Article
Biochemistry & Molecular Biology
Hyeok Kim, Soon-Jung Park, Jae-Hyun Park, Sunghun Lee, Bong-Woo Park, Soon Min Lee, Ji-Won Hwang, Jin-Ju Kim, Byeongmin Kang, Woo-Sup Sim, Hyo-Jin Kim, Seung Hwan Jeon, Dong-Bin Kim, Jinah Jang, Dong-Woo Cho, Sung-Hwan Moon, Hun-Jun Park, Kiwon Ban
Summary: Researchers have successfully used a combination of two different types of stem cells to repair failed hearts by creating new blood vessels. This dual stem cell treatment improves cardiac function and results in a higher number of larger and stronger new blood vessels.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Zi Guo, Zhaohui Mo
Summary: During vertebrate development, the cardiovascular system becomes functional earlier than other organs. Endothelial cells play a crucial role in vasculogenesis and angiogenesis, with cellular biology and epigenetics being important factors in these processes. There is growing interest in the role of proteins and signaling molecules in controlling embryonic vascular development, and the transplantation of iPSC-ECs shows promise in treating cardiovascular diseases. However, challenges in maintaining cell viability and function limit the clinical application of iPSC-ECs in regenerative medicine.
Review
Clinical Neurology
Antia Custodia, Alberto Ouro, Joao Sargento-Freitas, Marta Aramburu-Nunez, Juan Manuel Pias-Peleteiro, Pablo Hervella, Anna Rosell, Lino Ferreira, Jose Castillo, Daniel Romaus-Sanjurjo, Tomas Sobrino
Summary: Ischemic stroke is a common cause of death and disability in developed countries. Current therapeutic options are limited, so there is a need for novel treatments. Endothelial progenitor cells (EPCs) have been shown to repair damaged vessels and generate new ones. EPCs appear to be a promising target for stroke treatment, promoting re-endothelialization, angiogenesis, and vasculogenesis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Antonio Filippini, Luca Tamagnone, Alessio D'Alessio
Summary: Recent findings suggest that targeting endothelial cell metabolism may be an alternative strategy for antiangiogenic therapy and a novel approach for treating cardiovascular diseases. Understanding how endothelial cells adapt their metabolic status in response to changes in the tissue microenvironment could help develop innovative treatments to counteract abnormal blood vessel growth.
Review
Cell Biology
Mehdi Hassanpour, Amankeldi A. Salybekov, Shuzo Kobayashi, Takayuki Asahara
Summary: CD34 is a cell surface antigen expressed in stem/progenitor cells such as HSCs and EPCs, which are potential sources for regenerative therapy. CD34(+) cells have been shown to improve therapeutic angiogenesis through direct incorporation and paracrine activity. Preclinical, pilot, and clinical trials have demonstrated the safety and efficacy of CD34(+) cell therapy in various diseases. However, the clinical application of CD34(+) cell therapy has sparked debates and controversies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Yiting Zhang, Jianping Hu, Xiaoying Qu, Ke Hu
Summary: The circular RNA circRSU1 is upregulated in diabetic retinopathy patients and its interaction with miR-345-3p leads to increased TAZ levels, which contribute to the development of vascular dysfunction. Diabetic retinopathy is a major cause of visual impairment and blindness in adults with diabetes mellitus. Although circRNAs have been implicated in vascular progression, the exact role of circRNAs in diabetes-induced vascular complications remains largely unknown. The authors found that circRSU1 was significantly upregulated in diabetic retinopathy patients. Further experiments showed that knockdown of circRSU1 alleviated diabetes-induced retinal vascular dysfunction, including decreased levels of vascular endothelial growth factor, reduced inflammatory responses, and diminished oxidative stress. The study also revealed that circRSU1 interacts with miR-345-3p to upregulate TAZ expression, and downregulation of TAZ reversed the vascular dysfunction caused by increased circRSU1 expression under high glucose conditions. In conclusion, the overexpression of circRSU1 promotes vascular dysfunction through its interaction with miR-345-3p to increase TAZ levels in diabetic conditions. The findings suggest that circRSU1 may serve as a potential therapeutic target for treating vascular dysfunction in diabetes mellitus.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sabrina Summer, Eva Rossmanith, Markus Pasztorek, Constantin Fiedler, Marion Groeger, Sabine Rauscher, Viktoria Weber, Michael B. Fischer
Summary: Mesenchymal stem cells play a crucial role in supporting endothelial cells during tissue regeneration and new vessel formation. By co-culturing these cells in a specific microenvironment, complex vascular networks can be formed. Under dynamic flow conditions, mesenchymal stem cells can bind to damaged endothelial cells, potentially aiding in the healing process.
Review
Biotechnology & Applied Microbiology
Hiba Asrar, Abigail S. Tucker
Summary: Major organs and tissues require close association with the vasculature during development and for later function. Recent research has revealed novel roles for endothelial cells in tissue morphogenesis and differentiation, highlighting the importance of providing a vasculature when constructing tissues and organs for tissue engineering. Important signaling pathways regulating the cross talk between endothelial cells and their environment have been identified in various organ systems.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Hematology
Gregoire Detriche, Nicolas Gendron, Aurelien Philippe, Maxime Gruest, Paul Billoir, Elisa Rossi, Coralie L. Guerin, Anna Lokajczyk, Severine Brabant, Dominique Prie, Tristan Mirault, David M. Smadja
Summary: Gonadotropins increase ECFC-related angiogenesis and may be involved in thrombin generation in cardiovascular disease. Gonadotropins may act as biomarkers; moreover, we hypothesize that gonadotropin-blocking strategies may be a novel interesting therapeutic approach in atherosclerotic cardiovascular disease.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Oncology
Ghazaleh Hashemi, James Dight, Kiarash Khosrotehrani, Laura Sormani
Summary: Melanoma is an aggressive and potentially lethal form of skin cancer. The role of blood vessel formation, particularly endothelial progenitor cells (EPCs), in melanoma is of significance. Understanding the role of EPCs is important for understanding the abnormal vessel structures in melanoma. The effect of anti-angiogenic drugs on melanoma treatment needs further research.
Review
Medicine, General & Internal
Serena Barachini, Sandra Ghelardoni, Rosalinda Madonna
Summary: Vascular progenitor cells are activated to repair and form a neointima following various vascular damages. They not only play a role in resolving vascular lesions, but also contribute to neovascularization and angiogenesis associated with cancer. This review discusses the biology and pathophysiology of vascular progenitor cells, including their origins, stimuli, and activated pathways. It focuses on their involvement in tumor-induced vascular injury and their implications in promoting tumor angiogenesis during cancer proliferation and migration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Cell Biology
Fanchen Yan, Jing Li, Wei Zhang
Summary: Endothelial Progenitor Cells (EPCs) are precursor cells that can differentiate into vascular endothelial cells, protecting against dysfunction and tissue ischemia. They have been used in transplantation strategies for their beneficial effects on vasculogenesis and paracrine effects. Despite its importance, there are still challenges in the clinical application of EPCs. This review summarizes the characteristics of EPCs, their role in promoting healing of ischemic tissue through transplantation, and ways to improve efficiency. It also discusses the application of EPCs in neurological improvement, cardiovascular and respiratory diseases, and the challenges in clinical application.
Review
Biochemistry & Molecular Biology
Eshaan Patnaik, Matthew Lyons, Kimberly Tran, Debendra Pattanaik
Summary: Systemic sclerosis, also known as scleroderma, is an autoimmune disorder characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. Endothelial damage and activation occur early, possibly triggered by various factors, leading to defective angiogenesis and fibrosis. The aim of this review is to discuss the molecular aspect of endothelial dysfunction that contributes to the development of systemic sclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Kevin T. Campbell, Matthew B. Curtis, Joshua M. Massey, Kajetan Wysoczynski, Dustin J. Hadley, Steve C. George, Eduardo A. Silva
Summary: Lymphatic dysfunction is associated with the progression of several vascular disorders, and there are limited strategies currently available to promote new lymphatic vasculature. This study isolated lymphatic endothelial progenitor cells from human umbilical cord blood and found that they have the potential to promote lymphatic sprouts, highlighting the therapeutic potential of these cells. Delivery of lymphatic EPCs using alginate hydrogels also showed promise for possible therapeutic applications.
ACTA BIOMATERIALIA
(2021)
Article
Rheumatology
Jerome Avouac, Corinne Miceli-Richard, Alice Combier, Alexia Steelandt, Olivier Fogel, Alice Andree Mariaggi, Jean-Francois Meritet, Flore Rozenberg, Anna Molto, Yannick Allanore
Summary: This study aimed to identify factors influencing the humoral response to COVID-19 vaccination in RTX-treated patients. The results showed that B cell depletion was the main contributing factor to the antibody response in these patients, and monitoring CD19 levels may help determine the optimal timing for vaccination.
Review
Rheumatology
Michael Hughes, Elisabetta Zanatta, Robert D. Sandler, Jerome Avouac, Yannick Allanore
Summary: This study found that despite the heterogeneity and scarcity of vascular disease in SSc, there have been significant improvements in various vascular complications over time, leading to improved survival rates for patients.
Article
Rheumatology
Amber Vanhaecke, Maurizio Cutolo, Oliver Distler, Valeria Riccieri, Yannick Allanore, Christopher P. Denton, Eric Hachulla, Francesca Ingegnoli, Ellen Deschepper, Jerome Avouac, Suzana Jordan, David Launay, Karin Melsens, Carmen Pizzorni, Alberto Sulli, Massimiliano Vasile, Ariane L. Herrick, Vanessa Smith
Summary: Nailfold videocapillaroscopy (NVC) may be a promising biomarker in SSc, as it is associated with novel severe organ involvement/progression.
Correction
Medicine, General & Internal
Dianna M. Milewicz, Alan C. Braverman, Julie De Backer, Shaine A. Morris, Catherine Boileau, Irene H. Maumenee, Guillaume Jondeau, Arturo Evangelista, Reed E. Pyeritz
NATURE REVIEWS DISEASE PRIMERS
(2022)
Review
Biochemistry & Molecular Biology
Zakaria Mougin, Julia Huguet Herrero, Catherine Boileau, Carine Le Goff
Summary: Extracellular matrix (ECM) in the vascular wall is a dynamic structure composed of different molecules. Metalloproteases, including ADAMTS proteins, play a key role in maintaining ECM homeostasis. This review focuses on the potential role of ADAMTS proteins in the development of thoracic and abdominal aortic aneurysms, providing new insights on the involvement of the ADAMTS family in these pathologies.
Letter
Rheumatology
Jerome Avouac, Roba Ghossan, Omar Al Tabaa, Alice Combier, Alexia Steelandt, Marion Thomas, Olivier Fogel, Alice Andree Mariaggi, Jean-Francois Meritet, Flore Rozenberg, Anna Molto, Corinne Miceli-Richard, Yannick Allanore
Article
Biochemistry & Molecular Biology
Yara Azar, Marie-Helene Gannage-Yared, Elie Naous, Carine Ayoub, Yara Abou Khalil, Elise Chahine, Sandy Elbitar, Youmna Ghaleb, Catherine Boileau, Mathilde Varret, Petra El Khoury, Marianne Abifadel
Summary: Elevated levels of PCSK9 in adults have been associated with increased LDL-C, TG, and worse cardiovascular outcomes. However, few studies have analyzed the relation between PCSK9 and lipid parameters in pediatric populations. This study found that serum PCSK9 levels were significantly correlated with TC, LDL-C, and non-HDL-C levels in Lebanese school children. Further studies are needed to determine if PCSK9 measurements have additional value in predicting cardiovascular outcomes in pediatric populations.
Article
Rheumatology
Jerome Avouac, Anna Molto, Camelia Frantz, Sarah Wanono, Elise Descamps, Olivier Fogel, Alice Combier, Lucile Poiroux, Corinne Miceli-Richard, Yannick Allanore
Summary: This study identified patient-reported RA flares and increased CRP values as important indicators in teleconsultation, which are associated with therapeutic modification and the need for a face-to-face consultation.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Amandine Gouverneur, Jerome Avouac, Clement Prati, Jean-Luc Cracowski, Thierry Schaeverbeke, Antoine Pariente, Marie-Elise Truchetet
Summary: The use of baricitinib and tofacitinib is associated with an increased risk of venous thromboembolic events (VTE) and arterial thromboembolic events (ATE).
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Marianne Abifadel, Catherine Boileau
Summary: Atherosclerotic cardiovascular disease is a major cause of death worldwide, and familial hypercholesterolemia (FH) is a commonly inherited disease with significant risks. Advances in genetic research have greatly improved the diagnosis and treatment of FH, providing more therapeutic options.
JOURNAL OF INTERNAL MEDICINE
(2023)
Editorial Material
Rheumatology
Marion Thomas, Jerome Avouac
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Vincent Di Martino, Delphine Weil Verhoeven, Frank Verhoeven, Francois Aubin, Jerome Avouac, Lucine Vuitton, Frederic Liote, Thierry Thevenot, Daniel Wendling
Summary: Methotrexate is an important treatment for inflammatory rheumatic diseases, especially rheumatoid arthritis. Liver toxicity is a concern for long-term methotrexate therapy, particularly in patients with non-alcoholic fatty liver disease (NAFLD). Understanding the mechanisms of hepatotoxicity and liver fibrosis is crucial for pretreatment screening and long-term monitoring in patients with chronic liver disease.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Rheumatology
Jerome Avouac, Anne Cauvet, Cindy Orvain, Morgane Boulch, Francoise Tilotta, Ly Tu, Raphael Thuillet, Mina Ottaviani, Christophe Guignabert, Philippe Bousso, Yannick Allanore
Summary: This study aimed to investigate the efficacy of two B cell depletion strategies, including CD19-targeted CAR T cells, in a preclinical model of severe lung damages observed in systemic sclerosis. The study evaluated B cell depletion strategies in Fra-2 Tg mice. The results showed that CD19-targeted CAR-T cells in combination with anti-CD20 monoclonal antibody achieved deeper B cell depletion compared to anti-CD20 monoclonal antibody alone in both peripheral blood and lesional lungs of Fra-2 Tg mice. However, CAR-T cell infusion worsened the clinical score and increased mortality in Fra-2 Tg mice. CAR-T cell infusion also resulted in increased lung collagen content, histological fibrosis score, and right ventricular systolic pressure. CAR-T cells accumulated in lesional lungs and promoted T activation and inflammatory cytokine production. On the other hand, treatment with anti-CD20 monoclonal antibody alone had no impact on lung inflammation-driven fibrosis and pulmonary hypertension.
ARTHRITIS & RHEUMATOLOGY
(2023)
Letter
Rheumatology
Paola Vidal-Montal, Marion Thomas, Alice Combier, Alexia Steelandt, Corinne Miceli-Richard, Anna Molto, Javier Narvaez, Joan Miquel Nolla, Yannick Allanore, Jerome Avouac
Article
Engineering, Biomedical
Anne-Charlotte Ponsen, Richard Proust, Sabrina Soave, Francoise Mercier-Nome, Isabelle Garcin, Laurent Combettes, Jean-Jacques Lataillade, Georges Uzan
Summary: The zinc-supplemented calcium alginate compress, HEMO-IONIC, has a long-term positive effect on tissue repair by promoting angiogenesis, cell recruitment, and extracellular matrix maturation.
BIOACTIVE MATERIALS
(2022)
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.
