期刊
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
卷 43, 期 6, 页码 646-653出版社
OXFORD UNIV PRESS
DOI: 10.1093/jjco/hyt050
关键词
helical tomotherapy; spinal metastasis; stereotactic body radiotherapy; cord dose
类别
For several decades, radiotherapy has been widely used to treat metastatic vertebral tumors. This study was designed to assess the feasibility and early clinical outcomes of high-dose radiotherapy to treat such tumors, using helical tomotherapy. Between June 2009 and December 2011, 51 sites in 36 patients were treated with high-dose radiotherapy using helical tomotherapy for vertebral metastasis. Treatment outcomes and dosimetric analyses of spinal cord were retrospectively evaluated. Median follow-up was 11.5 months (range, 634.6) for surviving patients. The median total dose and the number of fractions in the primary helical tomotherapy arm were 2700 cGy and 3 fractions, respectively. Actuarial 6-month local control rates were 85.7, and symptomatic vertebral compression fractures developed in five patients after a median of 4.2 (range, 2.95.7) months. Among 13 patients with 19 metastatic sites who showed pre-treatment impairment in neurologic function, five patients (with seven sites) in whom symptoms were mild showed improvement in neuronal function. The median pre-treatment pain visual analog scale score of 7 decreased to a median of 3 after helical tomotherapy (P 0.001) at a median of 1 month (range, 0.53.2) of follow-up. No significant morbidity developed during follow-up except for one grade 3 esophagitis. The use of helical tomotherapy to treat metastatic vertebral tumors appears to be both safe and reliable in terms of local tumor control and early pain relief. Local progression and the risk of compression fracture in patients with pre-existing spinal instability remain the principal factors of limiting improved clinical and functional outcomes. Optimal dose-fractionation schemes and appropriate patient selection are required to achieve better outcomes with high-dose radiotherapy using helical tomotherapy.
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