Article
Medicine, General & Internal
Benita Hornung, Jannis Constantinidis, Vivian Thimsen, Abbas Agaimy, Michael Koch, Antoniu-Oreste Gostian, Matti Sievert, Sarina Katrin Mueller, Heinrich Iro, Konstantinos Mantsopoulos
Summary: This study investigated the histopathologic findings of parotid and parapharyngeal pleomorphic adenomas and drew conclusions on surgical strategy. Parapharyngeal pleomorphic adenomas have a more challenging histopathologic profile, indicating the need for experienced surgeons at high-volume centers to perform the surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Konstantinos Mantsopoulos, Matti Sievert, Ann-Kristin Iro, Sarina Katrin Mueller, Michael Koch, Mirco Schapher, Abbas Agaimy, Heinrich Iro
Summary: This study revealed significant differences in histopathological characteristics between pleomorphic adenomas of the parotid and submandibular glands, with submandibular PAs being characterized by an intact capsule, infrequent pseudopodia and satellite nodules.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuriko Murayama, Takeshi Kamitani, Koji Sagiyama, Yuzo Yamasaki, Tomoyuki Hida, Yuko Matsuura, Ryuji Yasumatsu, Hidetaka Yamamoto, Hidetake Yabuuchi, Kousei Ishigami
Summary: The study evaluated the utility of MRI in differentiating basal cell adenomas (BCAs) from other parotid tumors, showing that BCAs often have smooth margins and cystic components. The ADC values of BCAs were equivalent to PCs, significantly lower than PAs, and significantly higher than WTs.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Medicine, Research & Experimental
Konstantinos Mantsopoulos, Vivian Thimsen, Antoniu-Oreste Gostian, Sarina K. Mueller, Matti Sievert, Ann-Kristin Iro, Abbas Agaimy, Heinrich Iro
Summary: This study identified significant associations between histological subtypes of pleomorphic adenomas of the parotid gland and age, maximal diameter, incomplete capsule, pseudopodia, and satellite nodules.Various histologic subtypes have different capsule-producing properties with potential implications for tumor progression and behavior.
Article
Oncology
Jong-Lyel Roh
Summary: This study evaluated the functional and disease control outcomes of gland-preserving surgery via periauricular incision for pleomorphic adenoma of the parotid gland. The results showed that this surgical approach can achieve satisfactory functional, cosmetic, and disease control outcomes.
Review
Medicine, General & Internal
Hira Zahid Khan, Imran Mohib Khan
Summary: We report a rare case of simultaneous pleomorphic adenoma in the parotid gland and parapharyngeal space in a 65-year-old male. The patient presented with a left parotid lump and examination revealed the displacement of the left palatine tonsil. CT scan showed a separate lump in the left parapharyngeal space and FNAC suggested the presence of mucoepidermoid carcinoma. The superficial parotid lump was excised first, followed by the excision of the parapharyngeal growth. Histopathology confirmed both growths to be pleomorphic adenomas. Awareness and optimal investigation of synchronous salivary gland tumors is crucial for complete surgical excision and appropriate management.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2023)
Article
Otorhinolaryngology
Kyeong Suk Park, Jo Heon Kim, Dong Hoon Lee, Joon Kyoo Lee, Sang Chul Lim
Summary: This study analyzed the clinical characteristics and treatment outcomes of CXPA of the parotid gland. Approximately 90% of patients did not experience recurrence through surgery and postoperative radiation therapy.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ichita Kinoshita, Denan Jin, Masaaki Higashino, Tetsuya Terada, Yoshitaka Kurisu, Shinji Takai, Ryo Kawata
Summary: The study revealed that chymase derived from mast cells was significantly increased in the tumor tissues of RPA and CXPA, suggesting its involvement in the pathophysiology of these tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Otorhinolaryngology
Davide Lombardi, Michele Tomasoni, Alessio Nicolai, Alberto Paderno, Alberto Grammatica, Mara Arcuri, Davide Lancini, Simonetta Battocchio, Laura Ardighieri, Anna Bozzola, Frida Pittiani, Davide Farina, Luca Oscar Redaelli de Zinis, Piero Nicolai, Cesare Piazza
Summary: Patients with NPA were significantly older and treated with more conservative surgical procedures compared to those with PA. In PA, younger age, major pseudo-capsule defects, and surgical margins were the most relevant factors affecting local control.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shao-Nan He, Ren-Cai Lu, Jia-Long Zhou, Bo Wang, Guo-Li Bi, Kun-Hua Wu
Summary: This study found that semiquantitative magnetic resonance imaging parameters have high value in distinguishing pleomorphic adenoma (PA) from Warthin tumor (WT), especially in the early and delayed phases. T1-max TSc-CR in the early phase showed high sensitivity, specificity, and area under the curve at a cutoff value of 1.89, while T1-max TSc-CR in the delayed phase performed better at a cutoff value of 2.33. The combination of all semiquantitative parameters further improved the diagnostic efficiency.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xuewei Zheng, Chencui Huang, Baoting Yu, Shuo Liu, Tong Li, Yuyao Guan, Jun Ding
Summary: This study aimed to differentiate neurogenic tumors and pleomorphic adenomas in the parapharyngeal space using the texture characteristics of MRI-T2WI. The texture features of the region of interest were analyzed using PyRadiomics, and statistically significant differences were found in the selected texture features between the two groups. The diagnostic efficiency was evaluated using ROC curves.
Article
Multidisciplinary Sciences
Yu Pei, Wenlu Li
Summary: This study aimed to identify predictive factors for malignant transformation (MT) in recurrent parotid pleomorphic adenomas (PAs) based on preoperative clinical parameters. Patients with a clinical diagnosis of recurrent parotid PA were included retrospectively. Univariate and multivariate analyses were used to assess the association between clinicopathologic variables and MT occurrence. MT occurred in 11.8% of the 467 patients. Univariate analysis showed that three or more previous recurrences, newly developed facial nerve paralysis, difficulty in mouth opening, tumors with a diameter >= 2.4 cm, and abnormal neck lymph node enlargement were associated with MT. Multivariate analysis revealed that three or more previous recurrences, newly developed facial nerve paralysis, difficulty in mouth opening, and abnormal neck lymph node enlargement independently predicted MT occurrence.
SCIENTIFIC REPORTS
(2023)
Article
Otorhinolaryngology
Linda X. Yin, Kathryn M. Van Abel, Steven A. Rooker, Alex A. Nagelschneider, Kerry D. Olsen, Daniel L. Price, Jeffrey R. Janus, Jan L. Kasperbauer, Eric J. Moore
Summary: In patients with recurrent pleomorphic adenoma, risk factors for malignant transformation include age over 50, significant smoking history, and tumors larger than 2 cm. Clinical signs of malignancy may not always be present.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Yun-lin Zheng, Yi-neng Zheng, Chuan-fei Li, Jue-ni Gao, Xin-yu Zhang, Xin-yi Li, Di Zhou, Ming Wen
Summary: This study explores the value of different radiomic models based on multiphase CT in distinguishing parotid PA and BCA. The SVM model of the arterial and delayed phases demonstrated superior predictive efficiency and robustness. The combined model showed the best discriminatory capability.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
F. Al Zadjali, E. Chabrillac, S. Vergez
Summary: This study analysed the outcomes of surgery for pleomorphic adenoma of the parapharyngeal space in relation to the surgical approach. The study included 21 patients, with the most common surgical approach being transparotid-transcervical approach, followed by transoral robotic surgery and conventional transoral surgery. Post-operative complications were minimal and no recurrence occurred.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2023)
