Article
Veterinary Sciences
Francesca Corsi, Kevin Arteaga, Flavia Corsi, Marco Masi, Alexia Cattaneo, Paolo Selleri, Manuela Crasta, Claudio Peruccio, Adolfo Guandalini
Summary: This study provides normative data for tear film examination in healthy Holland Lop rabbits, showing associations between tear osmolarity and interferometry grades with age and sex.
BMC VETERINARY RESEARCH
(2022)
Article
Medicine, General & Internal
Swati Singh, Saumya Srivastav, Ashik Mohamed, Sayan Basu
Summary: This study investigated age- and sex-related differences in tear film parameters of a normal Indian population and examined their interparametric relationships. The findings suggest that tear meniscus height is minimally affected by age and independent of sex, non-invasive tear breakup time, and tear osmolarity. Tear breakup time and osmolarity show no significant age- and sex-related variation.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Sunil Shah, Debarun Dutta, Ankur Barua, Ludger Hanneken, Shehzad A. Naroo
Summary: The study aimed to determine the effects of Tixel (R) treatment on dry eye disease. The results showed that Tixel treatment significantly improved dry eye symptoms and had no adverse events.
CONTACT LENS & ANTERIOR EYE
(2023)
Review
Endocrinology & Metabolism
Stephanie Hiu Ling Poon, Janice Jing-Chee Cheung, Kendrick Co Shih, Yau Kei Chan
Summary: Thyroid Eye Disease (TED) is an autoimmune disease that affects the eye muscles and fat around the eyes. Currently, there are no established biomarkers to differentiate TED from Graves' Disease. However, studies have shown that some biomarkers, including a combination of biomarkers and the use of MRI, have high diagnostic power for TED. Further clinical investigations are needed to determine the specificity and sensitivity of these biomarkers on a larger sample of patients.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Ophthalmology
Young Hyun Kim, Thien C. Nguyen, Meng C. Lin, Cheng-Chun J. Peng, Clayton J. Radke
Summary: Hyperosmotic tears can stimulate the cornea and cause dry eye symptoms, but the use of soft contact lenses can protect the cornea from these effects. Current measurement methods for tear osmolarity during lens wear do not accurately reflect the osmolarity of the tear film that covers the cornea. Dry eye patients can benefit from contact lenses with low salt diffusivity to reduce their tear osmolarity to normal levels.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Ophthalmology
Young Hyun Kim, Meng C. Lin, Cheng-Chun Peng, Clayton J. Radke
Summary: The study demonstrates that wearing soft contact lenses can effectively protect the cornea from localized spikes of hyperosmolarity on the pre-lens tear film, reducing resulting pain sensations. Lower salt diffusivities increase this protective effect.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Biochemistry & Molecular Biology
Jeong-Sun Han, Sung Eun Kim, Jun-Qing Jin, Na Ri Park, Ji-Young Lee, Hong Lim Kim, Seong-Beom Lee, Suk-Woo Yang, Dong-Jun Lim
Summary: This study analyzed the exosomal proteins in tear fluids (TF) from patients with Thyroid eye disease (TED) and found that specific proteins were significantly increased in TED patients compared to control subjects. Orbital fibroblasts exposed to TF exosomes from TED patients showed higher levels of inflammatory cytokine production, suggesting a potential key role of these specific proteins in TED pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Anastasios-Georgios Konstas, Konstadinos G. Boboridis, Georgios P. Athanasopoulos, Anna-Bettina Haidich, Irini C. Voudouragkaki, Eirini Pagkalidou, Andreas Katsanos, L. Jay Katz
Summary: Switching to preservative-free glaucoma medications improves ocular surface health and IOP control. The use of 0.1% cyclosporine eye drops further reverses glaucoma therapy-related ocular surface disease (GTR-OSD).
Article
Medicine, General & Internal
Paola De La Parra-Colin, Karen Palacios-Aguirre, Andrea Perez-Pria-Kasusky, Rolando Espinosa-Morales, Alberto Hidalgo-Bravo
Summary: The study found that tear meniscus osmolarity measured by TearLab (R) showed low sensitivity, low specificity, and limited agreement with the TFOS DEWS II composite reference standard for dry eye disease diagnosis in patients with rheumatoid arthritis.
Review
Ophthalmology
Hugo Pena-Verdeal, Carlos Garcia-Resua, Jacobo Garcia-Queiruga, Belen Sabucedo-Villamarin, Eva Yebra-Pimentel, Maria Jesus Giraldez
Summary: The osmolarity of tear film varies throughout the day and can be influenced by factors such as time, health condition, and environment. Clinicians should consider the diurnal variations in tear film osmolarity when making diagnoses to ensure accuracy.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Article
Endocrinology & Metabolism
Soma Farag, Claire Feeney, Vickie Lee, Sonali Nagendran, Rajni Jain, Ahmad Aziz, Rashmi Akishar, Vassiliki Bravis, Karim Meeran
Summary: This study proposes a practical service evaluation model for multidisciplinary thyroid eye disease (MDTED) pathways, focusing on key performance indicators (KPIs) that can be implemented across most TED pathways. The study conducted a retrospective data collection from three MDTED clinics in London, providing valuable insights for units utilizing TEAMeD-5 and BOPSS audit criteria. Results showed that a significant percentage of patients had normal thyroid function at first clinic attendance and at discharge, highlighting the importance of early intervention and management in thyroid eye disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Dario Romano, Valentino De Ruvo, Paolo Fogagnolo, Roberta Farci, Luca Mario Rossetti
Summary: The study aimed to evaluate the impact of glaucoma surgery on the ocular surface in patients who received trabeculectomy. The results showed that patients with successful trabeculectomy had better ocular surface parameters compared to fellow medically treated eyes, including higher Tear break-up time and lower conjunctival hyperemia and corneal staining scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Ting-Ting Shi, Ru-Xuan Zhao, Zhong Xin, Zhi-Jia Hou, Hua Wang, Rong-Rong Xie, Dong-Mei Li, Jin-Kui Yang
Summary: Graves' ophthalmopathy, a manifestation of Graves' disease, is associated with a decline in patients' quality of life. This study explores the role of exosomes and different exosomal proteins in the pathogenesis of Graves' ophthalmopathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Tianyu Dong, Zhujun Fu, Xu Wang
Summary: Thyroid associated ophthalmopathy (TAO) is a common complication of Graves' disease, affecting about one-third of pediatric patients with Graves' disease. While Teprotumumab has been approved by the FDA for the treatment of TAO, its safety and efficacy in pediatric patients remain uncertain. Additional studies and efforts are needed for further development of Teprotumumab for pediatric use.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhihui Xu, Huijing Ye, Wei Xiao, Anqi Sun, Shenglan Yang, Te Zhang, Xiaotong Sha, Huasheng Yang
Summary: The low activity of AMPK in periorbital tissue of TAO patients may be closely related to the occurrence and development of inflammation and fibrosis. Metformin exerts its anti-inflammatory and antifibrotic effects in TAO by activating AMPK, suggesting that AMPK may be a potential target for TAO therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
