Article
Ophthalmology
An-Peng Pan, Yunjing Ma, Ruilin Hu, Xuejiao Cao, Yifen Wu, Kaijing Zhou, Ruixue Tu, Xu Shao, Shihao Chen, A-Yong Yu
Summary: The effect of tear film instability on dry eye disease was assessed through simultaneous real-time analysis, measuring visual performance and tear film optical quality. Metrics based on OSI were found to be potential indicators for assessing and diagnosing DED, correlating with subjective visual performance and patient-reported symptoms. Metrics based on FVA were quantifiable indicators for evaluating visual acuity decline in DED.
Article
Medicine, General & Internal
Lydia Hui-Peng Tan, Louis Tong
Summary: Functional visual acuity is reduced in severe dry eye disease and older individuals. Severe dry eye disease significantly impacts certain aspects of quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Cem Simsek, Takashi Kojima, Murat Dogru, Mari Tanaka, Yoji Takano, Tais Wakamatsu, Osama Ibrahim, Ikuko Toda, Kazuno Negishi, Kazuo Tsubota
Summary: This study aimed to investigate the early effects of alcohol intake on tear functions and ocular surface health. The results showed that alcohol consumption led to increased tear evaporation, shortened tear film break-up time, increased blink rates, as well as signs of tear film thinning on the ocular surface. These findings highlight the impact of alcohol intake on eye health and tear film stability.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Ophthalmology
David A. Leske, Sarah R. Hatt, Suzanne M. Wernimont, Yolanda S. Castaneda, Christina S. Cheng-Patel, Laura Liebermann, Eileen E. Birch, Jonathan M. Holmes
Summary: The study evaluated the relationship between visual acuity and eye-related quality of life and functional vision in children across different eye conditions using the Pediatric Eye Questionnaire (PedEyeQ). Results showed a significant negative correlation between worse-seeing-eye VA and PedEyeQ scores, indicating that both better-seeing-eye and worse-seeing-eye VA were associated with functional vision and eye-related quality of life in children.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Physiology
Timon Ax, Bergita Ganse, Fabian N. Fries, Nora Szentmary, Cintia S. de Paiva, Francesc March de Ribot, Slade O. Jensen, Berthold Seitz, Thomas J. Millar
Summary: Long-duration spaceflight can negatively impact human health, with dry eye disease being one of the most common ocular conditions experienced by astronauts. The prevalence and mechanisms of DED in astronauts, as well as its potential implications for long-duration spaceflight, including the influence of environmental factors, have been reviewed. Further research is needed to understand the pathophysiology and develop countermeasures, with neurostimulation showing promise as an in-flight option.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Ophthalmology
Hiroaki Kato, Norihiko Yokoi, Akihide Watanabe, Aoi Komuro, Yukiko Sonomura, Chie Sotozono, Shigeru Kinoshita
Summary: This study revealed the relationship between the severity of lid wiper epitheliopathy (LWE) in dry eye and tear volume, tear film stability, and blink.
Review
Ophthalmology
Stefano Barabino
Summary: Advanced age is a significant risk factor for dry eye disease (DED), with different ocular surface changes occurring in young and old patients. Tailored treatment strategies are necessary for DED patients of different age groups.
Article
Medicine, Research & Experimental
Tomohiro Ogami, Hiroki Asano, Takahiro Hiraoka, Yoshiaki Yamada, Tetsuro Oshika
Summary: The study showed that diquafosol ophthalmic solution is effective and safe for soft contact lens-related dry eye, improving symptoms and contrast sensitivity without adverse events.
ADVANCES IN THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Tatsuma Kishimoto, Waka Ishida, Isana Nakajima, Ken Fukuda, Kenji Yamashiro
Summary: Dry eye disease (DED) and allergic conjunctivitis have interactions and can exacerbate each other in mice, leading to ocular surface epithelial damage and aggravated allergic signs and symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Cristian Talens-Estarelles, Maria Mecho-Garcia, Colm McAlinden, Alejandro Cervino, Santiago Garcia-Lazaro, Jose Manuel Gonzalez-Meijome
Summary: The study assesses changes in visual function, optical and tear film quality in computer users and finds that computer users experience poorer visual function and quality at the end of a working day. Dry eye symptoms, tear film quality, and visual performance are all worse in computer users compared to control subjects. Therefore, the study highlights the importance of addressing eye fatigue and visual issues caused by computer use.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Medicine, General & Internal
Shu-Wen Chang, Wan-Lin Wu
Summary: The contribution of tear components to dry-eye symptoms/signs remains unclear. This study categorized patients into four types based on their Schirmer scores and lipid layer thickness (LLT). It found that lipid deficiency and aqueous deficiency were present in a significant proportion of patients, with a majority of lipid-deficient patients also having aqueous deficiency. The mixed type of patients had the highest symptom scores, shortest tear breakup time (FTBUT), and higher blink rates. Regression analysis showed that LLT and Schirmer score were significant contributors to FTBUT in all types. This study highlights the importance of subtyping dry eye based on aqueous and lipid components.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Wei Fang, Zhong-Xi Lin, Hui-Qing Yang, Lei Zhao, Da-Chuan Liu, Zhi-Qiang Pan
Summary: The morphology and function of the corneal nerve changed in patients with dry eyes or diabetes, but the corneal nerve closed-loop function decreased only in patients with both dry eyes and diabetes.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Medicine, General & Internal
Yan Shen, Jiajia Wang, Xingtao Zhou, Zhiqiang Yu, Jiaxu Hong, Qihua Le
Summary: This study aimed to investigate the impact of dry eye disease (DED) on uncorrected distance visual acuity (UDVA) and refractive status after small incision lenticule extraction (SMILE). The results showed that compared to the non-DED group, subjects in the DED group had better improvements in UDVA after SMILE. Age, contact lens daily wearing time, and tear meniscus height before surgery were identified as key factors in predicting UDVA after SMILE in contact lens wearers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Ian J. Saldanha, Rebecca Petris, Matthew Makara, Prabjot Channa, Esen K. Akpek
Summary: Among adult individuals with dry eye, the impact of the COVID-19 pandemic on dry eye-related visual function, reading efficiency, and dry eye treatments used was assessed. The pandemic-related eye strain may be affecting symptoms, performance, and ultimately employment, especially for those with moderate dry eye. Screen/reading time generally doubled during the pandemic, and a considerable proportion of respondents noted reduced work-related efficiency.
Article
Chemistry, Multidisciplinary
Deborah Lee, Seoyoon Song, Geonho Cho, Lucia C. Dalle Ore, Noah Malmstadt, Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon
Summary: This study reveals the important role of lysozyme in tear film lipid layer functionality, improving ocular health through increased tear evaporation and resistance to bacterial invasion.