Article
Biochemistry & Molecular Biology
Johan Lindqvist, Justin Kolb, Josine de Winter, Paola Tonino, Zaynab Hourani, Siegfried Labeit, Coen Ottenheijm, Henk Granzier
Summary: Nemaline myopathy is a disease characterized by skeletal muscle weakness and atrophy. This study found that levels of the protein MuRF1 are significantly increased in patients with nebulin-based Nemaline myopathy and mouse models of the disease. Knocking out the MuRF1 gene in mouse models led to increased muscle size but did not improve muscle function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dulce Peris-Moreno, Laura Cussonneau, Lydie Combaret, Cecile Polge, Daniel Taillandier
Summary: Skeletal muscle loss is a harmful side effect of chronic diseases, increasing mortality and morbidity. The ubiquitin proteasome system plays a key role in regulating muscle contraction and metabolism through targeting key proteins for degradation or activity modulation via E3 ubiquitin ligases.
Article
Biochemistry & Molecular Biology
Kristina Sharlo, Irina Lvova, Sergey Tyganov, Ksenia Zaripova, Svetlana Belova, Tatiana Kostrominova, Boris Shenkman, Tatiana Nemirovskaya
Summary: Skeletal muscle abnormalities and atrophy during unloading can be attributed to excess calcium accumulation, which may be caused by the inhibition of SERCA activity. Treating with SERCA activator CDN1163 can reduce calcium level, thus preventing negative consequences. In this study, unloading for 7 days led to increased fatigue, decreased mitochondrial markers and slow-type myosin, and disrupted calcium homeostasis in Soleus muscle. These changes were prevented by SERCA activation but had no effect on muscle atrophy.
Article
Food Science & Technology
Young-Sool Hah, Won Keong Lee, Sangyeob Lee, Jin-Hee Seo, Eun Ji Kim, Yeong-in Choe, Sang Gon Kim, Jun-Il Yoo
Summary: Sarcopenia, the loss of muscular mass and strength with aging, leads to functional impairment, increased risk of falls and fractures, and loss of independence. Coumestrol has been found to inhibit skeletal muscle loss, but its protective mechanism is poorly understood. This study investigated the protective effect of coumestrol against dexamethasone-induced muscle atrophy using in vitro and in vivo analyses. The results suggest that coumestrol may attenuate dexamethasone-induced muscle atrophy by blocking the ubiquitin-proteasome pathway through suppressing AMPK-FoxO1/3 signaling. Therefore, coumestrol could be a potential treatment for aging sarcopenia.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Young-Sool Hah, Won Keong Lee, Sangyeob Lee, Eun Ji Kim, Jung Hyeon Lee, Seung-Jun Lee, Yeong Ho Ji, Sang Gon Kim, Hyeong-Hwan Lee, Seo Yeon Hong, Jun-Il Yoo
Summary: Sarcopenia is the decline in muscle mass and strength with age, resulting in impaired daily functions and increased risk of falls and fractures. β-sitosterol has shown potential to prevent muscle loss and has a protective effect on muscle mass in mice and cell models.
Article
Geriatrics & Gerontology
Volker Adams, Antje Schauer, Antje Augstein, Virginia Kirchhoff, Runa Draskowski, Anett Jannasch, Keita Goto, Gemma Lyall, Anita Maennel, Peggy Barthel, Norman Mangner, Ephraim B. Winzer, Axel Linke, Siegfried Labeit
Summary: MyoMed-205 improved myocardial diastolic function and prevented SKM atrophy/function in the HFpEF animal model. Mechanistically, SKM benefited from attenuation of the ubiquitin proteasome system and increased synthesis/activity of proteins of the mitochondrial respiratory chain, while the myocardium benefited from reduced titin modifications and fibrosis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Dongmei Fan, Yue Wang, Bowei Liu, Fuzai Yin
Summary: This study found that low muscle mass is an independent risk factor for type 2 diabetes, and the hypoglycemic drug liraglutide can alleviate low muscle mass by inhibiting the expression of muscle-specific ubiquitin protease E3.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Chuncheng Liu, Lei Li, Mengxu Ge, Lijie Gu, Kuo Zhang, Yang Su, Yuying Zhang, Chang Liu, Miaomiao Lan, Yingying Yu, Tongtong Wang, Bing Zhang, Guangbin Zhou, Qingyong Meng
Summary: Research has shown that the miR-29ab1 cluster plays a critical role in maintaining skeletal muscle function by inhibiting muscle atrophy. MiR-29a and b can resist muscle atrophy, with MuRF1 being the direct target gene of miR-29a and b.
DNA AND CELL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Piao Wang, Seok Yong Kang, Su Jin Kim, Yong-Ki Park, Hyo Won Jung
Summary: This study investigated the effects of monotropein (MON) on improving dexamethasone (DEX)-induced muscle atrophy in mice and C2C12 mouse skeletal muscle cells. MON improved muscle atrophy by regulating catabolic states via the AKT/mTOR/FOXO3a signaling pathways and enhanced muscle function by increasing muscle mass and strength in mice.
Article
Biochemistry & Molecular Biology
Daniela Aravena-Canales, Jorge E. Aedo, Alfredo Molina, Juan Antonio Valdes
Summary: This study revealed that cortisol plays a complex regulatory role in the expression of atrogenes in rainbow trout skeletal muscle, with both early downregulation and later upregulation observed. Membrane-initiated cortisol action was found to regulate murf1 gene expression in rainbow trout myotubes, while having no significant effect on atrogin-1.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Plant Sciences
Young Mi Seok, Jae-Myung Yoo, Yoonju Nam, Jungeun Kim, Jin Soo Kim, Jun-Ho Son, Hyo Jung Kim
Summary: The study showed that mountain ginseng inhibits dexamethasone-induced muscle atrophy by decreasing MuRF1 and atrogin1, and has positive effects on L6 myotubes.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siegfried Labeit, Stephanie Hirner, Julijus Bogomolovas, Andre Cruz, Moldir Myrzabekova, Anselmo Moriscot, Thomas Scott Bowen, Volker Adams
Summary: The muscle-specific ubiquitin ligase MuRF1 is involved in regulating muscle catabolism during chronic wasting states, with potential implications for glucose and fat metabolism regulation. Knockout mice for MuRF1 and MuRF2 show elevated serum glucose, triglycerides, and perturbed signaling pathways related to glucose and fat metabolism. Adenoviral re-expression of MuRF1 in KO mice helps normalize metabolic parameters, while the inhibitors MyoMed-205 and MyoMed-946 show potential in attenuating muscle weakness in a mouse model for T2DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Education, Scientific Disciplines
Qi-Yu Xu, Quan-Bing Zhang, Yun Zhou, A-Ying Liu, Feng Wang
Summary: The study showed that ultrashort wave diathermy can effectively alleviate myogenic contracture and delay muscle atrophy during joint immobilization. This effect may be attributed to the increased expression of MyoD triggered by suppression of the MAFbx-1-mediated ubiquitin-proteasome pathway.
Article
Biochemistry & Molecular Biology
Fernando Ribeiro, Paula K. N. Alves, Luiz R. G. Bechara, Julio C. B. Ferreira, Siegfried Labeit, Anselmo S. Moriscot
Summary: This study investigated the protective effects of a small-molecule inhibitor called MyoMed-205 against early diaphragmatic dysfunction (DIDD) after 12 hours of unilateral diaphragm denervation. The results showed that a dosage of 50 mg/kg bw of MyoMed-205 effectively prevented early DIDD without causing acute toxicity. The findings suggest that inhibiting MuRF1 activity, such as with MyoMed-205, could be a potential therapeutic strategy for treating early DIDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ksenia A. Zaripova, Ekaterina P. Kalashnikova, Svetlana P. Belova, Tatiana Y. Kostrominova, Boris S. Shenkman, Tatiana L. Nemirovskaya
Summary: The findings suggest that PANX1 ATP-permeable channels play a crucial role in regulating muscle atrophy processes by modulating the expression of E3 ligases, as well as protein translation and elongation processes during unloading.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Valentino Coppa, Mario Marinelli, Nicola Specchia
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2019)
Article
Orthopedics
Luigi de Palma, Roberto Procaccini, Andrea Soccetti, Mario Marinelli
Article
Orthopedics
Luigi de Palma, Roberto Candelari, Ettore Antico, Rocco Politano, Eugenio Luniew, Maurizio Giordanengo, Silvio Di Giansante, Mario Marinelli, Enrico Paci
Article
Critical Care Medicine
A. Gigante, N. Setaro, M. Rotini, S. S. Finzi, M. Marinelli
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2018)
Review
Orthopedics
Valentino Coppa, Mario Marinelli, Monia Martiniani, Anna M. Giacchetta, Antonio P. Gigante, Nicola Specchia
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2020)
Article
Orthopedics
Daniele Massetti, Mario Marinelli, Giulia Facco, Danya Falcioni, Nicola Giampaolini, Nicola Specchia, Antonio Pompilio Gigante
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2020)
Article
Orthopedics
Senesi Letizia, Marinelli Mario, Ponzio Isabella, Facco Giulia, Falcioni Danya, Riccio Michele, Gigante Antonio
Summary: This retrospective study evaluates the frequency, incidence, treatment and outcomes of foot fractures, with a focus on complex trauma of the foot (CTF) which affects both soft tissue and bone. CTF leads to significant residual disability and profoundly affects quality of life, as observed in the study.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2021)
Review
Orthopedics
Marco Baldini, Valentino Coppa, Danya Falcioni, Elisa Senigagliesi, Mario Marinelli, Antonio Pompilio Gigante
Summary: The study aimed to analyze the safety and efficacy of resorbable Mg screws in orthopaedic procedures in skeletally immature patients. A total of 14 patients were retrospectively reviewed, showing stable fixation with Mg screws, good clinical and radiological results, and no adverse events. Systematic review revealed promising results in adults and limited evidence in children.
JOURNAL OF CHILDRENS ORTHOPAEDICS
(2021)
Letter
Orthopedics
Marco Baldini, Valentino Coppa, Danya Falcioni, Elisa Senigagliesi, Mario Marinelli, Antonio Pompilio Gigante
JOURNAL OF CHILDRENS ORTHOPAEDICS
(2022)
Article
Orthopedics
Marco Baldini, Valentino Coppa, Danya Falcioni, Giuseppe Cusano, Daniele Massetti, Mario Marinelli, Antonio Pompilio Gigante
Summary: This study compared the surgical fixation of medial epicondyle fractures using resorbable magnesium Herbert screws and K-wires in skeletally immature patients. Results showed no significant differences in alignment, pain, range of motion, and Mayo Elbow Performance Score between the two groups. However, the magnesium screws group potentially had a lower incidence of non-union and infection.
JOURNAL OF CHILDRENS ORTHOPAEDICS
(2022)
Article
Orthopedics
Ruben Zwiers, Johannes G. G. Dobbe, Geert J. Streekstra, Leendert Blankevoort, Johannes I. Wiegerinck, Mario Maas, C. Niek van Dijk
JOURNAL OF ISAKOS JOINT DISORDERS & ORTHOPAEDIC SPORTS MEDICINE
(2019)
Review
Pharmacology & Pharmacy
A. Gigante, V Coppa, M. Marinelli, N. Giampaolini, D. Falcioni, N. Specchia
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2019)
Article
Orthopedics
Valentino Coppa, Luca Dei Giudici, Stefano Cecconi, Mario Marinelli, Antonio Gigante
STRATEGIES IN TRAUMA AND LIMB RECONSTRUCTION
(2017)
Article
Orthopedics
Francesca Giovannini, Luigi de Palma, Andrea Panfighi, Mario Marinelli
STRATEGIES IN TRAUMA AND LIMB RECONSTRUCTION
(2016)
Article
Surgery
Marco Cianforlini, Mario Marinelli, Isabella Ponzio, Luigi de Palma
JOURNAL OF SURGICAL CASE REPORTS
(2014)
Review
Rheumatology
Maria Chiara Maccarone, Daniele Coraci, Gianluca Regazzo, Nicola Sarandria, Anna Scanu, Stefano Masiero
Summary: Long COVID syndrome refers to the new, returning, or persistent symptoms after the initial SARS-CoV-2 infection. Musculoskeletal symptoms have a significant impact on the quality of life in many patients. A literature review was conducted to explore the evolution of musculoskeletal symptoms in Long COVID syndrome. The findings highlight the need for interdisciplinary management and timely rehabilitative interventions.
Review
Rheumatology
Alexis Mathian, Renaud Felten, Marta E. Alarcon-Riquelme, Antony Psarras, Philippe Mertz, Francois Chasset, Edward M. Vital, Laurent Arnaud
Summary: Improved understanding of the molecular basis of innate immunity has led to the recognition of type I interferons (IFNs) as key mediators in the development of immunemediated inflammatory diseases (IMIDs). Pharmacological targeting of IFNs and their downstream signaling pathways, such as JAK1 and Tyk2, holds promise for the treatment of IMIDs.
Review
Rheumatology
Marie Robert, Marc Scherlinger
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and organ injury, involving the active role of platelets in the pathogenesis and disease progression. Platelets in SLE patients show intrinsic differences and can perpetuate inflammation by interacting with immune cells, thereby participating in organ damage and heightened cardiovascular mortality.
Review
Rheumatology
Jean Sibilia, Fabrice Berna, Jean-Gerard Bloch, Marc Scherlinger
Summary: Mind-body practices, such as mindfulness meditation, yoga, and Tai Chi, show promise in improving patient-reported outcomes in chronic rheumatic diseases, but their impact on inflammation and structural progression remains unclear.
Review
Rheumatology
Anne Tournadre, Marine Beauger
Summary: Obesity alters the characteristics of adipose tissue, leading to chronic low-grade inflammation, increased risk of chronic inflammatory diseases, and impact on treatment efficacy. Dietary and weight adjustments have a positive effect on improving inflammatory rheumatic diseases.
Article
Rheumatology
Romain Fore, Eric Liozon, Stephanie Dumonteil, Thomas Sene, Emmanuel Heron, Valentin Lacombe, Mathilde Leclercq, Julie Magnant, Clement Beuvon, Alexis Regent, Donatienne de Mornac, Maxime Samson, Perrine Smets, Jean-Francois Alexandra, Brigitte Granel, Pierre-Yves Robert, Muhammad Faiz Curumthaullee, Simon Parreau, Sylvain Palat, Holy Bezanahary, Kim Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
Summary: This study aimed to evaluate whether the use of intravenous pulse of methylprednisolone reduces the risk of bilateral visual ischemia in patients with giant cell arteritis. The results showed no significant difference in the incidence of bilateral visual ischemia between the group receiving intravenous pulse of methylprednisolone and the group receiving direct prednisone.
Review
Rheumatology
Florent Eymard, Judith Aron-Wisnewsky
Summary: Obesity is a major modifiable risk factor for osteoarthritis (OA) and is associated with poorer outcomes in terms of pain, functional limitations, and response to treatments. Bariatric surgery (BS) can significantly reduce symptoms and improve function in patients with symptomatic knee OA, but its impact on long-term complications of arthroplasties appears to be disappointing. Overall, BS shows promise in reducing OA symptoms and potentially slowing disease progression.
Review
Rheumatology
Georges Marouna, Christina Fissouna, Marina Villaverde, Jean-Marc Brondelloa, Yves-Marie Pers
Summary: Recent discoveries have shown that the presence of senescent cells in osteoarticular tissues plays a crucial role in the development of osteoarthritis (OA). However, the senescence-regulatory factors associated with OA still need to be identified. Additionally, there is a lack of diagnostic and prognostic biomarkers currently used in clinics to evaluate OA patients. In the future, detecting senescence-regulatory biomarkers in patient fluids, along with imaging and clinical examination, could become a promising method for diagnosing, monitoring, assessing progression, and predicting prognosis in OA patients.
Article
Rheumatology
Patrick Yousif, Vicky Nahra, Muhammad A. Khan, Marina Magrey
Summary: Axial psoriatic arthritis (axPsA) has unique clinical and radiographic features compared to axial spondyloarthritis (axSpA). IL-23 inhibitors may be effective in treating axPsA, but further clinical trials are needed. Developing classification criteria and assessment tools for axPsA is also necessary.
Review
Rheumatology
Baptiste Gerard, Florian Bailly, Anne-Priscille Trouvin
Summary: This review aims to critically evaluate the effectiveness and safety of pharmacological treatments for chronic pain in rheumatic diseases, providing guidance for clinicians in selecting appropriate treatment options. The recommended pharmacological treatments vary depending on the specific rheumatic disease.