Editorial Material
Critical Care Medicine
Daniel Z. Hodson, Giuliana G. Repetti, Daniel T. Hoesterey, Yejoo Jeon, Kinan Bachour, Roberto L. Mempin, Tisha S. Wang, Michael Levine
Summary: A 77-year-old woman with multiple medical conditions was referred to the emergency department for evaluation of hypoxia. She presented with dizziness, perioral cyanosis, and low oxygen saturation. In the emergency department, she also reported shortness of breath, lower extremity swelling, and lightheadedness.
Article
Emergency Medicine
Jessica T. Kent, David Carr
Summary: In cold environments, various conditions can lead to acute presentations in the Emergency Department, including primary acrocyanosis which is a rare disorder characterized by persistent skin color changes after cold exposure. Diagnosis of primary acrocyanosis can be missed, but prognosis is generally favorable compared to other acrosyndromes, and management typically involves lifestyle modifications and potential Rheumatology follow-up.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Infectious Diseases
Renske Meijer, Paula van Biezen, Gerrie Prins, Henk-Jan Boiten
Summary: A patient with dyspnea and painful ulcers developed multi-organ failure and tested positive for Chlamydia psittaci. Emphasizing the importance of a detailed history in establishing the correct diagnosis. Clinicians should be aware of psittacosis when observing dyspnea with multiorgan failure.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Noemie Luyts, Jan Daniluk, Ana Cristina Nogueira Freitas, Bahar Bazeli, Annelies Janssens, Marie Mulier, Wouter Everaerts, Thomas Voets
Summary: In this study, the effect of Phenazopyridine (PAP) on pain-related Transient Receptor Potential (TRP) channels was investigated. The results showed that PAP can rapidly and reversibly inhibit the cold and menthol sensitivity of TRPM8 channels. This suggests that the inhibition of TRPM8 may be the mechanism underlying the analgesic activity of PAP.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Physical
Marzieh Naderi, Saeid Asadpour, Mohsen Nekoeinia, Masoumeh Kooravand
Summary: This study describes the synthesis and characterization of FeMnO3 magnetic nanocatalysts, which were used for the degradation of phenazopyridine hydrochloride through the Sono-Fenton method. The optimal parameters for the degradation process were determined, and it was found that the FeMnO3 nanocatalysts exhibited high degradation efficiency. These nanocatalysts have the advantages of reusability, rapid reaction time, ease of synthesis, and lack of requirement for complex systems.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Neurosciences
Chong Wang, Yuan Zhang, Dongdong Zhao, Yuanhui Huo, Jieru Xie, Xian Zhang, Hong Luo, Huaxi Xu, Yun-wu Zhang
Summary: This study explores the promoter and transcription regulation mechanism of RPS23RG1, and finds that phenazopyridine has the potential to treat AD by regulating the transcription expression of RPS23RG1.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ailin Yousefi, Alireza Nezamzadeh-Ejhieh, Mehrosadat Mirmohammadi
Summary: Synthesized SnO2 and CuO nanoparticles were mechanically coupled in a SC catalyst, showing increased activity in phenazopyridine photodegradation. The catalyst also maintained good activity after 3 successive reusing runs.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Review
Hematology
Marco Cattaneo
Summary: Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by abnormal platelet production. Low-dose aspirin is recommended as the standard treatment for controlling vascular events in ET patients. However, some patients may display poor responsiveness to enteric coated aspirin. Twice daily aspirin administration has shown to overcome this problem and is considered safe with a favorable risk/benefit profile. The once daily regimen can still be used in patients with normalized platelet count to minimize potential gastrointestinal discomfort.
Article
Environmental Sciences
Masoumeh Sharifi Teshnizi, Mohammad Karimi
Summary: In this study, the morphology, characterization, and effectiveness of TiO2/graphene composite nanofiber photocatalysts in the treatment of pharmaceutical wastewater were investigated. Optimum conditions were determined, and the photocatalyst showed efficient degradation of pharmaceutical compounds and potential for practical and economic applications.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Obstetrics & Gynecology
Lauren E. Stewart, Moiuri Siddique, Kristin M. Jacobs, Christina A. Raker, Vivian W. Sung
Summary: This study compared the pain scores of women receiving intradetrusor onabotulinumtoxinA injections for idiopathic overactive bladder with preprocedure oral phenazopyridine or intravesical lidocaine. The results showed that the postprocedure pain was 2.7 mm lower in the phenazopyridine group than in the lidocaine group, demonstrating noninferiority. More than 90% of participants in both groups stated that the pain was tolerable. Provider perception of participant comfort and overall ease of procedure were not different between groups.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tetiana Stepanenko, Grzegorz Zajac, Artur Czajkowski, Wiktoria Rutkowska, Andrzej Gorecki, Katarzyna Maria Marzec, Jakub Dybas
Summary: In this study, a sulfhemoglobinemia model was established on living functional human erythrocytes to investigate the interaction between sulfur donors and hemoglobin. By employing various spectroscopic techniques, two hemoglobin adducts with sulfur attachments were successfully distinguished and characterized. It was found that sulfur attachment altered hemoglobin structure and caused changes in protein packing inside red blood cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Mohammad Khedri, Reza Maleki, Sina Ghaemi Khiavi, Mehdi Ghasemi, Ebrahim Ghasemy, Ahmad Miri Jahromi, Amir Razmjou
Summary: This study utilized Molecular Dynamics simulations and density functional theory calculations to investigate the adsorption behavior of phenazopyridine on three metal-organic frameworks, showing that IRMOF-16 exhibited the best adsorption performance and can be further improved through functionalization, pore size tuning, and hybrid framework formation.
APPLIED MATERIALS TODAY
(2021)
Article
Medicine, General & Internal
Alexis A. Koch, Laurence Stolzenberg, Prutha R. Pathak, Alexis R. Penot
Summary: This case presents a healthy 31-year-old patient who developed Methemoglobinemia after taking excessive doses of the over-the-counter medication phenazopyridine. The patient showed severe cyanosis and a "chocolate-brown" color of arterial blood, with confirmed methemoglobin levels. Prompt treatment with methylene blue and ascorbic acid resulted in a successful recovery. This case emphasizes the importance of discussing medication dosage with patients and recognizing the signs and symptoms of Methemoglobinemia.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Engineering, Environmental
Amir Mohammad Gholizadeh, Mahmoud Zarei, Masoud Ebratkhahan, Aliyeh Hasanzadeh
Summary: The research showed that using magnetite nanoparticles-activated carbon electrode in the electro-Fenton process can efficiently degrade Phenazopyridine (PhP) under optimal conditions. Various analyses were conducted to study the electrode structure, oxygen reduction activity, and degradation by-products, demonstrating the effectiveness of the method in removing PhP from polluted water.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Pharmacology & Pharmacy
Olivier Preynat-Seauve, Evelyne Bao-Vi Nguyen, Yvonne Westermaier, Margaux Heritier, Sebastien Tardy, Yves Cambet, Maxime Feyeux, Aurelie Caillon, Leonardo Scapozza, Karl-Heinz Krause
Summary: The study revealed that Phenazopyridine is a kinase inhibitor, impacting key kinases involved in neural differentiation and pain induction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sam R. Orde, Sheng-Ying Chung, Juan N. Pulido, Rakesh M. Suri, John M. Stulak, Jae K. Oh, Sorin Pislaru, Hector M. Michelena, Richard C. Daly, Garvan C. Kane
HEART LUNG AND CIRCULATION
(2020)
Article
Cardiac & Cardiovascular Systems
Hongju Zhang, Edward A. El-Am, Jeremy J. Thaden, Sorin V. Pislaru, Christopher G. Scott, Chayakrit Krittanawong, Anwar A. Chahal, Thomas J. Breen, Mackram F. Eleid, Rowlens M. Melduni, Kevin L. Greason, Robert B. McCully, Maurice Enriquez-Sarano, Jae K. Oh, Patricia A. Pellikka, Vuyisile T. Nkomo
Article
Cardiac & Cardiovascular Systems
Parvathi Balachandran, Hartzell Schaff, Brian D. Lahr, Anita Nguyen, Richard C. Daly, Simon Maltais, Sorin Pislaru, Joseph A. Dearani
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Vidhu Anand, Garvan C. Kane, Christopher G. Scott, Sorin Pislaru, Rosalyn O. Adigun, Robert B. McCully, Patricia A. Pellikka, Cristina Pislaru
Summary: This study aimed to evaluate the prognostic significance of peak exercise cardiac power and power reserve in patients with normal left ventricular ejection fraction. The results showed that both peak stress power/mass and power reserve were independently associated with mortality and heart failure at follow-up.
EUROPEAN HEART JOURNAL
(2021)
Editorial Material
Medicine, General & Internal
Jwan A. Naser, John M. Stulak, Ioana Petrescu, Sorin V. Pislaru
MAYO CLINIC PROCEEDINGS
(2022)
Article
Medicine, General & Internal
Nahoko Kato, Mayra Guerrero, Ratnasari Padang, Jennifer M. Amadio, Mackram F. Eleid, Christopher G. Scott, Alexander T. Lee, Sorin Pislaru, Vuyisile T. Nkomo, Patricia A. Pellikka
Summary: This study aimed to evaluate the prevalence and natural history of mitral annulus calcification (MAC) and associated mitral valve dysfunction (MVD) in patients undergoing clinically indicated echocardiography. The results showed that the prevalence of MAC was 23% among the evaluated adult patients, and the prevalence of MVD was more than twice as high in patients with MAC compared to those without MAC. Patients with both MAC and MVD had a higher mortality rate.
MAYO CLINIC PROCEEDINGS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Sorin Pislaru, Vuyisile T. Nkomo
Editorial Material
Cardiac & Cardiovascular Systems
Sidhartha G. Senapati, Michael S. Sabbah, Sorin Pislaru, Arashk Motiei
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Conor J. Kane, Kyla M. Lara-Breitinger, Mohamad S. Alabdaljabar, Vuyisile T. Nkomo, Ratnasari Padang, Cristina Pislaru, Garvan C. Kane, Christopher Scott, Sorin Pislaru, Grace Lin
Summary: This study aimed to investigate the interaction between pulmonary artery circulation and the right ventricle in patients with tricuspid valve regurgitation (TR) and its association with outcomes. The study found that the pulmonary artery pulsatility index (PAPi) can predict the risk in patients with moderate or severe TR, and low PAPi is associated with right ventricular dysfunction, right heart failure, and worse prognosis.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Jwan A. Naser, Eunjung Lee, Hector I. Michelena, Grace Lin, Patricia A. Pellikka, Vuyisile T. Nkomo, Peter A. Noseworthy, Paul A. Friedman, Zachi I. Attia, Sorin V. Pislaru
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jwan A. Naser, Eunjung Lee, Christopher G. Scott, Austin M. Kennedy, Patricia A. Pellikka, Grace Lin, Sorin Pislaru, Barry A. Borlaug
Summary: This study aimed to investigate the prevalence and incidence of DD in patients with new-onset AF compared with SR. The results showed that patients with new-onset AF have high-risk features for HFpEF at diagnosis and accelerated progression in DD over time.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Li-Tan Yang, Zi Ye, Muhammad Wajih Ullah, Joseph J. Maleszewski, Christopher G. Scott, Ratnasari Padang, Sorin Pislaru, Vuyisile T. Nkomo, Sunil Mankad, Patricia A. Pellikka, Jae K. Oh, Veronique L. Roger, Maurice Enriquez-Sarano, Hector Michelena
Summary: This study aimed to assess lifetime morbidity and long-term survival in patients with bicuspid aortic valve (BAV) in the community. The results showed that BAV patients have a high lifetime morbidity burden, with a high incidence of complications such as aortic stenosis or regurgitation, aortic surgery, aortic aneurysm, infective endocarditis, and aortic dissection. Compared to patients with typical valvulo-aortopathy, patients with complex valvulo-aortopathy have lower survival rates.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Sorin V. Pislaru
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Jwan A. Naser, Hector Michelena, Grace Lin, Christopher G. Scott, Eunjung Lee, Austin M. Kennedy, Peter A. Noseworthy, Patricia A. Pellikka, Vuyisile T. Nkomo, Sorin Pislaru
Summary: The aim of this study was to investigate the incidence, risk factors, and clinical significance of atrial functional mitral regurgitation (AFMR) in patients with atrial fibrillation (AF) or sinus rhythm (SR). The results showed that the incidence rate of >mild AFMR was 2.6 per 100 person-year in new-onset AF and 0.7 per 100 person-year in SR. Age, sex, left atrial volume index (LAVI), and diastolic dysfunction (DD) were independent risk factors for incident AFMR. AFMR was associated with increased risk of all-cause death.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jwan A. Naser, Arman Arghami, Mackram F. Eleid, Sorin Pislaru
Summary: This case highlights the importance of recognizing and properly diagnosing bioprosthetic tricuspid valve stenosis in patients with prosthetic valve replacements. Despite the patient having undergone echocardiography, the severity of stenosis was initially underestimated, emphasizing the need for a comprehensive evaluation in patients with a history of valve replacement.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2021)
