Article
Cell Biology
Xiao-Yu Liu, Li-Fei Zheng, Yan-Yan Fan, Qian-Ying Shen, Yao Qi, Guang-Wen Li, Qi Sun, Yue Zhang, Xiao-Yan Feng, Jin-Xia Zhu
Summary: In this study, the researchers investigate the effect of dopamine on gastric pepsinogen secretion through dopamine receptors expressed on chief cells or potential D2 receptors expressed on D cells. The findings suggest that dopamine promotes gastric pepsinogen secretion directly through D1-like receptors on chief cells and indirectly through D2 receptor-mediated suppression of somatostatin release.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Neurosciences
Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong Xu
Summary: The authors demonstrate that the effects of dopamine (DA) on serotonin (5-HT) neurons in a bidirectional manner regulate feeding behavior in mice. Activation of 5-HT neurons by DRD1 contributes to anorexia, which can be prevented by blocking DRD1. These findings provide insights into the interaction between DA and 5-HT neurons in the regulation of feeding behavior, which may be relevant to the pathophysiology of anorexia nervosa (AN).
NATURE NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Weiwei Guo, Sijia Fan, Dan Xiao, Chen He, Mengyuan Guan, Wei Xiong
Summary: This study reveals a neural projection from the dorsal raphe nucleus (DRN) to the reticulotegmental nucleus (RtTg) that mediates enhanced startle response under fear condition. The study identifies an inhibitory microcircuit within RtTg, consisting of GABAergic neurons in pericentral RtTg (RtTgP) and glutamatergic neurons in central RtTg (RtTgC). The conditioned fear-activated DRN 5-HTergic neurons send inhibitory projections to RtTgP GABAergic neurons, which upregulate neuronal activities of RtTgC glutamatergic neurons.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Debora Masini, Ole Kiehn
Summary: The study demonstrates that cell-type specific stimulation of brainstem neurons can restore severe locomotor deficit in mouse models of parkinsonism, suggesting a potential target for neuromodulatory restoration of locomotor function in Parkinson's disease.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Hiroko Ikeda, Risa Mikami, Naomi Yonemochi, John L. Waddington
Summary: The regulation of glucose metabolism by central dopamine D2 receptors is altered in type 1 and type 2 diabetic models. In type 1 diabetic models, dopamine D2 receptor stimulation or blockade does not affect glucose levels, while in type 2 diabetic models, it causes hyperglycemia. Additionally, hypothalamic dopaminergic function and hepatic glycogenolysis are decreased in type 1 diabetic models, which reduces hyperglycemia induced by dopamine D2 receptor stimulation or blockade.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kamran Tari, Soroush Khamoushian, Tayyebeh Madrakian, Abbas Afkhami, Marek Jan Los, Arash Ghoorchian, Mohammad Reza Samarghandi, Saeid Ghavami
Summary: This study investigates the potential of water-soluble polypyrrole nanoparticles (WS-PPyNPs) as a drug donor matrix for controlled transdermal iontophoresis of insulin (INS), showing significantly increased drug delivery compared to passive delivery. The separation of WS-PPyNPs and INS under cathodal stimulation led to higher drug permeation, highlighting the potential applicability of WS-PPyNPs in the development of controlled transdermal iontophoresis of INS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Malou Dongelmans, Romain Durand-de Cuttoli, Claire Nguyen, Maxime Come, Etienne K. Durante, Damien Lemoine, Raphael Britto, Tarek Ahmed Yahia, Sarah Mondoloni, Steve Didienne, Elise Bousseyrol, Bernadette Hannesse, Lauren M. Reynolds, Nicolas Torquet, Deniz Dalkara, Fabio Marti, Alexandre Mourot, Jeremie Naude, Philippe Faure
Summary: Chronic nicotine exposure affects decision-making processes, including exploratory behaviors, by increasing the tonic activity of VTA dopaminergic neurons and reducing exploration in mice. Long-term nicotine exposure alters brain circuits and leads to significant changes in decision-making strategies, impacting behaviors related and unrelated to drug seeking and consumption. The study also shows that optogenetically stimulating mice mimics the effects of chronic nicotine on dopamine neuron activity, highlighting a potential mechanism by which nicotine influences decision-making processes.
NATURE COMMUNICATIONS
(2021)
Review
Psychiatry
Vanja Mandic-Maravic, Roberto Grujicic, Luka Milutinovic, Ana Munjiza-Jovanovic, Milica Pejovic-Milovancevic
Summary: Autism spectrum disorders (ASD) are characterized by impairment in social communication and repetitive behaviors. The causes of ASD are complex, involving both genetic and environmental factors. Current treatments only target the non-specific symptoms, and no specific treatment for the core symptoms of ASD has been developed.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Tomoya Kitazaki, Yusuke Morimoto, So Yamashita, Daichi Anabuki, Shiori Tahara, Akira Nishiyama, Kenji Wada, Ichiro Ishimaru
Summary: This article introduces a method for remote blood glucose measurement using mid-infrared spectroscopic imaging, and verifies the strong correlation between the measurement results and invasive sensors. This technology is expected to be applied in real-time monitoring of diabetic patients and has the potential for further innovation.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Rachel J. Boyd, Sarah A. McClymont, Nelson B. Barrientos, Paul W. Hook, William D. Law, Rebecca J. Rose, Eric L. Waite, Jay Rathinavelu, Dimitrios Avramopoulos, Andrew S. McCallion
Summary: In order to overcome the limitations of in vivo human disease models, researchers often use model organism-derived cell lines to study disease mechanisms. However, many of these in vitro models lack genomic analysis to support their use as proxies for human cells and tissues. This study examines a mouse neural precursor cell line called SN4741, which has been used to study Parkinson's disease for over 25 years. The results suggest that SN4741 cells may reflect early aspects of neuronal differentiation but are not suitable as a proxy for dopaminergic neurons. This highlights the need for robust biological and genomic rationale when using in vitro models.
Article
Cell Biology
Junting Huang, Zizhen Zhang, Eder Gambeta, Lina Chen, Gerald W. Zamponi
Summary: Neuropathic pain is a challenging condition with limited treatment options. This study highlights the modulatory role of the ventrolateral orbitofrontal cortex (vlOFC) in neuropathic pain, demonstrating that specific activation of vlOFC neurons can inhibit hypersensitivity. Targeting this pathway could potentially offer relief for patients suffering from neuropathic pain.
Article
Pharmacology & Pharmacy
Yarim Elideth De la Luz-Cuellar, Ulises Coffeen, Francisco Mercado, Vinicio Granados-Soto
Summary: This study investigated the impact of sex on the antiallodynic activity of spinal dopamine D1 and D2-like receptors in a model of fibromyalgia-type pain in rats. The results showed that drugs targeting these receptors had a greater effect on female rats compared to male rats. Sex differences were also observed in a nerve injury model. These findings suggest that the antiallodynic effect of dopamine receptors in fibromyalgia-type pain is influenced by hormonal receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Laura Cutando, Emma Puighermanal, Laia Castell, Pauline Tarot, Morgane Belle, Federica Bertaso, Margarita Arango-Lievano, Fabrice Ango, Marcelo Rubinstein, Albert Quintana, Alain Chedotal, Manuel Mameli, Emmanuel Valjent
Summary: The study demonstrates that the dopamine D2 receptors in cerebellar Purkinje cells play a role in regulating synaptic efficacy and are involved in social behaviors, without affecting motor functions.
NATURE NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Martin Nagl, Denise Moennich, Niklas Rosier, Hannes Schihada, Alexei Sirbu, Nergis Konar, Irene Reyes-Resina, Gemma Navarro, Rafael Franco, Peter Kolb, Paolo Annibale, Steffen Pockes
Summary: This study describes the synthesis of a set of new fluorescent ligands for visualization of dopamine D-2-like receptors. The ligand UR-MN212 (20) showed high affinity for D-2-like receptors and moderate selectivity towards D-1-like receptors. It displayed rapid association with D2longR and can be used for fluorescence microscopy studies. The ligand's binding affinity was determined in a single-digit nanomolar range, consistent with radioligand binding data.
Article
Biochemistry & Molecular Biology
Edem K. Onyameh, Barbara A. Bricker, Suresh V. K. Eyunni, Chandrashekhar Voshavar, Uma M. Gonela, Edward Ofori, Andrea Jenkins, Seth Y. Ablordeppey
Summary: This study aims to investigate the relationship between antipsychotic drugs and their binding affinities at dopamine and serotonin receptor subtypes to potentially develop new drugs with enhanced efficacy. By synthesizing structurally modified compounds, a new analog with moderate binding affinity was identified and demonstrated antipsychotic-like activity in preliminary tests.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)