Article
Multidisciplinary Sciences
Karolina Vernmark, Annika Knutsen, Per Loftas, Xiao-Feng Sun, Mona Pathak
Summary: This study investigated the survival outcomes of rectal cancer patients with mucinous adenocarcinoma (MAC) and non-mucinous adenocarcinoma (NMAC) after adjuvant chemotherapy. The results showed that MAC patients had better overall survival and a trend towards improved cancer-specific survival after chemotherapy. In contrast, there was no significant improvement in survival for NMAC patients.
Article
Gastroenterology & Hepatology
Alexey Surov, Hans-Jonas Meyer, Maciej Pech, Maciej Powerski, Jasan Omari, Andreas Wienke
Summary: The study aimed to provide data on using diffusion-weighted imaging (DWI) to differentiate metastatic and non-metastatic lymph nodes in rectal cancer. However, no reliable ADC threshold was found to distinguish between the two types of lymph nodes.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Takuya Matsui, Noriaki Sakakura, Shin Koyama, Keita Nakanishi, Eiichi Sasaki, Seiichi Kato, Waki Hosoda, Yoshiko Murakami, Hiroaki Kuroda, Yasushi Yatabe
Summary: Invasive mucinous adenocarcinoma (IMA) is a rare subtype of invasive lung adenocarcinoma with differences in lymph node metastasis and KRAS mutations compared to non-IMA. Patients with IMA have a higher rate of intrapulmonary recurrence postoperatively, leading to significantly worse prognosis among those with lung recurrence compared to non-IMA patients. Overall survival rates at 5 years did not differ significantly between the two groups.
ANNALS OF THORACIC SURGERY
(2021)
Article
Biology
Fang-Jie Hu, Ying-Jie Li, Li Zhang, Deng-Bo Ji, Xin-Zhi Liu, Yong-Jiu Chen, Lin Wang, Ai-Wen Wu
Summary: A single-cell RNA sequencing analysis reveals molecular differences between mucinous adenocarcinoma and classical adenocarcinoma, providing insight into these two subtypes of colorectal cancer. Mucinous adenocarcinoma, a unique histological subtype, responds poorly to chemoradiotherapy and its prognosis compared to classical adenocarcinoma is controversial. The study findings show that mucinous adenocarcinoma cells exhibit goblet cell-like properties and express higher levels of goblet cell markers than classical adenocarcinoma cells. TFF3 and possibly RPS4X play essential roles in the transcriptional regulation of these molecules and the development of the mucinous adenocarcinoma mucus phenotype.
COMMUNICATIONS BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adarsh Ghosh, Richa Yadav, Shalimar, Shivanand Gamanagatti
Summary: This study evaluated the use of respiratory triggered unidirectional single-shot echo-planar imaging in diffusion imaging of the upper abdomen, and found no significant differences in diagnostic accuracy compared to routine diffusion imaging in identifying liver lesions in patients with chronic liver disease.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Wenzhao Yuan, Qiuyi Yu, Zhen Wang, Jiang Huang, Jienan Wang, Liling Long
Summary: This study conducted a meta-analysis of 13 studies and found that the mean ADC values and ADC ratios before and after neoadjuvant chemotherapy for osteosarcoma were significantly higher in good responders than in poor responders.
ACADEMIC RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Can Chen, Xi Chen, Jingting Jiang
Summary: The study aimed to determine the prognostic role of neoadjuvant radiotherapy (NRT) in patients with rectal mucinous adenocarcinoma (RMAC) using propensity-score matching (PSM). The results showed that NRT improved the survival rate of RMAC patients, particularly in stage II and III patients. This suggests that NRT has significant and positive implications for RMAC patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Melike Metin, Hasan Aydin, Mustafa Karaoglanoglu
Summary: This study aimed to evaluate the role of diffusion-weighted imaging (DWI) and contrast-enhanced MRI sequences in the differential diagnosis of RCC and oncocytoma. The results showed that ADC values and enhancement index were significantly lower in the RCC group compared to the oncocytoma group.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Silvia Tsvetkova, Katya Doykova, Anna Vasilska, Katya Sapunarova, Daniel Doykov, Vladimir Andonov, Petar Uchikov
Summary: DWI, ADC values, and ADC ratios are valuable additional techniques for distinguishing between benign and malignant breast lesions, with high sensitivity and specificity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Aritrick Chatterjee, Crystal Mercado, Roger M. Bourne, Ambereen Yousuf, Brittany Hess, Tatjana Antic, Scott Eggener, Aytekin Oto, Gregory S. Karczmar
Summary: This study validates the consistency between prostate tissue composition measured using hybrid multidimensional MRI and quantitative histologic evaluation, indicating that this technique can improve the diagnosis of prostate cancer.
Article
Oncology
Biao Li, Ketong Wu, Jiao Li, Qianyu Wu, Yue Wu, Xinhua Wang, Linghu Yu, Huabin Hu, Huaiming Wang, Wuteng Cao
Summary: This study aimed to explore the relationship between neoadjuvant mFOLFOX6 with or without preoperative radiotherapy and therapeutic efficacy in locally advanced rectal mucinous adenocarcinoma (RMAC). The results showed that the mFOLFOX6 plus radiation group had higher rates of sphincter preservation, pathological complete response, and tumor response compared to the mFOLFOX6 alone group.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenhuan Huang, Xuezhao Tu, Qi Lin, Zejuan Zhan, Ying Li, Jinkai Liu
Summary: This study aimed to retrospectively investigate whether magnetic resonance imaging (MRI) quantitative parameters can differentiate HER2 status in rectal cancer. The results showed that quantitative parameters were not able to discriminate HER2 status or evaluate treatment response in real time.
Review
Medicine, General & Internal
Yueh-Ting Tsai, Kuo-Chuan Hung, Yun-Ju Shih, Sher-Wei Lim, Cheng-Chun Yang, Yu-Ting Kuo, Jeon-Hor Chen, Ching-Chung Ko
Summary: This meta-analysis compared the preoperative apparent diffusion coefficient (ADC) values between low-grade meningiomas (LGMs) and high-grade meningiomas (HGMs). The results showed significantly lower ADC values in HGMs compared to LGMs. Additionally, ADC values could differentiate different histological types of LGMs and had correlations with Ki-67 index.
Article
Oncology
Alexey Surov, Maciej Pech, Hans-Jonas Meyer, Almir G. Bitencourt, Hiroshi Fujimoto, Gabrielle C. Baxter, Gorane Santamaria, Fiona J. Gilbert, Andreas Wienke
Summary: This study compared the ADC values between patients with pathological complete response (pCR) and those without, and found that ADC values were associated with pCR status. This finding can aid in selecting the appropriate patients for neoadjuvant chemotherapy (NAC) in clinical practice. However, further studies are needed to validate this finding due to the high overlap of ADC values in both groups.
Article
Radiology, Nuclear Medicine & Medical Imaging
Haodong Jia, Xueyan Jiang, Kaiyue Zhang, Jin Shang, Yu Zhang, Xin Fang, Fei Gao, Naiyu Li, Jiangning Dong
Summary: The study demonstrated that the nomogram model combining IVIM-DWI and radiomics features from the primary lesion of rectal adenocarcinoma is valuable in assessing non-enlarged lymph node metastasis preoperatively. This model had a better performance than other models, with a higher AUC in the training cohort, indicating its potential for clinical application.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)