Article
Multidisciplinary Sciences
Chung-Yuan Liao, Li-Chieh Wang, Jyh-Hong Lee, Kuan-Wen Wu, Yu-Tsan Lin, Yao-Hsu Yang, Bor-Luen Chiang, Hsin-Hui Yu
Summary: Growing pains is a common syndrome characterized by bilateral leg pain in children, without standardized diagnostic criteria. Elevated levels of alkaline phosphatase and lactate dehydrogenase may be associated with this condition.
SCIENTIFIC REPORTS
(2022)
Review
Pediatrics
Mary O'Keeffe, Steven J. Kamper, Laura Montgomery, Amanda Williams, Alexandra Martiniuk, Barbara Lucas, Amabile B. Dario, Michael S. Rathleff, Lise Hestbaek, Christopher M. Williams
Summary: This study examines the definitions of growing pains in the medical literature and finds a lack of consensus among studies. Lower limb pain is the most consistent characteristic, while other features such as pain in the evening or night, episodic or recurrent course, normal physical assessment, and bilateral pain are mentioned less frequently. The study highlights the need for clarity in defining growing pain and cautions clinicians against relying solely on this diagnosis for treatment decisions.
Article
Computer Science, Interdisciplinary Applications
Fuat Akal, Ezgi D. Batu, Hafize Emine Sonmez, Serife G. Karadag, Ferhat Demir, Nuray Aktay Ayaz, Betul Sozeri
Summary: Growing pains are the most common cause of recurrent musculoskeletal pain in children. This study used machine learning models to classify growing pains and identified relevant characteristics. The random forest algorithm showed the best performance for growing pains diagnosis, with an accuracy of 0.98, sensitivity of 0.99, and specificity of 0.97. This is the largest cohort study of children with growing pains and the first attempt to diagnose growing pains using machine learning techniques.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2022)
Article
Computer Science, Hardware & Architecture
Phil Laplante
Summary: Software engineering has a significant amount of progress to make before it can reach the level of other established scientific or engineering disciplines.
Editorial Material
Biochemistry & Molecular Biology
Jens Puschhof, Eran Elinav
Summary: Human microbiome research is transitioning from association-based studies to understanding the effects of active strains on the human body. Despite challenges, progress has been made in utilizing data-driven microbiome diagnostics and interventions, potentially leading to breakthroughs in precision medicine in the next decade.
Article
Clinical Neurology
Raimundo Pereira Silva-Neto, Adriana de Almeida Soares, Wallyson Pablo de Oliveira Souza, Ana Gabriela Krymchantowski, Carla Jevoux, Abouch Krymchantowski
Summary: This study aimed to investigate the relationship between growing pains (GP) and migraine in children and adolescents. The results showed that a significant number of patients with GP also had migraine symptoms. Furthermore, some patients who were previously asymptomatic for GP developed symptoms of growing pains during the follow-up period.
Review
Engineering, Biomedical
Aleczandria S. Tiffany, Brendan A. C. Harley
Summary: This review provides an overview of growth plates, their role in skeletal development, injuries and diseases associated with growth plates, and the opportunities and challenges for developing biomaterial models for studying growth plate biology and diseases. It also describes the potential of sophisticated in vitro biomaterial models for studying growth plate remodeling and developing tissue engineering applications.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Ecology
Samuel C. Ginther, Hayley Cameron, Craig R. White, Dustin J. Marshall
Summary: The study aims to investigate the prevalence of different reproductive metrics in species and analyze their relationships and compatibility. The results show that ambiguous reproductive metrics are generally poor predictors of reproductive mass per year, and the lack of data hinders the construction of comprehensive reproductive mass indicators.
GLOBAL ECOLOGY AND BIOGEOGRAPHY
(2022)
Article
Computer Science, Artificial Intelligence
Anna Lukkarinen, Rotem Shneor, Jyrki Wallenius
Summary: This study examines the characteristics and implications of maturation in the equity crowdfunding industry through the lens of industry life cycle theory. The findings suggest that equity crowdfunding is converging towards traditional entrepreneurial finance practice while still maintaining certain unique features, providing guidance for platform managers and entrepreneurs in planning fundraising campaigns.
DECISION SUPPORT SYSTEMS
(2022)
Article
Business
Liang Chen, Pengxiang Zhang, Sali Li, Scott F. Turner
Summary: Strategy research suggests firms should continuously introduce generational improvements on existing products to capture generative value, but this could potentially have negative impacts on consumers by disrupting their established behavioral patterns, especially for products with longer technological legacies.
STRATEGIC MANAGEMENT JOURNAL
(2022)
Article
Medical Laboratory Technology
Huamei Li, Bing Wang, Lin He, Ran Tao, Shiqiang Shang
Summary: The study found that serum levels of Ca, P, PINP, and PTH could be independent diagnostic factors associated with GP, and a combination of these factors can improve diagnostic potential, with the multivariable logistic regression analysis resulting in an AUC of 0.655.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Clinical Neurology
Marta Moraleda-Cibrian, Sean Edwards, Steven Kasten, Seth Warschausky, Steven Buchman, Louise O'Brien
Summary: This study examined the frequency and impact of sleep-related movement disorders and growing pains in young children with cleft palate. The results showed that children who reported PLMS and RLS were more likely to have sleep problems and exhibited more behavioral and emotional issues.
Article
Biodiversity Conservation
Scott D. Evans, James G. Gehling, Douglas H. Erwin, Mary L. Droser
Summary: By studying well-preserved Dickinsonia costata specimens, researchers tested competing hypotheses for module addition location and found patterns related to growth that share similarities with those regulated by morphogen gradients in metazoans today.
Article
Clinical Neurology
Dilsad Turkdogan, Ramin Mahmudov
Summary: Restless legs syndrome (RLS) and growing pains (GPs) share some clinical features, but a combined phenotype is very rare.
BRAIN & DEVELOPMENT
(2022)
Article
Economics
Shaoshuai Li, Zhigang Li, Jinlan Ni, Jia Yuan
Summary: Transboundary pollution spillovers have become a significant global issue. The study investigates the environmental externalities of pollution between China and South Korea and proposes a new identification strategy to examine the pollution spillovers. The evidence shows significant bilateral environmental externalities, highlighting the need for joint efforts to address environmental challenges.
CHINA ECONOMIC REVIEW
(2023)
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.