Article
Medicine, General & Internal
Jingsheng Cai, Fan Yang, Xun Wang
Summary: This study aims to investigate occult non-small cell lung cancer (NSCLC), an underappreciated tumor, and found that it is an aggressive tumor with poor prognosis. Surgery is the preferred treatment. More attention should be paid to this overlooked disease due to no evidence of tumor imaging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Fan Yang, Chunlan Ma, Jing Qiu, Xiaoli Feng, Kai Yang
Summary: This study identified 114 circRNAs that were differentially expressed in NSCLC tissue compared to paracancerous tissue levels, with 77 downregulated and 37 upregulated. CircRNA_001846 may serve as a promising diagnostic biomarker for NSCLC, associated with tumor differentiation, lymph node metastasis, and node metastasis stage.
Article
Multidisciplinary Sciences
Shawn J. Rice, Chandra P. Belani
Summary: Blood-based biomarkers, including systemic inflammation indicators and circulating factors, are associated with poor prognosis in lung cancer patients. Elevated levels of inflammation markers were found in non-small cell lung cancer (NSCLC) patients compared to small cell lung cancer (SCLC) and disease-free (DF) patients. Specific markers were identified as predictors of progression and overall survival in NSCLC patients, highlighting the potential for personalized treatment strategies.
Article
Biochemistry & Molecular Biology
Olga V. Kovaleva, Madina A. Rashidova, Daria V. Samoilova, Polina A. Podlesnaya, Rasul M. Tabiev, Valeria V. Mochalnikova, Alexei Gratchev
Summary: In this study, immune cell markers in NSCLC specimens were evaluated, with CD163 and CD206 showing prognostic value, especially in patients with squamous cell lung carcinoma and adenocarcinoma. Additionally, iNOS and CHID1 were found to be expressed in tumor cells and associated with prognosis, indicating potential as therapeutic targets in NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Medicine, General & Internal
Hollis Viray, Deepa Rangachari, Daniel B. Costa
Summary: The study reported initial data of trastuzumab deruxtecan in the treatment of lung cancers with ERBB2 mutations, including patients who had previously received ineffective ERBB2 tyrosine kinase inhibitors.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Qing Ye, Rehab Mohamed, Duaa Dakhlallah, Marieta Gencheva, Gangqing Hu, Martin C. Pearce, Siva Kumar Kolluri, Clay B. Marsh, Timothy D. Eubank, Alexey V. Ivanov, Nancy Lan Guo
Summary: This study demonstrated that high expression of ZNF71 KRAB is associated with poor survival outcomes in NSCLC patients, as well as with epithelial-to-mesenchymal transition and chemotherapy resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jacob G. Ellen, Etai Jacob, Nikos Nikolaou, Natasha Markuzon
Summary: This study presents a multimodal integration approach utilizing multiple omics data to predict NSCLC patient survival and identify patient subtypes. The results demonstrate that combining multiple modalities in survival prediction models outperforms using a single modality, with the combination of lncRNA and clinical data achieving the highest performance.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Jiehan Jiang, Zheng Jin, Yiqun Zhang, Ling Peng, Yue Zhang, Zhiruo Zhu, Yaohui Wang, De Tong, Yining Yang, Jianfei Wang, Yadong Yang, Kui Xiao
Summary: The development of immune checkpoint inhibitors has led to a revolutionary milestone in immune-oncology, but low response rates remain a major issue. This study identified TMB, PD-L1, and MATH as independent biomarkers, and demonstrated that mutational status of six immune-related pathways could predict overall survival after ICIs treatment. The pathway-model developed in this study showed promising accuracy in predicting immunotherapy efficacy, outperforming previous predictors in sensitivity and specificity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ciara Murphy, Gloria Gornes Pons, Anna Keogh, Lisa Ryan, Lorraine Mccarra, Chris Maria Jose, Shagun Kesar, Siobhan Nicholson, Gerard J. Fitzmaurice, Ronan Ryan, Vincent Young, Sinead Cuffe, Stephen P. Finn, Steven G. Gray
Summary: This study investigated the expression and potential clinical utility of JADE2 in non-small cell lung cancer (NSCLC). The results showed that JADE2 expression is significantly altered in NSCLC and high expression of JADE2 is associated with better overall survival. The study also identified associations between JADE2 expression and tumor mutational burden and immune cell infiltration, as well as potential new drugs targeting JADE2. Overall, JADE2 may have potential diagnostic, prognostic, and therapeutic implications in NSCLC.
Article
Medicine, General & Internal
John V. Heymach, David Harpole, Tetsuya Mitsudomi, Janis M. Taube, Gabriella Galffy, Maximilian Hochmair, Thomas Winder, Ruslan Zukov, Gabriel Garbaos, Shugeng Gao, Hiroaki Kuroda, Gyula Ostoros, Tho V. Tran, Jian You, Kang-Yun Lee, Lorenzo Antonuzzo, Zsolt Papai-Szekely, Hiroaki Akamatsu, Bivas Biswas, Alexander Spira, Jeffrey Crawford, Ha T. Le, Mike Aperghis, Gary J. Doherty, Helen Mann, Tamer M. Fouad, Martin Reck, AEGEAN Invest
Summary: In resectable non-small-cell lung cancer patients, perioperative durvalumab plus neoadjuvant chemotherapy showed significantly improved event-free survival and pathological complete response compared to neoadjuvant chemotherapy alone, with a similar safety profile.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Oncology
Xi Chen, Jianzhang Wu, Jiabing Wang
Summary: Pyroptosis, a distinct form of cell death, has shown potential as a therapeutic strategy and prognosis for NSCLC. However, activating pyroptosis in NSCLC treatment still poses challenges.
FRONTIERS IN ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Xianghui Yang, Liyong Deng, Min Li, Yongjie Zhou, Guihua Wang
Summary: This study evaluated the association between socioeconomic status (SES) factors and cancer-specific survival (CSS) in patients with non-small cell lung cancer (NSCLC). A novel TNM-SES staging system was proposed, which showed superior predictive value compared to the traditional TNM stage.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Kalliopi Andrikou, Tania Rossi, Alberto Verlicchi, Ilaria Priano, Paola Cravero, Marco Angelo Burgio, Lucio Crino, Sara Bandini, Paola Ulivi, Angelo Delmonte
Summary: Liquid biopsy, particularly the examination of circulating tumor cells (CTCs), has shown promise as a noninvasive method for detecting cancer-related biomarkers and monitoring treatment response in non-small cell lung cancer (NSCLC) patients. High CTC count has been correlated with poor prognosis, while a decrease in CTC count during treatment may indicate increased sensitivity to therapy. Additionally, molecular characterization of CTCs can provide valuable information on tumor biology and mechanisms of resistance to targeted treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Nathan Farrokhian, Jeff Maltas, Mina Dinh, Arda Durmaz, Patrick Ellsworth, Masahiro Hitomi, Erin McClure, Andriy Marusyk, Artem Kaznatcheev, Jacob G. Scott
Summary: In this study, the frequency-dependent interactions between a gefitinib-resistant non-small cell lung cancer population and its sensitive ancestor were measured experimentally. The cost of resistance was found to be insufficient in predicting competitive exclusion, and frequency-dependent growth rate measurements were necessary. Simulations showed that ecological growth effects can influence the predicted extinction time.
Article
Medicine, General & Internal
Heather Wakelee, Moishe Liberman, Terufumi Kato, Masahiro Tsuboi, Se-Hoon Lee, Shugeng Gao, Ke-Neng Chen, Christophe Dooms, Margarita Majem, Ekkehard Eigendorff, Gaston L. Martinengo, Olivier Bylicki, Delvys Rodriguez-Abreu, Jamie E. E. Chaft, Silvia Novello, Jing Yang, Steven M. M. Keller, Ayman Samkari, Jonathan D. D. Spicer
Summary: Among patients with resectable early-stage NSCLC, perioperative pembrolizumab improved event-free survival, major pathological response, and pathological complete response. The addition of pembrolizumab to neoadjuvant chemotherapy followed by surgery showed significant benefits compared to neoadjuvant chemotherapy alone followed by surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Keunok Jung, Jeong-Ah Kim, Ye-Jin Kim, Hyun Woo Lee, Chul-Ho Kim, Seokjin Haam, Yong-Sung Kim
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Oncology
Jin-Hyuk Choi, Yong Won Choi, Seok Yun Kang, Geum Sook Jeong, Hyun Woo Lee, Seong Hyun Jeong, Joon Seong Park, Mi Sun Ahn, Seung Soo Sheen
Article
Multidisciplinary Sciences
Bora Lee, Sang Hoon Chun, Ji Hyung Hong, In Sook Woo, Seoree Kim, Joon Won Jeong, Jae Jun Kim, Hyun Woo Lee, Sae Jung Na, Kyongmin Sarah Beck, Bomi Gil, Sungsoo Park, Ho Jung An, Yoon Ho Ko
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Jin Hyoung Kang, Jung Hye Kwon, Yun-Gyoo Lee, Keon Uk Park, Ho Jung An, Joohyuk Sohn, Young Mi Seol, Hyunwoo Lee, Hwan-Jung Yun, Jin Seok Ahn, Ji Hyun Yang, Hunho Song, Dong-Hoe Koo, Jin Young Kim, Gun Min Kim, Hwa Jung Kim
CANCER RESEARCH AND TREATMENT
(2020)
Article
Oncology
Hyun Chang, Yun-Gyoo Lee, Yoon Ho Ko, Jang Ho Cho, Jong-Kwon Choi, Keon Uk Park, Eun Joo Kang, Keun-Wook Lee, Sun Min Lim, Jin-Soo Kim, Hyun Woo Lee, Min Kyoung Kim, In Gyu Hwang, Sangwoo Kim, Byung-Ho Nam, Hye Ryun Kim
Article
Oncology
Young Wha Koh, Jae-Ho Han, Seokjin Haam, Hyun Woo Lee
Summary: The study found a correlation between immune-related gene expression signatures and the development of BM in LUAD patients after surgical resection. The 11 identified immune-related gene signatures showed promise in predicting the occurrence of BM and could potentially serve as useful indicators for personalized treatment options.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Seo Ree Kim, Ji Hyung Hong, Soo-Yoon Sung, Yeo Hyung Kim, Sang Hoon Chun, Hyun Woo Lee, Jung Soo Lee, Yoon Ho Ko
Summary: In the Korean population, the effects of EP-CCRT on OS and TFST are significantly more favorable than those of IP-CCRT. Dual-agent chemotherapy provides a better survival benefit than single-agent chemotherapy when CCRT fails. IP-based chemotherapy leads to better OS in platinum-resistant relapsed patients, while the opposite is observed for platinum-sensitive relapsed patients.
Article
Oncology
Tae-Hwan Kim, Hun Do Cho, Yong Won Choi, Hyun Woo Lee, Seok Yun Kang, Geum Sook Jeong, Jin-Hyuk Choi, Mi Sun Ahn, Seung-Soo Sheen
Summary: The study analyzed real-world data of patients with HER2-positive RPMGC treated with trastuzumab-based chemotherapy in a single center. The outcomes were comparable to the ToGA trial, and conversion surgery could be considered for suitable patients after a favorable response to chemotherapy.
Article
Oncology
Jung Soo Lee, Seoree Kim, Soo-Yoon Sung, Yeo Hyung Kim, Hyun Woo Lee, Ji Hyung Hong, Yoon Ho Ko
Summary: A large-scale cohort study in Korea found that irinotecan-based platinum chemotherapy showed significantly better overall survival and time to first subsequent therapy compared to etoposide-based platinum chemotherapy for extensive-disease small cell lung cancer (ED-SCLC).
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Seokjin Haam, Jae-Ho Han, Hyun Woo Lee, Young Wha Koh
Summary: This study identified a 17-gene expression signature related to tumor nonimmune microenvironment that could predict brain metastasis in lung adenocarcinoma after surgical resection. This signature, with 11 genes associated with extracellular matrix remodeling, showed high predictive power in four machine learning classifiers, especially in early-stage lung adenocarcinoma. Immunohistochemical expression of these genes corresponded with NanoString tests, indicating their potential as biological markers for predicting brain metastasis.
Article
Psychology, Multidisciplinary
Juho Park, Jun-Phil Uhm, Sanghoon Kim, Minjung Kim, Shintaro Sato, Hyun-Woo Lee
Summary: Sport community involvement can positively influence life satisfaction, especially during a pandemic. Fans can maintain resilience and acquire positive psychological resources through community involvement. Lowering stress levels is crucial for the positive impact of community involvement. These findings have implications for better management strategies and future research.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Hye Eun Byeon, Seokjin Haam, Jae Ho Han, Hyun Woo Lee, Young Wha Koh
Summary: Monoclonal antibodies targeting PD-1 and PD-L1 have shown improved clinical response and survival in NSCLC. The intrinsic gene signature of lung adenocarcinoma (LUAD) is a good predictive biomarker for responsiveness to PD-1 inhibitors. The intrinsic gene signature in LUAD is also correlated with other immune checkpoint targets.
Article
Immunology
Young Wha Koh, Bumhee Park, Se Hee Jung, Jae-Ho Han, Seokjin Haam, Hyun Woo Lee
Summary: We investigated the distribution of immune cell types and the response to PD-1/PD-L1 inhibitors according to EGFR mutation profile in lung adenocarcinoma. The results showed that EGFR wild-type carcinomas had higher numbers of certain immune cells compared to EGFR mutant carcinomas, and EGFR rare variants were predicted to have a better response to PD-1/PD-L1 inhibitors. Therefore, EGFR rare mutation form could be a potential target for PD-1/PD-L1 inhibitor therapy in lung adenocarcinoma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Psychology, Social
Hyun-Woo Lee, Kun Chang, Jun-Phil Uhm, Emmaculate Owiro
Summary: This study investigated the effects of avatar identification, social engagement, and avatar customization on users' enjoyment of the metaverse. The results showed that social engagement mediated the relationship between avatar identification and enjoyment, and the degree of avatar customization moderated this relationship.
CYBERPSYCHOLOGY BEHAVIOR AND SOCIAL NETWORKING
(2023)
Article
Oncology
Seung Tae Kim, Sung Yong Oh, Jeeyun Lee, Jung Hun Kang, Hyun Woo Lee, Myung Ah Lee, Byeong Seok Sohn, Ji Hyong Hong, Young Suk Park, Joon Oh Park, Ho Yeong Lim