Article
Radiology, Nuclear Medicine & Medical Imaging
Ping Lei, Yangming Leng, Jing Li, Renhong Zhou, Bo Liu
Summary: This study found that anatomical variations of the inner ear may be a predisposing factor in the pathogenesis of unilateral Meniere's disease (MD), but have less impact on ipsilateral delayed endolymphatic hydrops (DEH).
EUROPEAN RADIOLOGY
(2022)
Article
Otorhinolaryngology
Jiapei Xie, Weidong Zhang, Jingyi Zhu, Lian Hui, Songbai Li, Ling Ren, Fei Wang, Bo Zhang
Summary: The study aimed to investigate the grade of endolymphatic hydrops in patients with Meniere's disease and determine if MRI could assist in differential diagnosis between probable and definite Meniere's disease. Results showed a higher grade of endolymphatic hydrops in definite Meniere's disease patients compared to probable patients, suggesting MRI could be an effective tool in clinical differentiation.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Juliette Barlet, Alexis Vaussy, Yohan Ejzenberg, Michel Toupet, Charlotte Hautefort, Andre Gillibert, Arnaud Attye, Michael Eliezer
Summary: This study aimed to shorten the delay between gadolinium administration and MRI acquisition for hydrops evaluation using an optimized 3D-FLAIR sequence in Meniere's disease patients. The results showed that the signal intensity ratio at 2 h was not significantly inferior to that at 4 h, and the volume equivalence of endolymphatic structures was also proven between 2 and 4 h. The optimized sequence provided reliable diagnosis of endolymphatic hydrops and blood-labyrinthine-barrier impairment.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Emilia Wnuk, Magdalena Lachowska, Agnieszka Jasinska-Nowacka, Edyta Maj, Kazimierz Niemczyk
Summary: The study aimed to compare the consistency of MRI interpretation of inner ear structures in patients suspected of having or diagnosed with Meniere's disease (MD). The evaluation of cochlear endolymphatic hydrops (CoEH) and vestibular endolymphatic hydrops (VEH) showed significant differences between observers. However, the modified Bernaerts scale increased the sensitivity of endolymphatic hydrops (EH) diagnosis. Differentiating between normal and hydropic ears was easier than grading EH, making it a useful method for diagnosing MD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Jinye Li, Linsheng Wang, Na Hu, Xiao Kong, Xiaoqian Ge, Mengxiao Liu, Chuanting Li, Lixin Sun, Ruozhen Gong
Summary: This study aimed to investigate whether magnetic resonance imaging (MRI) can improve the diagnosis accuracy of probable and definite Meniere's disease (MD) through perilymphatic enhancement (PE) and endolymphatic hydrops (EH). The results showed that the combination evaluation of PE and EH parameters can enhance the diagnostic accuracy of probable and definite MD, suggesting that MRI findings are clinically valuable in the diagnosis of MD.
Article
Audiology & Speech-Language Pathology
Irumee Pai, Steve Connor
Summary: This study investigates the etiology of low-frequency air-bone gaps in Meniere's disease by comparing MRI features in two groups of patients. The findings suggest that direct contact between the dilated saccule and the stapes footplate is the underlying mechanism for LFABGs.
Review
Clinical Neurology
Justin L. Hoskin
Summary: Recent developments in Meniere's disease have led to the proposal of five subtypes, aiding in the development of appropriate treatment algorithms. Although newer treatments have not been developed, stepwise treatment algorithms have been suggested to improve patient care. New MRI modalities and serum testing hold promise as potential clinical clues and biomarkers for improved diagnosis and treatment.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Heng Xiao, Yibin Chen, Qinrong Huang, Min Huang, Yingying Zheng, Zheming Fang, Guohao Chen
Summary: This study aims to explore the predictive factors between Meniere's disease (MD) and vestibular migraine (VM) through gadolinium-enhanced magnetic resonance imaging (MRI) of the inner ear and clinical features. The results showed that 92% of MD patients had endolymphatic hydrops, while only 5.4% of VM patients had positive results. The incidence of migraine was 14% in the MD group and 67.7% in the VM group. Multivariate logistic regression analysis revealed that the higher the sum of the maximum slow phase velocity (SPV) of the ipsilateral ear, the higher the risk of VM occurrence. Carsickness, decreased asymmetric hearing loss (AHL), and increased sum of the maximum SPV in the ipsilateral side (SSPVI) may act as diagnostic predictors of VM.
Article
Otorhinolaryngology
Kento Koda, Kazuo Yasuhara, Shunichi Sugasawa, Gentaro Nagano, Mitsuhiko Katoh, Akinobu Kakigi
Summary: This study aimed to assess whether hearing improvement in patients with definite MD could be predicted using inner ear contrast magnetic resonance imaging (IEC-MRI) and pure-tone audiometry (PTA) at disease attack. The results showed that estimating hearing improvement using IEC-MRI was not possible, but PTA had the potential to predict hearing improvement at disease attack.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Surgery
Taeko Ito, Takashi Inoue, Hiroshi Inui, Toshiteru Miyasaka, Toshiaki Yamanaka, Kimihiko Kichikawa, Noriaki Takeda, Masato Kasahara, Tadashi Kitahara, Shinji Naganawa
Summary: The study presented a highly accurate method for diagnosing Meniere's disease by measuring the volume of the endolymphatic space. Results showed that the diagnostic accuracy of the new method was significantly better than that of traditional criteria, and effectiveness was confirmed through comparison between patients with Meniere's disease and healthy volunteers.
FRONTIERS IN SURGERY
(2021)
Article
Multidisciplinary Sciences
Jing Li, Yangming Leng, Hui Ma, Fan Yang, Bo Liu, Wenliang Fan
Summary: This study found that Meniere's disease is associated with functional reorganization in various brain networks, including the auditory, ventral attention, and limbic networks. These changes in connectivity may serve as potential biomarkers for predicting disease progression, evaluating disease severity, and understanding the pathophysiology of Meniere's disease.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Heng Xiao, Xiaojing Guo, Huimin Cai, Jianwei Lin, Chenxin Lin, Zheming Fang, Shengnan Ye
Summary: This study compared three methods of scoring endolymphatic hydrops in patients with Meniere's disease and found that the Inner Ear Structural Assignment Method (IESAM) had higher sensitivity and specificity in diagnosing definite Meniere's disease. The degree of endolymphatic hydrops was correlated with hearing thresholds. A comprehensive evaluation of the inner ear sub-unit structures may be necessary.
FRONTIERS IN NEUROLOGY
(2022)
Review
Otorhinolaryngology
Maria A. Mavrommatis, Vivian F. Kaul, Kevin Chow, Caleb J. Fan, Christopher P. Bellaire, Maura K. Cosetti, George B. Wanna, Enrique Perez
Summary: This study aimed to review the MRI-measured changes in endolymphatic hydrops (ELH) over time and after medical or surgical intervention in patients with Meniere's Disease (MD), as well as the association between ELH changes and MD symptomatology. The results showed that medical and surgical interventions often relieved vertigo symptoms in MD patients despite stable or increasing ELH volume. MRI may have greater clinical utility in diagnosing ELH rather than assessing treatment response.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Surgery
Rita Sousa, Carla Guerreiro, Tiago Eca, Jorge Campos, Leonel Luis
Summary: There were no differences in modiolar area between the best and worst ears in patients with definite MD. However, worse hearing function (PTA >= 25dB) and more pronounced endolymphatic hydrops seem to be associated with a smaller modiolar area. Additional research is needed to confirm and explore these findings.
FRONTIERS IN SURGERY
(2021)
Article
Clinical Neurology
Munehisa Fukushima, Yu Suekata, Takuya Kusumoto, Shiro Akahani, Hidehiko Okamoto, Hidenori Inohara, Noriaki Takeda
Summary: This study observed longitudinal changes in endolymphatic hydrops of Meniere's disease patients during the remission phase using 3-T magnetic resonance imaging. The results showed rupture-like shrinkage and regrowth of endolymphatic hydrops in both patients. The conclusion suggests that the remission phase with hearing improvement may be as important as vertigo attacks in Meniere's disease.
OTOLOGY & NEUROTOLOGY
(2021)
Letter
Public, Environmental & Occupational Health
Tsutomu Nakashima, Hirokazu Suzuki, Masaaki Teranishi
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Otorhinolaryngology
Hirokazu Suzuki, Masaaki Teranishi, Naomi Katayama, Tsutomu Nakashima, Saiko Sugiura, Michihiko Sone
Summary: Understanding the relationships among aging, cognitive function, and olfaction is crucial for diagnosing olfactory decline in older adults. Olfactory function declines in the early stages of neurodegenerative diseases, and both aging and cognitive impairment are associated with olfactory decline. Evaluating hyposmia and anosmia is essential for diagnosing neurodegenerative diseases, and assessing these factors can help identify dementia in patients with olfactory impairment.
AURIS NASUS LARYNX
(2021)
Letter
Geriatrics & Gerontology
Naoki Saji, Hiroyuki Suzuki, Naomi Katayama, Hyuma Makizako, Yasue Uchida, Tsutomu Nakashima
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Otorhinolaryngology
Saiko Sugiura, Yasue Uchida, Yukiko Nishita, Masaaki Teranishi, Mariko Shimono, Hirokazu Suzuki, Tsutomu Nakashima, Chikako Tange, Rei Otsuka, Fujiko Ando, Hiroshi Shimokata
Summary: The study found that the prevalence of hearing aid usage among Japanese community-dwelling elders with hearing loss is around 10%, and hearing levels remained a primary risk factor for cognitive impairment in this population. For those with moderate hearing loss, regular use of a hearing aid may have a protective effect against cognitive impairment.
AURIS NASUS LARYNX
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sung Jun Ahn, Toshiaki Taoka, Won-Jin Moon, Shinji Naganawa
Summary: Contrast-enhanced FLAIR, traditionally used to evaluate leptomeningeal disease, is now being explored for various other pathologies. However, the exact mechanism for its high sensitivity to low concentrations of gadolinium remains unclear, and challenges exist in its accurate application due to unoptimized parameters in clinical practice.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryota Horiguchi, Yasuo Takehara, Masataka Sugiyama, Ryota Hyodo, Tomohiro Komada, Masaya Matsushima, Shinji Naganawa, Takashi Mizuno, Yasuo Sakurai, Masayuki Sugimoto, Hiroshi Banno, Kimihiro Komori, Keiichi Itatani
Summary: The aim of this study was to investigate the impact of endovascular aneurysmal repair (EVAR) on the local hemodynamics of abdominal aortic aneurysm (AAA). The results showed a 1.7-fold increase in local energy loss (EL) after EVAR, with a greater increase in the deformed stent-graft subgroup. These findings could be a potential concern for frail patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Hiroyasu Umakoshi, Takashi Nihashi, Akira Takada, Naoki Hirasawa, Shunichi Ishihara, Yasuo Takehara, Shinji Naganawa, Matthew S. Davenport, Teruhiko Terasawa
Summary: Changing iodinated contrast media (ICM) can reduce the risk of recurrent immediate hypersensitivity reactions in patients with previous ICM-induced hypersensitivity reactions.
Article
Otorhinolaryngology
Yuka Kawade, Yasue Uchida, Saiko Sugiura, Hirokazu Suzuki, Mariko Shimono, Erina Ito, Anna Yoshihara, Izumi Kondo, Takashi Sakurai, Naoki Saji, Tsutomu Nakashima, Emiko Shimizu, Yasushi Fujimoto, Hiromi Ueda
Summary: The study aimed to evaluate the relationship between hearing ability and cognitive domains and determine the changes after introducing a hearing aid for 6 months. Pure tone audiometry and monosyllabic word discrimination score were used to assess hearing ability, and the Mini-Mental State Examination (MMSE) was used to evaluate cognitive domains. The results indicated a significant association between hearing ability and cognitive domains in individuals with impaired cognitive functions, suggesting a potential relationship between cognitive domains, hearing ability, and auditory compensation.
AURIS NASUS LARYNX
(2023)
Article
Geriatrics & Gerontology
Hirokazu Suzuki, Saiko Sugiura, Tsutomu Nakashima, Masaaki Teranishi, Mariko Shimono, Kenta Murotani, Takashi Sakurai, Yasue Uchida, Naoki Saji
Summary: Olfactory impairment is associated with cognitive impairment. This study aimed to explore the differences between subjective and objective olfactory impairment measurements in older adults and their relationship with cognitive impairment. The results showed that older age was related to decreased Open Essence scores, and dementia patients had significantly lower Open Essence scores compared to those with mild cognitive impairment and normal cognition. Cognitive impairment was associated with decreased Open Essence scores even after adjusting for age, sex, and education. Participants with dementia were unaware of their olfactory impairment based on odor questionnaire scores. Concomitant assessment of objective and subjective olfaction is useful for screening older adults with both olfactory and cognitive impairments.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Clinical Neurology
Tadao Yoshida, Shinji Naganawa, Masumi Kobayashi, Satofumi Sugimoto, Naomi Katayama, Tsutomu Nakashima, Yutaka Kato, Kazushige Ichikawa, Hiroshi Yamaguchi, Kazuki Nishida, Michihiko Sone
Summary: In this study, we evaluated the distribution of O-17-labeled saline in the inner ear after its intratympanic administration in human subjects. Magnetic resonance imaging revealed that O-17-labeled water permeated the cochlear basal turn and vestibule, causing endolymphatic hydrops and positional vertigo.
FRONTIERS IN NEUROLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Nivedita Agarwal, Laura D. Lewis, Lydiane Hirschler, Leonardo Rivera Rivera, Shinji Naganawa, Swati Rane Levendovszky, Geir Ringstad, Marijan Klarica, Joanna Wardlaw, Costantino Iadecola, Cheryl Hawkes, Roxana Octavia Carare, Jack Wells, Erik N. T. P. Bakker, Vartan Kurtcuoglu, Lynne Bilston, Maiken Nedergaard, Yuki Mori, Marcus Stoodley, Noam Alperin, Mony de Leon, Matthias J. P. van Osch
Summary: Neurofluids refer to all fluids in the brain and spine, including blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists have identified various fluid environments that interact harmoniously to support optimal brain function. Animal studies have been crucial in understanding the dynamics of neurofluids, while human studies are limited due to the lack of noninvasive imaging techniques. The future development of noninvasive MRI techniques holds promise in imaging neurofluid dynamics and identifying pathological processes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Letter
Multidisciplinary Sciences
Shinji Naganawa, Yutaka Kato, Tadao Yoshida, Michihiko Sone
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Tadashi Shiohama, Norihide Maikusa, Masahiro Kawaguchi, Jun Natsume, Yoshiyuki Hirano, Keito Saito, Jun-ichi Takanashi, Jacob Levman, Emi Takahashi, Koji Matsumoto, Hajime Yokota, Shinya Hattori, Keita Tsujimura, Daisuke Sawada, Tomoko Uchida, Tomozumi Takatani, Katsunori Fujii, Shinji Naganawa, Noriko Sato, Hiromichi Hamada, Andor W. J. M. Glaudemans
Summary: This study aims to provide normal reference values of global and regional brain volumes for children and adolescents of different sexes and age groups across multiple institutions. MRI examinations of 846 neurotypical participants were collected, and regional brain volumes were measured and analyzed using the CIVET 2.1.0. pipeline and ComBat-GAM harmonization. The results of this study can be used to evaluate the brain morphology of individuals in a clinical setting and investigate brain morphology in ultra-rare diseases.
Article
Otorhinolaryngology
Tadao Yoshida, Masumi Kobayashi, Satofumi Sugimoto, Shinji Naganawa, Michihiko Sone
Summary: Otitis media with antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV) is a new type of otitis media. Early detection and intervention can improve the hearing loss caused by OMAAV, but recovering the patient's hearing may be challenging if it continues to worsen and leads to deafness. Bilateral deafness can only be improved through cochlear implant (CI) surgery. This article presents two cases of cochlear calcification caused by OMAAV and emphasizes the importance of early detection through computed tomography scans and timely CI surgery for hearing improvement in patients with OMAAV-induced deafness.
AURIS NASUS LARYNX
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Shinji Naganawa, Rintaro Ito, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone