Article
Endocrinology & Metabolism
Maik Pietzner, Kathrin Budde, Malte Ruehlemann, Henry Voelzke, Georg Homuth, Frank U. Weiss, Markus M. Lerch, Fabian Frost
Summary: Exocrine pancreatic function is associated with changes in gut microbiota composition and blood metabolites, with a significant portion of the effect mediated through gut microbiota abundance changes, particularly affecting circulating serotonin and lysophosphatidylcholines.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Rheumatology
Lei Wang, Yiwen Wang, Pei Zhang, Chuan Song, Fei Pan, Gang Li, Lihua Peng, Yunsheng Yang, Zhimin Wei, Feng Huang
Summary: This study conducted a systematic review on the characteristics of gut microbiota in patients with Spondyloarthritis (SpA) compared to healthy controls, and found significant differences. Specific taxa-level differences were identified in different subtypes of SpA. The findings lay the groundwork for evidence-based microbial treatment.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Immunology
Zena Chen, Xuqi Zheng, Xinyu Wu, Jialing Wu, Xiaomin Li, Qiujing Wei, Xi Zhang, Linkai Fang, Ou Jin, Jieruo Gu
Summary: The study found that the gut microbiome was significantly restored in AS patients after adalimumab therapy, with a higher abundance of Comamonas in non-responders compared to responders, although no statistical difference was observed. These results suggest the potential of gut microbiome as biomarkers for therapeutic evaluation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pediatrics
Xinhe Sun, Yaoyao Cai, Wenwen Dai, Weiwei Jiang, Weibing Tang
Summary: There is an association between cholestatic liver disease and changes in microbiome composition. This study compared the differences in gut microbiome composition between infants with biliary atresia and infants with non-biliary atretic cholestasis, and identified biomarkers for identification and diagnosis of these two diseases.
Article
Parasitology
Soo Lim Kim, Jun Ho Choi, Myung-hee Yi, Seogwon Lee, Myungjun Kim, Singeun Oh, In-Yong Lee, Bo-Young Jeon, Tai-Soon Yong, Ju Yeong Kim
Summary: This study used NGS-based metabarcoding analysis to examine the gut microbiome of the striped field mouse and found that microbial composition varied with season and parasitic infection status. The results highlight the advantages of NGS technology in monitoring zoonotic disease reservoirs.
PARASITES & VECTORS
(2022)
Article
Immunology
Xiaolin Liu, Nina van Beek, Aleksa Cepic, Nadia A. Andreani, Cecilia J. Chung, Britt M. Hermes, Kaan Yilmaz, Sandrine Benoit, Kossara Drenovska, Sascha Gerdes, Regine Glaeser, Matthias Goebeler, Claudia Guenther, Anabelle von Georg, Christoph M. Hammers, Maike M. Holtsche, Franziska Huebner, Dimitra Kiritsi, Franziska Schauer, Beke Linnenmann, Laura Huilaja, Kaisa Tasanen-Maatta, Snejina Vassileva, Detlef Zillikens, Christian D. Sadik, Enno Schmidt, Saleh Ibrahim, John F. Baines
Summary: Bullous pemphigoid patients have altered gut microbiota composition and function, with decreased microbial diversity and overall changed microbial community. Disease-associated gut microbial features, including reduced Faecalibacterium prausnitzii and increased pathways related to gamma-aminobutyric acid metabolism, are observed in BP patients. These findings suggest that gut microbiota alterations may play a role in the development of bullous pemphigoid.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Jyoti Chhimwal, Prince Anand, Priyanka Mehta, Mohit Kumar Swarnkar, Vikram Patial, Rajesh Pandey, Yogendra Padwad
Summary: The importance of the gut-liver axis in the pathophysiology of metabolic dysfunction-associated fatty liver disease (MAFLD) is being investigated more closely in recent times. This study assesses the time-dependent gut dysbiosis in MAFLD, its implications in disease progression, and the role of plant-derived prebiotics in its attenuation.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Oxana M. Drapkina, German A. Ashniev, Olga A. Zlobovskaya, Adel A. Yafarova, Elena Dementeva, Anastasia N. Kaburova, Ivan O. Meshkov, Anna F. Sheptulina, Anton R. Kiselev, Anna Kontsevaya, Linar M. Zhamalov, Sergey N. Koretskiy, Mariya S. Pokrovskaya, Alexandra Akinshina, Anjelica Zagaynova, Mariia Lukashina, Andrey Kirillov, Ivan A. Abramov, Larisa R. Tolkacheva, Irina O. Bikaeva, Evgeniya Glazunova, German A. Shipulin, Maria M. Bobrova, Valentin V. Makarov, Anton A. Keskinov, Vladimir S. Yudin, Sergey M. Yudin
Summary: To further understand the pathogenesis of cardiovascular disease, this study explored the role of gut microbiota in atherosclerotic cardiovascular disease and heart failure, using multiple evaluation methods. The results showed some differences in microbiota composition between different disease groups and the control group, expanding the knowledge on the correlation between gut microbiota and cardiovascular diseases.
Review
Rheumatology
Victoria Navarro-Compan, Alexandre Sepriano, Bassel El-Zorkany, Desiree van der Heijde
Summary: Axial spondyloarthritis is a chronic inflammatory disease primarily affecting the axial skeleton, leading to symptoms such as chronic back pain and spinal stiffness. Diagnosis relies on recognizing clinical patterns and utilizing clinical, laboratory, and imaging features. Treatment options include non-steroidal anti-inflammatory drugs as first-line therapy, with biologics as a second-line option, showing efficacy in improving disease symptoms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Neurosciences
Kaijian Sun, Ying Cao, Yiting Chen, Qing Peng, Yugu Xie, Yunhao Luo, Hao Tian, Xin Li, Meiqin Zeng, Xin Zhang, Xifeng Li, Shixing Su, Xuying He, Chuanzhi Duan, Haitao Sun
Summary: In this study, the relationship between gut microbiome and symptomatic unruptured intracranial aneurysms (UIA) was investigated. It was found that there were significant differences in gut microbiome composition between symptomatic and asymptomatic UIA patients, with an enrichment of Clostridiales at the order level and alterations in the family levels of Ruminococcaceae. Functional differences were also observed, including a decreased propionate metabolism pathway and an enrichment of peptidoglycan biosynthesis pathways in patients with symptomatic UIA. These findings may have implications for the management and prognosis of UIA patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Veterinary Sciences
Shulin Fu, Yuzhen Yuan, Xinyue Tian, Linglu Zhou, Ling Guo, Dan Zhang, Jing He, Chun Peng, Yinsheng Qiu, Chun Ye, Yu Liu, Bingbing Zong
Summary: The gut microbiome plays a crucial role in maintaining host health, but excessive use of antibiotics can disrupt the gut flora and lead to serious diseases. This study aimed to investigate the impact of colistin on the composition of the gastrointestinal tract microbiome in piglets. The results showed that colistin can alter the microbiome composition in piglets, providing a new strategy for the rational use of colistin to protect animal and human health.
VETERINARY SCIENCES
(2022)
Article
Immunology
Chen Li, Yan Zhang, Qiulong Yan, Ruochun Guo, Changming Chen, Shenghui Li, Yue Zhang, Jinxin Meng, Jie Ma, Wei You, Zhisong Wu, Wen Sun
Summary: In this study, the gut virome of patients with ankylosing spondylitis (AS) was analyzed. AS patients showed a decrease in gut viral richness and an alteration of the overall viral structure. The study also identified differentially abundant viral operational taxonomic units (vOTUs) between AS patients and healthy controls, suggesting the potential of the gut virome for diagnosing AS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Syed Ishtiaq Anjum, Fahad Aldakheel, Ayesha Haleem Shah, Sanaullah Khan, Amjad Ullah, Riaz Hussain, Hikmatullah Khan, Mohammad Javed Ansari, Ahmed Hossam Mahmoud, Osama B. Mohammed
Summary: The gut microbiota of honey bees can be both symbiotic and pathogenic, playing a crucial role in bee survival and honey production. Through study of gut cultivable bacteria in honey bees from Pakistan, it was found that the forager Apis mellifera gut could act as a reservoir and potential vector of bacterial pathogens, with specific pathogenic bacteria such as Salmonella enterica and Shigella sonnei identified.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Feng Liao, Yilan Xia, Wenpeng Gu, Xiaoqing Fu, Bing Yuan
Summary: Compared to 16S rDNA sequencing, metagenomic sequencing is more suitable for the discovery and detection of pathogenic bacteria in the gut microbiota of seagulls. There are differences in the results of the two sequencing methods following the refinement of taxonomic levels.
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.