However, pure Zn is not ideal for these applications due to its low mechanical strength and localized degradation behavior. This study explores the alloying of Zn with selective transition metals (vanadium-V, chromium-Cr, and zirconium-Zr) to improve its properties. The blended alloys showed improved mechanical strength, suitable degradation rate, and acceptable biocompatibility, making them potential candidates for bioresorbable medical implants.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Xinghui Wei, Wenhao Zhou, Zhen Tang, Hao Wu, Yichao Liu, Hui Dong, Ning Wang, Hai Huang, Shusen Bao, Lei Shi, Xiaokang Li, Yufeng Zheng, Zheng Guo
Summary: This study enhanced the osseointegration capacity of PEEK materials through porous structural design and activated surface modification. The activated surface promoted cell proliferation, adhesion, osteoblast differentiation, and mineralization. The porous PEEK scaffolds facilitated vascular ingrowth and bone ingrowth, and the released Mg2+ accelerated early bone ingrowth by promoting angiogenesis.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Wenhao Zhou, Tian Bai, Lan Wang, Yan Cheng, Dandan Xia, Sen Yu, Yufeng Zheng
Summary: The combination of antimicrobial peptides and silver nanoparticles in a silk fibroin-based coating showed excellent infection-triggered antibacterial and osteointegration properties. The coating displayed sensitive pH-responsive behavior and a high antibacterial rate. In vivo experiments demonstrated enhanced osseointegration compared to untreated titanium implants.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jun Li, Chaofeng Wang, Shuilin Wu, Zhenduo Cui, Yufeng Zheng, Zhaoyang Li, Hui Jiang, Shengli Zhu, Xiangmei Liu
Summary: Currently, developing a self-disinfecting coating on touchscreens has become an urgent and meaningful task due to the increased public attention toward the spread of pathogenic viruses and bacteria. In this study, a ZnO-Fe2O3 superlattice nanofilm with engineered electronic defects is designed via atomic layer deposition for photocatalytic bactericidal and virucidal touchscreen. The nanofilm exhibits high antibacterial and antiviral efficacy (>90%) against drug-resistant bacteria and H1N1 viruses under simulated solar or low-power LED light irradiation, while also demonstrating excellent light transmission (>90%), abrasion resistance, and biocompatibility on touchscreens.
ADVANCED MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Pengxia Li, Bo Li, Caofeng Wang, Xiaoyan Zhao, Yufeng Zheng, Shuilin Wu, Jie Shen, Yu Zhang, Xiangmei Liu
Summary: Pathogenic bacterial infection and drug resistance pose a serious threat to human health. Phototherapy has emerged as a noninvasive and drug resistance-free approach for treating tissue infections. In this study, a Cu co-coordinated donor-acceptor type co-valent organic framework-like hydrogel was developed for the treatment of wound infection. The hydrogel exhibited photocatalytic and anti-inflammatory properties, achieving high bactericidal activity against Staphylococcus aureus and Escherichia coli under light irradiation. In vivo tests further demonstrated its ability to promote wound healing and tissue regeneration. This photocatalytic hydrogel offers a promising strategy for rapid reconstruction of infected tissues.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Chenxi Dou, Mingyang Zhang, Dechun Ren, Haibin Ji, Zhe Yi, Shaogang Wang, Zengqian Liu, Qiang Wang, Yufeng Zheng, Zhefeng Zhang, Rui Yang
Summary: A Mg-Ti composite with a bi-continuous and mutually interspersed architecture has been fabricated, showing potential as a new partially degradable and bioactive implant material.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Materials Science, Multidisciplinary
Yufeng Zheng, Xiao Liu, Danni Shen, Wenting Li, Yan Cheng, Ming Yang, Yuhui Kou, Baoguo Jiang
Summary: The study discusses the impact of metallic biomaterial implants on bone fracture healing and proposes the need for a precisely adaptable biomaterial that accurately recapitulates the targeted tissue at multiple levels. Compared to traditional bio-inert metallic implants, such as Co-based alloys and Ti alloys, biodegradable metal implants (Mg and Zn alloys) may introduce unexpected variables in bone repair due to their bioactive nature. The paper compares bone repair with and without metallic implants and proposes perspectives on the interactions between bone tissues and biodegradable metal implants, as well as suggestions for better mimicking in vivo biodegradation through in vitro experiments for further research and development of biodegradable metals.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuqian Qiao, Shuilin Wu, Yufeng Zheng, Chaofeng Wang, Zhaoyang Li, Yu Zhang, Shengli Zhu, Hui Jiang, Zhenduo Cui, Xiangmei Liu
Summary: Microwave (MV)-trigged dynamic therapy using MV-responsive materials shows promise for treating deep infection diseases, including life-threatening osteomyelitis, that are not effectively treated by antibiotics. Surface states of materials play a key role in the generation of free charges and the MV dynamic effects. A new MV responsive system, consisting of a 2D metal-organic framework (2D MOF) on oxidized carbon nanotube (CNT), is developed, which exhibits highly effective antimicrobial activity and eradicates Staphylococcus aureus infected rabbit tibia osteomyelitis under MV irradiation. This study represents a major advancement in antibiotic-free MV therapy for deep tissue bacterial infection.
Article
Chemistry, Multidisciplinary
Yuan Li, Shuilin Wu, Yufeng Zheng, Zhaoyang Li, Zhenduo Cui, Hui Jiang, Shengli Zhu, Xiangmei Liu
Summary: Interlayer interactions in 2D materials play a crucial role in promoting catalytic performance. This study demonstrates that asymmetric doping of metal nanoparticle clusters in g-C3N4 enhances catalytic efficiency by inducing microwave excitation of interlayer electron delocalization, leading to improved interlayer migration and enhanced microwave disinfection and pneumonia therapy. Hence, structurally modulated asymmetric doping of 2D materials can provide effective solutions for microwave-based disinfection and pneumonia therapy.
Review
Metallurgy & Metallurgical Engineering
Yuchien Hsu, Yupu Lu, Siyi Wang, Yufeng Zheng, Dandan Xia, Yunsong Liu
Summary: Magnesium alloys have great potential in tumor treatments due to their acceptable mechanical properties, good osteogenic and angiogenic properties. They can exhibit antitumor effect on various types of tumors and promote tissue regeneration after tumor elimination.
JOURNAL OF MAGNESIUM AND ALLOYS
(2023)
Article
Nanoscience & Nanotechnology
Chaofeng Wang, Wenchan Sun, Yiming Xiang, Shuilin Wu, Yufeng Zheng, Yu Zhang, Jie Shen, Lei Yang, Chunyong Liang, Xiangmei Liu
Summary: Sonodynamic-enhanced piezoelectric materials MoS2 and Cu(2)Oheterostructure that responds to exogenous ultrasound (US) and generates reactive oxygen for Staphylococcus aureus elimination are developed. Results show that the polariton charge induced by piezoelectric MoS2 nanosheets under US irradiation can accelerate the transfer of electric in Cu2O, and US irradiation induces valence conversion from Cu(I) to Cu(II), which can accelerate glutathione oxidation significantly and destroy the bacterial antioxidant defense system. The as-prepared piezoelectric-enhanced sonosensitizer possesses a highly effective antibacterial efficacy of 99.85% against S. aureus under US irradiation for 20 min, with good biocompatibility. Effective ultrasonic piezocatalytic therapy is offered through constructing heterogeneous interfaces with ultrasonic piezoelectric response.
